Gene: HTR3A

3359
5-HT-3|5-HT3A|5-HT3R|5HT3R|HTR3
5-hydroxytryptamine receptor 3A
protein-coding
11q23.2
Ensembl:ENSG00000166736 MIM:182139 Vega:OTTHUMG00000160494 UniprotKB:P46098
NG_013058.1
PubMed
0   ANCO-SNPs
CD|OD|ND|AD
13   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.377e-1 (AD)  8.261e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GJB30.667
HGFAC0.64
KCNG10.613
CDC60.611
ASB20.606
TAF7L0.597
LAMP50.594
PCDH80.594
TRERF10.593
CNR10.59

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CTNNA3-0.454
VRK2-0.452
WIPF1-0.45
SLCO1A2-0.449
ZFP57-0.448
SEPT10-0.431
RBP7-0.426
OPALIN-0.422
DTHD1-0.411
ADAMTS4-0.411

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00246ZiprasidoneSmall Molecule146939-27-7ApprovedTarget
DB00333MethadoneSmall Molecule76-99-3ApprovedTarget
DB00334OlanzapineSmall Molecule132539-06-1Approved|InvestigationalTarget
DB00363ClozapineSmall Molecule5786-21-0ApprovedTarget
DB00370MirtazapineSmall Molecule85650-52-8ApprovedTarget
DB00377PalonosetronSmall Molecule135729-56-5Approved|InvestigationalTarget
DB00408LoxapineSmall Molecule1977-10-2ApprovedTarget
DB00543AmoxapineSmall Molecule14028-44-5ApprovedTarget
DB00555LamotrigineSmall Molecule84057-84-1Approved|InvestigationalTarget
DB00604CisaprideSmall Molecule81098-60-4Approved|Investigational|WithdrawnTarget
DB00721ProcaineSmall Molecule59-46-1Approved|InvestigationalTarget
DB00726TrimipramineSmall Molecule739-71-9ApprovedTarget
DB00728RocuroniumSmall Molecule143558-00-3ApprovedTarget
DB00757DolasetronSmall Molecule115956-12-2Approved|InvestigationalTarget
DB00889GranisetronSmall Molecule109889-09-0Approved|InvestigationalTarget
DB00898EthanolSmall Molecule64-17-5ApprovedTarget
DB00904OndansetronSmall Molecule99614-02-5ApprovedTarget
DB00969AlosetronSmall Molecule122852-42-0Approved|WithdrawnTarget
DB00988DopamineSmall Molecule51-61-6ApprovedTarget
DB01043MemantineSmall Molecule19982-08-2Approved|InvestigationalTarget
DB01161ChloroprocaineSmall Molecule133-16-4ApprovedTarget
DB01199TubocurarineSmall Molecule57-95-4ApprovedTarget
DB01221KetamineSmall Molecule6740-88-1ApprovedTarget
DB01224QuetiapineSmall Molecule111974-69-7ApprovedTarget
DB01233MetoclopramideSmall Molecule364-62-5Approved|InvestigationalTarget
DB01238AripiprazoleSmall Molecule129722-12-9Approved|InvestigationalTarget
DB04885CilansetronSmall Molecule120635-74-7InvestigationalTarget
DB04917RenzaprideSmall Molecule112727-80-7InvestigationalTarget
DB05049DDP733Small Molecule-InvestigationalTarget
DB05642DDP-225Small Molecule476148-82-0InvestigationalTarget
DB06204TapentadolSmall Molecule175591-23-8ApprovedTarget
DB06422TicaloprideSmall Molecule202590-69-0InvestigationalTarget
DB08839SerotoninSmall Molecule50-67-9Investigational|NutraceuticalTarget
DB09068VortioxetineSmall Molecule508233-74-7Approved|InvestigationalTarget
DB09290RamosetronSmall Molecule132036-88-5Approved|InvestigationalTarget
DB11699TropisetronSmall Molecule89565-68-4Approved|InvestigationalTarget
DB01049Ergoloid mesylateSmall Molecule8067-24-1ApprovedTarget
DB09304SetiptilineSmall Molecule57262-94-9ApprovedTarget
DB13025TiaprideSmall Molecule51012-32-9Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0245661,1,1-trichloroethane"1,1,1-trichloroethane promotes the reaction [Serotonin results in increased activity of HTR3A protein]"12681521
C0657341-(3-chlorophenyl)biguanide1-(3-chlorophenyl)biguanide binds to and results in increased activity of HTR3A protein10884508
C0657341-(3-chlorophenyl)biguanide1-(3-chlorophenyl)biguanide results in increased activity of HTR3A protein9736758
C0657341-(3-chlorophenyl)biguanide1-(3-chlorophenyl)biguanide results in increased activity of [HTR3A protein binds to CHRNA4 protein]9736758
C1185591-bromopropane1-bromopropane affects the expression of HTR3A mRNA19576243
C0459182-methyl-5-HT2-methyl-5-HT binds to and results in increased activity of HTR3A protein15802305
C0459182-methyl-5-HT2-methyl-5-HT binds to and results in increased activity of HTR3A protein10884508
C0459182-methyl-5-HT2-methyl-5-HT results in increased activity of HTR3A protein9736758
C0459182-methyl-5-HT2-methyl-5-HT results in increased activity of [HTR3A protein binds to CHRNA4 protein]9736758
C0087454,4'-bisphenol F"4,4'-bisphenol F results in decreased expression of HTR3A mRNA"26186136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HTR3A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HTR3A mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of HTR3A mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of HTR3A gene27153756
D015760AlfentanilAlfentanil affects the activity of HTR3A protein18635474
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HTR3A mRNA16483693
D001279AtracuriumAtracurium results in decreased activity of HTR3A protein10648343
D001280AtrazineAtrazine results in increased expression of HTR3A mRNA22378314
D001381AzepinesAzepines analog binds to and results in decreased activity of HTR3A protein12593651
C042253bemesetronbemesetron results in decreased activity of HTR3A protein9736758
C042253bemesetronbemesetron results in decreased activity of [HTR3A protein binds to CHRNA4 protein]9736758
D001549BenzamidesBenzamides analog binds to and results in decreased activity of HTR3A protein12130853
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HTR3A mRNA22228805
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of HTR3A mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of HTR3A mRNA25181051|2614162
C006780bisphenol Abisphenol A results in increased expression of HTR3A mRNA26186136
D0200011-Butanol1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]17360702
D0200011-Butanol1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]17360702
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of HTR3A mRNA26472689
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of HTR3A mRNA16644059
D003024ClozapineClozapine binds to and results in decreased activity of HTR3A protein19696922
D003024ClozapineHTR3A protein affects the susceptibility to Clozapine20168265
D003024ClozapineClozapine binds to and results in decreased activity of HTR3A protein19696922
D003042CocaineHTR3A mutant form results in decreased susceptibility to Cocaine17559417
D003471CuprizoneCuprizone results in decreased expression of HTR3A mRNA27523638
C009160cyclonitecyclonite results in decreased expression of HTR3A mRNA25559034
C004712cytisinecytisine affects the activity of HTR3A protein9736758
C004712cytisinecytisine affects the activity of [HTR3A protein binds to CHRNA4 protein]9736758
D003609DactinomycinDactinomycin promotes the reaction [Dronabinol results in decreased activity of HTR3A protein]20800662
C014347decitabinedecitabine affects the expression of HTR3A mRNA23300844
D003671DEET[fipronil co-treated with DEET] results in increased expression of HTR3A mRNA27091632
D013759DronabinolDactinomycin promotes the reaction [Dronabinol results in decreased activity of HTR3A protein]20800662
D013759DronabinolDronabinol results in decreased activity of HTR3A protein20800662
D013759DronabinolDronabinol results in decreased activity of HTR3A protein20800662
D003907Dexamethasone[Dexamethasone co-treated with Metoclopramide] results in decreased activity of HTR3A protein15329590
D003907Dexamethasone[Dexamethasone co-treated with ramosetron] results in decreased activity of HTR3A protein15329590
D003907DexamethasoneDexamethasone results in decreased activity of HTR3A protein15329590
D003976DiazinonDiazinon results in increased expression of HTR3A mRNA18835401
D002945CisplatinCisplatin affects the expression of HTR3A mRNA23300844
D004026DieldrinDieldrin results in decreased expression of HTR3A mRNA18835401
D004298DopamineDopamine binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]17360702
D004298DopamineDopamine binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]17360702
D004298DopamineDopamine results in increased activity of HTR3A protein9736758
D004298DopamineDopamine results in increased activity of [HTR3A protein binds to CHRNA4 protein]9736758
C118739entinostatentinostat results in increased expression of HTR3A mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HTR3A mRNA"27188386
D000431EthanolEthanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]17360702
D000431EthanolEthanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]17360702
C082360fipronil[fipronil co-treated with DEET] results in increased expression of HTR3A mRNA27091632
C082360fipronilfipronil results in increased expression of HTR3A mRNA27091632
D005492Folic AcidFolic Acid results in decreased expression of HTR3A mRNA25006883
C059068GR 65630GR 65630 binds to HTR3A protein16041395
C059068GR 65630Metoclopramide inhibits the reaction [GR 65630 binds to HTR3A protein]16041395
C059068GR 65630GR 65630 binds to HTR3A protein20800662
D017829GranisetronGranisetron binds to and results in decreased activity of HTR3A protein10026168
D000441HexanolsHexanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]17360702
D000441HexanolsHexanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]17360702
D012701Serotonin1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]17360702
D012701Serotonin1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]17360702
D012701Serotonin1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]17360702
D012701Serotonin1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]17360702
D012701SerotoninEthanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]17360702
D012701SerotoninEthanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]17360702
D012701SerotoninHexanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]17360702
D012701SerotoninHexanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]17360702
D012701SerotoninOctanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]17360702
D012701SerotoninOctanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]17360702
D012701SerotoninPentanols promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]17360702
D012701SerotoninPentanols promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]17360702
D012701SerotoninSerotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]17360702
D012701SerotoninSerotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]17360702
D012701Serotonin"1,1,1-trichloroethane promotes the reaction [Serotonin results in increased activity of HTR3A protein]"12681521
D012701SerotoninSerotonin affects the localization of HTR3A protein alternative form17436349
D012701SerotoninSerotonin results in increased activity of HTR3A protein12681521
D012701SerotoninToluene promotes the reaction [Serotonin results in increased activity of HTR3A protein]12681521
D012701SerotoninTrichloroethylene promotes the reaction [Serotonin results in increased activity of HTR3A protein]12681521
D012701SerotoninSerotonin binds to and results in increased activity of HTR3A protein10884508
D012701SerotoninSerotonin binds to and results in increased activity of HTR3A protein10026168
D012701SerotoninSerotonin results in increased activity of [HTR3A protein binds to CHRNA4 protein]9736758
D004091HydromorphoneHydromorphone affects the activity of HTR3A protein18635474
C008261lead acetatelead acetate results in decreased expression of HTR3A mRNA22641619
D008070LipopolysaccharidesHTR3A protein promotes the reaction [Lipopolysaccharides results in increased secretion of CXCL8 protein]15802305
D008070LipopolysaccharidesHTR3A protein promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]15802305
D008070LipopolysaccharidesHTR3A protein promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]15802305
D008694MethamphetamineHTR3A mRNA affects the susceptibility to Methamphetamine19689456
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of HTR3A mRNA"20188158
D008775Methylprednisolone[Methylprednisolone co-treated with Metoclopramide] results in decreased activity of HTR3A protein15329590
D008775Methylprednisolone[Methylprednisolone co-treated with ramosetron] results in decreased activity of HTR3A protein15329590
D008775MethylprednisoloneMethylprednisolone results in decreased activity of HTR3A protein15329590
D008787Metoclopramide[Dexamethasone co-treated with Metoclopramide] results in decreased activity of HTR3A protein15329590
D008787Metoclopramide[Methylprednisolone co-treated with Metoclopramide] results in decreased activity of HTR3A protein15329590
D008787MetoclopramideMetoclopramide binds to and results in decreased activity of HTR3A protein15329590
D008787MetoclopramideMetoclopramide inhibits the reaction [GR 65630 binds to HTR3A protein]16041395
D008787MetoclopramideMetoclopramide results in decreased activity of HTR3A protein16041395
D008787MetoclopramideMetoclopramide binds to and results in decreased activity of HTR3A protein10884508
D008787MetoclopramideMetoclopramide binds to and results in decreased activity of HTR3A protein17201744
D008787MetoclopramideMetoclopramide binds to HTR3A protein12130853|1259365
C049430mivacuriummivacurium results in decreased activity of HTR3A protein10648343
D009020MorphineMorphine results in increased expression of HTR3A mRNA21178816
D009532NickelNickel affects the expression of HTR3A mRNA18835401
D000442OctanolsOctanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]17360702
D000442OctanolsOctanols inhibits the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]17360702
D017294OndansetronOndansetron affects the reaction [vortioxetine binds to and affects the activity of HTR3A protein]21486038
D017294OndansetronOndansetron binds to and results in decreased activity of HTR3A protein11919526
D017294OndansetronOndansetron binds to and results in decreased activity of HTR3A protein10884508
D017294OndansetronOndansetron binds to and results in decreased activity of HTR3A protein17201744
D017294OndansetronOndansetron binds to HTR3A protein12130853
D017294OndansetronOndansetron binds to and results in decreased activity of HTR3A protein10648343
C083418palonosetronpalonosetron binds to and results in increased activity of HTR3A protein21808994
D000439PentanolsPentanols promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]17360702
D000439PentanolsPentanols promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]17360702
C008846phenyl biguanidephenyl biguanide binds to and results in increased activity of HTR3A protein21414306
D011192Potassium DichromatePotassium Dichromate results in increased expression of HTR3A mRNA23608068
D0004331-Propanol1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]]17360702
D0004331-Propanol1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]17360702
D011441PropylthiouracilPropylthiouracil results in increased expression of HTR3A mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in decreased expression of HTR3A mRNA27029645
D011725PyridinesPyridines analog binds to and results in decreased activity of HTR3A protein12593651
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of HTR3A mRNA19059307
C071315ramosetron[Dexamethasone co-treated with ramosetron] results in decreased activity of HTR3A protein15329590
C071315ramosetron[Methylprednisolone co-treated with ramosetron] results in decreased activity of HTR3A protein15329590
C071315ramosetronramosetron binds to and results in decreased activity of HTR3A protein15329590
C071315ramosetronramosetron binds to HTR3A protein17652911
C071315ramosetronramosetron binds to HTR3A protein17652911
C071741remifentanilremifentanil affects the activity of HTR3A protein18635474
C061870rocuroniumrocuronium results in decreased activity of HTR3A protein10648343
C089730rosiglitazonerosiglitazone results in increased expression of HTR3A mRNA25572481
C017947sodium arsenitesodium arsenite results in increased expression of HTR3A mRNA12760830
D012989Soil PollutantsSoil Pollutants results in decreased expression of HTR3A protein23953925
D012989Soil PollutantsSoil Pollutants results in increased expression of HTR3A mRNA23953925
D017409SufentanilSufentanil affects the activity of HTR3A protein18635474
D013629TamoxifenTamoxifen affects the expression of HTR3A mRNA14699072
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in decreased expression of HTR3A mRNA19059307
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of HTR3A mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to HTR3A promoter]19654925
D014050TolueneToluene promotes the reaction [Serotonin results in increased activity of HTR3A protein]12681521
D014241TrichloroethyleneTrichloroethylene promotes the reaction [Serotonin results in increased activity of HTR3A protein]12681521
C012589trichostatin Atrichostatin A results in decreased expression of HTR3A mRNA15901671
C045504tropisetrontropisetron binds to and results in decreased activity of HTR3A protein10884508
D014403TubocurarineTubocurarine binds to and results in decreased activity of HTR3A protein10884508
D014403TubocurarineTubocurarine affects the activity of [HTR3A protein binds to CHRNA4 protein]9736758
D014403TubocurarineTubocurarine binds to and results in decreased activity of HTR3A protein10026168
D014403TubocurarineTubocurarine results in decreased activity of HTR3A protein10648343|9736758
D014635Valproic AcidValproic Acid affects the expression of HTR3A mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of HTR3A mRNA24383497|2800136
D014635Valproic AcidValproic Acid results in decreased expression of HTR3A mRNA15901671
D014673Vecuronium BromideVecuronium Bromide results in decreased activity of HTR3A protein10648343
C557874vortioxetineOndansetron affects the reaction [vortioxetine binds to and affects the activity of HTR3A protein]21486038
C557874vortioxetinevortioxetine binds to and affects the activity of HTR3A protein21486038
C557874vortioxetinevortioxetine binds to and results in decreased activity of HTR3A protein21486038

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004888transmembrane signaling receptor activity-IEA-  
GO:0005230extracellular ligand-gated ion channel activityCONTRIBUTES_TOIBA21873635  
GO:0005515protein binding-IPI17392525  
GO:0022850serotonin-gated cation-selective channel activity-IDA7565620  9950429  
GO:0051378serotonin binding-IDA7565620  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-IBA21873635  
GO:0007210serotonin receptor signaling pathway-IEA-  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0032414positive regulation of ion transmembrane transporter activity-IEA-  
GO:0034220ion transmembrane transport-IBA21873635  
GO:0034220ion transmembrane transport-IEA-  
GO:0042220response to cocaine-IEA-  
GO:0042391regulation of membrane potential-IBA21873635  
GO:0045471response to ethanol-IEA-  
GO:0050877nervous system process-IBA21873635  
GO:0071363cellular response to growth factor stimulus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0030054cell junction-IEA-  
GO:0030424axon-IEA-  
GO:0032154cleavage furrow-IDA19799413  
GO:0043005neuron projection-IBA21873635  
GO:0043025neuronal cell body-IEA-  
GO:0045202synapse-IBA21873635  
GO:0045211postsynaptic membrane-IEA-  
GO:1904602serotonin-activated cation-selective channel complex-IDA9950429  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionTAS
R-HSA-112315Transmission across Chemical SynapsesTAS
R-HSA-112316Neuronal SystemTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20838391Functional genetic variants that increase synaptic serotonin and 5-HT3 receptor sensitivity predict alcohol and drug dependence. (2011 Nov)Enoch MAMol Psychiatry
19185213HTR3B is associated with alcoholism with antisocial behavior and alpha EEG power--an intermediate phenotype for alcoholism and co-morbid behaviors. (2009 Feb)Ducci FAlcohol
20021265Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy. (2010)Goecke TWActa Obstet Gynecol Scand
22924764Array-based profiling of DNA methylation changes associated with alcohol dependence. (2013 Jan)Zhang HAlcohol Clin Exp Res
24772465Epigenetic and pharmacological regulation of 5HT3 receptors controls compulsive ethanol seeking in mice. (2014 Mar)Barker JMEur J Neurosci
22933845Polymorphisms of the serotonin transporter and receptor genes: susceptibility to substance abuse. (2012 Jun)Herman AISubst Abuse Rehabil
26227246Susceptibility loci for heroin and cocaine addiction in the serotonergic and adrenergic pathways in populations of different ancestry. (2015)Levran OPharmacogenomics
19214139From mouse to man: the 5-HT3 receptor modulates physical dependence on opioid narcotics. (2009 Mar)Chu LFPharmacogenet Genomics
25655461Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms. (2015 Apr 15)Manzardo AMGene
23290502Serotonin transporter and receptor genes significantly impact nicotine dependence through genetic interactions in both European American and African American smokers. (2013 May 1)Yang ZDrug Alcohol Depend
23897038Determination of genotype combinations that can predict the outcome of the treatment of alcohol dependence using the 5-HT(3) antagonist ondansetron. (2013 Sep)Johnson BAAm J Psychiatry
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