Gene: HTR2C

3358
5-HT1C|5-HT2C|5-HTR2C|5HTR2C|HTR1C
5-hydroxytryptamine receptor 2C
protein-coding
Xq23
Ensembl:ENSG00000147246 MIM:312861 Vega:OTTHUMG00000022226 UniprotKB:P28335
NG_012082.2
PubMed
0   ANCO-SNPs
CD|ND|AD
12   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COCH0.82
IL13RA20.789
ANKRD34B0.775
KLHL130.774
HS6ST20.768
PEG100.761
TENM10.755
GLRA20.75
PCDH11X0.726
VAT1L0.726

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZIC2-0.475
CSAG1-0.454
HIGD1B-0.447
CDKN2C-0.441
MSX1-0.435
ANPEP-0.427
PPP1R13L-0.425
ZIC5-0.404
PCOLCE-0.402
RGL3-0.401

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00193TramadolSmall Molecule27203-92-5Approved|InvestigationalTarget
DB00215CitalopramSmall Molecule59729-33-8ApprovedTarget
DB00246ZiprasidoneSmall Molecule146939-27-7ApprovedTarget
DB00247MethysergideSmall Molecule361-37-5ApprovedTarget
DB00248CabergolineSmall Molecule81409-90-7ApprovedTarget
DB00268RopiniroleSmall Molecule91374-21-9Approved|InvestigationalTarget
DB00321AmitriptylineSmall Molecule50-48-6ApprovedTarget
DB00334OlanzapineSmall Molecule132539-06-1Approved|InvestigationalTarget
DB00363ClozapineSmall Molecule5786-21-0ApprovedTarget
DB00370MirtazapineSmall Molecule85650-52-8ApprovedTarget
DB00408LoxapineSmall Molecule1977-10-2ApprovedTarget
DB00413PramipexoleSmall Molecule104632-26-0Approved|InvestigationalTarget
DB00420PromazineSmall Molecule58-40-2ApprovedTarget
DB00434CyproheptadineSmall Molecule129-03-3ApprovedTarget
DB00458ImipramineSmall Molecule50-49-7ApprovedTarget
DB00472FluoxetineSmall Molecule54910-89-3ApprovedTarget
DB00477ChlorpromazineSmall Molecule50-53-3Approved|InvestigationalTarget
DB00540NortriptylineSmall Molecule72-69-5ApprovedTarget
DB00543AmoxapineSmall Molecule14028-44-5ApprovedTarget
DB00574FenfluramineSmall Molecule458-24-2Approved|Illicit|Investigational|WithdrawnTarget
DB00589LisurideSmall Molecule18016-80-3Approved|InvestigationalTarget
DB00623FluphenazineSmall Molecule69-23-8ApprovedTarget
DB00656TrazodoneSmall Molecule19794-93-5Approved|InvestigationalTarget
DB00696ErgotamineSmall Molecule113-15-5ApprovedTarget
DB00714ApomorphineSmall Molecule58-00-4Approved|InvestigationalTarget
DB00726TrimipramineSmall Molecule739-71-9ApprovedTarget
DB00734RisperidoneSmall Molecule106266-06-2Approved|InvestigationalTarget
DB00777PropiomazineSmall Molecule362-29-8ApprovedTarget
DB00805MinaprineSmall Molecule25905-77-5ApprovedTarget
DB00934MaprotilineSmall Molecule10262-69-8Approved|InvestigationalTarget
DB01079TegaserodSmall Molecule145158-71-0Approved|Investigational|WithdrawnTarget
DB01142DoxepinSmall Molecule1668-19-5Approved|InvestigationalTarget
DB01149NefazodoneSmall Molecule83366-66-9Approved|WithdrawnTarget
DB01151DesipramineSmall Molecule50-47-5Approved|InvestigationalTarget
DB01186PergolideSmall Molecule66104-22-1Approved|Investigational|WithdrawnTarget
DB01191DexfenfluramineSmall Molecule3239-44-9Approved|Illicit|Investigational|WithdrawnTarget
DB01200BromocriptineSmall Molecule25614-03-3Approved|InvestigationalTarget
DB01224QuetiapineSmall Molecule111974-69-7ApprovedTarget
DB01238AripiprazoleSmall Molecule129722-12-9Approved|InvestigationalTarget
DB01239ChlorprothixeneSmall Molecule113-59-7Approved|Investigational|WithdrawnTarget
DB01242ClomipramineSmall Molecule303-49-1Approved|InvestigationalTarget
DB01267PaliperidoneSmall Molecule144598-75-4ApprovedTarget
DB01392YohimbineSmall Molecule146-48-5Approved|InvestigationalTarget
DB01403MethotrimeprazineSmall Molecule60-99-1Approved|InvestigationalTarget
DB01454MidomafetamineSmall Molecule42542-10-9Experimental|Illicit|InvestigationalTarget
DB015374-Bromo-2,5-dimethoxyphenethylamineSmall Molecule66142-81-2Experimental|IllicitTarget
DB04871LorcaserinSmall Molecule616202-92-7ApprovedTarget
DB04884DapoxetineSmall Molecule119356-77-3InvestigationalTarget
DB05492Epicept NP-1Small Molecule-InvestigationalTarget
DB06144SertindoleSmall Molecule106516-24-9Approved|Investigational|WithdrawnTarget
DB06148MianserinSmall Molecule24219-97-4Approved|InvestigationalTarget
DB06216AsenapineSmall Molecule65576-45-6ApprovedTarget
DB06229OcaperidoneSmall Molecule129029-23-8InvestigationalTarget
DB06446DotarizineSmall Molecule84625-59-2InvestigationalTarget
DB06512DeramciclaneSmall Molecule120444-71-5InvestigationalTarget
DB06594AgomelatineSmall Molecule138112-76-2Approved|InvestigationalTarget
DB09014CaptodiameSmall Molecule486-17-9Approved|InvestigationalTarget
DB09194EtoperidoneSmall Molecule52942-31-1WithdrawnTarget
DB09195LorpiprazoleSmall Molecule108785-69-9ApprovedTarget
DB12110m-ChlorophenylpiperazineSmall Molecule6640-24-0InvestigationalTarget
DB12163SarpogrelateSmall Molecule125926-17-2InvestigationalTarget
DB139402,5-Dimethoxy-4-ethylthioamphetamineSmall Molecule185562-00-9ExperimentalTarget
DB01049Ergoloid mesylateSmall Molecule8067-24-1ApprovedTarget
DB09304SetiptilineSmall Molecule57262-94-9ApprovedTarget
DB13025TiaprideSmall Molecule51012-32-9Approved|InvestigationalTarget
DB00477ChlorpromazineSmall Molecule50-53-3Approved|InvestigationalTarget
DB01221KetamineSmall Molecule6740-88-1ApprovedTarget
DB06678EsmirtazapineSmall Molecule61337-87-9InvestigationalTarget
ID Drug Name Action PubMed
C5016561,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta(b)(1,4)diazepino(6,7,1hj)indole"HTR2C gene SNP results in decreased susceptibility to 1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta(b)(1,4)diazepino(6,7,1hj)indole"24618688
C5016561,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta(b)(1,4)diazepino(6,7,1hj)indole"1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta(b)(1,4)diazepino(6,7,1hj)indole binds to and results in increased activity of HTR2C protein"19107466|1934795
C5074201,3,4,14b-tetrahydro-2,10-dimethyl-2H,10H-pyrazino(2,1-d)pyrrolo(1,2-b) (1,2,5)benzotriazepine"1,3,4,14b-tetrahydro-2,10-dimethyl-2H,10H-pyrazino(2,1-d)pyrrolo(1,2-b) (1,2,5)benzotriazepine analog binds to HTR2C protein"16223499
C0150681-(3-chlorophenyl)piperazine[1-(3-chlorophenyl)piperazine binds to and results in increased activity of HTR2C protein] which results in increased susceptibility to Cocaine10541732
C0150681-(3-chlorophenyl)piperazine1-(3-chlorophenyl)piperazine binds to and results in increased activity of HTR2C protein10541732|1700000
C0184061-(3-trifluoromethylphenyl)piperazine1-(3-trifluoromethylphenyl)piperazine binds to and results in increased activity of HTR2C protein10764922|8001637
C1185591-bromopropane1-bromopropane results in increased expression of HTR2C mRNA19576243
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of HTR2C mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of HTR2C mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of HTR2C mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of HTR2C mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of HTR2C mRNA"25510870
C0039432,5-dimethoxy-4-bromoamphetamine"2,5-dimethoxy-4-bromoamphetamine binds to and results in increased activity of HTR2C protein"8386235
C0453922-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine"2-chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine binds to HTR2C protein"9723970
C0087454,4'-bisphenol F"4,4'-bisphenol F results in decreased expression of HTR2C mRNA"26186136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HTR2C mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HTR2C mRNA"27188386
C0148966-chloro-2-(1-piperazinyl)pyrazine[6-chloro-2-(1-piperazinyl)pyrazine binds to and results in increased activity of HTR2C protein] which results in increased susceptibility to Cocaine10541732
C0148966-chloro-2-(1-piperazinyl)pyrazine6-chloro-2-(1-piperazinyl)pyrazine binds to and results in increased activity of HTR2C protein16521035
C0148966-chloro-2-(1-piperazinyl)pyrazine6-chloro-2-(1-piperazinyl)pyrazine binds to and results in increased activity of HTR2C protein10541732|1614667
C1078206-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline inhibits the reaction [Mianserin results in increased expression of HTR2C protein]18083778
C1078206-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline inhibits the reaction [mirtazapine results in increased expression of HTR2C protein]18083778
C1078206-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline binds to and results in decreased activity of HTR2C protein11605085|1180686
C4616576-methoxymianserin6-methoxymianserin binds to HTR2C protein12109911
C4165347-fluoro-2-oxo-4-(2-(4-(thieno(3,2-c)pyridin-4-yl)piperazin-1-yl)ethyl)-1,2-dihydroquinoline-1-acetamide"7-fluoro-2-oxo-4-(2-(4-(thieno(3,2-c)pyridin-4-yl)piperazin-1-yl)ethyl)-1,2-dihydroquinoline-1-acetamide affects the activity of HTR2C protein"23611293
C4098747-methyl-6,7,8,9,14,15-hexahydro-5H-benz(d)indolo(2,3-g)azecine"7-methyl-6,7,8,9,14,15-hexahydro-5H-benz(d)indolo(2,3-g)azecine binds to HTR2C protein"15183906
C1078218-(5-(5-amino-2,4-dimethoxyphenyl)-5-oxopentyl)-1,3,8-triazaspiro(4.5)decane-2,4-dione"8-(5-(5-amino-2,4-dimethoxyphenyl)-5-oxopentyl)-1,3,8-triazaspiro(4.5)decane-2,4-dione binds to and results in decreased activity of HTR2C protein"19733155
C4345848-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine"8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine inhibits the reaction [mesulergine binds to HTR2C protein]"11927170
C540311A-836339A-836339 binds to HTR2C protein18931146
C095427A 86929A 86929 binds to HTR2C protein8558425
C496492abrineabrine results in decreased expression of HTR2C mRNA22595364
D016604Aflatoxin B1Aflatoxin B1 affects the expression of HTR2C protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of HTR2C gene27153756
D000639AmitriptylineAmitriptyline binds to HTR2C protein18083778
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HTR2C mRNA16483693
D000068180AripiprazoleAripiprazole binds to and affects the activity of HTR2C protein21823597
C015001arsenitearsenite results in increased methylation of HTR2C promoter23974009
D001280AtrazineAtrazine results in decreased expression of HTR2C mRNA25929836
D004958EstradiolEstradiol affects the expression of HTR2C mRNA12008023
D004958Estradiol[Estradiol co-treated with Sertraline] affects the expression of HTR2C mRNA18650020
D004958EstradiolEstradiol promotes the reaction [Sertraline results in increased expression of HTR2C mRNA]18650020
D004958EstradiolEstradiol results in increased expression of HTR2C mRNA20068009
C006780bisphenol A[bisphenol A co-treated with Genistein] results in increased methylation of HTR2C gene28505145
C006780bisphenol Abisphenol A results in decreased expression of HTR2C mRNA25181051|2618613
C006780bisphenol Abisphenol A results in increased methylation of HTR2C gene28505145
D002220Carbamazepine[Fluoxetine co-treated with Venlafaxine Hydrochloride co-treated with Carbamazepine] results in decreased expression of HTR2C mRNA22701549
D002220CarbamazepineCarbamazepine inhibits the reaction [Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]]19700373
D002220CarbamazepineCarbamazepine inhibits the reaction [Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]]19439326
D002220CarbamazepineCarbamazepine inhibits the reaction [Pilocarpine results in decreased expression of HTR2C mRNA]19439326
D002220CarbamazepineCarbamazepine inhibits the reaction [Pilocarpine results in decreased expression of HTR2C protein]19439326
D002220CarbamazepineCarbamazepine inhibits the reaction [Pilocarpine results in increased expression of HTR2C mRNA]19700373
D002746ChlorpromazineChlorpromazine results in decreased activity of HTR2C protein23611293
D004390ChlorpyrifosChlorpyrifos results in decreased expression of HTR2C mRNA18668222
D015283CitalopramCitalopram binds to HTR2C protein18083778
D002997ClomipramineClomipramine binds to HTR2C protein18083778
D002997ClomipramineClomipramine results in increased expression of HTR2C protein20619828
D003024ClozapineClozapine binds to HTR2C protein16983399
D003024ClozapineHTR2C gene polymorphism affects the susceptibility to Clozapine19142101|1914211
D003024ClozapineHTR2C gene SNP affects the susceptibility to Clozapine15635667
D003024ClozapineHTR2C promoter SNP affects the susceptibility to Clozapine12668355
D003024ClozapineHTR2C protein affects the susceptibility to Clozapine19142101
D003024ClozapineClozapine binds to HTR2C protein9723970
D003024ClozapineClozapine results in decreased expression of HTR2C mRNA17868938
D003042Cocaine[1-(3-chlorophenyl)piperazine binds to and results in increased activity of HTR2C protein] which results in increased susceptibility to Cocaine10541732
D003042Cocaine[6-chloro-2-(1-piperazinyl)pyrazine binds to and results in increased activity of HTR2C protein] which results in increased susceptibility to Cocaine10541732
D003042CocaineHTR2C mutant form results in increased susceptibility to Cocaine12427861
D003042CocaineHTR2C protein affects the reaction [Cocaine results in increased abundance of Dopamine]12427861
D003042CocaineCocaine results in decreased expression of HTR2C mRNA16076954
C518685CP-809,101"CP-809,101 binds to and results in increased activity of HTR2C protein"16949622
D003471CuprizoneCuprizone affects the expression of HTR2C mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of HTR2C mRNA20106945
D003976DiazinonDiazinon results in decreased expression of HTR2C mRNA17452286
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of HTR2C mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of HTR2C mRNA15620428
D004026DieldrinDieldrin affects the expression of HTR2C mRNA18835401
D004041Dietary FatsDietary Fats results in increased expression of HTR2C mRNA18721800
D002117CalcitriolCalcitriol results in increased expression of HTR2C mRNA16002434|2159239
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of HTR2C mRNA21592394
D004298DopamineHTR2C protein affects the reaction [Cocaine results in increased abundance of Dopamine]12427861
C118739entinostatentinostat results in increased expression of HTR2C mRNA26272509
D005277FenfluramineFenfluramine binds to HTR2C protein10617681
D005473FluoxetineFluoxetine binds to HTR2C protein18083778
D005473FluoxetineFluoxetine binds to and results in increased activity of HTR2C protein19662385
D005473Fluoxetine[Fluoxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein19662385
D005473Fluoxetine[[Fluoxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein19662385
D005473Fluoxetine[[Fluoxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein19662385
D005473FluoxetineFluoxetine results in increased expression of HTR2C mRNA21083617
D005473FluoxetineFluoxetine results in increased expression of HTR2C mRNA alternative form15659601
D005473Fluoxetine[Fluoxetine co-treated with Venlafaxine Hydrochloride co-treated with Carbamazepine] results in decreased expression of HTR2C mRNA22701549
D005473FluoxetineFluoxetine binds to and results in decreased activity of HTR2C protein9050900
D005473FluoxetineFluoxetine inhibits the reaction [Serotonin binds to and results in increased activity of HTR2C protein]9050900
D005473Fluoxetine[Fluoxetine results in increased abundance of Serotonin] which results in decreased expression of HTR2C mRNA21554931
D005476FluphenazineFluphenazine binds to HTR2C protein17606915
D005492Folic AcidFolic Acid results in increased expression of HTR2C mRNA25006883
C102777gamma-mangostingamma-mangostin results in increased expression of HTR2C mRNA21440614
C102777gamma-mangostinSerotonin inhibits the reaction [gamma-mangostin results in increased expression of HTR2C mRNA]21440614
D019833Genistein[bisphenol A co-treated with Genistein] results in increased methylation of HTR2C gene28505145
D006220HaloperidolHaloperidol results in decreased expression of HTR2C mRNA17868938
D012701SerotoninSerotonin affects the expression of HTR2C mRNA21083617
D012701SerotoninFluoxetine inhibits the reaction [Serotonin binds to and results in increased activity of HTR2C protein]9050900
D012701Serotonin[Fluoxetine results in increased abundance of Serotonin] which results in decreased expression of HTR2C mRNA21554931
D012701SerotoninSerotonin binds to and results in increased activity of HTR2C protein9050900
D012701SerotoninSerotonin inhibits the reaction [gamma-mangostin results in increased expression of HTR2C mRNA]21440614
C082359imidaclopridimidacloprid results in increased expression of HTR2C mRNA27782041
D007099ImipramineImipramine results in increased expression of HTR2C mRNA21440614
D007650KetanserinKetanserin results in increased expression of HTR2C mRNA21440614
C008261lead acetatelead acetate affects the expression of HTR2C mRNA21864555
C008261lead acetatelead acetate results in decreased expression of HTR2C mRNA22641619
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of HTR2C mRNA12057914
D008070LipopolysaccharidesHTR2C protein affects the susceptibility to Lipopolysaccharides12479973
C506658lorcaserinlorcaserin binds to and results in increased activity of HTR2C protein22011982
D008152LoxapineLoxapine analog binds to HTR2C protein9723970
D008152LoxapineLoxapine binds to HTR2C protein9723970
D000069056Lurasidone HydrochlorideLurasidone Hydrochloride binds to HTR2C protein20404009
C031649mesulerginemesulergine binds to HTR2C protein18083778
C031649mesulergineCarbamazepine inhibits the reaction [Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]]19700373
C031649mesulergineCarbamazepine inhibits the reaction [Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]]19439326
C031649mesulerginemesulergine binds to HTR2C protein19439326|1970037
C031649mesulerginePilocarpine affects the reaction [mesulergine binds to HTR2C protein]19700373
C031649mesulerginePilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]19439326
C031649mesulerginePlant Extracts inhibits the reaction [Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]]19700373
C031649mesulerginePlant Extracts inhibits the reaction [Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]]19439326
C031649mesulergine"8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine inhibits the reaction [mesulergine binds to HTR2C protein]"11927170
C031649mesulerginemesulergine binds to HTR2C protein11927170
D008694Methamphetamine[Mianserin binds to and results in decreased activity of HTR2C protein] which results in decreased susceptibility to Methamphetamine15213358
D008694MethamphetamineHTR2C protein affects the susceptibility to Methamphetamine11751031
D008731MethoxychlorMethoxychlor results in decreased expression of HTR2C mRNA27103539
C445068methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate"methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate results in decreased activity of HTR2C protein"28790194
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of HTR2C protein"26068050
D008803Mianserin6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline inhibits the reaction [Mianserin results in increased expression of HTR2C protein]18083778
D008803MianserinMianserin binds to and affects the activity of HTR2C protein18083778
D008803MianserinMianserin results in increased expression of HTR2C protein18083778
D008803MianserinMianserin binds to and results in decreased activity of HTR2C protein10978843
D008803Mianserin[Mianserin binds to and results in decreased activity of HTR2C protein] which results in decreased susceptibility to Methamphetamine15213358
D008803MianserinMianserin binds to and results in decreased activity of HTR2C protein15213358|7673653
C035133mirtazapine6-chloro-5-methyl-1-((2-(2-methylpyrid-3-yloxy)pyrid-5-yl)carbamoyl)indoline inhibits the reaction [mirtazapine results in increased expression of HTR2C protein]18083778
C035133mirtazapinemirtazapine binds to and affects the activity of HTR2C protein18083778
C035133mirtazapinemirtazapine results in increased expression of HTR2C protein18083778
C001801mitragyninemitragynine binds to HTR2C protein27192616
D009151Mustard GasMustard Gas results in increased expression of HTR2C mRNA15674844
C051752nefazodonenefazodone binds to HTR2C protein18083778
C058272norclozapinenorclozapine binds to and results in decreased activity of HTR2C protein15542624
D009642NorfenfluramineNorfenfluramine binds to HTR2C protein10617681
C036139norfluoxetinenorfluoxetine binds to HTR2C protein18083778
D009661NortriptylineNortriptyline results in decreased expression of HTR2C protein8131152
C106996NRA 0045NRA 0045 binds to HTR2C protein9223539
C076029olanzapineHTR2C gene polymorphism affects the susceptibility to olanzapine19142110
C076029olanzapineHTR2C gene polymorphism results in increased susceptibility to olanzapine19434072
C076029olanzapineHTR2C gene SNP affects the susceptibility to olanzapine15666332
C076029olanzapineHTR2C protein affects the susceptibility to olanzapine19434072
C076029olanzapineolanzapine binds to HTR2C protein16983399
C076029olanzapineolanzapine binds to HTR2C protein24389121
D010100OxygenOxygen deficiency results in increased expression of HTR2C mRNA24236059
D017374ParoxetineParoxetine binds to and results in increased activity of HTR2C protein19662385
D017374Paroxetine[Paroxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein19662385
D017374Paroxetine[[Paroxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein19662385
D017374Paroxetine[[Paroxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein19662385
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of HTR2C mRNA"25510870
C000593032PGW5 compoundPGW5 compound binds to HTR2C protein24389121
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HTR2C mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of HTR2C mRNA26272509
D010862PilocarpineCarbamazepine inhibits the reaction [Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]]19700373
D010862PilocarpineCarbamazepine inhibits the reaction [Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]]19439326
D010862PilocarpineCarbamazepine inhibits the reaction [Pilocarpine results in decreased expression of HTR2C mRNA]19439326
D010862PilocarpineCarbamazepine inhibits the reaction [Pilocarpine results in decreased expression of HTR2C protein]19439326
D010862PilocarpineCarbamazepine inhibits the reaction [Pilocarpine results in increased expression of HTR2C mRNA]19700373
D010862PilocarpinePilocarpine affects the reaction [mesulergine binds to HTR2C protein]19700373
D010862PilocarpinePilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]19439326
D010862PilocarpinePilocarpine results in decreased expression of HTR2C mRNA19439326
D010862PilocarpinePilocarpine results in decreased expression of HTR2C protein19439326
D010862PilocarpinePilocarpine results in increased expression of HTR2C mRNA19700373
D010862PilocarpinePilocarpine results in increased expression of HTR2C protein19700373
D010862PilocarpinePlant Extracts inhibits the reaction [Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]]19700373
D010862PilocarpinePlant Extracts inhibits the reaction [Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]]19439326
D010862PilocarpinePlant Extracts inhibits the reaction [Pilocarpine results in decreased expression of HTR2C mRNA]19439326
D010862PilocarpinePlant Extracts inhibits the reaction [Pilocarpine results in decreased expression of HTR2C protein]19439326
D010862PilocarpinePlant Extracts inhibits the reaction [Pilocarpine results in increased expression of HTR2C mRNA]19700373
D010936Plant ExtractsPlant Extracts inhibits the reaction [Pilocarpine affects the reaction [mesulergine binds to HTR2C protein]]19700373
D010936Plant ExtractsPlant Extracts inhibits the reaction [Pilocarpine inhibits the reaction [mesulergine binds to HTR2C protein]]19439326
D010936Plant ExtractsPlant Extracts inhibits the reaction [Pilocarpine results in decreased expression of HTR2C mRNA]19439326
D010936Plant ExtractsPlant Extracts inhibits the reaction [Pilocarpine results in decreased expression of HTR2C protein]19439326
D010936Plant ExtractsPlant Extracts inhibits the reaction [Pilocarpine results in increased expression of HTR2C mRNA]19700373
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in decreased expression of HTR2C mRNA27989595
D011192Potassium DichromatePotassium Dichromate results in increased expression of HTR2C mRNA23608068
D011441PropylthiouracilPropylthiouracil results in increased expression of HTR2C mRNA24780913
D018967RisperidoneHTR2C gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein]19997080
D018967RisperidoneHTR2C gene polymorphism affects the susceptibility to Risperidone19142101
D018967RisperidoneHTR2C protein affects the susceptibility to Risperidone19142101
D018967RisperidoneHTR2C protein results in increased susceptibility to Risperidone19997080
D016713RitanserinRitanserin binds to and results in decreased activity of HTR2C protein10762688|1604754
D016713RitanserinRitanserin binds to HTR2C protein9087973
C103848Ro 60-0175Ro 60-0175 binds to and results in increased activity of HTR2C protein11605085|1789902
C084711S 20098S 20098 analog binds to HTR2C protein22301214
C084711S 20098S 20098 binds to HTR2C protein22301214
C064294sarpogrelatesarpogrelate binds to HTR2C protein16880620
C094868SB 206553SB 206553 results in increased expression of HTR2C protein18083778
C094868SB 206553SB 206553 binds to and results in decreased activity of HTR2C protein16521035
C094868SB 206553SB 206553 binds to and results in decreased activity of HTR2C protein10327425|1600112
C094868SB 206553SB 206553 results in decreased activity of HTR2C protein9085055
C118947SB 228357SB 228357 binds to and results in decreased activity of HTR2C protein10188965
C406343SB 243213SB 243213 binds to and results in decreased activity of HTR2C protein11489455
C534628SCH 23390SCH 23390 binds to and results in increased activity of HTR2C protein19733155
D012601Scopolamine HydrobromideScopolamine Hydrobromide results in increased expression of HTR2C mRNA17540011
D018490Serotonin AgentsSerotonin Agents affects the activity of HTR2C protein17105947
D020280Sertraline[Estradiol co-treated with Sertraline] affects the expression of HTR2C mRNA18650020
D020280SertralineEstradiol promotes the reaction [Sertraline results in increased expression of HTR2C mRNA]18650020
D020280SertralineSertraline results in increased expression of HTR2C mRNA18650020
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of HTR2C mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of HTR2C mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HTR2C mRNA23871856
D013849ThimerosalThimerosal results in increased expression of HTR2C mRNA27188386
C009495titanium dioxidetitanium dioxide results in decreased expression of HTR2C mRNA23557971
D014196TrazodoneTrazodone binds to HTR2C protein18083778
D014196TrazodoneTrazodone binds to and results in decreased activity of HTR2C protein15614572|1962343
D014212TretinoinTretinoin results in decreased expression of HTR2C mRNA21934132
C012589trichostatin Atrichostatin A results in increased expression of HTR2C mRNA24935251
D014635Valproic AcidValproic Acid affects the expression of HTR2C mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of HTR2C mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of HTR2C mRNA24935251|2800136
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of HTR2C gene25560391
D000069470Venlafaxine Hydrochloride[Fluoxetine co-treated with Venlafaxine Hydrochloride co-treated with Carbamazepine] results in decreased expression of HTR2C mRNA22701549
C111237vorinostatvorinostat results in decreased expression of HTR2C mRNA27188386
C092292ziprasidoneziprasidone binds to HTR2C protein7562537

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001587Gq/11-coupled serotonin receptor activity-IDA18703043  
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0004993G-protein coupled serotonin receptor activity-IBA21873635  
GO:0004993G-protein coupled serotonin receptor activity-IDA7582481  
GO:0008144drug binding-IDA12970106  15831837  18703043  
GO:0030594neurotransmitter receptor activity-IBA21873635  
GO:0051378serotonin binding-IDA7582481  15831837  19057895  
GO:00718861-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding-IDA19057895  
GO ID GO Term Qualifier Evidence PubMed
GO:0001662behavioral fear response-ISS-  
GO:0006182cGMP biosynthetic process-IDA12970106  
GO:0006874cellular calcium ion homeostasis-IDA19057895  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger-IBA21873635  
GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway-IDA12970106  
GO:0007208phospholipase C-activating serotonin receptor signaling pathway-ISS-  
GO:0007210serotonin receptor signaling pathway-IMP18703043  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0007268chemical synaptic transmission-TAS9241279  
GO:0007626locomotory behavior-IEA-  
GO:0007631feeding behavior-ISS-  
GO:0010513positive regulation of phosphatidylinositol biosynthetic process-IDA19057895  
GO:0031644regulation of neurological system process-ISS-  
GO:0032098regulation of appetite-ISS-  
GO:0042493response to drug-IBA21873635  
GO:0042493response to drug-IDA18703043  
GO:0043397regulation of corticotropin-releasing hormone secretion-ISS-  
GO:0045600positive regulation of fat cell differentiation-IEA-  
GO:0051209release of sequestered calcium ion into cytosol-IBA21873635  
GO:0051209release of sequestered calcium ion into cytosol-IMP18703043  
GO:0051482positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway-ISS-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IDA19057895  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA12970106  18703043  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IMP18703043  
GO:0030425dendrite-IBA21873635  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
hsa04540Gap junction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375280Amine ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-390666Serotonin receptorsTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
10494451HTR2C Cys23Ser polymorphism in relation to CSF monoamine metabolite concentrations and DSM-III-R psychiatric diagnoses. (1999 Sep 15)Lappalainen JBiol Psychiatry
12218658Antisocial alcoholism and serotonin-related polymorphisms: association tests. (2002 Sep)Hill EMPsychiatr Genet
29032150Functional analysis of schizophrenia genes using GeneAnalytics program and integrated databases. (2018 Jan 30)Sundararajan TGene
24618688Variation within the serotonin (5-HT) 5-HT(2)C receptor system aligns with vulnerability to cocaine cue reactivity. (2014 Mar 11)Anastasio NCTransl Psychiatry
22545912Association of genetic, psychological and behavioral factors with sleep bruxism in a Japanese population. (2012 Jun)Abe YJ Sleep Res
11134668Pharmacogenetics and the serotonin system: initial studies and future directions. (2000 Dec 27)Veenstra-VanderWeele JEur J Pharmacol
19193342Multiple genetic factors in olanzapine-induced weight gain in schizophrenia patients: a cohort study. (2008 Sep)Ujike HJ Clin Psychiatry
10776672An association study between alcoholism and the serotonergic receptor genes. (2000 Mar)Himei AAlcohol Clin Exp Res
16770336Why do young women smoke? II. Role of traumatic life experience, psychological characteristics and serotonergic genes. (2006 Aug)Lerer EMol Psychiatry
22933845Polymorphisms of the serotonin transporter and receptor genes: susceptibility to substance abuse. (2012 Jun)Herman AISubst Abuse Rehabil
28492956Relationship between the rs1414334 C/G polymorphism in the HTR2C gene and smoking in patients treated with atypical antipsychotics. (2018 Apr 15)Rico-Gomis JMAdicciones
15304380Analysis of 5-hydroxytryptamine 2c receptor gene promoter variants as alcohol-dependence risk factors. (2004 Sep-Oct)Mottagui-Tabar SAlcohol Alcohol