Gene: HTR1F

3355
5-HT-1F|5-HT1F|5HT6|HTR1EL|MR77
5-hydroxytryptamine receptor 1F
protein-coding
3p11.2-p11.1
Ensembl:ENSG00000179097 MIM:182134 Vega:OTTHUMG00000159008 UniprotKB:P30939
NC_000003.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.626e-1 (AD)  3.552e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYNPO20.635
SETBP10.602
RAPH10.599
PHACTR20.58
CCDC680.571
NRIP10.57
PIK3CA0.564
ZNF8520.563
CNTNAP50.561
ATF7IP0.558

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IZUMO4-0.378
S100A1-0.372
BCL7C-0.35
ABHD1-0.349
CLDND2-0.343
FAM229A-0.341
MPST-0.333
CHADL-0.332
C22orf31-0.332
BTBD17-0.328

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00216EletriptanSmall Molecule143322-58-1Approved|InvestigationalTarget
DB00247MethysergideSmall Molecule361-37-5ApprovedTarget
DB00315ZolmitriptanSmall Molecule139264-17-8Approved|InvestigationalTarget
DB00669SumatriptanSmall Molecule103628-46-2Approved|InvestigationalTarget
DB00696ErgotamineSmall Molecule113-15-5ApprovedTarget
DB00952NaratriptanSmall Molecule121679-13-8Approved|InvestigationalTarget
DB00953RizatriptanSmall Molecule144034-80-0ApprovedTarget
DB06148MianserinSmall Molecule24219-97-4Approved|InvestigationalTarget
DB01049Ergoloid mesylateSmall Molecule8067-24-1ApprovedTarget
DB09304SetiptilineSmall Molecule57262-94-9ApprovedTarget
DB13025TiaprideSmall Molecule51012-32-9Approved|InvestigationalTarget
DB01221KetamineSmall Molecule6740-88-1ApprovedTarget
ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of HTR1F mRNA17585979
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HTR1F mRNA16483693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HTR1F mRNA22228805
C006780bisphenol Abisphenol A results in decreased expression of HTR1F mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of HTR1F mRNA26186136
D001761BleomycinBleomycin results in decreased expression of HTR1F mRNA15808516
C018475butyraldehydebutyraldehyde results in decreased expression of HTR1F mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of HTR1F promoter22457795
D002211CapsaicinHTR1F protein inhibits the reaction [Capsaicin results in increased expression of FOS protein]12110114
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of HTR1F mRNA18636392
D003471CuprizoneCuprizone results in increased expression of HTR1F mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of HTR1F mRNA20106945
C014347decitabinedecitabine results in decreased methylation of HTR1F gene27923600
D003976DiazinonDiazinon affects the expression of HTR1F mRNA17452286
C039281furanfuran results in increased methylation of HTR1F gene22079235
D008694MethamphetamineMethamphetamine results in increased expression of HTR1F mRNA19564919
C025256nonylphenolnonylphenol results in decreased expression of HTR1F mRNA15620428
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of HTR1F mRNA18636392
C009495titanium dioxidetitanium dioxide results in increased expression of HTR1F mRNA23557971

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0004993G-protein coupled serotonin receptor activity-IBA21873635  
GO:0004993G-protein coupled serotonin receptor activity-IDA8380639  
GO:0004993G-protein coupled serotonin receptor activity-IMP21422162  
GO:0030594neurotransmitter receptor activity-IBA21873635  
GO:0051378serotonin binding-IDA8380639  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger-IBA21873635  
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger-TAS8380639  
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-IMP21422162  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0007268chemical synaptic transmission-TAS8380639  
GO:0098664G-protein coupled serotonin receptor signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IMP21422162  
GO:0030425dendrite-IBA21873635  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375280Amine ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-390666Serotonin receptorsTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17763112Genome-wide linkage analysis for smoking-related regions, with replication in two ethnically diverse populations. (2007 Sep)Pomerleau OFNicotine Tob Res