Gene: HTR1A

3350
5-HT-1A|5-HT1A|5HT1a|ADRB2RL1|ADRBRL1|G-21|PFMCD
5-hydroxytryptamine receptor 1A
protein-coding
5q12.3
Ensembl:ENSG00000178394 MIM:109760 Vega:OTTHUMG00000162279 UniprotKB:P08908
NG_032816.1
PubMed
ND|AD
9   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.121e-1 (AD)  1.182e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CNGB10.854
MTUS20.848
HS6ST30.829
RASGRF20.824
C1QL30.824
GRM10.823
LRRTM40.823
FBXL180.821
SYN30.82
GRM50.819

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.517
C19orf18-0.497
APOM-0.486
BCL7C-0.486
GNG11-0.471
COPZ2-0.469
SNHG18-0.467
S100A16-0.461
MYL3-0.461
SERTAD3-0.458

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00216EletriptanSmall Molecule143322-58-1Approved|InvestigationalTarget
DB00246ZiprasidoneSmall Molecule146939-27-7ApprovedTarget
DB00247MethysergideSmall Molecule361-37-5ApprovedTarget
DB00248CabergolineSmall Molecule81409-90-7ApprovedTarget
DB00268RopiniroleSmall Molecule91374-21-9Approved|InvestigationalTarget
DB00315ZolmitriptanSmall Molecule139264-17-8Approved|InvestigationalTarget
DB00321AmitriptylineSmall Molecule50-48-6ApprovedTarget
DB00334OlanzapineSmall Molecule132539-06-1Approved|InvestigationalTarget
DB00363ClozapineSmall Molecule5786-21-0ApprovedTarget
DB00408LoxapineSmall Molecule1977-10-2ApprovedTarget
DB00413PramipexoleSmall Molecule104632-26-0Approved|InvestigationalTarget
DB00458ImipramineSmall Molecule50-49-7ApprovedTarget
DB00477ChlorpromazineSmall Molecule50-53-3Approved|InvestigationalTarget
DB00490BuspironeSmall Molecule36505-84-7Approved|InvestigationalTarget
DB00540NortriptylineSmall Molecule72-69-5ApprovedTarget
DB00543AmoxapineSmall Molecule14028-44-5ApprovedTarget
DB00571PropranololSmall Molecule525-66-6Approved|InvestigationalTarget
DB00589LisurideSmall Molecule18016-80-3Approved|InvestigationalTarget
DB00656TrazodoneSmall Molecule19794-93-5Approved|InvestigationalTarget
DB00669SumatriptanSmall Molecule103628-46-2Approved|InvestigationalTarget
DB00696ErgotamineSmall Molecule113-15-5ApprovedTarget
DB00714ApomorphineSmall Molecule58-00-4Approved|InvestigationalTarget
DB00726TrimipramineSmall Molecule739-71-9ApprovedTarget
DB00734RisperidoneSmall Molecule106266-06-2Approved|InvestigationalTarget
DB00866AlprenololSmall Molecule13655-52-2Approved|WithdrawnTarget
DB00904OndansetronSmall Molecule99614-02-5ApprovedTarget
DB00952NaratriptanSmall Molecule121679-13-8Approved|InvestigationalTarget
DB00960PindololSmall Molecule13523-86-9Approved|InvestigationalTarget
DB00988DopamineSmall Molecule51-61-6ApprovedTarget
DB01142DoxepinSmall Molecule1668-19-5Approved|InvestigationalTarget
DB01149NefazodoneSmall Molecule83366-66-9Approved|WithdrawnTarget
DB01151DesipramineSmall Molecule50-47-5Approved|InvestigationalTarget
DB01186PergolideSmall Molecule66104-22-1Approved|Investigational|WithdrawnTarget
DB01200BromocriptineSmall Molecule25614-03-3Approved|InvestigationalTarget
DB01224QuetiapineSmall Molecule111974-69-7ApprovedTarget
DB01238AripiprazoleSmall Molecule129722-12-9Approved|InvestigationalTarget
DB01267PaliperidoneSmall Molecule144598-75-4ApprovedTarget
DB01359PenbutololSmall Molecule38363-40-5Approved|InvestigationalTarget
DB01392YohimbineSmall Molecule146-48-5Approved|InvestigationalTarget
DB01614AcepromazineSmall Molecule61-00-7ApprovedTarget
DB01616AlverineSmall Molecule150-59-4Approved|InvestigationalTarget
DB01618MolindoneSmall Molecule7416-34-4ApprovedTarget
DB01621PipotiazineSmall Molecule39860-99-6Approved|InvestigationalTarget
DB01622ThioproperazineSmall Molecule316-81-4ApprovedTarget
DB04829Lysergic Acid DiethylamideSmall Molecule50-37-3Illicit|Investigational|WithdrawnTarget
DB04884DapoxetineSmall Molecule119356-77-3InvestigationalTarget
DB04888BifeprunoxSmall Molecule350992-10-8InvestigationalTarget
DB04908FlibanserinSmall Molecule167933-07-5Approved|InvestigationalTarget
DB04946IloperidoneSmall Molecule133454-47-4ApprovedTarget
DB04970LesopitronSmall Molecule132449-46-8InvestigationalTarget
DB05271RotigotineSmall Molecule99755-59-6ApprovedTarget
DB05339MN-305Small Molecule-InvestigationalTarget
DB05509LI-301Small Molecule-InvestigationalTarget
DB06016CariprazineSmall Molecule839712-12-8Approved|InvestigationalTarget
DB06148MianserinSmall Molecule24219-97-4Approved|InvestigationalTarget
DB06216AsenapineSmall Molecule65576-45-6ApprovedTarget
DB06393XaliprodenSmall Molecule135354-02-8InvestigationalTarget
DB06446DotarizineSmall Molecule84625-59-2InvestigationalTarget
DB06454SarizotanSmall Molecule351862-32-3InvestigationalTarget
DB06506RepinotanSmall Molecule144980-29-0InvestigationalTarget
DB06538RobalzotanSmall Molecule169758-66-1InvestigationalTarget
DB06684VilazodoneSmall Molecule163521-12-8ApprovedTarget
DB08807BopindololSmall Molecule62658-63-3ApprovedTarget
DB08810CinitaprideSmall Molecule66564-14-5Approved|InvestigationalTarget
DB08815LurasidoneSmall Molecule367514-87-2Approved|InvestigationalTarget
DB08922PerospironeSmall Molecule150915-41-6ApprovedTarget
DB09061CannabidiolSmall Molecule13956-29-1Approved|InvestigationalTarget
DB09068VortioxetineSmall Molecule508233-74-7Approved|InvestigationalTarget
DB09128BrexpiprazoleSmall Molecule913611-97-9Approved|InvestigationalTarget
DB09167DosulepinSmall Molecule113-53-1ApprovedTarget
DB09244PirlindoleSmall Molecule60762-57-4ApprovedTarget
DB09289TianeptineSmall Molecule72797-41-2Approved|InvestigationalTarget
DB12061PardoprunoxSmall Molecule269718-84-5InvestigationalTarget
DB01049Ergoloid mesylateSmall Molecule8067-24-1ApprovedTarget
DB09304SetiptilineSmall Molecule57262-94-9ApprovedTarget
DB13025TiaprideSmall Molecule51012-32-9Approved|InvestigationalTarget
DB01221KetamineSmall Molecule6740-88-1ApprovedTarget
ID Drug Name Action PubMed
C5043171-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-((5-(4-fluorophenyl)-3-pyridinyl)methyl)piperazine"[N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to and results in decreased activity of HTR1A protein] which results in increased susceptibility to 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-((5-(4-fluorophenyl)-3-pyridinyl)methyl)piperazine"15996562
C1069731,2-benzisothiazol-3(2H)-one, 2-(4-(4-(7-chloro-2,3-dihydro-1,4-benzodioxin-5-yl)-1-piperazinyl)butyl)-, 1,1-dioxide"1,2-benzisothiazol-3(2H)-one, 2-(4-(4-(7-chloro-2,3-dihydro-1,4-benzodioxin-5-yl)-1-piperazinyl)butyl)-, 1,1-dioxide binds to and results in decreased activity of HTR1A protein"9163561
C1069731,2-benzisothiazol-3(2H)-one, 2-(4-(4-(7-chloro-2,3-dihydro-1,4-benzodioxin-5-yl)-1-piperazinyl)butyl)-, 1,1-dioxide"1,2-benzisothiazol-3(2H)-one, 2-(4-(4-(7-chloro-2,3-dihydro-1,4-benzodioxin-5-yl)-1-piperazinyl)butyl)-, 1,1-dioxide binds to and results in decreased activity of HTR1A protein"22050051
C1069731,2-benzisothiazol-3(2H)-one, 2-(4-(4-(7-chloro-2,3-dihydro-1,4-benzodioxin-5-yl)-1-piperazinyl)butyl)-, 1,1-dioxide"1,2-benzisothiazol-3(2H)-one, 2-(4-(4-(7-chloro-2,3-dihydro-1,4-benzodioxin-5-yl)-1-piperazinyl)butyl)-, 1,1-dioxide binds to HTR1A protein"12023549
C1069731,2-benzisothiazol-3(2H)-one, 2-(4-(4-(7-chloro-2,3-dihydro-1,4-benzodioxin-5-yl)-1-piperazinyl)butyl)-, 1,1-dioxide"1,2-benzisothiazol-3(2H)-one, 2-(4-(4-(7-chloro-2,3-dihydro-1,4-benzodioxin-5-yl)-1-piperazinyl)butyl)-, 1,1-dioxide binds to and results in decreased activity of HTR1A protein"22050051
C1069731,2-benzisothiazol-3(2H)-one, 2-(4-(4-(7-chloro-2,3-dihydro-1,4-benzodioxin-5-yl)-1-piperazinyl)butyl)-, 1,1-dioxide"1,2-benzisothiazol-3(2H)-one, 2-(4-(4-(7-chloro-2,3-dihydro-1,4-benzodioxin-5-yl)-1-piperazinyl)butyl)-, 1,1-dioxide binds to and affects the activity of HTR1A protein"9809859
C1069731,2-benzisothiazol-3(2H)-one, 2-(4-(4-(7-chloro-2,3-dihydro-1,4-benzodioxin-5-yl)-1-piperazinyl)butyl)-, 1,1-dioxide"1,2-benzisothiazol-3(2H)-one, 2-(4-(4-(7-chloro-2,3-dihydro-1,4-benzodioxin-5-yl)-1-piperazinyl)butyl)-, 1,1-dioxide binds to and results in decreased activity of HTR1A protein"22050051|9548383
C0588951-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine binds to and results in decreased activity of HTR1A protein9163561
C0588951-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine binds to and results in decreased activity of HTR1A protein15482641
C0588951-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine[1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine binds to and results in decreased activity of HTR1A protein] which results in decreased susceptibility to Methamphetamine15213358
C0588951-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine[1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine binds to and results in decreased activity of HTR1A protein] which results in decreased susceptibility to Serotonin16528294
C0588951-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine binds to and results in decreased activity of HTR1A protein10764922|1521335
C5074201,3,4,14b-tetrahydro-2,10-dimethyl-2H,10H-pyrazino(2,1-d)pyrrolo(1,2-b) (1,2,5)benzotriazepine"1,3,4,14b-tetrahydro-2,10-dimethyl-2H,10H-pyrazino(2,1-d)pyrrolo(1,2-b) (1,2,5)benzotriazepine analog binds to HTR1A protein"16223499
C4042071-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-3,4-dihydro-5-methoxy-2(1H)-quinolinone"1-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-3,4-dihydro-5-methoxy-2(1H)-quinolinone binds to and results in increased activity of HTR1A protein"11907181
C0150681-(3-chlorophenyl)piperazine[1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to 1-(3-chlorophenyl)piperazine8539317
C0150681-(3-chlorophenyl)piperazine[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to 1-(3-chlorophenyl)piperazine8539317
C0928241-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride[1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to 1-(3-chlorophenyl)piperazine8539317
C0928241-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride[1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine8539317
C0928241-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride[1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine8539317
C0928241-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloridetertatolol inhibits the reaction [[1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine]8539317
C0928241-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloridetertatolol inhibits the reaction [[1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine]8539317
C0928241-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein8539317
C1185591-bromopropane1-bromopropane results in decreased expression of HTR1A mRNA19576243
C010654(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane"(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane binds to and affects the activity of HTR1A protein"15482641
C010654(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane"(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane binds to HTR1A protein"2891550
C010654(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane"Chlorprothixene inhibits the reaction [(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane binds to HTR1A protein]"2891550
C5704012-(6-((3,4-dihydro-2H-chromen-2-ylmethyl)amino)hexyl)tetrahydro-1H-pyrrolo(1,2-c)imidazole-1,3(2H)-dione"2-(6-((3,4-dihydro-2H-chromen-2-ylmethyl)amino)hexyl)tetrahydro-1H-pyrrolo(1,2-c)imidazole-1,3(2H)-dione binds to and results in increased activity of HTR1A protein"22029386
C0453922-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine"2-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine binds to HTR1A protein"9723970
C480819(3-exo)-8-benzoyl-N-(((2S)7-chloro-2,3-dihydro-1,4-benzodioxin-1-yl)methyl)-8-azabicyclo(3.2.1)octane-3-methanamine monohydrochloride"(3-exo)-8-benzoyl-N-(((2S)7-chloro-2,3-dihydro-1,4-benzodioxin-1-yl)methyl)-8-azabicyclo(3.2.1)octane-3-methanamine monohydrochloride binds to and results in increased activity of HTR1A protein"12902993
C0872054-(2'-methoxyphenyl)-1-(2'-(N-(2''-pyridinyl)-4-iodobenzamido)ethyl)piperazine4-(2'-methoxyphenyl)-1-(2'-(N-(2''-pyridinyl)-4-iodobenzamido)ethyl)piperazine inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Morphine]10640309
C0872054-(2'-methoxyphenyl)-1-(2'-(N-(2''-pyridinyl)-4-iodobenzamido)ethyl)piperazine4-(2'-methoxyphenyl)-1-(2'-(N-(2''-pyridinyl)-4-iodobenzamido)ethyl)piperazine binds to and results in decreased activity of HTR1A protein10640309
C0087454,4'-bisphenol F"4,4'-bisphenol F results in decreased expression of HTR1A mRNA"26186136
C0795494-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine binds to and affects the activity of HTR1A protein9163561
C0795494-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine[4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine binds to and results in increased activity of HTR1A] which results in decreased susceptibility to Scopolamine Hydrobromide10578133
C0795494-(benzodioxan-5-yl)-1-(indan-2-yl)piperazineN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [[4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine binds to and results in increased activity of HTR1A] which results in decreased susceptibility to Scopolamine Hydrobromide]10578133
C0795494-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine binds to and results in increased activity of HTR1A protein18581099
C0470875-carboxamidotryptamine5-carboxamidotryptamine binds to and results in increased activity of HTR1A protein15482641
C0251455-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole"5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole binds to and affects the activity of HTR1A protein"9163561
C0574465-methylurapidil5-methylurapidil binds to and results in increased activity of HTR1A protein15482641
C0574465-methylurapidil5-methylurapidil binds to and results in increased activity of HTR1A protein7906241
C4345848-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine"8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine affects the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein]"11927170
C0838288-hydroxy-2-(N-n-propyl-N-(3'-iodo-2'-propenyl)amino)tetralin8-hydroxy-2-(N-n-propyl-N-(3'-iodo-2'-propenyl)amino)tetralin binds to and results in increased activity of HTR1A protein18573488
C0838288-hydroxy-2-(N-n-propyl-N-(3'-iodo-2'-propenyl)amino)tetralinHTR1A protein results in increased susceptibility to 8-hydroxy-2-(N-n-propyl-N-(3'-iodo-2'-propenyl)amino)tetralin18573488
C0838288-hydroxy-2-(N-n-propyl-N-(3'-iodo-2'-propenyl)amino)tetralinN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [HTR1A protein results in increased susceptibility to 8-hydroxy-2-(N-n-propyl-N-(3'-iodo-2'-propenyl)amino)tetralin]18573488
C095427A 86929A 86929 binds to HTR1A protein8558425
D000242Cyclic AMPArachidonic Acid metabolite inhibits the reaction [HTR1A protein inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]11356925
D000242Cyclic AMPHTR1A protein inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]11356925
D000242Cyclic AMP[JB-788 binds to and results in increased activity of HTR1A protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]20580787
D000242Cyclic AMPMelitten inhibits the reaction [HTR1A protein inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]11356925
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of HTR1A gene27153756
D000393Air PollutantsAir Pollutants analog results in increased expression of HTR1A mRNA21757418
C014959albiflorinalbiflorin affects the expression of HTR1A26475043
C050408alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanolalpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol binds to and results in increased activity of HTR1A protein19283364
C010846alverinealverine binds to HTR1A protein11697552
C439263AM 1241AM 1241 binds to HTR1A protein18931146
D000639AmitriptylineAmitriptyline results in increased expression of HTR1A protein1589591
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HTR1A mRNA16483693
D045930Anabolic AgentsAnabolic Agents results in decreased expression of HTR1A protein16914188
D001058Apomorphine[1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine8539317
D001058Apomorphine[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine8539317
D001058Apomorphinetertatolol inhibits the reaction [[1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine]8539317
D001058Apomorphinetertatolol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine]8539317
D016718Arachidonic AcidArachidonic Acid metabolite inhibits the reaction [HTR1A protein inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]11356925
D000068180AripiprazoleAripiprazole binds to and affects the activity of HTR1A protein21823597
D000068180AripiprazoleAripiprazole binds to and results in increased activity of HTR1A protein17069544
D000068180AripiprazoleAripiprazole binds to and results in increased activity of HTR1A protein15830832|1741423
D000068180AripiprazoleAripiprazole binds to HTR1A protein18363460
D001151ArsenicArsenic results in increased activity of HTR1A protein18573533
C015001arsenitearsenite results in increased methylation of HTR1A promoter23974009
D001280AtrazineAtrazine results in decreased expression of HTR1A mRNA25929836
C473959befiradolbefiradol binds to and results in increased activity of HTR1A protein12595749
D001549BenzamidesBenzamides analog binds to and results in increased activity of HTR1A protein8676355
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HTR1A mRNA19428949
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HTR1A mRNA22212102
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HTR1A mRNA21839799
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of HTR1A mRNA20823114
D004958EstradiolEstradiol promotes the reaction [PARP1 protein binds to HTR1A promoter mutant form]21990073
D004958Estradiol[Estradiol promotes the reaction [PARP1 protein binds to HTR1A promoter mutant form]] which results in decreased expression of HTR1A mRNA21990073|2199007
D004958Estradiol[Estradiol co-treated with Sertraline] affects the expression of HTR1A mRNA18650020
D004958EstradiolEstradiol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in decreased activity of HTR1A protein] which results in increased expression of OXT protein modified form]22265196
D004958EstradiolEstradiol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in decreased activity of HTR1A protein] which results in increased expression of POMC protein modified form]22265196
D004958EstradiolEstradiol results in decreased expression of HTR1A protein22265196
D004958EstradiolEstradiol results in increased expression of HTR1A mRNA22265196
D004958EstradiolGPER1 protein affects the reaction [Estradiol results in decreased expression of HTR1A protein]22265196
C509981bifeprunox[N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to and results in decreased activity of HTR1A protein] which results in increased susceptibility to bifeprunox15996562
C063249binospirone mesylatebinospirone mesylate binds to and results in increased activity of HTR1A protein15482641
C063249binospirone mesylatebinospirone mesylate binds to and affects the activity of HTR1A protein11526961
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of HTR1A mRNA26186136
C006780bisphenol Abisphenol A results in decreased methylation of HTR1A promoter27271280
C006780bisphenol Abisphenol A results in decreased methylation of HTR1A promoter27312807
C006780bisphenol Abisphenol A results in increased methylation of HTR1A promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of HTR1A mRNA25181051|2618613
C053428BMY 7378BMY 7378 binds to and results in increased activity of HTR1A protein15482641
D002065BuspironeBuspirone binds to and results in increased activity of HTR1A protein9163561
D002065BuspironeBuspirone binds to and affects the activity of HTR1A protein15482641
D002065BuspironeBuspirone binds to and results in decreased activity of HTR1A protein2207497
D002065BuspironeBuspirone binds to and results in decreased activity of HTR1A protein15899244
D002065BuspironeBuspirone binds to and results in increased activity of HTR1A protein10640309|1092107
D002065BuspironeBuspirone binds to HTR1A protein11494197
D002118CalciumCalcium results in increased activity of HTR1A protein11356925
D002220Carbamazepine[Fluoxetine co-treated with Venlafaxine Hydrochloride co-treated with Carbamazepine] results in decreased expression of HTR1A mRNA22701549
C043211carvedilolcarvedilol binds to HTR1A protein2462161
C043211carvedilolcarvedilol inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein]2462161
D002749Chlorprothixene"Chlorprothixene inhibits the reaction [(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane binds to HTR1A protein]"2891550
D004390ChlorpyrifosChlorpyrifos affects the expression of HTR1A mRNA17452286|1883540
D004390ChlorpyrifosChlorpyrifos results in increased expression of HTR1A17035140
C017133chromous chlorideHTR1A protein results in increased susceptibility to chromous chloride19211994
D002994ClofibrateClofibrate results in decreased expression of HTR1A mRNA17585979
D003024ClozapineClozapine binds to and affects the activity of HTR1A protein15482641
D003024ClozapineClozapine binds to HTR1A protein9723970
D003042CocaineCocaine inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein]9723786
D005576ColforsinArachidonic Acid metabolite inhibits the reaction [HTR1A protein inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]11356925
D005576ColforsinHTR1A protein inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]11356925
D005576Colforsin[JB-788 binds to and results in increased activity of HTR1A protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]20580787
D005576ColforsinMelitten inhibits the reaction [HTR1A protein inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]11356925
D003471CuprizoneCuprizone results in decreased expression of HTR1A mRNA26577399
D003474CurcuminCurcumin affects the expression of HTR1A mRNA17617388
D003634DDTDDT results in decreased expression of HTR1A mRNA28263910
D003891DesipramineDesipramine inhibits the reaction [IFNA1 protein results in decreased expression of HTR1A mRNA]15885359
D003891DesipramineDesipramine inhibits the reaction [IFNA1 protein results in decreased expression of HTR1A protein]15885359
D003891DesipramineDesipramine results in increased expression of HTR1A protein1589591
D003907DexamethasoneDexamethasone results in increased expression of HTR1A protein16160705
D003976DiazinonDiazinon promotes the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein]17035140
D003976DiazinonDiazinon results in increased expression of HTR1A protein17035140
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of HTR1A mRNA20823114
D004026DieldrinDieldrin results in decreased expression of HTR1A mRNA18835401
D004316DoxepinDoxepin results in increased expression of HTR1A protein1589591
C063828eltoprazineeltoprazine binds to and affects the activity of HTR1A protein9163561
C115127eptapironeeptapirone binds to and results in increased activity of HTR1A protein12398907
D000431EthanolEthanol results in increased expression of HTR1A mRNA18672336
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of HTR1A mRNA29097150
C013528etoperidoneetoperidone binds to HTR1A protein7855217
C056895flesinoxanflesinoxan binds to and results in increased activity of HTR1A protein9163561
C056895flesinoxanPindolol inhibits the reaction [flesinoxan binds to and results in increased activity of HTR1A protein]9163561
C056895flesinoxanUH 301 inhibits the reaction [flesinoxan binds to and results in increased activity of HTR1A protein]9163561
C056895flesinoxanWAY 100135 inhibits the reaction [flesinoxan binds to and results in increased activity of HTR1A protein]9163561
C056895flesinoxanflesinoxan binds to and affects the activity of HTR1A protein9809859
C056895flesinoxanflesinoxan binds to and results in increased activity of HTR1A protein9548383
C056895flesinoxanflesinoxan binds to and results in increased activity of HTR1A protein7906241
D005473FluoxetineFluoxetine results in decreased expression of HTR1A mRNA17761399
D005473FluoxetineFluoxetine inhibits the reaction [IFNA1 protein results in decreased expression of HTR1A mRNA]15885359
D005473FluoxetineFluoxetine inhibits the reaction [IFNA1 protein results in decreased expression of HTR1A protein]15885359
D005473FluoxetineHTR1A gene polymorphism results in increased susceptibility to Fluoxetine16302021
D005473FluoxetineHTR1A promoter polymorphism affects the susceptibility to Fluoxetine16458487
D005473FluoxetineHTR1A protein results in increased susceptibility to Fluoxetine16302021|1645848
D005473FluoxetineFluoxetine results in increased expression of HTR1A mRNA21083617
D005473Fluoxetine[Fluoxetine co-treated with Venlafaxine Hydrochloride co-treated with Carbamazepine] results in decreased expression of HTR1A mRNA22701549
D005473FluoxetineFluoxetine affects the expression of HTR1A26475043
D005473FluoxetineFluoxetine inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein]10665824
D005473FluoxetineFluoxetine inhibits the reaction [HTR1A protein results in increased uptake of Serotonin]11106871
D005473FluoxetineFluoxetine results in decreased expression of HTR1A mRNA10665824
D005473FluoxetineHTR1A protein results in increased susceptibility to Fluoxetine18573488
D005473FluoxetineN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [HTR1A protein results in increased susceptibility to Fluoxetine]18573488
D005473FluoxetineN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide promotes the reaction [Fluoxetine inhibits the reaction [HTR1A protein results in increased uptake of Serotonin]]11106871
C039979gepironegepirone binds to and results in increased activity of HTR1A protein11070179|1122049
C119994GR 46611GR 46611 binds to HTR1A protein15152026
D006153Guanosine DiphosphateGuanosine Diphosphate affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]21126535
D006160Guanosine TriphosphateGuanosine Triphosphate affects the reaction [Serotonin binds to HTR1A protein]21126535
D006160Guanosine TriphosphateGuanosine Triphosphate affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]21126535
D006160Guanosine TriphosphateManganese inhibits the reaction [Guanosine Triphosphate affects the reaction [Serotonin binds to HTR1A protein]]21126535
D012701SerotoninSerotonin binds to and affects the activity of HTR1A protein17202474
D012701SerotoninSerotonin results in increased expression of HTR1A mRNA21083617
D012701Serotonin[1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine binds to and results in decreased activity of HTR1A protein] which results in decreased susceptibility to Serotonin16528294
D012701Serotonin[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in increased susceptibility to Serotonin16528294
D012701SerotoninFluoxetine inhibits the reaction [HTR1A protein results in increased uptake of Serotonin]11106871
D012701SerotoninGuanosine Diphosphate affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]21126535
D012701SerotoninGuanosine Triphosphate affects the reaction [Serotonin binds to HTR1A protein]21126535
D012701SerotoninGuanosine Triphosphate affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]21126535
D012701SerotoninHTR1A protein affects the susceptibility to Serotonin16528294
D012701SerotoninHTR1A protein results in increased uptake of Serotonin11106871
D012701SerotoninMagnesium affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]21126535
D012701SerotoninManganese affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]21126535
D012701SerotoninManganese inhibits the reaction [Guanosine Triphosphate affects the reaction [Serotonin binds to HTR1A protein]]21126535
D012701SerotoninN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide promotes the reaction [Fluoxetine inhibits the reaction [HTR1A protein results in increased uptake of Serotonin]]11106871
D012701SerotoninSerotonin binds to HTR1A protein21126535
D012701SerotoninSerotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]21126535
D012701Serotonin[N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide results in decreased activity of HTR1A protein] inhibits the reaction [Serotonin results in decreased susceptibility to Pilocarpine]15140183
D017367Serotonin Uptake InhibitorsHTR1A gene polymorphism affects the susceptibility to Serotonin Uptake Inhibitors19800133
D017367Serotonin Uptake InhibitorsSerotonin Uptake Inhibitors results in decreased activity of HTR1A protein22265196
C062018HU 211HU 211 results in increased activity of HTR1A protein20438810
C062018HU 211HU 211 results in increased expression of HTR1A mRNA20438810
D007099ImipramineImipramine affects the expression of HTR1A mRNA17617388
C043077ipsapironeipsapirone binds to and results in increased activity of HTR1A protein9163561
C043077ipsapironeipsapirone binds to and results in increased activity of HTR1A protein14767715
C043077ipsapironeipsapirone binds to and results in increased activity of HTR1A protein12398907|2250574
C554161JB-788JB-788 binds to and results in increased activity of HTR1A protein20580787
C554161JB-788[JB-788 binds to and results in increased activity of HTR1A protein] inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]20580787
D008070LipopolysaccharidesHTR1A protein affects the susceptibility to Lipopolysaccharides12479973
D008152LoxapineLoxapine analog binds to HTR1A protein9723970
D008152LoxapineLoxapine binds to HTR1A protein9723970
D000069056Lurasidone HydrochlorideLurasidone Hydrochloride binds to and results in increased activity of HTR1A protein20404009
D008274MagnesiumMagnesium affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]21126535
D008345ManganeseManganese affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]21126535
D008345ManganeseManganese inhibits the reaction [Guanosine Triphosphate affects the reaction [Serotonin binds to HTR1A protein]]21126535
C085838MDL 75608AMDL 75608A binds to and results in increased activity of HTR1A protein7906241
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in increased expression of HTR1A mRNA20823114
D008555MelittenMelitten inhibits the reaction [HTR1A protein inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]11356925
C014655methamidophosmethamidophos affects the activity of HTR1A protein23596261
C014655methamidophosmethamidophos inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein]21871486
D008694MethamphetamineHTR1A gene SNP results in increased susceptibility to Methamphetamine19747927
D008694Methamphetamine[1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine binds to and results in decreased activity of HTR1A protein] which results in decreased susceptibility to Methamphetamine15213358
D008719MethiothepinMethiothepin binds to and results in decreased activity of HTR1A protein15482641
D008719MethiothepinMethiothepin binds to and results in decreased activity of HTR1A protein2207497
D003189p-Methoxy-N-methylphenethylaminep-Methoxy-N-methylphenethylamine results in increased activity of HTR1A protein16415902
C035133mirtazapinemirtazapine binds to and results in increased activity of HTR1A protein12897636|1651187
D009020Morphine4-(2'-methoxyphenyl)-1-(2'-(N-(2''-pyridinyl)-4-iodobenzamido)ethyl)piperazine inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Morphine]10640309
D009020Morphine[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Morphine10640309
C518313N-((2,2-dimethyl-2,3-dihydrobenzofuran-7-yloxy)ethyl)-3-(cyclopent-1-enyl)benzylamine"N-((2,2-dimethyl-2,3-dihydrobenzofuran-7-yloxy)ethyl)-3-(cyclopent-1-enyl)benzylamine binds to and results in increased activity of HTR1A protein"17300168
C518313N-((2,2-dimethyl-2,3-dihydrobenzofuran-7-yloxy)ethyl)-3-(cyclopent-1-enyl)benzylamine"N-((2,2-dimethyl-2,3-dihydrobenzofuran-7-yloxy)ethyl)-3-(cyclopent-1-enyl)benzylamine binds to and results in increased activity of HTR1A protein"19695244
C090413N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamideN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to and results in decreased activity of HTR1A protein9163561
C090413N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamideN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide analog binds to HTR1A protein21520940
C090413N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamideN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide analog inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein]21520940
C090413N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamideN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to and results in decreased activity of HTR1A protein15482641
C090413N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamideN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to and results in decreased activity of HTR1A protein15136721|1641508
C090413N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide[N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to and results in decreased activity of HTR1A protein] which results in increased activity of DDC protein16415089
C090413N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamideGuanosine Diphosphate affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]21126535
C090413N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamideGuanosine Triphosphate affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]21126535
C090413N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamideMagnesium affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]21126535
C090413N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamideManganese affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]21126535
C090413N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamideN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to and affects the activity of HTR1A protein9809859
C090413N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamideN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to and results in decreased activity of HTR1A protein12589378|1599656
C090413N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide"[N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to and results in decreased activity of HTR1A protein] which results in increased susceptibility to 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-((5-(4-fluorophenyl)-3-pyridinyl)methyl)piperazine"15996562
C090413N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide[N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to and results in decreased activity of HTR1A protein] which results in increased susceptibility to bifeprunox15996562
C090413N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide[N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to and results in decreased activity of HTR1A protein] which results in increased susceptibility to sarizotan15996562
C090413N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide[N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to and results in decreased activity of HTR1A protein] which results in increased susceptibility to ziprasidone15996562
C090413N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamideN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein21126535
C090413N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamideN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [[4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine binds to and results in increased activity of HTR1A] which results in decreased susceptibility to Scopolamine Hydrobromide]10578133
C090413N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamideN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [HTR1A protein results in increased susceptibility to 8-hydroxy-2-(N-n-propyl-N-(3'-iodo-2'-propenyl)amino)tetralin]18573488
C090413N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamideN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [HTR1A protein results in increased susceptibility to Fluoxetine]18573488
C090413N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamideN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [HTR1A protein results in increased susceptibility to Risperidone]17530476
C090413N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamideN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide promotes the reaction [Fluoxetine inhibits the reaction [HTR1A protein results in increased uptake of Serotonin]]11106871
C090413N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide[[Remoxipride results in decreased activity of DRD2 protein] co-treated with [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide results in decreased activity of HTR1A protein]] results in increased susceptibility to Pilocarpine15140183
C090413N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamideSerotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]21126535
C090413N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamideN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to and results in decreased activity of HTR1A protein10771018|1107017
C090413N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide[N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to and results in decreased activity of HTR1A protein] which results in decreased susceptibility to Nicotine10771018
C090413N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamideN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide results in decreased activity of HTR1A protein11220492|1514018
C090413N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide[N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide results in decreased activity of HTR1A protein] inhibits the reaction [Serotonin results in decreased susceptibility to Pilocarpine]15140183
C518644N-(4-(4-(3-aminocarbonyl-phenyl)-piperazin-1-yl)-butyl)-4-bromo-benzamideN-(4-(4-(3-aminocarbonyl-phenyl)-piperazin-1-yl)-butyl)-4-bromo-benzamide binds to HTR1A protein17170312
D000068577NebivololNebivolol binds to HTR1A protein2462161
D000068577NebivololNebivolol inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein]2462161
C051752nefazodonenefazodone binds to HTR1A protein7855217
D009538NicotineNicotine results in decreased expression of HTR1A protein21324836
D009538Nicotine[N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to and results in decreased activity of HTR1A protein] which results in decreased susceptibility to Nicotine10771018
C055895N,N-dipropylcarboxamidotryptamine"N,N-dipropylcarboxamidotryptamine binds to and results in increased activity of HTR1A protein"15482641
D009277Nandrolone[testosterone 17 beta-cypionate co-treated with Nandrolone co-treated with testosterone undecanoate] results in decreased expression of HTR1A protein16914188
C561226N-propylnoraporphin-11-yl 5-(1,2-dithiolan-3-yl)pentanoate"N-propylnoraporphin-11-yl 5-(1,2-dithiolan-3-yl)pentanoate binds to and results in increased activity of HTR1A protein"21591752
C106996NRA 0045NRA 0045 binds to HTR1A protein9223539
C025589ochratoxin Aochratoxin A results in increased expression of HTR1A mRNA27346841
D016627OxidopamineOxidopamine results in decreased expression of HTR1A mRNA18707801
D016627Oxidopaminestepholidine inhibits the reaction [Oxidopamine results in decreased expression of HTR1A mRNA]18707801
D0173718-Hydroxy-2-(di-n-propylamino)tetralin8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein9163561
D0173718-Hydroxy-2-(di-n-propylamino)tetralin8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein14767715|1548264
D0173718-Hydroxy-2-(di-n-propylamino)tetralinN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide analog inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein]21520940
D0173718-Hydroxy-2-(di-n-propylamino)tetralin8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein21871486
D0173718-Hydroxy-2-(di-n-propylamino)tetralinmethamidophos inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein]21871486
D0173718-Hydroxy-2-(di-n-propylamino)tetralin4-(2'-methoxyphenyl)-1-(2'-(N-(2''-pyridinyl)-4-iodobenzamido)ethyl)piperazine inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Morphine]10640309
D0173718-Hydroxy-2-(di-n-propylamino)tetralin"8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine affects the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein]"11927170
D0173718-Hydroxy-2-(di-n-propylamino)tetralin8-Hydroxy-2-(di-n-propylamino)tetralin binds to and affects the activity of HTR1A protein9809859
D0173718-Hydroxy-2-(di-n-propylamino)tetralin[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in decreased activity of HTR1A protein] which results in increased expression of OXT protein modified form22265196
D0173718-Hydroxy-2-(di-n-propylamino)tetralin[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in decreased activity of HTR1A protein] which results in increased expression of POMC protein modified form22265196
D0173718-Hydroxy-2-(di-n-propylamino)tetralin8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein10665824|1259122
D0173718-Hydroxy-2-(di-n-propylamino)tetralin[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to 1-(3-chlorophenyl)piperazine8539317
D0173718-Hydroxy-2-(di-n-propylamino)tetralin[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine8539317
D0173718-Hydroxy-2-(di-n-propylamino)tetralin[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Morphine10640309
D0173718-Hydroxy-2-(di-n-propylamino)tetralin[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine8539317
D0173718-Hydroxy-2-(di-n-propylamino)tetralin[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in increased susceptibility to Serotonin16528294
D0173718-Hydroxy-2-(di-n-propylamino)tetralin8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein11927170|1476771
D0173718-Hydroxy-2-(di-n-propylamino)tetralin8-Hydroxy-2-(di-n-propylamino)tetralin results in increased activity of HTR1A protein18622176
D0173718-Hydroxy-2-(di-n-propylamino)tetralin[8-Hydroxy-2-(di-n-propylamino)tetralin results in increased activity of HTR1A protein] which results in decreased susceptibility to Pilocarpine2533336
D0173718-Hydroxy-2-(di-n-propylamino)tetralinCocaine inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein]9723786
D0173718-Hydroxy-2-(di-n-propylamino)tetralinDiazinon promotes the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein]17035140
D0173718-Hydroxy-2-(di-n-propylamino)tetralinEstradiol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in decreased activity of HTR1A protein] which results in increased expression of OXT protein modified form]22265196
D0173718-Hydroxy-2-(di-n-propylamino)tetralinEstradiol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in decreased activity of HTR1A protein] which results in increased expression of POMC protein modified form]22265196
D0173718-Hydroxy-2-(di-n-propylamino)tetralinFluoxetine inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein]10665824
D0173718-Hydroxy-2-(di-n-propylamino)tetralinParathion inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein]17035140
D0173718-Hydroxy-2-(di-n-propylamino)tetralinStreptozocin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased activity of HTR1A protein]18622176
D0173718-Hydroxy-2-(di-n-propylamino)tetralintertatolol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine]8539317
D0173718-Hydroxy-2-(di-n-propylamino)tetralintertatolol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine]8539317
D0173718-Hydroxy-2-(di-n-propylamino)tetralin8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in decreased activity of HTR1A protein22265196
D0173718-Hydroxy-2-(di-n-propylamino)tetralin8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein10640309|1066990
D0173718-Hydroxy-2-(di-n-propylamino)tetralin8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein22029386|2462161
D0173718-Hydroxy-2-(di-n-propylamino)tetralin8-Hydroxy-2-(di-n-propylamino)tetralin results in increased activity of HTR1A protein2533336
D0173718-Hydroxy-2-(di-n-propylamino)tetralincarvedilol inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein]2462161
D0173718-Hydroxy-2-(di-n-propylamino)tetralinNebivolol inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein]2462161
D0173718-Hydroxy-2-(di-n-propylamino)tetralinPindolol inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein]2462161
D0173718-Hydroxy-2-(di-n-propylamino)tetralinPropranolol inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein]2462161
C096294osemozotanosemozotan binds to and results in increased activity of HTR1A protein16952156
D010278ParathionParathion affects the expression of HTR1A protein18773955
D010278ParathionParathion inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein]17035140
D010278ParathionParathion results in decreased expression of HTR1A protein17035140|1961608
D010278ParathionParathion results in increased expression of HTR1A protein19616088
C480679pardoprunoxpardoprunox binds to and results in increased activity of HTR1A protein21591752
D010703Phorbol EstersPhorbol Esters results in decreased activity of HTR1A protein11356925
D010830Physostigmine[1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine8539317
D010830Physostigmine[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine8539317
D010830Physostigminetertatolol inhibits the reaction [[1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine]8539317
D010830Physostigminetertatolol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine]8539317
C510463PiclozotanPiclozotan binds to and results in increased activity of HTR1A protein22029386
D010862Pilocarpine[8-Hydroxy-2-(di-n-propylamino)tetralin results in increased activity of HTR1A protein] which results in decreased susceptibility to Pilocarpine2533336
D010862Pilocarpine[[Remoxipride results in decreased activity of DRD2 protein] co-treated with [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide results in decreased activity of HTR1A protein]] results in increased susceptibility to Pilocarpine15140183
D010862Pilocarpine[N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide results in decreased activity of HTR1A protein] inhibits the reaction [Serotonin results in decreased susceptibility to Pilocarpine]15140183
D010869PindololPindolol inhibits the reaction [flesinoxan binds to and results in increased activity of HTR1A protein]9163561
D010869PindololPindolol binds to and affects the activity of HTR1A protein9809859
D010869PindololPindolol binds to and results in decreased activity of HTR1A protein2207497
D010869PindololPindolol binds to and results in decreased activity of HTR1A protein15542624|8386235
D010869PindololPindolol binds to HTR1A protein2462161
D010869PindololPindolol inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein]2462161
D011433PropranololPropranolol binds to HTR1A protein2462161
D011433PropranololPropranolol inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin binds to HTR1A protein]2462161
D011814QuipazineQuipazine binds to and affects the activity of HTR1A protein15482641
D017330Remoxipride[[Remoxipride results in decreased activity of DRD2 protein] co-treated with [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide results in decreased activity of HTR1A protein]] results in increased susceptibility to Pilocarpine15140183
C111221repinotan hydrochloriderepinotan hydrochloride binds to and results in increased activity of HTR1A protein20802053|2202938
D012110ReserpineReserpine results in decreased expression of HTR1A protein26114099
D018967RisperidoneHTR1A protein results in increased susceptibility to Risperidone17530476
D018967RisperidoneN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [HTR1A protein results in increased susceptibility to Risperidone]17530476
C108607robalzotanrobalzotan binds to and results in decreased activity of HTR1A protein12589378
C443959sarizotansarizotan binds to and results in increased activity of HTR1A protein14767715
C443959sarizotan[N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to and results in decreased activity of HTR1A protein] which results in increased susceptibility to sarizotan15996562
C443959sarizotansarizotan binds to HTR1A protein14767715
C443959sarizotansarizotan binds to and results in increased activity of HTR1A protein11723272|1461494
D012601Scopolamine Hydrobromide[4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine binds to and results in increased activity of HTR1A] which results in decreased susceptibility to Scopolamine Hydrobromide10578133
D012601Scopolamine HydrobromideN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide inhibits the reaction [[4-(benzodioxan-5-yl)-1-(indan-2-yl)piperazine binds to and results in increased activity of HTR1A] which results in decreased susceptibility to Scopolamine Hydrobromide]10578133
D020280Sertraline[Estradiol co-treated with Sertraline] affects the expression of HTR1A mRNA18650020
D020280SertralineSertraline results in increased expression of HTR1A mRNA18650020
C017947sodium arsenitesodium arsenite results in decreased expression of HTR1A mRNA25128769
D012999SomanSoman results in decreased expression of HTR1A mRNA19281266
D013134SpiperoneSpiperone binds to and results in decreased activity of HTR1A protein15482641
D013134SpiperoneSpiperone binds to and results in decreased activity of HTR1A protein2207497
C010513stepholidinestepholidine binds to and results in increased activity of HTR1A protein18707801
C010513stepholidinestepholidine inhibits the reaction [Oxidopamine results in decreased expression of HTR1A mRNA]18707801
D013311StreptozocinStreptozocin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased activity of HTR1A protein]18622176
D014284TriiodothyronineTriiodothyronine results in increased expression of HTR1A mRNA17403546
C055267tandospironetandospirone binds to and results in increased activity of HTR1A protein11070179|1188975
C518393technetium 99m tricarbonyl 4-((2-methoxyphenyl)piperazin-1-yl)dithioformatetechnetium 99m tricarbonyl 4-((2-methoxyphenyl)piperazin-1-yl)dithioformate binds to HTR1A protein17074495
C005632tertatololtertatolol inhibits the reaction [[1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine]8539317
C005632tertatololtertatolol inhibits the reaction [[1-((4-fluorobenzoylamino)ethyl)-4-(7-methoxy-1-naphthyl)piperazine hydrochloride binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine]8539317
C005632tertatololtertatolol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Apomorphine]8539317
C005632tertatololtertatolol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Physostigmine]8539317
C016131testosterone 17 beta-cypionate[testosterone 17 beta-cypionate co-treated with Nandrolone co-treated with testosterone undecanoate] results in decreased expression of HTR1A protein16914188
C010792testosterone undecanoate[testosterone 17 beta-cypionate co-treated with Nandrolone co-treated with testosterone undecanoate] results in decreased expression of HTR1A protein16914188
D019284ThapsigarginThapsigargin results in increased activity of HTR1A protein11356925
D013974ThyroxineThyroxine results in increased expression of HTR1A mRNA17403546
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of HTR1A protein27633979
D014196TrazodoneTrazodone binds to HTR1A protein7855217
D014196TrazodoneTrazodone results in decreased expression of HTR1A protein12127910
D014196TrazodoneTrazodone results in increased expression of HTR1A protein1589591
D014196TrazodoneTrazodone binds to HTR1A protein19711746
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of HTR1A mRNA23537331
C064282UH 301UH 301 inhibits the reaction [flesinoxan binds to and results in increased activity of HTR1A protein]9163561
C015568urapidilurapidil binds to and results in increased activity of HTR1A protein9829161
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of HTR1A gene25560391
D000069470Venlafaxine Hydrochloride[Fluoxetine co-treated with Venlafaxine Hydrochloride co-treated with Carbamazepine] results in decreased expression of HTR1A mRNA22701549
C557874vortioxetinevortioxetine binds to and results in increased activity of HTR1A protein21486038
C081293WAY 100135WAY 100135 inhibits the reaction [flesinoxan binds to and results in increased activity of HTR1A protein]9163561
C081293WAY 100135WAY 100135 binds to and results in decreased activity of HTR1A protein16047547|1858539
C081293WAY 100135WAY 100135 binds to and results in increased activity of HTR1A protein12398907
C092292ziprasidone[N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to and results in decreased activity of HTR1A protein] which results in increased susceptibility to ziprasidone15996562
C092292ziprasidoneziprasidone binds to HTR1A protein7562537

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0004993G-protein coupled serotonin receptor activity-IBA21873635  
GO:0004993G-protein coupled serotonin receptor activity-IDA8393041  
GO:0004993G-protein coupled serotonin receptor activity-IMP22957663  
GO:0005515protein binding-IPI22035699  24157794  
GO:0030594neurotransmitter receptor activity-IBA21873635  
GO:0051378serotonin binding-IBA21873635  
GO:0090722receptor-receptor interaction-IDA24157794  
GO ID GO Term Qualifier Evidence PubMed
GO:0001662behavioral fear response-ISS-  
GO:0007186G-protein coupled receptor signaling pathway-IMP22957663  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger-IBA21873635  
GO:0007198adenylate cyclase-inhibiting serotonin receptor signaling pathway-IBA21873635  
GO:0007198adenylate cyclase-inhibiting serotonin receptor signaling pathway-IDA8393041  
GO:0007210serotonin receptor signaling pathway-ISS-  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0008283cell proliferation-IEA-  
GO:0008284positive regulation of cell proliferation-TAS1330092  
GO:0014062regulation of serotonin secretion-ISS-  
GO:0035640exploration behavior-ISS-  
GO:0042053regulation of dopamine metabolic process-ISS-  
GO:0042310vasoconstriction-IEA-  
GO:0042428serotonin metabolic process-ISS-  
GO:0046883regulation of hormone secretion-IEA-  
GO:0050795regulation of behavior-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA22957663  
GO:0030425dendrite-IBA21873635  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375280Amine ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-390666Serotonin receptorsTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19170664Association between Val66Met brain-derived neurotrophic factor (BDNF) gene polymorphism and post-treatment relapse in alcohol dependence. (2009 Apr)Wojnar MAlcohol Clin Exp Res
22545912Association of genetic, psychological and behavioral factors with sleep bruxism in a Japanese population. (2012 Jun)Abe YJ Sleep Res
11134668Pharmacogenetics and the serotonin system: initial studies and future directions. (2000 Dec 27)Veenstra-VanderWeele JEur J Pharmacol
10776672An association study between alcoholism and the serotonergic receptor genes. (2000 Mar)Himei AAlcohol Clin Exp Res
16770336Why do young women smoke? II. Role of traumatic life experience, psychological characteristics and serotonergic genes. (2006 Aug)Lerer EMol Psychiatry
21621273Association of polymorphisms in HTR2A, HTR1A and TPH2 genes with suicide attempts in alcohol dependence: a preliminary report. (2011 Nov 30)Wrzosek MPsychiatry Res
26352193Alcohol Dependence and Genetic Variability in the Serotonin Pathway among Currently and Formerly Alcohol-Dependent Males. (2015)Plemenitas ANeuropsychobiology
18562131Genetic variation in the serotonin pathway and smoking cessation with nicotine replacement therapy: new data from the Patch in Practice trial and pooled analyses. (2008 Nov 1)David SPDrug Alcohol Depend
23216389Genome-wide significant association signals in IPO11-HTR1A region specific for alcohol and nicotine codependence. (2013 May)Zuo LAlcohol Clin Exp Res