Gene info: ID 3351

Gene: HTR1B

GENE ID: 3351

Description: 5-hydroxytryptamine receptor 1B

Gene type: protein-coding

Location: 6q14.1

dbXrefs: Ensembl:ENSG00000135312 MIM:182131 Vega:OTTHUMG00000015066 UniprotKB:P28222

RefSeq: NC_000006.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 28

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.511e-1 (AD) 6.104e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MKL2	0.772
SMCR8	0.765
SGPP2	0.752
PLEKHM3	0.742
SLC12A6	0.742
MYO9A	0.737
CDYL2	0.731
GRM5	0.73
ADCY3	0.722
RPS6KA6	0.709

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ENDOU	-0.425
PLA2G5	-0.422
RBP1	-0.416
ASCL1	-0.416
HMX1	-0.414
S100A1	-0.414
SLC22A6	-0.409
BCL7C	-0.406
RARRES2	-0.402
PON1	-0.402

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00216	Eletriptan	Small Molecule	143322-58-1	Approved\|Investigational	Target
DB00246	Ziprasidone	Small Molecule	146939-27-7	Approved	Target
DB00247	Methysergide	Small Molecule	361-37-5	Approved	Target
DB00248	Cabergoline	Small Molecule	81409-90-7	Approved	Target
DB00268	Ropinirole	Small Molecule	91374-21-9	Approved\|Investigational	Target
DB00315	Zolmitriptan	Small Molecule	139264-17-8	Approved\|Investigational	Target
DB00320	Dihydroergotamine	Small Molecule	511-12-6	Approved\|Investigational	Target
DB00321	Amitriptyline	Small Molecule	50-48-6	Approved	Target
DB00334	Olanzapine	Small Molecule	132539-06-1	Approved\|Investigational	Target
DB00363	Clozapine	Small Molecule	5786-21-0	Approved	Target
DB00408	Loxapine	Small Molecule	1977-10-2	Approved	Target
DB00413	Pramipexole	Small Molecule	104632-26-0	Approved\|Investigational	Target
DB00543	Amoxapine	Small Molecule	14028-44-5	Approved	Target
DB00571	Propranolol	Small Molecule	525-66-6	Approved\|Investigational	Target
DB00589	Lisuride	Small Molecule	18016-80-3	Approved\|Investigational	Target
DB00669	Sumatriptan	Small Molecule	103628-46-2	Approved\|Investigational	Target
DB00696	Ergotamine	Small Molecule	113-15-5	Approved	Target
DB00714	Apomorphine	Small Molecule	58-00-4	Approved\|Investigational	Target
DB00904	Ondansetron	Small Molecule	99614-02-5	Approved	Target
DB00918	Almotriptan	Small Molecule	154323-57-6	Approved\|Investigational	Target
DB00952	Naratriptan	Small Molecule	121679-13-8	Approved\|Investigational	Target
DB00953	Rizatriptan	Small Molecule	144034-80-0	Approved	Target
DB00960	Pindolol	Small Molecule	13523-86-9	Approved\|Investigational	Target
DB00998	Frovatriptan	Small Molecule	158747-02-5	Approved\|Investigational	Target
DB01186	Pergolide	Small Molecule	66104-22-1	Approved\|Investigational\|Withdrawn	Target
DB01200	Bromocriptine	Small Molecule	25614-03-3	Approved\|Investigational	Target
DB01224	Quetiapine	Small Molecule	111974-69-7	Approved	Target
DB01238	Aripiprazole	Small Molecule	129722-12-9	Approved\|Investigational	Target
DB01359	Penbutolol	Small Molecule	38363-40-5	Approved\|Investigational	Target
DB01392	Yohimbine	Small Molecule	146-48-5	Approved\|Investigational	Target
DB04884	Dapoxetine	Small Molecule	119356-77-3	Investigational	Target
DB06096	NXN-188	Small Molecule	-	Investigational	Target
DB06216	Asenapine	Small Molecule	65576-45-6	Approved	Target
DB08807	Bopindolol	Small Molecule	62658-63-3	Approved	Target
DB09068	Vortioxetine	Small Molecule	508233-74-7	Approved\|Investigational	Target
DB01049	Ergoloid mesylate	Small Molecule	8067-24-1	Approved	Target
DB09304	Setiptiline	Small Molecule	57262-94-9	Approved	Target
DB13025	Tiapride	Small Molecule	51012-32-9	Approved\|Investigational	Target
DB01221	Ketamine	Small Molecule	6740-88-1	Approved	Target

ID	Drug Name	Action	PubMed
C117663	1-(3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl)-4-(2-(3-fluorophenyl)ethyl)piperazine	"1-(3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl)-4-(2-(3-fluorophenyl)ethyl)piperazine binds to HTR1B protein"	11888550
C117663	1-(3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl)-4-(2-(3-fluorophenyl)ethyl)piperazine	"1-(3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl)-4-(2-(3-fluorophenyl)ethyl)piperazine binds to HTR1B protein"	11888550
C018406	1-(3-trifluoromethylphenyl)piperazine	1-(3-trifluoromethylphenyl)piperazine binds to and results in increased activity of HTR1B protein	10764922
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of HTR1B mRNA"	25510870
C112429	2-(((3-(morpholinylmethyl)-2H-chromen-8-yl)oxy)methyl)morpholine	2-(((3-(morpholinylmethyl)-2H-chromen-8-yl)oxy)methyl)morpholine binds to and results in decreased activity of HTR1B protein	19014464
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of HTR1B mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of HTR1B mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of HTR1B mRNA"	25510870
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of HTR1B mRNA"	25510870
C065046	3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo(3,2-b)pyrid-5-one	"[3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo(3,2-b)pyrid-5-one binds to and results in increased activity of HTR1B protein] which affects the susceptibility to Cocaine"	9822762
C065046	3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo(3,2-b)pyrid-5-one	"3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo(3,2-b)pyrid-5-one binds to HTR1B protein"	11888550
C065046	3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo(3,2-b)pyrid-5-one	"3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo(3,2-b)pyrid-5-one binds to and results in increased activity of HTR1B protein"	15056481\|1901446
C103477	3-(3-(dimethylamino)propyl)-4-hydroxy-N-(4-(4-pyridinyl)phenyl)benzamide	3-(3-(dimethylamino)propyl)-4-hydroxy-N-(4-(4-pyridinyl)phenyl)benzamide binds to and results in decreased activity of HTR1B protein	15056481
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of HTR1B mRNA"	18648102
C047087	5-carboxamidotryptamine	5-carboxamidotryptamine binds to HTR1B protein	11888550
C047087	5-carboxamidotryptamine	5-carboxamidotryptamine binds to HTR1B protein	11888550
C025145	5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole	"5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole binds to HTR1B protein"	11888550
C025145	5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole	"[5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole binds to and results in increased activity of HTR1B protein] which affects the susceptibility to Cocaine"	9822762
C025145	5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole	"5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole binds to HTR1B protein"	11888550
C025145	5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole	"5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole binds to and results in increased activity of HTR1B protein"	9822762
D000082	Acetaminophen	Acetaminophen results in decreased expression of HTR1B mRNA	22230336
D000242	Cyclic AMP	HTR1B affects the reaction [almotriptan inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]	11134654
C409045	almotriptan	HTR1B affects the reaction [almotriptan inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]	11134654
C409045	almotriptan	almotriptan binds to and results in decreased activity of HTR1B protein	11134656
C409045	almotriptan	almotriptan binds to and results in increased activity of HTR1B protein	11907491
C409045	almotriptan	almotriptan binds to HTR1B protein	11134654
C100822	alniditan	alniditan binds to HTR1B protein	11888550
C100822	alniditan	alniditan binds to HTR1B protein	11888550
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of HTR1B mRNA	21298039
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of HTR1B mRNA	16483693
D000661	Amphetamine	HTR1B protein results in increased susceptibility to Amphetamine	19817843
D045930	Anabolic Agents	Anabolic Agents affects the expression of HTR1B protein	17201468
C075631	anpirtoline	anpirtoline binds to HTR1B protein	11888550
C075631	anpirtoline	anpirtoline binds to HTR1B protein	11888550
D004958	Estradiol	Estradiol affects the expression of HTR1B mRNA	12008023
D004958	Estradiol	[Estradiol co-treated with Plant Preparations] results in decreased expression of HTR1B mRNA	26945725
D004958	Estradiol	Estradiol results in decreased expression of HTR1B mRNA	26945725
C006780	bisphenol A	bisphenol A results in decreased expression of HTR1B mRNA	25181051\|2618613
C006780	bisphenol A	bisphenol A results in increased expression of HTR1B mRNA	29097150
C101699	BMS 181101	BMS 181101 binds to HTR1B protein	11888550
C101699	BMS 181101	BMS 181101 binds to HTR1B protein	11888550
C108532	BRL 15572	BRL 15572 binds to and results in increased activity of HTR1B protein	9303567
D002211	Capsaicin	HTR1B protein promotes the reaction [donitriptan results in decreased susceptibility to Capsaicin]	16880765
D002211	Capsaicin	HTR1B protein inhibits the reaction [Capsaicin results in increased expression of FOS protein]	12110114
D002220	Carbamazepine	[Fluoxetine co-treated with Venlafaxine Hydrochloride co-treated with Carbamazepine] results in decreased expression of HTR1B mRNA	22701549
C052561	CGS 12066B	CGS 12066B binds to HTR1B protein	11888550
C052561	CGS 12066B	CGS 12066B binds to HTR1B protein	11888550
D004390	Chlorpyrifos	Chlorpyrifos affects the expression of HTR1B mRNA	18835401
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HTR1B gene	20938992
D015283	Citalopram	Citalopram results in decreased expression of HTR1B protein	18157704
D003042	Cocaine	HTR1B mutant form results in increased susceptibility to Cocaine	9603521
D003042	Cocaine	"[3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo(3,2-b)pyrid-5-one binds to and results in increased activity of HTR1B protein] which affects the susceptibility to Cocaine"	9822762
D003042	Cocaine	"[5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole binds to and results in increased activity of HTR1B protein] which affects the susceptibility to Cocaine"	9822762
D003042	Cocaine	Cocaine affects the activity of HTR1B protein	17074068
D003042	Cocaine	[CP 94253 binds to and results in increased activity of HTR1B protein] which affects the susceptibility to Cocaine	9822762
D005576	Colforsin	HTR1B affects the reaction [almotriptan inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]]	11134654
C097067	CP 94253	[CP 94253 binds to and results in increased activity of HTR1B protein] which affects the susceptibility to Cocaine	9822762
C097067	CP 94253	CP 94253 binds to and results in increased activity of HTR1B protein	11396515\|1745237
D003471	Cuprizone	Cuprizone results in decreased expression of HTR1B mRNA	26577399
C047975	cyanopindolol	cyanopindolol binds to HTR1B protein	11888550
C047975	cyanopindolol	cyanopindolol binds to HTR1B protein	11888550
C047975	cyanopindolol	[cyanopindolol results in decreased activity of HTR1B protein] which results in decreased susceptibility to Pilocarpine	2533336
C047975	cyanopindolol	cyanopindolol results in decreased activity of HTR1B protein	2533336
D003976	Diazinon	Diazinon results in increased expression of HTR1B mRNA	17452286
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in increased expression of HTR1B mRNA	15620428
C514241	dihydroethidine	dihydroethidine binds to HTR1B protein	11888550
C514241	dihydroethidine	dihydroethidine binds to HTR1B protein	11888550
D019813	1,2-Dimethylhydrazine	"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of HTR1B mRNA"	27840820
C120143	donitriptan	HTR1B protein promotes the reaction [donitriptan results in decreased susceptibility to Capsaicin]	16880765
C115647	eletriptan	eletriptan binds to and results in increased activity of HTR1B protein	11301495
C115647	eletriptan	eletriptan binds to and results in increased activity of HTR1B protein	10427351\|1199361
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of HTR1B mRNA	29097150
D005473	Fluoxetine	Fluoxetine affects the expression of HTR1B mRNA	20525077
D005473	Fluoxetine	[Fluoxetine co-treated with Venlafaxine Hydrochloride co-treated with Carbamazepine] results in decreased expression of HTR1B mRNA	22701549
D005473	Fluoxetine	Fluoxetine results in decreased expression of HTR1B mRNA	10861803\|8914125
D005473	Fluoxetine	Fluoxetine results in increased expression of HTR1B mRNA	10665824
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HTR1B gene	20938992
C108128	frovatriptan	frovatriptan binds to and results in increased activity of HTR1B protein	12028324
D019833	Genistein	Genistein results in increased expression of HTR1B mRNA	21782745
C090701	GR 127935	GR 127935 binds to HTR1B protein	11888550
C090701	GR 127935	GR 127935 binds to HTR1B protein	11888550
C090701	GR 127935	GR 127935 binds to and results in decreased activity of HTR1B protein	10780831\|1139651
C090701	GR 127935	GR 127935 results in decreased activity of HTR1B protein	9085055
C119994	GR 46611	GR 46611 binds to HTR1B protein	11888550
C119994	GR 46611	GR 46611 binds to HTR1B protein	11888550
D012701	Serotonin	Serotonin binds to HTR1B protein	11888550
D012701	Serotonin	Serotonin binds to and affects the activity of HTR1B protein	17202474
D012701	Serotonin	Serotonin binds to HTR1B protein	11888550
D012701	Serotonin	Serotonin binds to and results in increased activity of HTR1B protein	20204739
D020120	Iodocyanopindolol	Iodocyanopindolol binds to HTR1B protein	8937629
D020120	Iodocyanopindolol	sarpogrelate inhibits the reaction [Iodocyanopindolol binds to HTR1B protein]	8937629
D020120	Iodocyanopindolol	sarpogrelate metabolite inhibits the reaction [Iodocyanopindolol binds to HTR1B protein]	8937629
C085632	L 694247	L 694247 binds to HTR1B protein	11888550
C085632	L 694247	L 694247 binds to HTR1B protein	11888550
C008261	lead acetate	lead acetate results in decreased expression of HTR1B mRNA	21891863
C008261	lead acetate	lead acetate results in decreased expression of HTR1B mRNA	11578147
D008711	Metergoline	Metergoline binds to HTR1B protein	11888550
D008711	Metergoline	Metergoline binds to HTR1B protein	11888550
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of HTR1B gene	20938992
D008719	Methiothepin	Methiothepin binds to HTR1B protein	11888550
D008719	Methiothepin	Methiothepin binds to HTR1B protein	11888550
C030589	methylmercury cysteine	methylmercury cysteine results in decreased expression of HTR1B mRNA	19465457
D008784	Methysergide	Methysergide binds to HTR1B protein	11888550
D008784	Methysergide	Methysergide binds to HTR1B protein	11888550
C478959	N-(1-(2,3-dihydro(1,4)dioxin-5-yl)piperidi-4-yl)indan-2-ylamine	"N-(1-(2,3-dihydro(1,4)dioxin-5-yl)piperidi-4-yl)indan-2-ylamine binds to HTR1B protein"	11888550
C478959	N-(1-(2,3-dihydro(1,4)dioxin-5-yl)piperidi-4-yl)indan-2-ylamine	"N-(1-(2,3-dihydro(1,4)dioxin-5-yl)piperidi-4-yl)indan-2-ylamine binds to HTR1B protein"	11888550
C090413	N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide	N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to and results in decreased activity of HTR1B protein	15542624
C108531	N-(3-(2-dimethylamino)ethoxy-4-methoxyphenyl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-(1,1'-biphenyl)-4-carboxamide	"N-(3-(2-dimethylamino)ethoxy-4-methoxyphenyl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-(1,1'-biphenyl)-4-carboxamide binds to and results in increased activity of HTR1B protein"	9303567
C108531	N-(3-(2-dimethylamino)ethoxy-4-methoxyphenyl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-(1,1'-biphenyl)-4-carboxamide	"N-(3-(2-dimethylamino)ethoxy-4-methoxyphenyl)-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-(1,1'-biphenyl)-4-carboxamide binds to and results in decreased activity of HTR1B protein"	17291490
C107225	N-(4-methoxy-3-(4-methylpiperazin-1-yl)phenyl)-3-methyl-4-(4-pyridyl)benzamide	N-(4-methoxy-3-(4-methylpiperazin-1-yl)phenyl)-3-methyl-4-(4-pyridyl)benzamide binds to HTR1B protein	11888550
C106783	naratriptan	naratriptan binds to HTR1B protein	9170336
C106783	naratriptan	naratriptan binds to and results in increased activity of HTR1B protein	10427351\|9170336
D009538	Nicotine	Nicotine results in increased activity of [HTR1B protein binds to HTR2A protein]	21316381
D010269	Paraquat	Paraquat results in decreased expression of HTR1B mRNA	18198484
D017374	Paroxetine	Paroxetine results in decreased expression of HTR1B mRNA	10861803
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of HTR1B mRNA"	25510870
D010862	Pilocarpine	[cyanopindolol results in decreased activity of HTR1B protein] which results in decreased susceptibility to Pilocarpine	2533336
D010869	Pindolol	Pindolol binds to HTR1B protein	11888550
D010869	Pindolol	Pindolol binds to HTR1B protein	11888550
D010869	Pindolol	Pindolol binds to and results in decreased activity of HTR1B protein	15542624\|8386235
D010936	Plant Extracts	Plant Extracts results in decreased expression of HTR1B mRNA	23557933
D028321	Plant Preparations	[Estradiol co-treated with Plant Preparations] results in decreased expression of HTR1B mRNA	26945725
D028321	Plant Preparations	Plant Preparations results in decreased expression of HTR1B mRNA	26945725
C112854	PNU 109291	PNU 109291 binds to HTR1B protein	11888550
D011433	Propranolol	Propranolol binds to HTR1B protein	11888550
D011433	Propranolol	Propranolol binds to HTR1B protein	11888550
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of HTR1B mRNA	24780913
D016713	Ritanserin	Ritanserin binds to HTR1B protein	11888550
C093622	rizatriptan	rizatriptan binds to and results in increased activity of HTR1B protein	10427351
C064294	sarpogrelate	sarpogrelate inhibits the reaction [Iodocyanopindolol binds to HTR1B protein]	8937629
C064294	sarpogrelate	sarpogrelate metabolite inhibits the reaction [Iodocyanopindolol binds to HTR1B protein]	8937629
C108518	SB 22489G	SB 22489G binds to HTR1B protein	11888550
C108518	SB 22489G	SB 22489G binds to HTR1B protein	11888550
C108518	SB 22489G	SB 22489G binds to and results in decreased activity of HTR1B protein	16880765\|1745237
D018170	Sumatriptan	Sumatriptan binds to HTR1B protein	11888550
D018170	Sumatriptan	Sumatriptan binds to and results in increased activity of HTR1B protein	11301495
D018170	Sumatriptan	Sumatriptan binds to HTR1B protein	11888550
D018170	Sumatriptan	Sumatriptan binds to and results in increased activity of HTR1B protein	17499925
C005632	tertatolol	tertatolol binds to HTR1B protein	11888550
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of HTR1B mRNA	21570461\|2468072
D014635	Valproic Acid	Valproic Acid affects the expression of HTR1B mRNA	17292431
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of HTR1B gene	25560391
D000069470	Venlafaxine Hydrochloride	[Fluoxetine co-treated with Venlafaxine Hydrochloride co-treated with Carbamazepine] results in decreased expression of HTR1B mRNA	22701549
C557874	vortioxetine	vortioxetine binds to and affects the activity of HTR1B protein	21486038
C089750	zolmitriptan	zolmitriptan binds to and results in increased activity of HTR1B protein	10427351\|9660035

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004930	G-protein coupled receptor activity	-	IBA	21873635
GO:0004993	G-protein coupled serotonin receptor activity	-	IBA	21873635
GO:0004993	G-protein coupled serotonin receptor activity	-	IDA	1315531
GO:0005515	protein binding	-	IPI	25416956 25910212
GO:0008144	drug binding	-	IEA	-
GO:0030594	neurotransmitter receptor activity	-	IBA	21873635
GO:0051378	serotonin binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002031	G-protein coupled receptor internalization	-	IEA	-
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	-	IBA	21873635
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	-	TAS	1559993
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	-	IDA	8882600
GO:0007198	adenylate cyclase-inhibiting serotonin receptor signaling pathway	-	IDA	1315531
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway	-	IEA	-
GO:0007268	chemical synaptic transmission	-	IBA	21873635
GO:0007268	chemical synaptic transmission	-	IEA	-
GO:0014059	regulation of dopamine secretion	-	IEA	-
GO:0014063	negative regulation of serotonin secretion	-	ISS	-
GO:0032229	negative regulation of synaptic transmission, GABAergic	-	IEA	-
GO:0035690	cellular response to drug	-	IDA	1315531
GO:0042220	response to cocaine	-	IEA	-
GO:0042310	vasoconstriction	-	IEA	-
GO:0042756	drinking behavior	-	IEA	-
GO:0045471	response to ethanol	-	IEA	-
GO:0046849	bone remodeling	-	IEA	-
GO:0050795	regulation of behavior	-	IEA	-
GO:0051385	response to mineralocorticoid	-	IEA	-
GO:0051967	negative regulation of synaptic transmission, glutamatergic	-	IEA	-
GO:0071312	cellular response to alkaloid	-	IDA	1315531
GO:0071502	cellular response to temperature stimulus	-	IEA	-
GO:1904707	positive regulation of vascular smooth muscle cell proliferation	-	IMP	25871906

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IEA	-
GO:0005886	plasma membrane	-	IDA	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	IMP	1315531
GO:0030425	dendrite	-	IBA	21873635

KEGG ID	KEGG Term
hsa04080	Neuroactive ligand-receptor interaction

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375280	Amine ligand-binding receptors	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-390666	Serotonin receptors	TAS
R-HSA-418594	G alpha (i) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
16344719	Association analysis of polymorphisms in serotonin 1B receptor (HTR1B) gene with heroin addiction: a comparison of molecular and statistically estimated haplotypes. (2006 Jan)	Proudnikov D	Pharmacogenet Genomics
11134668	Pharmacogenetics and the serotonin system: initial studies and future directions. (2000 Dec 27)	Veenstra-VanderWeele J	Eur J Pharmacol
22028400	Cigarette experimentation in Mexican origin youth: psychosocial and genetic determinants. (2012 Jan)	Wilkinson AV	Cancer Epidemiol Biomarkers Prev
22064162	Genome-wide association study of comorbid depressive syndrome and alcohol dependence. (2012 Feb)	Edwards AC	Psychiatr Genet
25655461	Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms. (2015 Apr 15)	Manzardo AM	Gene
12022963	Association study of novel human serotonin 5-HT(1B) polymorphisms with alcohol dependence in Taiwanese Han. (2002 Jun 1)	Sun HF	Biol Psychiatry
9819067	Linkage of antisocial alcoholism to the serotonin 5-HT1B receptor gene in 2 populations. (1998 Nov)	Lappalainen J	Arch Gen Psychiatry
12218658	Antisocial alcoholism and serotonin-related polymorphisms: association tests. (2002 Sep)	Hill EM	Psychiatr Genet
11104852	The HTR1B 861G>C receptor polymorphism among patients suffering from alcoholism, major depression, anxiety disorders and narcolepsy. (2000 Dec 4)	Fehr C	Psychiatry Res
12496953	Substance abuse disorder and major depression are associated with the human 5-HT1B receptor gene (HTR1B) G861C polymorphism. (2003 Jan)	Huang YY	Neuropsychopharmacology
21172311	Association between the 5-HTR1B gene polymorphisms and alcohol dependence in a Han Chinese population. (2011 Feb 28)	Cao JX	Brain Res
22005095	A haplotype analysis is consistent with the role of functional HTR1B variants in alcohol dependence. (2012 Apr 1)	Contini V	Drug Alcohol Depend
21906503	Different phenotypic and genotypic presentations in alcohol dependence: age at onset matters. (2011 Sep)	Chen YC	J Stud Alcohol Drugs
23177301	[Genetic polymorphisms as tool indicators for individual vulnerability to smoking behaviour]. (2013 Jan 19)	Barrot C	Med Clin (Barc)
12437478	DNA variation and psychopharmacology of the human serotonin receptor 1B (HTR1B) gene. (2002 Nov)	Sanders AR	Pharmacogenomics
22933845	Polymorphisms of the serotonin transporter and receptor genes: susceptibility to substance abuse. (2012 Jun)	Herman AI	Subst Abuse Rehabil
22106445	HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a cohort of Caucasians and African Americans: an evaluation of gene-environment interactions and candidate genes. (2012 Jan 1)	Edwards TL	Am J Epidemiol
15698927	No association between the serotonin 1B receptor gene and schizophrenia in a case-control and family-based association study. (2005 Mar 11)	Duan S	Neurosci Lett
26842247	Association Study of Gene Polymorphisms in GABA, Serotonin, Dopamine, and Alcohol Metabolism Pathways with Alcohol Dependence in Taiwanese Han Men. (2016 Feb)	Wu LS	Alcohol Clin Exp Res
28923721	Evidence of sexual dimorphism of HTR1B gene on major adult ADHD comorbidities. (2017 Dec)	Muller D	J Psychiatr Res
21886584	Association Between 5HT1b Receptor Gene and Methamphetamine Dependence. (2011 Mar)	Ujike H	Curr Neuropharmacol
16770336	Why do young women smoke? II. Role of traumatic life experience, psychological characteristics and serotonergic genes. (2006 Aug)	Lerer E	Mol Psychiatry
11751038	Polymorphism of the 5-HT1B receptor gene (HTR1B): strong within-locus linkage disequilibrium without association to antisocial substance dependence. (2002 Jan)	Kranzler HR	Neuropsychopharmacology
26352193	Alcohol Dependence and Genetic Variability in the Serotonin Pathway among Currently and Formerly Alcohol-Dependent Males. (2015)	Plemenitas A	Neuropsychobiology
27629278	Evaluation of a Novel Difficulty of Smoking Cessation Phenotype Based on Number of Quit Attempts. (2017 Apr 1)	Stevens VL	Nicotine Tob Res
17217931	Diplotypes of the human serotonin 1B receptor promoter predict growth hormone responses to sumatriptan in abstinent alcohol-dependent men. (2007 Apr 15)	Moss HB	Biol Psychiatry
20575831	Evaluation of an allelic association of the serotonin 5-HT1B G681C polymorphism with antisocial alcoholism in the German population. (2000 Apr 1)	Sander T	Addict Biol
23799031	Profiling of childhood adversity-associated DNA methylation changes in alcoholic patients and healthy controls. (2013)	Zhang H	PLoS One