Gene: APLP2

334
APLP-2|APPH|APPL2|CDEBP
amyloid beta precursor like protein 2
protein-coding
11q24.3
Ensembl:ENSG00000084234 MIM:104776 Vega:OTTHUMG00000165767 UniprotKB:Q06481
NG_029770.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.570e-1 (AD)  5.392e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg01738638chr11:129938601APLP24.580e-9Maternal smoking in pregnancy27040690
cg01738638chr11:129938601APLP27.250e-8Maternal smoking in pregnancy27040690
cg14219124chr11:129992297APLP22.780e-8Smoking28686328

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PKM0.966
CS0.965
AP2B10.965
EIF4H0.962
PSAP0.96
PSMD20.959
GHITM0.958
UQCRC20.956
PITPNA0.954
ARF30.953

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.834
OR4F29-0.8
MTRNR2L6-0.297
MTRNR2L9-0.284
SH2D1A-0.28
MTRNR2L10-0.271
CTNNA3-0.255
TNFRSF13B-0.244
KLRB1-0.24
KLF17-0.238

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of APLP2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of APLP2 mRNA"21346803
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of APLP2 mRNA"20206263
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of APLP2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APLP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APLP2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of APLP2 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of APLP2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 affects the expression of APLP2 mRNA19770486
C068073Am 580Am 580 results in increased expression of APLP2 mRNA16982809
D006710HomocysteineHomocysteine results in decreased expression of APLP2 mRNA17326132
D000643Ammonium ChlorideAmmonium Chloride affects the expression of APLP2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of APLP2 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of APLP2 mRNA27829220
C006632arsenic trioxide[Tretinoin co-treated with arsenic trioxide] results in increased expression of APLP2 mRNA15894607
D001280AtrazineAtrazine results in decreased expression of APLP2 mRNA25929836
D001280AtrazineAtrazine results in increased expression of APLP2 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of APLP2 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of APLP2 mRNA"20018196
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of APLP2 mRNA"19150397
D004958EstradiolEstradiol results in decreased expression of APLP2 mRNA16705744
D001622BetaineBetaine inhibits the reaction [Copper deficiency affects the expression of APLP2 protein]25150618
C095105bexarotenebexarotene results in increased expression of APLP2 mRNA16648578
C006780bisphenol Abisphenol A results in increased expression of APLP2 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of APLP2 mRNA15336504
C584509C646 compoundC646 compound results in decreased expression of APLP2 mRNA26191083
D002104CadmiumCadmium results in decreased expression of APLP2 mRNA23369406
D002220CarbamazepineCarbamazepine affects the expression of APLP2 mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of APLP2 mRNA17484886
D003300CopperBetaine inhibits the reaction [Copper deficiency affects the expression of APLP2 protein]25150618
D003300CopperCopper deficiency affects the expression of APLP2 protein25150618
D003300CopperAPLP2 protein binds to and results in increased susceptibility to Copper11784781
D003300CopperAPLP2 protein binds to Copper17396163|2485565
D003300CopperCopper affects the localization of APLP2 protein24855651
D003300Copper[APLP2 protein co-treated with Copper] results in decreased degradation of GPC1 protein modified form15677459
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of APLP2 mRNA15467011
D016572CyclosporineCyclosporine results in decreased expression of APLP2 mRNA19770486
C014347decitabinedecitabine affects the methylation of APLP2 gene17630775
C014347decitabinedecitabine results in increased expression of APLP2 mRNA17908484
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of APLP2 mRNA]27941970
D003976DiazinonDiazinon results in increased methylation of APLP2 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of APLP2 mRNA21266533
D002945CisplatinCisplatin inhibits the reaction [Piroxicam results in decreased expression of APLP2 mRNA]21858171
D004492Edetic AcidEdetic Acid inhibits the reaction [Zinc affects the localization of APLP2 protein]24855651
D005419FlavonoidsFlavonoids results in decreased expression of APLP2 mRNA18035473
D019833GenisteinESR1 promotes the reaction [Genistein results in decreased expression of APLP2 protein]20884965
D019833GenisteinGenistein results in decreased expression of APLP2 mRNA16705744
D019833GenisteinGenistein results in decreased expression of APLP2 protein20884965
D005978GlutathioneGlutathione deficiency results in increased expression of APLP2 mRNA15345336
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of APLP2 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of APLP2 mRNA22904298|2479639
C410337K 7174K 7174 results in increased expression of APLP2 mRNA24086573
D007854LeadLead affects the expression of APLP2 mRNA28903495
D007854LeadLead affects the splicing of APLP2 mRNA28903495
D007854LeadLead results in decreased expression of APLP2 mRNA19921347
C045463leflunomideleflunomide results in increased expression of APLP2 mRNA24136188
D008746Methylazoxymethanol AcetateMethylazoxymethanol Acetate results in increased expression of APLP2 mRNA28349193
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of APLP2 mRNA23103053
C078131N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamideN-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of APLP2 protein]16279945
C078131N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamideN-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide results in decreased secretion of APLP2 protein16279945
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of APLP2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of APLP2 mRNA"25554681
C495708N-benzyloxycarbonyl-valyl-leucyl-leucinalN-benzyloxycarbonyl-valyl-leucyl-leucinal results in decreased secretion of APLP2 protein16279945
C051752nefazodonenefazodone results in decreased expression of APLP2 mRNA24136188
C012655nimesulidenimesulide results in decreased expression of APLP2 mRNA24136188
C005290oxybenzoneoxybenzone results in increased expression of APLP2 mRNA22721600
D017239PaclitaxelAPLP2 protein affects the susceptibility to Paclitaxel16217747
D010634PhenobarbitalPhenobarbital affects the expression of APLP2 mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APLP2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of APLP2 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of APLP2 mRNA16221962
C006253pirinixic acidpirinixic acid results in decreased expression of APLP2 mRNA19162173
D010894PiroxicamCisplatin inhibits the reaction [Piroxicam results in decreased expression of APLP2 mRNA]21858171
D010894PiroxicamPiroxicam results in decreased expression of APLP2 mRNA21858171
D010936Plant ExtractsPlant Extracts results in increased expression of APLP2 mRNA23557933
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of APLP2 mRNA19162173
C089730rosiglitazonerosiglitazone results in increased expression of APLP2 mRNA16982809
D012601Scopolamine HydrobromideScopolamine Hydrobromide results in increased expression of APLP2 mRNA12818353
D012643SeleniumSelenium results in increased expression of APLP2 mRNA19244175
D012834SilverSilver results in increased expression of APLP2 mRNA26551752
D012969Sodium FluorideSodium Fluoride results in increased expression of APLP2 mRNA27862939
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in increased expression of APLP2 mRNA16214533
D013739TestosteroneTestosterone results in decreased expression of APLP2 mRNA20403060
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of APLP2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of APLP2 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of APLP2 mRNA16054898
D013755Tetradecanoylphorbol AcetateN-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of APLP2 protein]16279945
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased secretion of APLP2 protein16279945
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of APLP2 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of APLP2 mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of APLP2 mRNA28065790
D014212Tretinoin[Tretinoin co-treated with arsenic trioxide] results in increased expression of APLP2 mRNA15894607
D014212TretinoinTretinoin results in increased expression of APLP2 mRNA15894607|1605412
D014212TretinoinTretinoin results in increased expression of APLP2 protein16150056|1627994
D014212TretinoinTretinoin results in increased metabolism of and results in increased secretion of APLP2 protein16150056
D014241TrichloroethyleneTrichloroethylene results in decreased expression of APLP2 mRNA19448997
C012589trichostatin Atrichostatin A affects the expression of APLP2 mRNA28542535
D014520UrethaneUrethane results in increased expression of APLP2 mRNA28818685
C406224valdecoxibvaldecoxib results in decreased expression of APLP2 mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of APLP2 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of APLP2 mRNA19101580|2317975
D014810Vitamin EVitamin E results in increased expression of APLP2 mRNA19244175
D024483Vitamin K 3Vitamin K 3 affects the expression of APLP2 mRNA20044591
D014873Water PollutantsWater Pollutants results in decreased expression of APLP2 mRNA23591932
D015032ZincAPLP2 protein binds to Zinc24855651
D015032ZincEdetic Acid inhibits the reaction [Zinc affects the localization of APLP2 protein]24855651
D015032ZincZinc affects the localization of APLP2 protein24855651
D015032ZincZinc promotes the reaction [APLP1 protein binds to APLP2 protein]24855651
D015032ZincZinc promotes the reaction [APLP2 protein binds to APLP2 protein]24855651
D015032ZincZinc promotes the reaction [APP protein binds to APLP2 protein]24855651

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-NAS7702756  
GO:0004867serine-type endopeptidase inhibitor activity-IEA-  
GO:0005515protein binding-IPI8855266  16193067  20195357  20936779  21293490  
GO:0008201heparin binding-IEA-  
GO:0042802identical protein binding-IPI16193067  
GO:0046914transition metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002576platelet degranulation-TAS-  
GO:0007186G-protein coupled receptor signaling pathway-NAS8220435  
GO:0010951negative regulation of endopeptidase activity-IEA-  
GO:0043687post-translational protein modification-TAS-  
GO:0044267cellular protein metabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA7702756  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005886plasma membrane-TAS-  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-NAS8485127  
GO:0031092platelet alpha granule membrane-TAS-  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS
R-HSA-8957275Post-translational protein phosphorylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16707114Nicotine modulates expression of amyloid precursor protein and amyloid precursor-like protein 2 in mouse brain and in SH-SY5Y neuroblastoma cells. (2006 Jun 6)Gutala RBrain Res