Gene info: ID 333

Gene: APLP1

GENE ID: 333

Synonyms: APLP

Description: amyloid beta precursor like protein 1

Gene type: protein-coding

Location: 19q13.12

dbXrefs: Ensembl:ENSG00000105290 MIM:104775 Vega:OTTHUMG00000180692 UniprotKB:P51693

RefSeq: NC_000019.10

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.247e-1 (AD) 5.859e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MAP7D1	0.942
ARL8A	0.941
ROGDI	0.934
IGSF8	0.926
APBB1	0.921
RNF220	0.92
ANAPC5	0.916
IPO13	0.913
TBC1D10B	0.911
C12orf76	0.909

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.732
OR4F29	-0.726
SIX1	-0.368
GJB2	-0.356
KCNJ15	-0.354
IL18RAP	-0.351
FOXL1	-0.349
TFPI2	-0.337
CXCR2	-0.337
CLEC12A	-0.33

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01593	Zinc	Small Molecule	7440-66-6	Approved\|Investigational	Target
DB09130	Copper	Small Molecule	7440-50-8	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of APLP1 mRNA"	21394737
C585004	2-monochloropropanediol	2-monochloropropanediol results in decreased expression of APLP1 mRNA	28522335
D000082	Acetaminophen	Acetaminophen results in increased expression of APLP1 mRNA	22230336
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of APLP1 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of APLP1 mRNA	21632981
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in increased expression of APLP1 mRNA	21298039
D001151	Arsenic	Arsenic affects the methylation of APLP1 gene	25304211
D001280	Atrazine	Atrazine results in increased expression of APLP1 mRNA	22378314
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of APLP1 mRNA	20106945\|2163298
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of APLP1 mRNA	22228805
D004958	Estradiol	Estradiol results in increased expression of APLP1 mRNA	22467019
C006780	bisphenol A	bisphenol A results in decreased expression of APLP1 mRNA	23557687
C006780	bisphenol A	bisphenol A affects the expression of APLP1 mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of APLP1 mRNA	25181051
D003300	Copper	APLP1 protein binds to Copper	24855651
D003300	Copper	Copper affects the localization of APLP1 protein	24855651
D003300	Copper	Copper results in increased expression of APLP1 mRNA	16629173
D016572	Cyclosporine	Cyclosporine results in decreased expression of APLP1 mRNA	27989131
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of APLP1 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of APLP1 mRNA	27392435
D004026	Dieldrin	Dieldrin affects the expression of APLP1 mRNA	22546817
C014476	diethyl maleate	diethyl maleate results in decreased expression of APLP1 mRNA	25270620
D004492	Edetic Acid	Edetic Acid inhibits the reaction [Zinc affects the localization of APLP1 protein]	24855651
C044101	endotoxin, Escherichia coli	"endotoxin, Escherichia coli results in increased expression of APLP1 mRNA"	15919760
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of APLP1 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of APLP1 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of APLP1 mRNA	17942748
D005047	Etoposide	Etoposide results in decreased expression of APLP1 mRNA	25270620
D006534	Heptachlor Epoxide	Heptachlor Epoxide results in increased expression of APLP1 mRNA	25270620
C029424	hydrazine	hydrazine results in decreased expression of APLP1 mRNA	15282401
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of APLP1 mRNA	27392435
D007657	Ketone Bodies	Ketone Bodies results in increased expression of APLP1 mRNA	16807920
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of APLP1 mRNA	15919760
D008345	Manganese	Manganese results in increased expression of APLP1 mRNA	18284614\|2018875
D008345	Manganese	Manganese results in increased expression of APLP1 protein	18284614\|2018875
D008727	Methotrexate	Methotrexate affects the expression of APLP1 mRNA	18502557
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of APLP1 mRNA	28001369
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of APLP1 mRNA"	20188158
C119536	nickel acetate	NFE2L2 protein inhibits the reaction [nickel acetate results in increased expression of APLP1 mRNA]	23023193
C119536	nickel acetate	nickel acetate results in decreased expression of APLP1 mRNA	23023193
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of APLP1 mRNA"	21673326
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of APLP1 mRNA]"	21673326
D010862	Pilocarpine	Pilocarpine results in decreased expression of APLP1 mRNA	19448684
C006253	pirinixic acid	pirinixic acid results in decreased expression of APLP1 mRNA	17426115
C006253	pirinixic acid	pirinixic acid results in increased expression of APLP1 mRNA	23811191
D011794	Quercetin	Quercetin results in increased expression of APLP1 mRNA	21632981
D012524	Sarin	Sarin results in increased expression of APLP1 mRNA	19522546
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of APLP1 mRNA	25895662
D013629	Tamoxifen	Tamoxifen affects the expression of APLP1 mRNA	17555576
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of APLP1 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of APLP1 mRNA	17942748
D013853	Thioacetamide	Thioacetamide results in increased expression of APLP1 mRNA	23411599
C009495	titanium dioxide	titanium dioxide results in decreased expression of APLP1 mRNA	23557971
D014212	Tretinoin	BDNF protein inhibits the reaction [Tretinoin results in increased N-linked glycosylation of APLP1 protein]	16150056
D014212	Tretinoin	Tretinoin results in increased expression of APLP1 protein	16150056
D014212	Tretinoin	Tretinoin results in increased N-linked glycosylation of APLP1 protein	16150056
C012589	trichostatin A	trichostatin A results in decreased expression of APLP1 mRNA	15901671
D014635	Valproic Acid	Valproic Acid results in decreased expression of APLP1 mRNA	15901671
D014635	Valproic Acid	Valproic Acid affects the expression of APLP1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of APLP1 mRNA	23179753\|2915479
C025643	vinclozolin	vinclozolin results in decreased expression of APLP1 mRNA	23034163
D015032	Zinc	APLP1 protein binds to Zinc	24855651
D015032	Zinc	Edetic Acid inhibits the reaction [Zinc affects the localization of APLP1 protein]	24855651
D015032	Zinc	Zinc affects the localization of APLP1 protein	24855651
D015032	Zinc	Zinc promotes the reaction [APLP1 protein binds to APLP1 protein]	24855651
D015032	Zinc	Zinc promotes the reaction [APLP1 protein binds to APLP2 protein]	24855651
D015032	Zinc	Zinc promotes the reaction [APP protein binds to APLP1 protein]	24855651

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	16169070 16193067 21293490
GO:0008201	heparin binding	-	IEA	-
GO:0031694	alpha-2A adrenergic receptor binding	-	IPI	16531006
GO:0031695	alpha-2B adrenergic receptor binding	-	IPI	16531006
GO:0031696	alpha-2C adrenergic receptor binding	-	IPI	16531006
GO:0042802	identical protein binding	-	IPI	16193067 21930949
GO:0046914	transition metal ion binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006897	endocytosis	-	IEA	-
GO:0006915	apoptotic process	-	IEA	-
GO:0007155	cell adhesion	-	IEA	-
GO:0007399	nervous system development	-	TAS	9521588
GO:0009887	animal organ morphogenesis	-	TAS	9521588
GO:0071874	cellular response to norepinephrine stimulus	-	IDA	16531006
GO:0106072	negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway	-	IDA	16531006

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005604	basement membrane	-	TAS	9521588
GO:0005886	plasma membrane	-	IDA	16531006
GO:0016021	integral component of membrane	-	IEA	-
GO:0048471	perinuclear region of cytoplasm	-	IDA	16531006

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26581503	Systems genetics of intravenous cocaine self-administration in the BXD recombinant inbred mouse panel. (2016 Feb)	Dickson PE	Psychopharmacology (Berl)