Gene info: ID 3356

Gene: HTR2A

GENE ID: 3356

Synonyms: 5-HT2A|HTR2

Description: 5-hydroxytryptamine receptor 2A

Gene type: protein-coding

Location: 13q14.2

dbXrefs: Ensembl:ENSG00000102468 MIM:182135 Vega:OTTHUMG00000016881 UniprotKB:P28223

RefSeq: NG_013011.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: CD|OD|ND|AD

# Publications: 29

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.365e-1 (AD) 6.121e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
AAK1	0.963
KCNV1	0.961
OLFM3	0.959
GABRA1	0.956
HCN1	0.955
STXBP5L	0.955
CHRM3	0.954
LRFN5	0.952
PRICKLE1	0.951
ATRNL1	0.95

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HEY2	-0.613
REST	-0.59
YES1	-0.586
RAB13	-0.577
CSAG1	-0.576
RAI14	-0.576
WWTR1	-0.568
ROM1	-0.567
CNN2	-0.566
SNHG18	-0.565

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00246	Ziprasidone	Small Molecule	146939-27-7	Approved	Target
DB00247	Methysergide	Small Molecule	361-37-5	Approved	Target
DB00248	Cabergoline	Small Molecule	81409-90-7	Approved	Target
DB00268	Ropinirole	Small Molecule	91374-21-9	Approved\|Investigational	Target
DB00321	Amitriptyline	Small Molecule	50-48-6	Approved	Target
DB00334	Olanzapine	Small Molecule	132539-06-1	Approved\|Investigational	Target
DB00363	Clozapine	Small Molecule	5786-21-0	Approved	Target
DB00370	Mirtazapine	Small Molecule	85650-52-8	Approved	Target
DB00408	Loxapine	Small Molecule	1977-10-2	Approved	Target
DB00409	Remoxipride	Small Molecule	80125-14-0	Approved\|Withdrawn	Target
DB00413	Pramipexole	Small Molecule	104632-26-0	Approved\|Investigational	Target
DB00420	Promazine	Small Molecule	58-40-2	Approved	Target
DB00434	Cyproheptadine	Small Molecule	129-03-3	Approved	Target
DB00458	Imipramine	Small Molecule	50-49-7	Approved	Target
DB00477	Chlorpromazine	Small Molecule	50-53-3	Approved\|Investigational	Target
DB00502	Haloperidol	Small Molecule	52-86-8	Approved	Target
DB00540	Nortriptyline	Small Molecule	72-69-5	Approved	Target
DB00543	Amoxapine	Small Molecule	14028-44-5	Approved	Target
DB00555	Lamotrigine	Small Molecule	84057-84-1	Approved\|Investigational	Target
DB00574	Fenfluramine	Small Molecule	458-24-2	Approved\|Illicit\|Investigational\|Withdrawn	Target
DB00589	Lisuride	Small Molecule	18016-80-3	Approved\|Investigational	Target
DB00604	Cisapride	Small Molecule	81098-60-4	Approved\|Investigational\|Withdrawn	Target
DB00623	Fluphenazine	Small Molecule	69-23-8	Approved	Target
DB00656	Trazodone	Small Molecule	19794-93-5	Approved\|Investigational	Target
DB00679	Thioridazine	Small Molecule	50-52-2	Approved\|Withdrawn	Target
DB00696	Ergotamine	Small Molecule	113-15-5	Approved	Target
DB00714	Apomorphine	Small Molecule	58-00-4	Approved\|Investigational	Target
DB00715	Paroxetine	Small Molecule	61869-08-7	Approved\|Investigational	Target
DB00726	Trimipramine	Small Molecule	739-71-9	Approved	Target
DB00734	Risperidone	Small Molecule	106266-06-2	Approved\|Investigational	Target
DB00751	Epinastine	Small Molecule	80012-43-7	Approved\|Investigational	Target
DB00777	Propiomazine	Small Molecule	362-29-8	Approved	Target
DB00805	Minaprine	Small Molecule	25905-77-5	Approved	Target
DB00843	Donepezil	Small Molecule	120014-06-4	Approved	Target
DB00875	Flupentixol	Small Molecule	2709-56-0	Approved\|Investigational\|Withdrawn	Target
DB00924	Cyclobenzaprine	Small Molecule	303-53-7	Approved	Target
DB00933	Mesoridazine	Small Molecule	5588-33-0	Approved\|Investigational	Target
DB00934	Maprotiline	Small Molecule	10262-69-8	Approved\|Investigational	Target
DB01069	Promethazine	Small Molecule	60-87-7	Approved\|Investigational	Target
DB01079	Tegaserod	Small Molecule	145158-71-0	Approved\|Investigational\|Withdrawn	Target
DB01142	Doxepin	Small Molecule	1668-19-5	Approved\|Investigational	Target
DB01149	Nefazodone	Small Molecule	83366-66-9	Approved\|Withdrawn	Target
DB01151	Desipramine	Small Molecule	50-47-5	Approved\|Investigational	Target
DB01186	Pergolide	Small Molecule	66104-22-1	Approved\|Investigational\|Withdrawn	Target
DB01200	Bromocriptine	Small Molecule	25614-03-3	Approved\|Investigational	Target
DB01224	Quetiapine	Small Molecule	111974-69-7	Approved	Target
DB01238	Aripiprazole	Small Molecule	129722-12-9	Approved\|Investigational	Target
DB01239	Chlorprothixene	Small Molecule	113-59-7	Approved\|Investigational\|Withdrawn	Target
DB01242	Clomipramine	Small Molecule	303-49-1	Approved\|Investigational	Target
DB01267	Paliperidone	Small Molecule	144598-75-4	Approved	Target
DB01392	Yohimbine	Small Molecule	146-48-5	Approved\|Investigational	Target
DB01403	Methotrimeprazine	Small Molecule	60-99-1	Approved\|Investigational	Target
DB01442	MMDA	Small Molecule	13674-05-0	Experimental\|Illicit	Target
DB01454	Midomafetamine	Small Molecule	42542-10-9	Experimental\|Illicit\|Investigational	Target
DB01488	Dimethyltryptamine	Small Molecule	61-50-7	Experimental\|Illicit	Target
DB01537	4-Bromo-2,5-dimethoxyphenethylamine	Small Molecule	66142-81-2	Experimental\|Illicit	Target
DB01614	Acepromazine	Small Molecule	61-00-7	Approved	Target
DB01618	Molindone	Small Molecule	7416-34-4	Approved	Target
DB01621	Pipotiazine	Small Molecule	39860-99-6	Approved\|Investigational	Target
DB01622	Thioproperazine	Small Molecule	316-81-4	Approved	Target
DB01623	Thiothixene	Small Molecule	3313-26-6	Approved	Target
DB01624	Zuclopenthixol	Small Molecule	53772-83-1	Approved\|Investigational	Target
DB04599	Aniracetam	Small Molecule	72432-10-1	Experimental	Target
DB04842	Fluspirilene	Small Molecule	1841-19-6	Approved\|Investigational	Target
DB04908	Flibanserin	Small Molecule	167933-07-5	Approved\|Investigational	Target
DB04946	Iloperidone	Small Molecule	133454-47-4	Approved	Target
DB05079	HY10275	Small Molecule	-	Investigational	Target
DB05227	APD791	Small Molecule	-	Investigational	Target
DB05316	Pimavanserin	Small Molecule	706779-91-1	Approved\|Investigational	Target
DB05492	Epicept NP-1	Small Molecule	-	Investigational	Target
DB05687	BL-1020	Small Molecule	-	Investigational	Target
DB06016	Cariprazine	Small Molecule	839712-12-8	Approved\|Investigational	Target
DB06077	Lumateperone	Small Molecule	313368-91-1	Investigational	Target
DB06144	Sertindole	Small Molecule	106516-24-9	Approved\|Investigational\|Withdrawn	Target
DB06148	Mianserin	Small Molecule	24219-97-4	Approved\|Investigational	Target
DB06216	Asenapine	Small Molecule	65576-45-6	Approved	Target
DB06229	Ocaperidone	Small Molecule	129029-23-8	Investigational	Target
DB06288	Amisulpride	Small Molecule	71675-85-9	Approved\|Investigational	Target
DB06446	Dotarizine	Small Molecule	84625-59-2	Investigational	Target
DB06512	Deramciclane	Small Molecule	120444-71-5	Investigational	Target
DB08810	Cinitapride	Small Molecule	66564-14-5	Approved\|Investigational	Target
DB08815	Lurasidone	Small Molecule	367514-87-2	Approved\|Investigational	Target
DB08839	Serotonin	Small Molecule	50-67-9	Investigational\|Nutraceutical	Target
DB08922	Perospirone	Small Molecule	150915-41-6	Approved	Target
DB08927	Amperozide	Small Molecule	75558-90-6	Experimental	Target
DB09016	Butriptyline	Small Molecule	35941-65-2	Approved	Target
DB09061	Cannabidiol	Small Molecule	13956-29-1	Approved\|Investigational	Target
DB09128	Brexpiprazole	Small Molecule	913611-97-9	Approved\|Investigational	Target
DB09167	Dosulepin	Small Molecule	113-53-1	Approved	Target
DB09194	Etoperidone	Small Molecule	52942-31-1	Withdrawn	Target
DB09195	Lorpiprazole	Small Molecule	108785-69-9	Approved	Target
DB09223	Blonanserin	Small Molecule	132810-10-7	Approved\|Investigational	Target
DB09225	Zotepine	Small Molecule	26615-21-4	Approved\|Investigational\|Withdrawn	Target
DB09286	Pipamperone	Small Molecule	1893-33-0	Approved\|Investigational	Target
DB12163	Sarpogrelate	Small Molecule	125926-17-2	Investigational	Target
DB12465	Ketanserin	Small Molecule	74050-98-9	Investigational	Target
DB12555	Nelotanserin	Small Molecule	839713-36-9	Investigational	Target
DB12693	Ritanserin	Small Molecule	87051-43-2	Investigational	Target
DB13940	2,5-Dimethoxy-4-ethylthioamphetamine	Small Molecule	185562-00-9	Experimental	Target
DB13948	N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine	Small Molecule	1391489-32-9	Experimental	Target
DB01049	Ergoloid mesylate	Small Molecule	8067-24-1	Approved	Target
DB09304	Setiptiline	Small Molecule	57262-94-9	Approved	Target
DB13025	Tiapride	Small Molecule	51012-32-9	Approved\|Investigational	Target
DB00477	Chlorpromazine	Small Molecule	50-53-3	Approved\|Investigational	Target
DB01221	Ketamine	Small Molecule	6740-88-1	Approved	Target
DB06678	Esmirtazapine	Small Molecule	61337-87-9	Investigational	Target

ID	Drug Name	Action	PubMed
C432747	1,1-dimethylbutyl-1-deoxy-Delta(9)-THC	"1,1-dimethylbutyl-1-deoxy-Delta(9)-THC results in increased expression of HTR2A mRNA"	22791651
C432747	1,1-dimethylbutyl-1-deoxy-Delta(9)-THC	"iodopravadoline inhibits the reaction [1,1-dimethylbutyl-1-deoxy-Delta(9)-THC results in increased expression of HTR2A mRNA]"	22791651
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of HTR2A mRNA"	19162173
C507420	1,3,4,14b-tetrahydro-2,10-dimethyl-2H,10H-pyrazino(2,1-d)pyrrolo(1,2-b) (1,2,5)benzotriazepine	"1,3,4,14b-tetrahydro-2,10-dimethyl-2H,10H-pyrazino(2,1-d)pyrrolo(1,2-b) (1,2,5)benzotriazepine analog binds to HTR2A protein"	16223499
C015068	1-(3-chlorophenyl)piperazine	1-(3-chlorophenyl)piperazine binds to and results in increased activity of HTR2A protein	16314884
C015068	1-(3-chlorophenyl)piperazine	HTR2A gene SNP results in increased susceptibility to 1-(3-chlorophenyl)piperazine	16314884
C015068	1-(3-chlorophenyl)piperazine	HTR2A protein affects the susceptibility to 1-(3-chlorophenyl)piperazine	16314884
C118559	1-bromopropane	1-bromopropane results in decreased expression of HTR2A mRNA	19576243
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of HTR2A mRNA"	23829299
C009407	2,5,2',5'-tetrachlorobiphenyl	"2,5,2',5'-tetrachlorobiphenyl results in increased expression of HTR2A mRNA"	23829299
C045392	2-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine	"2-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine binds to HTR2A protein"	9723970
C054649	3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol	"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol affects the localization of HTR2A protein"	22791651\|2315187
C054649	3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol	"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol promotes the reaction [HTR2A protein binds to DRD2 protein]"	22791651
C054649	3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol	"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of and results in increased activity of HTR2A protein"	23151877
C054649	3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol	"3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of HTR2A mRNA"	22791651\|2315187
C054649	3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol	"JTE 907 inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of HTR2A mRNA]"	23151877
C008745	4,4'-bisphenol F	"4,4'-bisphenol F results in decreased expression of HTR2A mRNA"	26186136
C015952	4-iodo-2,5-dimethoxyphenylisopropylamine	"4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein"	16314884
C015952	4-iodo-2,5-dimethoxyphenylisopropylamine	"HTR2A gene SNP results in decreased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine"	16314884
C015952	4-iodo-2,5-dimethoxyphenylisopropylamine	"HTR2A protein affects the susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine"	16314884
C015952	4-iodo-2,5-dimethoxyphenylisopropylamine	"[Alprenolol co-treated with Cocaine] affects the reaction [HTR2A protein results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine]"	8392199
C015952	4-iodo-2,5-dimethoxyphenylisopropylamine	"Cocaine inhibits the reaction [HTR2A protein results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine]"	8392199
C015952	4-iodo-2,5-dimethoxyphenylisopropylamine	"HTR2A protein results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine"	8392199
C015952	4-iodo-2,5-dimethoxyphenylisopropylamine	"[Yohimbine co-treated with Cocaine] affects the reaction [HTR2A protein results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine]"	8392199
C015952	4-iodo-2,5-dimethoxyphenylisopropylamine	"4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein"	10773215\|1248220
C015952	4-iodo-2,5-dimethoxyphenylisopropylamine	"[4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein] which results in increased secretion of and results in increased abundance of Dopamine"	10773215
C015952	4-iodo-2,5-dimethoxyphenylisopropylamine	"4-iodo-2,5-dimethoxyphenylisopropylamine results in increased activity of HTR2A protein"	18622176
C015952	4-iodo-2,5-dimethoxyphenylisopropylamine	"Cocaine promotes the reaction [[4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein] which results in increased secretion of and results in increased abundance of Dopamine]"	10773215
C015952	4-iodo-2,5-dimethoxyphenylisopropylamine	"HTR2A protein affects the susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine"	22983118
C015952	4-iodo-2,5-dimethoxyphenylisopropylamine	"Ketanserin inhibits the reaction [[4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein] which results in increased secretion of and results in increased abundance of Dopamine]"	10773215
C015952	4-iodo-2,5-dimethoxyphenylisopropylamine	"Ketanserin inhibits the reaction [Cocaine promotes the reaction [[4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein] which results in increased secretion of and results in increased abundance of Dopamine]]"	10773215
C015952	4-iodo-2,5-dimethoxyphenylisopropylamine	"Streptozocin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased activity of HTR2A protein]"	18622176
C489251	5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone	"5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of HTR2A mRNA]"	22952915
C461657	6-methoxymianserin	6-methoxymianserin binds to HTR2A protein	12109911
C416534	7-fluoro-2-oxo-4-(2-(4-(thieno(3,2-c)pyridin-4-yl)piperazin-1-yl)ethyl)-1,2-dihydroquinoline-1-acetamide	"7-fluoro-2-oxo-4-(2-(4-(thieno(3,2-c)pyridin-4-yl)piperazin-1-yl)ethyl)-1,2-dihydroquinoline-1-acetamide affects the activity of HTR2A protein"	23611293
C409874	7-methyl-6,7,8,9,14,15-hexahydro-5H-benz(d)indolo(2,3-g)azecine	"7-methyl-6,7,8,9,14,15-hexahydro-5H-benz(d)indolo(2,3-g)azecine binds to and results in decreased activity of HTR2A protein"	15183906
C409874	7-methyl-6,7,8,9,14,15-hexahydro-5H-benz(d)indolo(2,3-g)azecine	"7-methyl-6,7,8,9,14,15-hexahydro-5H-benz(d)indolo(2,3-g)azecine binds to and results in decreased activity of HTR2A protein"	12447918
C434584	8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine	"8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine inhibits the reaction [Ketanserin binds to HTR2A protein]"	11927170
D000082	Acetaminophen	Acetaminophen results in decreased activity of HTR2A protein	10849027
D000082	Acetaminophen	Acetaminophen results in decreased expression of HTR2A mRNA	25128769
D000082	Acetaminophen	sodium arsenite inhibits the reaction [Acetaminophen results in decreased expression of HTR2A mRNA]	25128769
C039668	adinazolam	adinazolam results in decreased expression of HTR2A protein	1664741
D000324	Adrenocorticotropic Hormone	Adrenocorticotropic Hormone affects the expression of HTR2A mRNA	18239281
D000324	Adrenocorticotropic Hormone	Bupropion inhibits the reaction [Adrenocorticotropic Hormone affects the expression of HTR2A mRNA]	18239281
C014959	albiflorin	albiflorin affects the expression of HTR2A	26475043
C095512	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]"	18976543
C095512	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[volinanserin binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]"	18976543
C095512	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [HTR2A protein results in increased secretion of Corticosterone]"	19304867
C095512	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [HTR2A protein results in increased secretion of OXT protein]"	19304867
C095512	alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide	"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [olanzapine results in decreased activity of HTR2A protein]"	19304867
C066169	alpha-phenyl-1-(2-phenylethyl)-4-piperidinemethanol	[alpha-phenyl-1-(2-phenylethyl)-4-piperidinemethanol binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Cocaine	10764922
C066169	alpha-phenyl-1-(2-phenylethyl)-4-piperidinemethanol	alpha-phenyl-1-(2-phenylethyl)-4-piperidinemethanol binds to and results in decreased activity of HTR2A protein	18930597
C066169	alpha-phenyl-1-(2-phenylethyl)-4-piperidinemethanol	[alpha-phenyl-1-(2-phenylethyl)-4-piperidinemethanol binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Vincristine	18930597
C066169	alpha-phenyl-1-(2-phenylethyl)-4-piperidinemethanol	[alpha-phenyl-1-(2-phenylethyl)-4-piperidinemethanol binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Zalcitabine	17888573
C066169	alpha-phenyl-1-(2-phenylethyl)-4-piperidinemethanol	alpha-phenyl-1-(2-phenylethyl)-4-piperidinemethanol binds to and results in decreased activity of HTR2A protein	10764922
D000526	Alprenolol	"[Alprenolol co-treated with Cocaine] affects the reaction [HTR2A protein results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine]"	8392199
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of HTR2A mRNA	16483693
D000068180	Aripiprazole	Aripiprazole binds to and results in decreased activity of HTR2A protein	21823597
D000068180	Aripiprazole	Aripiprazole binds to and results in increased activity of HTR2A protein	16314884
D000068180	Aripiprazole	Aripiprazole inhibits the reaction [Ketanserin binds to HTR2A protein]	16314884
D000068180	Aripiprazole	HTR2A gene SNP results in decreased susceptibility to Aripiprazole	16314884
D000068180	Aripiprazole	HTR2A protein affects the susceptibility to Aripiprazole	16314884
D000068180	Aripiprazole	Aripiprazole binds to and results in decreased activity of HTR2A protein	16569800\|1706954
D000068180	Aripiprazole	Aripiprazole binds to HTR2A protein	18363460
D001151	Arsenic	Arsenic affects the methylation of HTR2A gene	25304211
D001549	Benzamides	Benzamides analog binds to and results in decreased activity of HTR2A protein	8676355
D001562	Benzimidazoles	Benzimidazoles analog binds to HTR2A protein	21509803
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of HTR2A mRNA	26377693
D004958	Estradiol	Estradiol affects the expression of HTR2A mRNA	12008023
D004958	Estradiol	[Estradiol co-treated with Sertraline] affects the expression of HTR2A mRNA	18650020
D004958	Estradiol	Estradiol promotes the reaction [Sertraline results in increased expression of HTR2A mRNA]	18650020
C070515	bisindolylmaleimide I	bisindolylmaleimide I results in increased expression of HTR2A mRNA	22791651
C006780	bisphenol A	bisphenol A results in decreased expression of HTR2A mRNA	25181051
D016642	Bupropion	Bupropion inhibits the reaction [Adrenocorticotropic Hormone affects the expression of HTR2A mRNA]	18239281
D002065	Buspirone	Buspirone results in decreased expression of HTR2A protein	1664741
D002118	Calcium	HTR2A protein promotes the reaction [[Freund's Adjuvant results in increased activity of TRPV1 protein] which results in increased transport of Calcium]	16901936
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of HTR2A mRNA	12832660\|1664405
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of HTR2A	17035140
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of HTR2A mRNA	17452286
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of HTR2A mRNA alternative form	17452286
D002928	Cinanserin	Cinanserin binds to and results in decreased activity of HTR2A protein	10764922\|9085399
D003024	Clozapine	Clozapine analog binds to HTR2A protein	11997696
D003024	Clozapine	Clozapine binds to and results in decreased activity of HTR2A protein	16314884\|2052132
D003024	Clozapine	Clozapine binds to HTR2A protein	11997696\|1698339
D003024	Clozapine	Clozapine inhibits the reaction [Ketanserin binds to HTR2A protein]	16314884
D003024	Clozapine	HTR2A gene SNP results in increased susceptibility to Clozapine	16314884
D003024	Clozapine	HTR2A protein affects the susceptibility to Clozapine	16314884
D003024	Clozapine	Clozapine results in increased expression of HTR2A mRNA	15542763
D003024	Clozapine	"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]"	18976543
D003024	Clozapine	Clozapine binds to and results in decreased activity of HTR2A protein	18976543
D003024	Clozapine	[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein	18976543
D003024	Clozapine	[[Clozapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein	18976543
D003024	Clozapine	Clozapine binds to HTR2A protein	9723970
D003024	Clozapine	Clozapine promotes the reaction [Phencyclidine results in decreased activity of HTR2A protein]	15380371
D003024	Clozapine	Clozapine results in decreased activity of HTR2A protein	15380371
D003024	Clozapine	Clozapine results in decreased expression of HTR2A mRNA	14751426\|1786893
D003024	Clozapine	Clozapine results in decreased expression of HTR2A protein	14751426
C079149	clozapine N-oxide	clozapine N-oxide results in decreased expression of HTR2A protein	14751426
D003042	Cocaine	[alpha-phenyl-1-(2-phenylethyl)-4-piperidinemethanol binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Cocaine	10764922
D003042	Cocaine	"[Alprenolol co-treated with Cocaine] affects the reaction [HTR2A protein results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine]"	8392199
D003042	Cocaine	"Cocaine inhibits the reaction [HTR2A protein results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine]"	8392199
D003042	Cocaine	HTR2A protein affects the susceptibility to Cocaine	10773209
D003042	Cocaine	[Metergoline binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Cocaine	10764922
D003042	Cocaine	[Methiothepin binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Cocaine	10764922
D003042	Cocaine	[Mianserin binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Cocaine	10764922
D003042	Cocaine	"[Yohimbine co-treated with Cocaine] affects the reaction [HTR2A protein results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine]"	8392199
D003042	Cocaine	Cocaine affects the activity of HTR2A protein	10773215\|1725986
D003042	Cocaine	"Cocaine promotes the reaction [[4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein] which results in increased secretion of and results in increased abundance of Dopamine]"	10773215
D003042	Cocaine	"Ketanserin inhibits the reaction [Cocaine promotes the reaction [[4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein] which results in increased secretion of and results in increased abundance of Dopamine]]"	10773215
D005576	Colforsin	"Colforsin inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of HTR2A mRNA]"	22791651
D003345	Corticosterone	"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [HTR2A protein results in increased secretion of Corticosterone]"	19304867
D003345	Corticosterone	Corticosterone results in increased expression of HTR2A mRNA	15755911\|1836385
D003345	Corticosterone	HTR2A protein results in increased secretion of Corticosterone	19304867
D003345	Corticosterone	[Ketanserin binds to and results in decreased activity of HTR2A protein] inhibits the reaction [Methamphetamine results in increased secretion of Corticosterone]	19879056
C500528	cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester	cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester inhibits the reaction [Ketanserin binds to HTR2A protein]	20600638
C500528	cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester	cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester results in decreased expression of HTR2A protein	20600638
D016572	Cyclosporine	Cyclosporine inhibits the reaction [Paraquat affects the localization of HTR2A protein]	25947082
C037304	cyhalothrin	cyhalothrin results in increased expression of HTR2A protein	22366556
C017160	cypermethrin	cypermethrin promotes the reaction [cypermethrin results in increased expression of HTR2A mRNA]	25288152
C017160	cypermethrin	cypermethrin promotes the reaction [cypermethrin results in increased expression of HTR2A protein]	25288152
C017160	cypermethrin	cypermethrin results in increased expression of HTR2A mRNA	25288152
C017160	cypermethrin	cypermethrin results in increased expression of HTR2A protein	25288152
D003533	Cyproheptadine	Cyproheptadine binds to and results in decreased activity of HTR2A protein	17031071
D003533	Cyproheptadine	Cyproheptadine binds to and results in decreased activity of HTR2A protein	15068403
D016047	Zalcitabine	HTR2A gene results in increased susceptibility to Zalcitabine	17888573
D016047	Zalcitabine	[alpha-phenyl-1-(2-phenylethyl)-4-piperidinemethanol binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Zalcitabine	17888573
D016047	Zalcitabine	Zalcitabine results in increased expression of HTR2A protein	17888573
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of HTR2A mRNA	23914054
D003891	Desipramine	Desipramine results in decreased expression of HTR2A	2553044
D003891	Desipramine	Desipramine results in decreased expression of HTR2A protein	1664741
D003907	Dexamethasone	Dexamethasone results in increased expression of HTR2A protein	16160705
D003976	Diazinon	Diazinon promotes the reaction [Ketanserin binds to HTR2A protein]	17035140
D003976	Diazinon	Diazinon results in increased expression of HTR2A mRNA	17452286
D003976	Diazinon	Diazinon results in increased expression of HTR2A protein	17035140
D003992	Dibucaine	Dibucaine inhibits the reaction [Paraquat affects the localization of HTR2A protein]	25947082
D004041	Dietary Fats	Dietary Fats results in increased expression of HTR2A protein	27133527
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of HTR2A mRNA	17942915
D004052	Diethylnitrosamine	MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of HTR2A mRNA]	17942915
C113896	dimethoxy-4-indophenyl-2-aminopropane	dimethoxy-4-indophenyl-2-aminopropane binds to and results in increased activity of HTR2A protein	19347958
D004130	N,N-Dimethyltryptamine	"HTR2A gene SNP results in decreased susceptibility to N,N-Dimethyltryptamine"	16314884
D004130	N,N-Dimethyltryptamine	"HTR2A protein affects the susceptibility to N,N-Dimethyltryptamine"	16314884
D004130	N,N-Dimethyltryptamine	"N,N-Dimethyltryptamine binds to and results in increased activity of HTR2A protein"	16314884
D004130	N,N-Dimethyltryptamine	"N,N-Dimethyltryptamine binds to and results in increased activity of HTR2A protein"	16342002
C007517	diphenyleneiodonium	diphenyleneiodonium inhibits the reaction [Paraquat affects the localization of HTR2A protein]	25947082
D004298	Dopamine	"[4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein] which results in increased secretion of and results in increased abundance of Dopamine"	10773215
D004298	Dopamine	"Cocaine promotes the reaction [[4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein] which results in increased secretion of and results in increased abundance of Dopamine]"	10773215
D004298	Dopamine	"Ketanserin inhibits the reaction [[4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein] which results in increased secretion of and results in increased abundance of Dopamine]"	10773215
D004298	Dopamine	"Ketanserin inhibits the reaction [Cocaine promotes the reaction [[4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein] which results in increased secretion of and results in increased abundance of Dopamine]]"	10773215
C074283	estradiol 3-benzoate	estradiol 3-benzoate results in increased expression of HTR2A mRNA	17398000
C074283	estradiol 3-benzoate	estradiol 3-benzoate results in increased expression of HTR2A protein	17398000
C074283	estradiol 3-benzoate	Raloxifene Hydrochloride inhibits the reaction [estradiol 3-benzoate results in increased expression of HTR2A mRNA]	17398000
C074283	estradiol 3-benzoate	Raloxifene Hydrochloride inhibits the reaction [estradiol 3-benzoate results in increased expression of HTR2A protein]	17398000
D005277	Fenfluramine	Fenfluramine binds to HTR2A protein	10617681
D005473	Fluoxetine	Fluoxetine results in decreased activity of HTR2A protein	19445393\|2046451
D005473	Fluoxetine	Fluoxetine results in increased expression of HTR2A mRNA	21083617
D005473	Fluoxetine	HTR2A protein affects the susceptibility to Fluoxetine	10773209
D005473	Fluoxetine	Fluoxetine affects the expression of HTR2A	26475043
D005476	Fluphenazine	Fluphenazine binds to HTR2A protein	17606915
D016666	Fluvoxamine	HTR2A gene SNP affects the susceptibility to Fluvoxamine	12607287
D005620	Freund's Adjuvant	Freund's Adjuvant results in increased expression of HTR2A mRNA	16901936
D005620	Freund's Adjuvant	HTR2A protein promotes the reaction [[Freund's Adjuvant results in increased activity of TRPV1 protein] which results in increased transport of Calcium]	16901936
C102777	gamma-mangostin	gamma-mangostin results in increased expression of HTR2A mRNA	21440614
C102777	gamma-mangostin	Serotonin inhibits the reaction [gamma-mangostin results in increased expression of HTR2A mRNA]	21440614
C081021	Go 6976	Go 6976 results in increased expression of HTR2A mRNA	22791651
C090701	GR 127935	GR 127935 binds to and results in decreased activity of HTR2A protein	9109356
C090701	GR 127935	[[volinanserin binds to and results in decreased activity of HTR2A protein] which co-treated with GR 127935] results in decreased susceptibility to Methamphetamine	11751031
D006220	Haloperidol	Haloperidol binds to HTR2A protein	7520908
D006220	Haloperidol	Haloperidol binds to HTR2A protein	12191584
D006220	Haloperidol	[Phencyclidine co-treated with Haloperidol] affects the activity of HTR2A protein	15380371
D012701	Serotonin	HTR2A protein affects the reaction [Serotonin results in increased activity of PLD1 protein]	18621911
D012701	Serotonin	Ketanserin inhibits the reaction [HTR2A protein affects the reaction [Serotonin results in increased activity of PLD1 protein]]	18621911
D012701	Serotonin	HTR2A gene SNP results in decreased susceptibility to Serotonin	16314884
D012701	Serotonin	HTR2A protein affects the susceptibility to Serotonin	16314884
D012701	Serotonin	Serotonin binds to and results in increased activity of HTR2A protein	16314884
D012701	Serotonin	[Serotonin binds to and results in increased activity of HTR2A protein] which results in increased expression of and results in increased secretion of IL6 protein	11076827
D012701	Serotonin	HTR2A protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]	11880652
D012701	Serotonin	Serotonin results in increased expression of HTR2A mRNA	21083617
D012701	Serotonin	HTR2A protein affects the susceptibility to Serotonin	16528294\|8627522
D012701	Serotonin	[Ketanserin binds to and results in decreased activity of HTR2A protein] inhibits the reaction [Methamphetamine results in decreased abundance of Serotonin]	19879056
D012701	Serotonin	[Ketanserin binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Serotonin	16528294
D012701	Serotonin	Phenoxybenzamine affects the reaction [Serotonin binds to HTR2A protein]	8627522
D012701	Serotonin	Serotonin binds to HTR2A protein	8627522
D012701	Serotonin	Serotonin inhibits the reaction [gamma-mangostin results in increased expression of HTR2A mRNA]	21440614
C062018	HU 211	HU 211 inhibits the reaction [Ketanserin binds to HTR2A protein]	20600638
C062018	HU 211	HU 211 results in decreased expression of HTR2A protein	20600638
D007099	Imipramine	Imipramine results in decreased expression of HTR2A	2553044
D007099	Imipramine	Imipramine results in increased expression of HTR2A mRNA	21440614
C094023	iodopravadoline	"iodopravadoline inhibits the reaction [1,1-dimethylbutyl-1-deoxy-Delta(9)-THC results in increased expression of HTR2A mRNA]"	22791651
C094023	iodopravadoline	"iodopravadoline inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of HTR2A mRNA]"	22791651\|2315187
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of HTR2A mRNA	26752646
C422645	JTE 907	"JTE 907 inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of HTR2A mRNA]"	23151877
C422645	JTE 907	"JTE 907 inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of HTR2A mRNA]"	23151877
D007650	Ketanserin	Ketanserin inhibits the reaction [HTR2A protein affects the reaction [Serotonin results in increased activity of PLD1 protein]]	18621911
D007650	Ketanserin	Aripiprazole inhibits the reaction [Ketanserin binds to HTR2A protein]	16314884
D007650	Ketanserin	Clozapine inhibits the reaction [Ketanserin binds to HTR2A protein]	16314884
D007650	Ketanserin	Ketanserin binds to and results in decreased activity of HTR2A protein	17031071
D007650	Ketanserin	Ketanserin binds to HTR2A protein	16314884\|2891550
D007650	Ketanserin	Ketanserin results in decreased activity of HTR2A protein	22048642
D007650	Ketanserin	Quetiapine Fumarate inhibits the reaction [Ketanserin binds to HTR2A protein]	16314884
D007650	Ketanserin	Spiperone inhibits the reaction [Ketanserin binds to HTR2A protein]	2891550
D007650	Ketanserin	ziprasidone inhibits the reaction [Ketanserin binds to HTR2A protein]	16314884
D007650	Ketanserin	cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester inhibits the reaction [Ketanserin binds to HTR2A protein]	20600638
D007650	Ketanserin	HU 211 inhibits the reaction [Ketanserin binds to HTR2A protein]	20600638
D007650	Ketanserin	Ketanserin binds to and results in decreased activity of HTR2A protein	10978843
D007650	Ketanserin	Ketanserin binds to HTR2A protein	20600638
D007650	Ketanserin	"8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine inhibits the reaction [Ketanserin binds to HTR2A protein]"	11927170
D007650	Ketanserin	Diazinon promotes the reaction [Ketanserin binds to HTR2A protein]	17035140
D007650	Ketanserin	Ketanserin binds to and results in decreased activity of HTR2A protein	10773215\|1878434
D007650	Ketanserin	[Ketanserin binds to and results in decreased activity of HTR2A protein] inhibits the reaction [Methamphetamine results in decreased abundance of Serotonin]	19879056
D007650	Ketanserin	[Ketanserin binds to and results in decreased activity of HTR2A protein] inhibits the reaction [Methamphetamine results in increased secretion of Corticosterone]	19879056
D007650	Ketanserin	[Ketanserin binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Serotonin	16528294
D007650	Ketanserin	Ketanserin binds to HTR2A protein	11927170
D007650	Ketanserin	"Ketanserin inhibits the reaction [[4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein] which results in increased secretion of and results in increased abundance of Dopamine]"	10773215
D007650	Ketanserin	"Ketanserin inhibits the reaction [Cocaine promotes the reaction [[4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein] which results in increased secretion of and results in increased abundance of Dopamine]]"	10773215
D007650	Ketanserin	Ketanserin inhibits the reaction [Tramadol results in increased activity of HTR2A protein]	18417104
D007650	Ketanserin	Risperidone inhibits the reaction [Ketanserin binds to HTR2A protein]	11927170
D007650	Ketanserin	Ketanserin results in increased expression of HTR2A mRNA	21440614
D007650	Ketanserin	Ketanserin binds to and results in decreased activity of HTR2A protein	10669905\|1076492
D001556	Lindane	Lindane results in increased expression of HTR2A mRNA	25572523
D018021	Lithium Chloride	Lithium Chloride results in decreased expression of HTR2A mRNA	23527032
C052424	lomerizine	lomerizine results in decreased activity of HTR2A protein	19783864
D008152	Loxapine	Loxapine analog binds to HTR2A protein	9723970
D008152	Loxapine	Loxapine binds to HTR2A protein	9723970
C105748	lubazodone hydrochloride	lubazodone hydrochloride binds to HTR2A protein	21823597
D000069056	Lurasidone Hydrochloride	Lurasidone Hydrochloride binds to HTR2A protein	20404009
C417213	LY 367265	LY 367265 binds to HTR2A protein	21823597
C115236	MDL 100,151	"MDL 100,151 binds to and results in decreased activity of HTR2A protein"	7498321
D008711	Metergoline	[Metergoline binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Cocaine	10764922
D008711	Metergoline	Metergoline binds to and results in decreased activity of HTR2A protein	10764922
C014655	methamidophos	methamidophos affects the activity of HTR2A protein	23596261
D008694	Methamphetamine	[Ketanserin binds to and results in decreased activity of HTR2A protein] inhibits the reaction [Methamphetamine results in decreased abundance of Serotonin]	19879056
D008694	Methamphetamine	[Ketanserin binds to and results in decreased activity of HTR2A protein] inhibits the reaction [Methamphetamine results in increased secretion of Corticosterone]	19879056
D008694	Methamphetamine	[volinanserin binds to and results in decreased activity of HTR2A protein] inhibits the reaction [SB 206553 results in increased susceptibility to Methamphetamine]	11751031
D008694	Methamphetamine	[[volinanserin binds to and results in decreased activity of HTR2A protein] which co-treated with GR 127935] results in decreased susceptibility to Methamphetamine	11751031
D008719	Methiothepin	[Methiothepin binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Cocaine	10764922
D008719	Methiothepin	Methiothepin binds to and results in decreased activity of HTR2A protein	10764922
C445068	methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate	"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate results in decreased activity of HTR2A protein"	28790194
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"HTR2A protein affects the susceptibility to N-Methyl-3,4-methylenedioxyamphetamine"	22983118
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of HTR2A protein"	26068050
D008803	Mianserin	Mianserin binds to and results in decreased activity of HTR2A protein	10978843
D008803	Mianserin	[Mianserin binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Cocaine	10764922
D008803	Mianserin	Mianserin binds to and results in decreased activity of HTR2A protein	10764922\|7673653
C035133	mirtazapine	mirtazapine binds to and results in decreased activity of HTR2A protein	28623179
D016686	Monocrotaline	Monocrotaline results in increased expression of HTR2A mRNA	25460361
D016686	Monocrotaline	Quercetin inhibits the reaction [Monocrotaline results in increased expression of HTR2A mRNA]	25460361
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of HTR2A mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of HTR2A mRNA"	25554681
C051752	nefazodone	nefazodone binds to and results in decreased activity of HTR2A protein	15730347
C051752	nefazodone	nefazodone binds to HTR2A protein	21823597
C051752	nefazodone	nefazodone results in decreased activity of HTR2A protein	11488371\|1276693
D009532	Nickel	Nickel results in decreased expression of HTR2A mRNA	18835401
D009538	Nicotine	Nicotine results in increased activity of [HTR1B protein binds to HTR2A protein]	21316381
C007350	nitrofen	nitrofen results in increased expression of HTR2A mRNA	24888825
C007350	nitrofen	nitrofen results in increased expression of HTR2A protein	24888825
C058272	norclozapine	norclozapine results in decreased expression of HTR2A mRNA	14751426
C058272	norclozapine	norclozapine results in decreased expression of HTR2A protein	14751426
D009642	Norfenfluramine	Norfenfluramine binds to HTR2A protein	10617681
C553580	N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide	"ARRB2 mutant form inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of HTR2A mRNA]"	23174265
C553580	N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide	"Colforsin inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of HTR2A mRNA]"	22791651
C553580	N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide	"iodopravadoline inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of HTR2A mRNA]"	22791651\|2315187
C553580	N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide	"JTE 907 inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of HTR2A mRNA]"	23151877
C553580	N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide	"N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of HTR2A mRNA"	22791651\|2315187
C553580	N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide	"N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of HTR2A protein"	22791651\|2315187
C553580	N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide	"PD 198306 affects the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of HTR2A mRNA]"	22791651
C553580	N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide	"PD 198306 inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of HTR2A mRNA]"	22791651\|2315187
C553580	N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide	"PD 198306 inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of HTR2A protein]"	23151877
C553580	N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide	"Pertussis Toxin inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of HTR2A mRNA]"	22791651
C553580	N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide	"Pertussis Toxin inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of HTR2A protein]"	22791651
C553580	N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide	"Phorbol 12,13-Dibutyrate inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of HTR2A mRNA]"	22791651
C553580	N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide	"SR 11302 inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of HTR2A mRNA]"	22791651
C106996	NRA 0045	NRA 0045 binds to and results in decreased activity of HTR2A protein	9179395
C106996	NRA 0045	NRA 0045 binds to HTR2A protein	9223539
C076029	olanzapine	olanzapine binds to and results in decreased activity of HTR2A protein	20521326
C076029	olanzapine	olanzapine binds to HTR2A protein	16983399
C076029	olanzapine	olanzapine binds to HTR2A protein	24389121
C076029	olanzapine	"[alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide results in decreased activity of JAK2 protein] inhibits the reaction [olanzapine results in decreased activity of HTR2A protein]"	19304867
C076029	olanzapine	olanzapine binds to and results in decreased activity of HTR2A protein	18976543
C076029	olanzapine	[olanzapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein	18976543
C076029	olanzapine	[[olanzapine binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein	18976543
C076029	olanzapine	olanzapine results in decreased activity of HTR2A protein	19304867
D010126	Ozone	Ozone results in increased expression of HTR2A protein	23570994
D000068882	Paliperidone Palmitate	Paliperidone Palmitate binds to and results in decreased activity of HTR2A protein	19713555
D000068882	Paliperidone Palmitate	Paliperidone Palmitate binds to HTR2A protein	7520908
D000068882	Paliperidone Palmitate	Paliperidone Palmitate binds to HTR2A protein	22437487
D000068882	Paliperidone Palmitate	Paliperidone Palmitate binds to and results in decreased activity of HTR2A protein	19066856
D019308	Palmitic Acid	Palmitic Acid results in increased expression of HTR2A protein	27133527
D010269	Paraquat	Cyclosporine inhibits the reaction [Paraquat affects the localization of HTR2A protein]	25947082
D010269	Paraquat	Dibucaine inhibits the reaction [Paraquat affects the localization of HTR2A protein]	25947082
D010269	Paraquat	diphenyleneiodonium inhibits the reaction [Paraquat affects the localization of HTR2A protein]	25947082
D010269	Paraquat	Paraquat affects the localization of HTR2A protein	25947082
D010269	Paraquat	Paraquat results in decreased expression of HTR2A mRNA	17077588
D010278	Parathion	Parathion results in decreased expression of HTR2A protein	17035140
D017374	Paroxetine	HTR2A gene polymorphism affects the susceptibility to Paroxetine	17503984
C410127	PCB 180	PCB 180 results in increased expression of HTR2A mRNA	23829299
C475178	PD 198306	"PD 198306 affects the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of HTR2A mRNA]"	22791651
C475178	PD 198306	"PD 198306 inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of HTR2A mRNA]"	22791651\|2315187
C475178	PD 198306	"PD 198306 inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of HTR2A protein]"	23151877
C539977	perphenazine GABA ester	perphenazine GABA ester binds to and results in decreased activity of HTR2A protein	18757185
D037342	Pertussis Toxin	"Pertussis Toxin inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of HTR2A mRNA]"	22791651
D037342	Pertussis Toxin	"Pertussis Toxin inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of HTR2A protein]"	22791651
C000593032	PGW5 compound	PGW5 compound binds to HTR2A protein	24389121
D010622	Phencyclidine	Clozapine promotes the reaction [Phencyclidine results in decreased activity of HTR2A protein]	15380371
D010622	Phencyclidine	[Phencyclidine co-treated with Haloperidol] affects the activity of HTR2A protein	15380371
D010622	Phencyclidine	Phencyclidine results in decreased activity of HTR2A protein	15380371
D010643	Phenoxybenzamine	Phenoxybenzamine affects the reaction [Serotonin binds to HTR2A protein]	8627522
D015240	Phorbol 12,13-Dibutyrate	"Phorbol 12,13-Dibutyrate inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of HTR2A mRNA]"	22791651
C510793	pimavanserin	pimavanserin binds to and results in decreased activity of HTR2A protein	17519387\|1853467
D010879	Piperazines	Piperazines analog binds to HTR2A protein	21509803
C034177	pirenperone	pirenperone binds to and results in decreased activity of HTR2A protein	10764922\|9085399
D011070	Poly I-C	Poly I-C results in increased expression of HTR2A mRNA	24889602
D011374	Progesterone	Progesterone results in increased expression of HTR2A mRNA	21540246
D011374	Progesterone	Progesterone results in increased expression of HTR2A mRNA	20726854
D011441	Propylthiouracil	Propylthiouracil results in increased expression of HTR2A mRNA	24780913
D011562	Psilocybin	Psilocybin binds to and results in increased activity of HTR2A protein	12496954
D011794	Quercetin	Quercetin inhibits the reaction [Monocrotaline results in increased expression of HTR2A mRNA]	25460361
D000069348	Quetiapine Fumarate	Quetiapine Fumarate inhibits the reaction [Ketanserin binds to HTR2A protein]	16314884
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride affects the expression of HTR2A mRNA	14699072
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride inhibits the reaction [estradiol 3-benzoate results in increased expression of HTR2A mRNA]	17398000
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride inhibits the reaction [estradiol 3-benzoate results in increased expression of HTR2A protein]	17398000
D018967	Risperidone	HTR2A gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein]	19997080
D018967	Risperidone	HTR2A gene SNP results in increased susceptibility to Risperidone	16314884
D018967	Risperidone	HTR2A protein affects the susceptibility to Risperidone	16314884
D018967	Risperidone	HTR2A protein results in increased susceptibility to Risperidone	19997080
D018967	Risperidone	Risperidone binds to and results in decreased activity of HTR2A protein	16314884
D018967	Risperidone	Risperidone binds to HTR2A protein	7520908
D018967	Risperidone	Risperidone binds to and results in decreased activity of HTR2A protein	16948927
D018967	Risperidone	Risperidone binds to HTR2A protein	12191584\|2243748
D018967	Risperidone	Risperidone inhibits the reaction [Ketanserin binds to HTR2A protein]	11927170
D016713	Ritanserin	Ritanserin binds to and results in decreased activity of HTR2A protein	17031071
D016713	Ritanserin	Ritanserin binds to HTR2A protein	8937629
D016713	Ritanserin	Ritanserin binds to and results in decreased activity of HTR2A protein	10762688\|1112440
C064294	sarpogrelate	sarpogrelate binds to and results in decreased activity of HTR2A protein	17031071\|1967203
C064294	sarpogrelate	sarpogrelate binds to and results in decreased activity of HTR2A protein mutant form	17031071
C064294	sarpogrelate	sarpogrelate binds to HTR2A protein	16974069
C064294	sarpogrelate	sarpogrelate metabolite binds to and results in decreased activity of HTR2A protein	17031071
C064294	sarpogrelate	sarpogrelate binds to HTR2A protein	8937629
C064294	sarpogrelate	sarpogrelate metabolite binds to HTR2A protein	8937629
C064294	sarpogrelate	sarpogrelate binds to and affects the activity of HTR2A protein	26824242
C064294	sarpogrelate	sarpogrelate binds to and results in decreased activity of HTR2A protein	11076827\|1145520
C094868	SB 206553	[volinanserin binds to and results in decreased activity of HTR2A protein] inhibits the reaction [SB 206553 results in increased susceptibility to Methamphetamine]	11751031
D020280	Sertraline	[Estradiol co-treated with Sertraline] affects the expression of HTR2A mRNA	18650020
D020280	Sertraline	Estradiol promotes the reaction [Sertraline results in increased expression of HTR2A mRNA]	18650020
D020280	Sertraline	Sertraline results in increased expression of HTR2A mRNA	18650020
C017947	sodium arsenite	sodium arsenite inhibits the reaction [Acetaminophen results in decreased expression of HTR2A mRNA]	25128769
C017947	sodium arsenite	sodium arsenite results in decreased expression of HTR2A mRNA	25128769
D013134	Spiperone	Spiperone inhibits the reaction [Ketanserin binds to HTR2A protein]	2891550
D013134	Spiperone	Spiperone binds to and results in decreased activity of HTR2A protein	21414306
C106195	SR 11302	"SR 11302 inhibits the reaction [N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-1,4-dihydro-6-methylindeno(1,2-c)pyrazole-3-carboxamide results in increased expression of HTR2A mRNA]"	22791651
C076033	SR 46349B	SR 46349B binds to and results in decreased activity of HTR2A protein	16001122
D013311	Streptozocin	"Streptozocin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased activity of HTR2A protein]"	18622176
D013629	Tamoxifen	Tamoxifen affects the expression of HTR2A mRNA	14699072
D014028	Tobacco Smoke Pollution	"5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone inhibits the reaction [Tobacco Smoke Pollution results in increased expression of HTR2A mRNA]"	22952915
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of HTR2A protein	27633979
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of HTR2A mRNA	22952915
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of HTR2A protein	22952915
D014147	Tramadol	Ketanserin inhibits the reaction [Tramadol results in increased activity of HTR2A protein]	18417104
D014147	Tramadol	Tramadol results in increased activity of HTR2A protein	18417104
D014147	Tramadol	Tramadol results in increased expression of HTR2A mRNA	18417104
D014196	Trazodone	Trazodone binds to and results in decreased activity of HTR2A protein	15614572\|1962343
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of HTR2A mRNA	23537331
C030820	tryptamine	HTR2A gene SNP results in decreased susceptibility to tryptamine	16314884
C030820	tryptamine	HTR2A protein affects the susceptibility to tryptamine	16314884
C030820	tryptamine	tryptamine binds to and results in increased activity of HTR2A protein	16314884
D014635	Valproic Acid	Valproic Acid results in decreased methylation of HTR2A gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of HTR2A gene	25560391
D014750	Vincristine	[alpha-phenyl-1-(2-phenylethyl)-4-piperidinemethanol binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Vincristine	18930597
D014750	Vincristine	Vincristine results in increased expression of HTR2A protein	18930597
C079049	volinanserin	volinanserin affects the activity of HTR2A protein	23611293
C079049	volinanserin	volinanserin binds to and results in decreased activity of HTR2A protein	19331461
C079049	volinanserin	"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[[volinanserin binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein]"	18976543
C079049	volinanserin	volinanserin binds to and results in decreased activity of HTR2A protein	18976543
C079049	volinanserin	[volinanserin binds to and results in decreased activity of HTR2A protein] inhibits the reaction [SB 206553 results in increased susceptibility to Methamphetamine]	11751031
C079049	volinanserin	[[volinanserin binds to and results in decreased activity of HTR2A protein] which co-treated with GR 127935] results in decreased susceptibility to Methamphetamine	11751031
C079049	volinanserin	[volinanserin binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein	18976543
C079049	volinanserin	[[volinanserin binds to and results in decreased activity of HTR2A protein] which results in increased phosphorylation of JAK2 protein] which results in increased expression of RGS7 protein	18976543
C079049	volinanserin	volinanserin binds to and results in decreased activity of HTR2A protein	10188965\|1125956
D015016	Yohimbine	"[Yohimbine co-treated with Cocaine] affects the reaction [HTR2A protein results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine]"	8392199
C092292	ziprasidone	ziprasidone inhibits the reaction [Ketanserin binds to HTR2A protein]	16314884
C092292	ziprasidone	ziprasidone binds to and results in decreased activity of HTR2A protein	7562537

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001618	virus receptor activity	-	IEA	-
GO:0001965	G-protein alpha-subunit binding	-	IEA	-
GO:0004930	G-protein coupled receptor activity	-	IBA	21873635
GO:0004993	G-protein coupled serotonin receptor activity	-	IBA	21873635
GO:0004993	G-protein coupled serotonin receptor activity	-	IDA	7582481 15862800
GO:0008144	drug binding	-	IDA	15831837 15862800 18703043
GO:0030594	neurotransmitter receptor activity	-	IBA	21873635
GO:0044877	protein-containing complex binding	-	IEA	-
GO:0051378	serotonin binding	-	IDA	7582481 15831837 15862800 19057895
GO:0071886	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	-	IDA	19057895

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001659	temperature homeostasis	-	IEA	-
GO:0006874	cellular calcium ion homeostasis	-	IDA	16517693 19057895
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	-	IBA	21873635
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway	-	IBA	21873635
GO:0007202	activation of phospholipase C activity	-	IDA	16517693
GO:0007208	phospholipase C-activating serotonin receptor signaling pathway	-	IEA	-
GO:0007210	serotonin receptor signaling pathway	-	IMP	18703043
GO:0007268	chemical synaptic transmission	-	IBA	21873635
GO:0007268	chemical synaptic transmission	-	TAS	9109547
GO:0007568	aging	-	IEA	-
GO:0007613	memory	-	IEA	-
GO:0008219	cell death	-	IEA	-
GO:0008284	positive regulation of cell proliferation	-	IEA	-
GO:0010513	positive regulation of phosphatidylinositol biosynthetic process	-	IDA	19057895
GO:0014059	regulation of dopamine secretion	-	IEA	-
GO:0014065	phosphatidylinositol 3-kinase signaling	-	IDA	16517693
GO:0014824	artery smooth muscle contraction	-	IEA	-
GO:0014832	urinary bladder smooth muscle contraction	-	IEA	-
GO:0030431	sleep	-	IEA	-
GO:0042493	response to drug	-	IBA	21873635
GO:0042493	response to drug	-	IDA	15862800 18703043
GO:0043267	negative regulation of potassium ion transport	-	IEA	-
GO:0043406	positive regulation of MAP kinase activity	-	IEA	-
GO:0044380	protein localization to cytoskeleton	-	IEA	-
GO:0045600	positive regulation of fat cell differentiation	-	IEA	-
GO:0045821	positive regulation of glycolytic process	-	IEA	-
GO:0045907	positive regulation of vasoconstriction	-	IEA	-
GO:0046718	viral entry into host cell	-	IEA	-
GO:0048148	behavioral response to cocaine	-	IEA	-
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	-	IEA	-
GO:0050965	detection of temperature stimulus involved in sensory perception of pain	-	IEA	-
GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	-	IEA	-
GO:0051209	release of sequestered calcium ion into cytosol	-	IBA	21873635
GO:0051209	release of sequestered calcium ion into cytosol	-	IDA	15862800
GO:0051209	release of sequestered calcium ion into cytosol	-	IMP	18703043
GO:0051967	negative regulation of synaptic transmission, glutamatergic	-	IEA	-
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IDA	19057895

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005829	cytosol	-	IEA	-
GO:0005886	plasma membrane	-	IDA	15862800 18703043
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	IEA	-
GO:0005901	caveola	-	IEA	-
GO:0030424	axon	-	IEA	-
GO:0030425	dendrite	-	IBA	21873635
GO:0031410	cytoplasmic vesicle	-	IEA	-
GO:0043025	neuronal cell body	-	IEA	-
GO:0043198	dendritic shaft	-	IEA	-
GO:0070852	cell body fiber	-	IEA	-

KEGG ID	KEGG Term
hsa04020	Calcium signaling pathway
hsa04080	Neuroactive ligand-receptor interaction
hsa04540	Gap junction

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375280	Amine ligand-binding receptors	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-390666	Serotonin receptors	TAS
R-HSA-416476	G alpha (q) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25069264	[Haplotype analysis of serotonin 2A receptor gene polymorphisms and smoking behavior]. (2013 Nov)	Narita S	Nihon Shinkei Seishin Yakurigaku Zasshi
25660313	Meta-analysis of six genes (BDNF, DRD1, DRD3, DRD4, GRIN2B and MAOA) involved in neuroplasticity and the risk for alcohol dependence. (2015 Apr 1)	Forero DA	Drug Alcohol Depend
19170664	Association between Val66Met brain-derived neurotrophic factor (BDNF) gene polymorphism and post-treatment relapse in alcohol dependence. (2009 Apr)	Wojnar M	Alcohol Clin Exp Res
26983355	The serotonin-2A receptor polymorphism and clinical symptoms in mood disorders, schizophrenia and alcohol dependence in Japan. (2003 Jun)	Terayama H	Acta Neuropsychiatr
22545912	Association of genetic, psychological and behavioral factors with sleep bruxism in a Japanese population. (2012 Jun)	Abe Y	J Sleep Res
11134668	Pharmacogenetics and the serotonin system: initial studies and future directions. (2000 Dec 27)	Veenstra-VanderWeele J	Eur J Pharmacol
21621273	Association of polymorphisms in HTR2A, HTR1A and TPH2 genes with suicide attempts in alcohol dependence: a preliminary report. (2011 Nov 30)	Wrzosek M	Psychiatry Res
22028400	Cigarette experimentation in Mexican origin youth: psychosocial and genetic determinants. (2012 Jan)	Wilkinson AV	Cancer Epidemiol Biomarkers Prev
25161819	Genetic, psychosocial, and demographic factors associated with social disinhibition in Mexican-origin youth. (2014 Jul)	Archer NP	Brain Behav
26203295	Altered placental DNA methylation patterns associated with maternal smoking: current perspectives. (2015 May 7)	Maccani JZ	Adv Genomics Genet
15564892	The serotonin-2A receptor polymorphism and smoking behavior in Japan. (2004 Dec)	Terayama H	Psychiatr Genet
18552399	Association between the Stin2 VNTR polymorphism of the serotonin transporter gene and treatment outcome in alcohol-dependent patients. (2008 Sep-Oct)	Florez G	Alcohol Alcohol
22933845	Polymorphisms of the serotonin transporter and receptor genes: susceptibility to substance abuse. (2012 Jun)	Herman AI	Subst Abuse Rehabil
22661198	Serotonin 2A receptor gene (HTR2A) polymorphism in alcohol-dependent patients. (2012)	Wrzosek M	Pharmacol Rep
24178752	Association of the HTR2A gene with alcohol and heroin abuse. (2014 Mar)	Cao J	Hum Genet
23241418	Association study of 37 genes related to serotonin and dopamine neurotransmission and neurotrophic factors in cocaine dependence. (2013 Feb)	Fernandez-Castillo N	Genes Brain Behav
21930285	The CC genotype in HTR2A T102C polymorphism is associated with behavioral impulsivity in alcohol-dependent patients. (2012 Jan)	Jakubczyk A	J Psychiatr Res
12218658	Antisocial alcoholism and serotonin-related polymorphisms: association tests. (2002 Sep)	Hill EM	Psychiatr Genet
29032150	Functional analysis of schizophrenia genes using GeneAnalytics program and integrated databases. (2018 Jan 30)	Sundararajan T	Gene
19742166	Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 variations does not impact alcohol dependence disorder features. (2009 Jul)	Drago A	Int J Environ Res Public Health
23321485	The CC genotype in the T102C HTR2A polymorphism predicts relapse in individuals after alcohol treatment. (2013 Apr)	Jakubczyk A	J Psychiatr Res
16770336	Why do young women smoke? II. Role of traumatic life experience, psychological characteristics and serotonergic genes. (2006 Aug)	Lerer E	Mol Psychiatry
22046326	'Smoking genes': a genetic association study. (2011)	Verde Z	PLoS One
29333880	Pharmacogenetic analysis of opioid dependence treatment dose and dropout rate. (2018)	Crist RC	Am J Drug Alcohol Abuse
19193342	Multiple genetic factors in olanzapine-induced weight gain in schizophrenia patients: a cohort study. (2008 Sep)	Ujike H	J Clin Psychiatry
10776672	An association study between alcoholism and the serotonergic receptor genes. (2000 Mar)	Himei A	Alcohol Clin Exp Res
26616111	Disorder-specific genetic factors in obsessive-compulsive disorder: A comprehensive meta-analysis. (2016 Apr)	Taylor S	Am J Med Genet B Neuropsychiatr Genet
28900078	[Polymorphic Variants of Glutamate Receptor (GRIK5, GRIN2B) and Serotonin Receptor (HTR2A) Genes Are Associated with Chronic Obstructive Pulmonary Disease]. (2017 Jul-Aug)	Korytina GF	Mol Biol (Mosk)
19328219	Differential role of serotonergic polymorphisms in alcohol and heroin dependence. (2009 Jun 15)	Saiz PA	Prog Neuropsychopharmacol Biol Psychiatry