Gene: HTR2B

3357
5-HT(2B)|5-HT-2B|5-HT2B
5-hydroxytryptamine receptor 2B
protein-coding
2q37.1
Ensembl:ENSG00000135914 MIM:601122 Vega:OTTHUMG00000133222 UniprotKB:P41595
NC_000002.12
PubMed
0   ANCO-SNPs
AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.297e-2 (AD)  6.179e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TDGF10.44
SEMA3G0.439
TRPC30.437
EXPH50.428
C1QTNF70.426
IGF20.426
TMPPE0.415
SCUBE30.407
CXCL120.403
NR2F2-AS10.402

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLEC18B-0.294
AQP1-0.273
PROC-0.267
KIF19-0.265
UNC5CL-0.258
TK1-0.258
MORN5-0.251
NRN1L-0.251
CLDND2-0.248
IP6K3-0.245

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00216EletriptanSmall Molecule143322-58-1Approved|InvestigationalTarget
DB00247MethysergideSmall Molecule361-37-5ApprovedTarget
DB00248CabergolineSmall Molecule81409-90-7ApprovedTarget
DB00268RopiniroleSmall Molecule91374-21-9Approved|InvestigationalTarget
DB00320DihydroergotamineSmall Molecule511-12-6Approved|InvestigationalTarget
DB00334OlanzapineSmall Molecule132539-06-1Approved|InvestigationalTarget
DB00353MethylergometrineSmall Molecule113-42-8ApprovedTarget
DB00370MirtazapineSmall Molecule85650-52-8ApprovedTarget
DB00413PramipexoleSmall Molecule104632-26-0Approved|InvestigationalTarget
DB00508TriflupromazineSmall Molecule146-54-3ApprovedTarget
DB00543AmoxapineSmall Molecule14028-44-5ApprovedTarget
DB00574FenfluramineSmall Molecule458-24-2Approved|Illicit|Investigational|WithdrawnTarget
DB00589LisurideSmall Molecule18016-80-3Approved|InvestigationalTarget
DB00696ErgotamineSmall Molecule113-15-5ApprovedTarget
DB00714ApomorphineSmall Molecule58-00-4Approved|InvestigationalTarget
DB00805MinaprineSmall Molecule25905-77-5ApprovedTarget
DB01079TegaserodSmall Molecule145158-71-0Approved|Investigational|WithdrawnTarget
DB01142DoxepinSmall Molecule1668-19-5Approved|InvestigationalTarget
DB01186PergolideSmall Molecule66104-22-1Approved|Investigational|WithdrawnTarget
DB01200BromocriptineSmall Molecule25614-03-3Approved|InvestigationalTarget
DB01239ChlorprothixeneSmall Molecule113-59-7Approved|Investigational|WithdrawnTarget
DB01242ClomipramineSmall Molecule303-49-1Approved|InvestigationalTarget
DB01392YohimbineSmall Molecule146-48-5Approved|InvestigationalTarget
DB01454MidomafetamineSmall Molecule42542-10-9Experimental|Illicit|InvestigationalTarget
DB04829Lysergic Acid DiethylamideSmall Molecule50-37-3Illicit|Investigational|WithdrawnTarget
DB05461OPC-28326Small Molecule-InvestigationalTarget
DB05492Epicept NP-1Small Molecule-InvestigationalTarget
DB06016CariprazineSmall Molecule839712-12-8Approved|InvestigationalTarget
DB06148MianserinSmall Molecule24219-97-4Approved|InvestigationalTarget
DB06216AsenapineSmall Molecule65576-45-6ApprovedTarget
DB06229OcaperidoneSmall Molecule129029-23-8InvestigationalTarget
DB09286PipamperoneSmall Molecule1893-33-0Approved|InvestigationalTarget
DB01049Ergoloid mesylateSmall Molecule8067-24-1ApprovedTarget
DB09304SetiptilineSmall Molecule57262-94-9ApprovedTarget
DB13025TiaprideSmall Molecule51012-32-9Approved|InvestigationalTarget
DB00477ChlorpromazineSmall Molecule50-53-3Approved|InvestigationalTarget
DB01221KetamineSmall Molecule6740-88-1ApprovedTarget
DB06678EsmirtazapineSmall Molecule61337-87-9InvestigationalTarget
ID Drug Name Action PubMed
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]"18758753
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]"18758753
C0150681-(3-chlorophenyl)piperazine1-(3-chlorophenyl)piperazine binds to and results in increased activity of HTR2B protein21414306
C0924301-(5-(2-thenyloxy)-1H-indol-3-yl)propan-2-amine1-(5-(2-thenyloxy)-1H-indol-3-yl)propan-2-amine binds to and results in increased activity of HTR2B protein21414306
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HTR2B mRNA"23196670
C5448654,5,7a,8,9,10,11,11a-octohydro-7H-10-methylindolol(1,7bc)(2,6)-napthyridine"4,5,7a,8,9,10,11,11a-octohydro-7H-10-methylindolol(1,7bc)(2,6)-napthyridine results in decreased expression of HTR2B protein"20374255
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of HTR2B mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of HTR2B mRNA]17585979
D000447AldehydesAldehydes results in decreased expression of HTR2B mRNA25014914
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of HTR2B mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HTR2B mRNA16483693
D000068180AripiprazoleAripiprazole binds to HTR2B protein18363460
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of HTR2B mRNA26377693
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]18758753
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]18758753
C006780bisphenol Abisphenol A results in increased expression of HTR2B mRNA27685785|2927551
C006780bisphenol Abisphenol A results in increased expression of HTR2B mRNA26063408
C006780bisphenol Abisphenol A results in decreased expression of HTR2B mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of HTR2B gene28505145
D000069286BortezomibBortezomib results in decreased expression of HTR2B mRNA20977926
C018475butyraldehydebutyraldehyde results in decreased expression of HTR2B mRNA26079696
C047047cabergolinecabergoline binds to and results in increased activity of HTR2B protein17202450|1770656
C047047cabergolinecabergoline results in increased activity of HTR2B protein18251828
D002118CalciumCalcium promotes the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]18758753
D002118CalciumCalcium promotes the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]18758753
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of HTR2B mRNA17484886
D004390ChlorpyrifosChlorpyrifos results in decreased expression of HTR2B mRNA17452286
D004390ChlorpyrifosChlorpyrifos results in increased expression of HTR2B mRNA18835401
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of HTR2B mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of HTR2B mRNA]17585979
D003300Copper[Disulfiram binds to Copper] which results in increased expression of HTR2B mRNA24690739
D003533CyproheptadineCyproheptadine binds to and results in decreased activity of HTR2B protein19346455
D000069439DasatinibDasatinib results in increased expression of HTR2B mRNA20579391
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of HTR2B mRNA28628672
D003976DiazinonDiazinon results in decreased expression of HTR2B mRNA18835401
D004026DieldrinDieldrin affects the expression of HTR2B mRNA18835401
D004041Dietary FatsDietary Fats results in increased expression of HTR2B protein27133527
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of HTR2B mRNA27565560
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of HTR2B protein27565560
D004087DihydroergotamineDihydroergotamine binds to and results in increased activity of HTR2B protein17202450
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of HTR2B mRNA24690739
D004878ErgotamineErgotamine binds to and results in increased activity of HTR2B protein11104741
D004878ErgotamineErgotamine binds to and results in increased activity of HTR2B protein17202450
D018683Excitatory Amino Acid AgentsHTR2B protein inhibits the reaction [Fluoxetine inhibits the reaction [Excitatory Amino Acid Agents results in increased phosphorylation of MAPK1 protein]]21320410
D018683Excitatory Amino Acid AgentsHTR2B protein inhibits the reaction [Fluoxetine inhibits the reaction [Excitatory Amino Acid Agents results in increased phosphorylation of MAPK3 protein]]21320410
D005277FenfluramineFenfluramine binds to HTR2B protein10617681
D005277FenfluramineHTR2B gene mutant form results in increased susceptibility to Fenfluramine14659797
D005277FenfluramineFenfluramine binds to and results in increased activity of HTR2B protein17202450
D005473Fluoxetine"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]"18758753
D005473Fluoxetine"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]"18758753
D005473Fluoxetinebisindolylmaleimide I inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]18758753
D005473Fluoxetinebisindolylmaleimide I inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]18758753
D005473FluoxetineCalcium promotes the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]18758753
D005473FluoxetineCalcium promotes the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]18758753
D005473FluoxetineFluoxetine binds to and results in increased activity of HTR2B protein19662385
D005473Fluoxetine[Fluoxetine binds to and results in increased activity of HTR2B protein] which results in increased activity of MAPK1 protein19662385
D005473Fluoxetine[[Fluoxetine binds to and results in increased activity of HTR2B protein] which results in increased activity of MAPK1 protein] which results in increased expression of PLA2G4A protein19662385
D005473Fluoxetine[Fluoxetine binds to and results in increased activity of HTR2B protein] which results in increased activity of MAPK3 protein19662385
D005473Fluoxetine[[Fluoxetine binds to and results in increased activity of HTR2B protein] which results in increased activity of MAPK3 protein] which results in increased expression of PLA2G4A protein19662385
D005473FluoxetineFluoxetine promotes the reaction [mesulergine binds to HTR2B protein]11930908
D005473FluoxetineFluoxetine results in increased activity of HTR2B protein18758753
D005473Fluoxetine[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein18758753
D005473Fluoxetine[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein18758753
D005473FluoxetineFluoxetine results in increased expression of and results in increased activity of HTR2B protein11930908
D005473Fluoxetine[Fluoxetine results in increased expression of and results in increased activity of HTR2B protein] which results in increased metabolism of Glycogen11930908
D005473FluoxetineFluoxetine results in increased expression of HTR2B mRNA21083617
D005473FluoxetineHTR2B protein inhibits the reaction [Fluoxetine inhibits the reaction [Excitatory Amino Acid Agents results in increased phosphorylation of MAPK1 protein]]21320410
D005473FluoxetineHTR2B protein inhibits the reaction [Fluoxetine inhibits the reaction [Excitatory Amino Acid Agents results in increased phosphorylation of MAPK3 protein]]21320410
D005473FluoxetineHTR2B protein promotes the reaction [Fluoxetine results in increased expression of ADARB1 mRNA]21320410
D005473FluoxetineHTR2B protein promotes the reaction [Fluoxetine results in increased expression of ADARB1 protein]21320410
D005473FluoxetineHTR2B protein promotes the reaction [Fluoxetine results in increased expression of GRIK2 mRNA]21320410
D005473FluoxetineHTR2B protein promotes the reaction [Fluoxetine results in increased expression of GRIK2 protein]21320410
D005473FluoxetineN-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea promotes the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]18758753
D005473FluoxetineN-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea promotes the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]18758753
D005473FluoxetineN-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]18758753
D005473FluoxetineN-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]18758753
D005473Fluoxetinetyrphostin AG 1478 inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]18758753
D005473Fluoxetinetyrphostin AG 1478 inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]18758753
D005620Freund's AdjuvantFreund's Adjuvant results in increased expression of HTR2B mRNA20846436
C039281furanfuran results in increased expression of HTR2B mRNA27387713
D006003Glycogen[Fluoxetine results in increased expression of and results in increased activity of HTR2B protein] which results in increased metabolism of Glycogen11930908
D012701SerotoninSerotonin results in increased expression of HTR2B mRNA21083617
D012701SerotoninHTR2B protein affects the susceptibility to Serotonin8627522
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of HTR2B mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HTR2B mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of HTR2B mRNA28628672
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in increased expression of HTR2B mRNA"23090859
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of HTR2B mRNA12057914
D008090LisurideLisuride binds to and results in decreased activity of HTR2B protein16614540
D008238Lysergic Acid DiethylamideLysergic Acid Diethylamide analog binds to and results in increased activity of HTR2B protein14659797
D015122MercaptopurineMercaptopurine results in increased expression of HTR2B mRNA23358152
C031649mesulergineFluoxetine promotes the reaction [mesulergine binds to HTR2B protein]11930908
C031649mesulerginemesulergine binds to HTR2B protein11930908
D008694MethamphetamineMethamphetamine results in decreased expression of HTR2B mRNA15644446
D0151043,4-Methylenedioxyamphetamine"3,4-Methylenedioxyamphetamine binds to and results in increased activity of HTR2B protein"19092640
D008755MethylergonovineMethylergonovine binds to and results in increased activity of HTR2B protein11104741
D008755MethylergonovineMethylergonovine binds to and results in increased activity of HTR2B protein19092640
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine binds to and results in increased activity of HTR2B protein"17202450
D008784MethysergideMethysergide binds to and results in increased activity of HTR2B protein17202450
D015735MifepristoneMifepristone results in increased expression of HTR2B mRNA17584828
D015544Inositol 1,4,5-Trisphosphate"HTR2B protein mutant form results in decreased abundance of Inositol 1,4,5-Trisphosphate"15625277
C092756N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)ureaN-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea promotes the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]18758753
C092756N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)ureaN-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea promotes the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]18758753
C092756N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)ureaN-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea inhibits the reaction [Norepinephrine results in increased expression of HTR2B protein]20374255
C092756N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)ureaN-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea results in decreased expression of HTR2B protein20374255
C078131N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamideN-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]18758753
C078131N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamideN-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]18758753
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of HTR2B mRNA27935865
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of HTR2B mRNA27935865
D009638NorepinephrineN-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea inhibits the reaction [Norepinephrine results in increased expression of HTR2B protein]20374255
D009638NorepinephrineNorepinephrine results in increased expression of HTR2B protein20374255
D009642NorfenfluramineNorfenfluramine binds to and results in increased activity of HTR2B protein10617681|1110474
D009642NorfenfluramineNorfenfluramine binds to and results in increased activity of HTR2B protein19092640
D019308Palmitic AcidPalmitic Acid results in increased expression of HTR2B protein27133527
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of HTR2B mRNA26705709
C046012pentanalpentanal results in decreased expression of HTR2B mRNA26079696
D010479PergolidePergolide binds to and results in increased activity of HTR2B protein17202450|1770656
D010479PergolidePergolide results in increased activity of HTR2B protein18251828
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of HTR2B mRNA27935865
C006253pirinixic acidpirinixic acid results in increased expression of HTR2B mRNA18301758
D059808PolyphenolsPolyphenols results in decreased expression of HTR2B mRNA16293270
D011374ProgesteroneProgesterone results in decreased expression of HTR2B mRNA21795739
C005556propionaldehydepropionaldehyde results in decreased expression of HTR2B mRNA26079696
D016713RitanserinRitanserin binds to and results in decreased activity of HTR2B protein10978843
C103848Ro 60-0175Ro 60-0175 binds to and results in increased activity of HTR2B protein17899022
C094868SB 206553SB 206553 binds to and results in decreased activity of HTR2B protein16521035
C094868SB 206553SB 206553 binds to and results in decreased activity of HTR2B protein10327425|1600112
C118948SB 215505SB 215505 binds to and results in decreased activity of HTR2B protein10188965
C118947SB 228357SB 228357 binds to and results in decreased activity of HTR2B protein10188965
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HTR2B mRNA25613284
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK1 protein]18758753
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [[Fluoxetine results in increased activity of HTR2B protein] which results in increased phosphorylation of MAPK3 protein]18758753
D014635Valproic AcidValproic Acid results in decreased methylation of HTR2B gene29154799
C025643vinclozolinvinclozolin results in increased expression of HTR2B mRNA23034163
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of HTR2B mRNA27935865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001965G-protein alpha-subunit binding-IMP15625277  
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0004993G-protein coupled serotonin receptor activity-IBA21873635  
GO:0004993G-protein coupled serotonin receptor activity-IDA7582481  7926008  15862800  
GO:0005096GTPase activator activity-ISS-  
GO:0008144drug binding-IDA7926008  12970106  15625277  15831837  15862800  17609583  
18703043  19307114  
GO:0030594neurotransmitter receptor activity-IBA21873635  
GO:0051378serotonin binding-IDA7582481  7926008  15625277  15831837  15862800  17609583  
19057895  
GO ID GO Term Qualifier Evidence PubMed
GO:0001755neural crest cell migration-ISS-  
GO:0001819positive regulation of cytokine production-IDA19023134  
GO:0001938positive regulation of endothelial cell proliferation-IMP19308295  
GO:0002031G-protein coupled receptor internalization-IEA-  
GO:0003007heart morphogenesis-ISS-  
GO:0003300cardiac muscle hypertrophy-ISS-  
GO:0006182cGMP biosynthetic process-IDA12970106  
GO:0006874cellular calcium ion homeostasis-IDA16517693  19057895  
GO:0007186G-protein coupled receptor signaling pathway-IMP15625277  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger-IBA21873635  
GO:0007202activation of phospholipase C activity-IDA16517693  19057895  
GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway-ISS-  
GO:0007210serotonin receptor signaling pathway-IMP18703043  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0007610behavior-IEA-  
GO:0008284positive regulation of cell proliferation-IDA15625277  
GO:0008284positive regulation of cell proliferation-IMP15925089  
GO:0010507negative regulation of autophagy-IMP20099302  
GO:0010513positive regulation of phosphatidylinositol biosynthetic process-IDA19057895  
GO:0014033neural crest cell differentiation-ISS-  
GO:0014065phosphatidylinositol 3-kinase signaling-IDA16517693  
GO:0014827intestine smooth muscle contraction-IMP7599919  9186750  
GO:0016310phosphorylation-IMP19308295  
GO:0019722calcium-mediated signaling-IMP8882600  
GO:0042310vasoconstriction-IMP15625277  
GO:0042493response to drug-IDA15625277  15862800  18703043  
GO:0043066negative regulation of apoptotic process-ISS-  
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling-IEP12761501  
GO:0043406positive regulation of MAP kinase activity-IDA15625277  
GO:0043547positive regulation of GTPase activity-IEA-  
GO:0048598embryonic morphogenesis-ISS-  
GO:0050715positive regulation of cytokine secretion-ISS-  
GO:0050795regulation of behavior-IMP21179162  
GO:0051000positive regulation of nitric-oxide synthase activity-IDA15625277  
GO:0051209release of sequestered calcium ion into cytosol-IDA15862800  
GO:0051209release of sequestered calcium ion into cytosol-IMP8882600  18566482  18703043  
GO:0051781positive regulation of cell division-ISS-  
GO:0060548negative regulation of cell death-IMP20099302  
GO:0070371ERK1 and ERK2 cascade-IMP19308295  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IDA19057895  
GO:0070528protein kinase C signaling-IMP20099302  
GO:0071502cellular response to temperature stimulus-ISS-  
GO:0098664G-protein coupled serotonin receptor signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IDA15925089  
GO:0005886plasma membrane-IDA7926008  12970106  15625277  15862800  18703043  19023134  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IEA-  
GO:0030054cell junction-IEA-  
GO:0030425dendrite-IBA21873635  
GO:0043005neuron projection-IEA-  
GO:0045202synapse-IEA-  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
hsa04540Gap junction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375280Amine ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-390666Serotonin receptorsTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22924764Array-based profiling of DNA methylation changes associated with alcohol dependence. (2013 Jan)Zhang HAlcohol Clin Exp Res
26575222Impulsive alcohol-related risk-behavior and emotional dysregulation among individuals with a serotonin 2B receptor stop codon. (2015 Nov 17)Tikkanen RTransl Psychiatry