Gene info: ID 3337

Gene: DNAJB1

GENE ID: 3337

Synonyms: HSPF1|Hdj1|Hsp40|RSPH16B|Sis1

Description: DnaJ heat shock protein family (Hsp40) member B1

Gene type: protein-coding

Location: 19p13.12

dbXrefs: Ensembl:ENSG00000132002 MIM:604572 Vega:OTTHUMG00000183289 UniprotKB:P25685

RefSeq: NC_000019.10

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.331e-1 (AD) 6.949e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg12138514	chr19:14625610	DNAJB1	3'UTR	3.628e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HSPA1B	0.954
HSPA1A	0.946
SERPINH1	0.895
HSPA6	0.878
HSPB1	0.874
HSPD1	0.837
MKNK2	0.804
DNAJB4	0.803
BAG3	0.788
G0S2	0.782

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MAP10	-0.346
OR4F29	-0.335
OR4F5	-0.325
ZNF223	-0.293
NUDT18	-0.291
SCGB2B2	-0.291
STARD6	-0.288
ZNF449	-0.286
TMEM86A	-0.283
KIF20B	-0.282

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in decreased expression of DNAJB1 mRNA"	26377693
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of DNAJB1 mRNA"	21346803
C012796	2-butenal	2-butenal results in increased expression of DNAJB1 mRNA	20471460
C026137	3-hydroxyacetanilide	3-hydroxyacetanilide results in decreased expression of DNAJB1 mRNA	18544908
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNAJB1 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNAJB1 mRNA"	27188386
C517041	(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of DNAJB1 mRNA"	19561079
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of DNAJB1 mRNA"	21346803
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNAJB1 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNAJB1 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of DNAJB1 mRNA	21420995\|2223033
D000082	Acetaminophen	Acetaminophen affects the expression of DNAJB1 mRNA	15606129\|1756273
D000082	Acetaminophen	Acetaminophen results in increased expression of DNAJB1 mRNA	11264010\|1254078
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of DNAJB1 mRNA	17585979
D000082	Acetaminophen	"O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Acetaminophen results in increased expression of DNAJB1 mRNA]"	12540782
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DNAJB1 mRNA]	17585979
D000082	Acetaminophen	Acetaminophen affects the expression of DNAJB1 mRNA	18246545
D000082	Acetaminophen	Acetaminophen results in increased expression of DNAJB1 mRNA	17202762\|1824654
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [elesclomol results in increased expression of DNAJB1 mRNA]	18723479
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of DNAJB1 gene	27153756
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in increased expression of DNAJB1 mRNA"	23195993
D015766	Albendazole	[Ivermectin co-treated with Albendazole] results in increased expression of DNAJB1 mRNA	16861626
C006632	arsenic trioxide	arsenic trioxide results in increased expression of DNAJB1 mRNA	19417148\|2045855
C006632	arsenic trioxide	arsenic trioxide results in increased expression of DNAJB1 protein	20724260
C006632	arsenic trioxide	KNK 437 inhibits the reaction [arsenic trioxide results in increased expression of DNAJB1 protein]	20724260
D017638	Asbestos, Crocidolite	"Asbestos, Crocidolite results in increased expression of DNAJB1 mRNA"	25351596
C547126	AZM551248	AZM551248 results in decreased expression of DNAJB1 mRNA	22323515
C028559	bathocuproine sulfonate	[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of DNAJB1 mRNA	15477007
C487081	belinostat	belinostat results in increased expression of DNAJB1 mRNA	19606018
C030935	benz(a)anthracene	benz(a)anthracene results in decreased expression of DNAJB1 mRNA	26377693
D001554	Benzene	Benzene results in decreased expression of DNAJB1 mRNA	19162166
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in decreased expression of DNAJB1 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene metabolite results in increased expression of DNAJB1 mRNA	24356939
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of DNAJB1 mRNA	24356939
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of DNAJB1 mRNA	19770486\|2156981
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of DNAJB1 mRNA	25566086
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of DNAJB1 protein	15525353
D004958	Estradiol	Estradiol results in increased expression of DNAJB1 mRNA	20106945
C044887	beta-methylcholine	beta-methylcholine affects the expression of DNAJB1 mRNA	21179406
D001663	Bilirubin	Bilirubin affects the expression of DNAJB1 mRNA	20196124
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of DNAJB1 mRNA	28628672
C006780	bisphenol A	bisphenol A affects the expression of DNAJB1 mRNA	25181051
D000069286	Bortezomib	Bortezomib results in increased expression of DNAJB1 mRNA	15509775
D002065	Buspirone	Buspirone results in increased expression of DNAJB1 mRNA	24136188
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of DNAJB1 mRNA	15336504
C584509	C646 compound	C646 compound results in decreased expression of DNAJB1 mRNA	26191083
D002104	Cadmium	Cadmium results in increased expression of DNAJB1 mRNA	11985888
D002104	Cadmium	Cadmium results in increased expression of DNAJB1 mRNA	16020198\|2112074
D002104	Cadmium	Cadmium results in increased expression of DNAJB1 protein	16729991
C028031	cadmium acetate	cadmium acetate results in increased expression of DNAJB1 mRNA	18155341
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of DNAJB1 mRNA	11985888
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of DNAJB1 mRNA	18804290
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of DNAJB1 mRNA	19010381\|2211074
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of DNAJB1 protein	16729991
C037123	cadmium sulfate	cadmium sulfate results in increased expression of DNAJB1 mRNA	12064557
D002220	Carbamazepine	Carbamazepine affects the expression of DNAJB1 mRNA	24752500
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of DNAJB1 mRNA	25270620\|2733941
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of DNAJB1 mRNA	18346771
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of DNAJB1 mRNA	18804290
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNAJB1 mRNA"	27188386
C100187	chloropicrin	chloropicrin results in increased expression of DNAJB1 mRNA	26352163
D002737	Chloroprene	Chloroprene results in increased expression of DNAJB1 mRNA	23125180
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of DNAJB1 mRNA	20691718
D002793	Cholic Acids	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of DNAJB1 mRNA	27344345
D002793	Cholic Acids	[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of DNAJB1 mRNA	27344345
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of DNAJB1 mRNA	28472532
D002922	Ciguatoxins	Ciguatoxins affects the expression of DNAJB1 mRNA	18353800
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of DNAJB1 mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DNAJB1 mRNA]	17585979
C018021	cobaltous chloride	cobaltous chloride results in increased expression of DNAJB1 mRNA	19320972\|1937684
C018021	cobaltous chloride	cobaltous chloride results in increased expression of DNAJB1 mRNA	24386269
D003300	Copper	[Disulfiram binds to Copper] which results in decreased expression of DNAJB1 mRNA	24690739
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of DNAJB1 mRNA	20971185
D003300	Copper	[Organoselenium Compounds binds to Copper] which results in increased expression of DNAJB1 mRNA	25167922
D019327	Copper Sulfate	Copper Sulfate results in increased expression of DNAJB1 mRNA	19549813
C029892	cupric chloride	cupric chloride results in increased expression of DNAJB1 mRNA	17211630
C030973	cupric oxide	cupric oxide results in increased expression of DNAJB1 mRNA	22077320
D003520	Cyclophosphamide	Cyclophosphamide metabolite results in increased expression of DNAJB1 mRNA	24356939
D003520	Cyclophosphamide	Cyclophosphamide affects the expression of DNAJB1 mRNA	18246545
D016572	Cyclosporine	Cyclosporine results in increased expression of DNAJB1 mRNA	20106945\|2556210
C515055	darinaparsin	darinaparsin results in increased expression of DNAJB1 mRNA	19417148
D013759	Dronabinol	Dronabinol results in decreased expression of DNAJB1 mRNA	18454173
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of DNAJB1 mRNA	28628672
D003976	Diazinon	Diazinon results in increased expression of DNAJB1 mRNA	24356939
D003976	Diazinon	Diazinon results in increased methylation of DNAJB1 gene	22964155
C020735	dibutyldichlorotin	dibutyldichlorotin results in increased expression of DNAJB1 mRNA	24356939
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of DNAJB1 mRNA	21266533
D002945	Cisplatin	Cisplatin results in increased expression of DNAJB1 mRNA	27392435
D004008	Diclofenac	Diclofenac affects the expression of DNAJB1 mRNA	24752500
D004026	Dieldrin	Dieldrin results in decreased expression of DNAJB1 mRNA	28385952
D004041	Dietary Fats	Dietary Fats results in decreased expression of DNAJB1 mRNA	25016146
D004041	Dietary Fats	Dietary Fats results in increased expression of DNAJB1 mRNA	18042831
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of DNAJB1 mRNA	21318169
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of DNAJB1 mRNA	21318169
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of DNAJB1 mRNA	18691550
D004052	Diethylnitrosamine	IKBKB protein inhibits the reaction [Diethylnitrosamine results in decreased expression of DNAJB1 mRNA]	18691550
D004052	Diethylnitrosamine	[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of DNAJB1 mRNA	18253720
D004147	Dioxins	Dioxins affects the expression of DNAJB1 mRNA	20463971
D004221	Disulfiram	[Disulfiram binds to Copper] which results in decreased expression of DNAJB1 mRNA	24690739
D004237	Diuron	Diuron results in increased expression of DNAJB1 mRNA	21551480
D004317	Doxorubicin	Doxorubicin results in decreased expression of DNAJB1 mRNA	15033991
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of DNAJB1 mRNA"	23811387
C512195	elesclomol	Acetylcysteine inhibits the reaction [elesclomol results in increased expression of DNAJB1 mRNA]	18723479
C512195	elesclomol	elesclomol results in increased expression of DNAJB1 mRNA	18723479
D004642	Emodin	Emodin results in increased expression of DNAJB1 mRNA	16045814
C044101	endotoxin, Escherichia coli	"endotoxin, Escherichia coli results in increased expression of DNAJB1 mRNA"	15919760
C109476	epoxiconazole	epoxiconazole results in increased expression of DNAJB1 mRNA	29038839
D004997	Ethinyl Estradiol	[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of DNAJB1 mRNA	27344345
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of DNAJB1 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of DNAJB1 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DNAJB1 mRNA	17942748
D011345	Fenofibrate	[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of DNAJB1 mRNA	18253720
C020748	ferrous sulfate	DNAJB1 protein results in decreased susceptibility to ferrous sulfate	11359866
D005485	Flutamide	Flutamide results in increased expression of DNAJB1 mRNA	24136188
D005912	Gliotoxin	Gliotoxin results in increased expression of DNAJB1 mRNA	18346771
D006861	Hydrogen Peroxide	DNAJB1 protein results in decreased susceptibility to Hydrogen Peroxide	11359866
C031927	hydroquinone	hydroquinone results in increased expression of DNAJB1 mRNA	15452088
C013038	hydroxyhydroquinone	hydroxyhydroquinone results in increased expression of DNAJB1 mRNA	17572062
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of DNAJB1 mRNA	28628672
D007213	Indomethacin	Indomethacin results in increased expression of DNAJB1 mRNA	18299717
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of DNAJB1 mRNA	28628672
D007559	Ivermectin	[Ivermectin co-treated with Albendazole] results in increased expression of DNAJB1 mRNA	16861626
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of DNAJB1 mRNA	23086925
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of DNAJB1 mRNA	27432991
C410337	K 7174	K 7174 results in increased expression of DNAJB1 mRNA	24086573
C410027	KNK 437	KNK 437 inhibits the reaction [arsenic trioxide results in increased expression of DNAJB1 protein]	20724260
C008261	lead acetate	lead acetate results in increased expression of DNAJB1 mRNA	21829687
C045463	leflunomide	leflunomide affects the expression of DNAJB1 mRNA	28988120
C045463	leflunomide	leflunomide results in increased expression of DNAJB1 mRNA	24136188
C052901	lemongrass oil	lemongrass oil affects the expression of DNAJB1 mRNA	25976427
C052901	lemongrass oil	lemongrass oil results in increased expression of DNAJB1 mRNA	25660481
C018584	linalool	linalool results in increased expression of DNAJB1 mRNA	20536181
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of DNAJB1 mRNA"	18346771
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of DNAJB1 mRNA	15919760
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DNAJB1 mRNA"	27188386
D008694	Methamphetamine	[Methamphetamine co-treated with SCH 23390] results in increased expression of DNAJB1 mRNA	19564919
D008694	Methamphetamine	Methamphetamine results in increased expression of DNAJB1 mRNA	19564919
D008694	Methamphetamine	SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of DNAJB1 mRNA]	19564919
D008727	Methotrexate	Methotrexate affects the expression of DNAJB1 mRNA	18502557
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of DNAJB1 mRNA	24356939\|2800136
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of DNAJB1 mRNA	23649840
D015655	1-Methyl-4-phenylpyridinium	DNAJB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SNCA mRNA]	16678164
D015655	1-Methyl-4-phenylpyridinium	DNAJB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SNCA protein]	16678164
C016599	mono-(2-ethylhexyl)phthalate	mono-(2-ethylhexyl)phthalate results in increased expression of DNAJB1 mRNA	24356939
C437683	motexafin gadolinium	motexafin gadolinium inhibits the reaction [Zinc Acetate results in decreased expression of DNAJB1 mRNA]	16357179
C437683	motexafin gadolinium	motexafin gadolinium results in increased expression of DNAJB1 mRNA	16357179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of DNAJB1 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of DNAJB1 mRNA"	25554681
D009285	Naphthoquinones	Naphthoquinones results in increased expression of DNAJB1 mRNA	23811387
D015058	1-Naphthylisothiocyanate	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of DNAJB1 mRNA	27344345
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of DNAJB1 mRNA	20551477
C051752	nefazodone	nefazodone results in increased expression of DNAJB1 mRNA	24136188
D009532	Nickel	Nickel results in increased expression of DNAJB1 mRNA	23195993
C028007	nickel monoxide	nickel monoxide results in decreased expression of DNAJB1 mRNA	19167457
D009534	Niclosamide	Niclosamide results in increased expression of DNAJB1 mRNA	26452273
C012655	nimesulide	nimesulide results in increased expression of DNAJB1 mRNA	24136188
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of DNAJB1 mRNA	20971185
C107010	O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate	"O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Acetaminophen results in increased expression of DNAJB1 mRNA]"	12540782
D016566	Organoselenium Compounds	[Organoselenium Compounds binds to Copper] which results in increased expression of DNAJB1 mRNA	25167922
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of DNAJB1 mRNA	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of DNAJB1 mRNA]	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of DNAJB1 mRNA]	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	Particulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of DNAJB1 mRNA]	17655762
C472349	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine	Vehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of DNAJB1 mRNA]	17655762
D000073878	Palm Oil	Palm Oil results in increased expression of DNAJB1 mRNA	18042831
D010269	Paraquat	DNAJB1 protein results in decreased susceptibility to Paraquat	11359866
D052638	Particulate Matter	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of DNAJB1 mRNA]	17655762
D052638	Particulate Matter	Particulate Matter affects the expression of DNAJB1 mRNA	17655762
D052638	Particulate Matter	Particulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of DNAJB1 mRNA]	17655762
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of DNAJB1 mRNA	18593933
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased expression of DNAJB1 mRNA	23948077
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of DNAJB1 mRNA	25868421
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of DNAJB1 mRNA	19162173\|2131816
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of DNAJB1 mRNA	26794494
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of DNAJB1 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in decreased expression of DNAJB1 mRNA	19270015
D010634	Phenobarbital	Phenobarbital results in increased expression of DNAJB1 mRNA	19482888\|2309116
D010634	Phenobarbital	Phenobarbital results in decreased expression of DNAJB1 mRNA	19162173
D010695	Phlorhizin	Phlorhizin results in decreased expression of DNAJB1 mRNA	22538082
D010695	Phlorhizin	Phlorhizin results in increased expression of DNAJB1 mRNA	22538082
D016226	Phosphorus, Dietary	"Phosphorus, Dietary affects the expression of DNAJB1 mRNA"	17651324
C006253	pirinixic acid	pirinixic acid results in decreased expression of DNAJB1 mRNA	17426115
C006253	pirinixic acid	pirinixic acid results in increased expression of DNAJB1 mRNA	18301758\|2131816
C006253	pirinixic acid	PPARA protein affects the reaction [pirinixic acid results in increased expression of DNAJB1 mRNA]	21318169
C006253	pirinixic acid	pirinixic acid results in increased expression of DNAJB1 mRNA	19162173\|2131816
D010894	Piroxicam	Piroxicam results in decreased expression of DNAJB1 mRNA	21858171
D011374	Progesterone	Progesterone results in increased expression of DNAJB1 mRNA	18037150
D011411	Propanil	Propanil results in increased expression of DNAJB1 mRNA	24356939
C045950	propiconazole	propiconazole results in increased expression of DNAJB1 mRNA	19363144\|2127805
C015586	propiverine	propiverine affects the localization of DNAJB1 protein	29273565
C031280	pyrazole	pyrazole results in increased expression of DNAJB1 mRNA	17945193
C020972	pyrrolidine dithiocarbamic acid	[pyrrolidine dithiocarbamic acid co-treated with bathocuproine sulfonate] results in increased expression of DNAJB1 mRNA	15477007
C020972	pyrrolidine dithiocarbamic acid	pyrrolidine dithiocarbamic acid results in increased expression of DNAJB1 mRNA	15477007
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride results in increased expression of DNAJB1 mRNA	16497877
C031389	resorcinol	resorcinol results in decreased expression of DNAJB1 mRNA	22623647
C064116	S-(1,1,2,2-tetrafluoroethyl)cysteine	"S-(1,1,2,2-tetrafluoroethyl)cysteine results in increased expression of DNAJB1 mRNA"	16678137
C534628	SCH 23390	[Methamphetamine co-treated with SCH 23390] results in increased expression of DNAJB1 mRNA	19564919
C534628	SCH 23390	SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of DNAJB1 mRNA]	19564919
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of DNAJB1 mRNA	25351596
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of DNAJB1 mRNA	19073995
D012834	Silver	Silver results in increased expression of DNAJB1 mRNA	26014281\|2895954
D012835	Silver Nitrate	Silver Nitrate analog results in increased expression of DNAJB1 mRNA	22831968
D012906	Smoke	Smoke affects the expression of DNAJB1 mRNA	23693141
C017947	sodium arsenite	sodium arsenite results in increased expression of DNAJB1 mRNA	12679051\|1276083
C017947	sodium arsenite	sodium arsenite results in increased expression of DNAJB1 protein	16729991
C017947	sodium arsenite	sodium arsenite results in increased expression of DNAJB1 mRNA	16014739\|2527062
C017947	sodium arsenite	sodium arsenite results in increased expression of DNAJB1 protein	16729991
C016104	sodium bichromate	sodium bichromate results in decreased expression of DNAJB1 mRNA	12760830
D012999	Soman	Soman results in increased expression of DNAJB1 mRNA	19281266
D013629	Tamoxifen	Tamoxifen affects the expression of DNAJB1 mRNA	17555576\|2093736
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of DNAJB1 mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of DNAJB1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DNAJB1 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of DNAJB1 mRNA	21215274
D013792	Thalidomide	Thalidomide analog results in increased expression of DNAJB1 mRNA	20525221
D013849	Thimerosal	Thimerosal results in increased expression of DNAJB1 mRNA	16870260
D013853	Thioacetamide	Thioacetamide results in increased methylation of DNAJB1 promoter	27914986
C009495	titanium dioxide	titanium dioxide results in decreased expression of DNAJB1 mRNA	23557971\|2776080
C009495	titanium dioxide	titanium dioxide results in increased expression of DNAJB1 mRNA	23409001
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of DNAJB1 mRNA	22363418\|2740439
D014050	Toluene	Toluene results in decreased expression of DNAJB1 mRNA	22166486
D014050	Toluene	Toluene results in increased expression of DNAJB1 mRNA	22166486
D014212	Tretinoin	Tretinoin results in decreased expression of DNAJB1 mRNA	20117194
C012589	trichostatin A	trichostatin A results in increased expression of DNAJB1 mRNA	19606018
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of DNAJB1 mRNA"	26179874
C057693	troglitazone	troglitazone results in increased expression of DNAJB1 mRNA	28973697
D014415	Tunicamycin	Tunicamycin results in decreased expression of DNAJB1 mRNA	20196124
D014520	Urethane	Urethane results in increased expression of DNAJB1 mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in increased expression of DNAJB1 mRNA	29154799
D001335	Vehicle Emissions	oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of DNAJB1 mRNA]	17655762
D001335	Vehicle Emissions	Vehicle Emissions affects the expression of DNAJB1 mRNA	17655762
D001335	Vehicle Emissions	Vehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of DNAJB1 mRNA]	17655762
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of DNAJB1 gene	25560391
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of DNAJB1 mRNA	19465080
C025643	vinclozolin	vinclozolin affects the expression of DNAJB1 mRNA	19015723
C025643	vinclozolin	vinclozolin results in decreased expression of DNAJB1 mRNA	23034163
D014750	Vincristine	Vincristine results in decreased expression of DNAJB1 mRNA	23649840
D024483	Vitamin K 3	Vitamin K 3 affects the expression of DNAJB1 mRNA	20044591
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of DNAJB1 mRNA	18593933
D019345	Zinc Acetate	motexafin gadolinium inhibits the reaction [Zinc Acetate results in decreased expression of DNAJB1 mRNA]	16357179
D019345	Zinc Acetate	Zinc Acetate results in decreased expression of DNAJB1 mRNA	16357179

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001671	ATPase activator activity	-	IDA	20060297 23921388 24318877
GO:0001671	ATPase activator activity	-	TAS	-
GO:0003714	transcription corepressor activity	-	IDA	9499401
GO:0005515	protein binding	-	IPI	9499401 17024176 21044950 23921388 25036637 27120771 27173435
GO:0030544	Hsp70 protein binding	-	IBA	21873635
GO:0030544	Hsp70 protein binding	-	IPI	23921388
GO:0045296	cadherin binding	-	HDA	25468996
GO:0051082	unfolded protein binding	-	IBA	21873635
GO:0051082	unfolded protein binding	-	IDA	21231916
GO:0051087	chaperone binding	-	IBA	21873635
GO:0051087	chaperone binding	-	IPI	21231916
GO:0051117	ATPase binding	-	IPI	23921388

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0006986	response to unfolded protein	-	TAS	8975727
GO:0030900	forebrain development	-	IEA	-
GO:0032781	positive regulation of ATPase activity	-	IDA	23921388
GO:0051085	chaperone cofactor-dependent protein refolding	-	IBA	21873635
GO:0051085	chaperone cofactor-dependent protein refolding	-	IDA	18620420
GO:0090084	negative regulation of inclusion body assembly	-	IDA	21231916
GO:0097201	negative regulation of transcription from RNA polymerase II promoter in response to stress	-	IDA	9499401
GO:1900034	regulation of cellular response to heat	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	HDA	21630459
GO:0005634	nucleus	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005730	nucleolus	-	IEA	-
GO:0005737	cytoplasm	-	IDA	25468996
GO:0005829	cytosol	-	IBA	21873635
GO:0005829	cytosol	-	IDA	21231916
GO:0005829	cytosol	-	TAS	-
GO:0043025	neuronal cell body	-	IEA	-
GO:0043197	dendritic spine	-	IEA	-
GO:0061827	sperm head	-	IEA	-
GO:0070062	extracellular exosome	-	HDA	19056867

KEGG ID	KEGG Term
hsa04141	Protein processing in endoplasmic reticulum

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-2262752	Cellular responses to stress	TAS
R-HSA-3371453	Regulation of HSF1-mediated heat shock response	TAS
R-HSA-3371497	HSP90 chaperone cycle for steroid hormone receptors (SHR)	TAS
R-HSA-3371556	Cellular response to heat stress	TAS
R-HSA-3371568	Attenuation phase	TAS
R-HSA-3371571	HSF1-dependent transactivation	TAS
R-HSA-5683057	MAPK family signaling cascades	TAS
R-HSA-5687128	MAPK6/MAPK4 signaling	TAS
R-HSA-8953897	Cellular responses to external stimuli	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29574730	Cigarette smoke modifies neutrophil chemotaxis, neutrophil extracellular trap formation and inflammatory response-related gene expression. (2018 Mar 25)	White PC	J Periodontal Res