Gene: APOA2

336
Apo-AII|ApoA-II|apoAII
apolipoprotein A2
protein-coding
1q23.3
Ensembl:ENSG00000158874 MIM:107670 Vega:OTTHUMG00000034346 UniprotKB:P02652
NG_012043.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.010e-1 (AD)  4.598e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FGA0.659
AMBP0.654
APOC30.654
FGB0.627
FGG0.626
ORM10.6
APOH0.551
ALB0.546
HP0.542
CRP0.539

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GYPE-0.289
SPATA18-0.278
LRRC2-0.269
GJB4-0.258
ZNF658-0.255
ARHGAP24-0.253
LRRC3C-0.251
SOSTDC1-0.249
CLCN5-0.248
PAX3-0.246

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0122771,2-diamino-4-nitrobenzene"1,2-diamino-4-nitrobenzene results in decreased expression of APOA2 mRNA"17070881
C0353141-nitropropane1-nitropropane results in increased expression of APOA2 mRNA17070881
C0467282,2'-azobis(2-amidinopropane)"2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA2 protein"12576517
C0467282,2'-azobis(2-amidinopropane)"[Butylated Hydroxytoluene co-treated with Pentetic Acid] inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA2 protein]"12576517
C0467282,2'-azobis(2-amidinopropane)"Butylated Hydroxytoluene inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA2 protein]"12576517
C0467282,2'-azobis(2-amidinopropane)"Pentetic Acid inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA2 protein]"12576517
C0109142,4-diaminotoluene"2,4-diaminotoluene results in decreased expression of APOA2 mRNA"17070881
C0252352,6-diaminotoluene"2,6-diaminotoluene results in decreased expression of APOA2 mRNA"17070881
C0147062-nitro-4-phenylenediamine2-nitro-4-phenylenediamine results in decreased expression of APOA2 mRNA17070881
C0166172-nitropropane2-nitropropane results in decreased expression of APOA2 mRNA17070881
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of APOA2 mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APOA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APOA2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APOA2 mRNA"27188386
C0286764-acetylaminofluorene4-acetylaminofluorene results in decreased expression of APOA2 mRNA17070881
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APOA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APOA2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APOA2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of APOA2 mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of APOA2 mRNA23358195
D000082AcetaminophenAcetaminophen results in decreased expression of APOA2 mRNA15120968
D016604Aflatoxin B1Aflatoxin B1 affects the expression of APOA2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of APOA2 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of APOA2 mRNA19770486
C103303alitretinoinalitretinoin results in increased expression of APOA2 mRNA8668150
C103303alitretinoinRXRA promotes the reaction [alitretinoin results in increased expression of APOA2 mRNA]8668150
D000643Ammonium ChlorideAmmonium Chloride affects the expression of APOA2 mRNA16483693
D001262AtenololAtenolol results in decreased expression of APOA2 protein2193493
C547126AZM551248AZM551248 results in decreased expression of APOA2 mRNA22323515
D004958EstradiolEstradiol results in increased expression of APOA2 mRNA25470364
D004958Estradiol[Estradiol co-treated with Plant Preparations] results in decreased expression of APOA2 mRNA26945725
C095105bexarotenebexarotene results in increased expression of APOA2 mRNA8668150
C095105bexaroteneRXRA promotes the reaction [bexarotene results in increased expression of APOA2 mRNA]8668150
C095105bexarotenebexarotene results in decreased expression of APOA2 mRNA16648578
D001629BezafibrateBezafibrate results in increased expression of APOA2 protein7893284|8017468
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of APOA2 mRNA25470364
C006780bisphenol Abisphenol A results in increased expression of APOA2 mRNA25470364
C006780bisphenol Abisphenol A results in increased expression of APOA2 mRNA26364221
C006780bisphenol Abisphenol A results in decreased expression of APOA2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of APOA2 gene28505145
D002084Butylated Hydroxytoluene"[Butylated Hydroxytoluene co-treated with Pentetic Acid] inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA2 protein]"12576517
D002084Butylated Hydroxytoluene"Butylated Hydroxytoluene inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA2 protein]"12576517
D002104CadmiumAPOA2 protein binds to Cadmium23896426
D002110Caffeine[Ephedrine co-treated with Caffeine] results in decreased expression of APOA2 protein16324916
D002110CaffeineCaffeine results in decreased expression of APOA2 mRNA25868845
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of APOA2 mRNA11566570
C026690cerous chloridecerous chloride results in increased expression of APOA2 mRNA23573234
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APOA2 mRNA"27188386
D004390Chlorpyrifos[Copper co-treated with Chlorpyrifos] results in decreased expression of APOA2 mRNA21356183
D008076Cholesterol, HDL"APOA2 protein results in increased abundance of Cholesterol, HDL"16511610
D008076Cholesterol, HDL"[[Fibric Acids results in increased expression of APOA1] co-treated with [Fibric Acids results in increased expression of APOA2]] results in increased abundance of Cholesterol, HDL"11123853
D002995Clofibric AcidClofibric Acid affects the expression of APOA2 mRNA17602206
D003000ClonidineClonidine results in decreased expression of APOA2 protein2193493
D003300Copper[Copper co-treated with Chlorpyrifos] results in decreased expression of APOA2 mRNA21356183
D003300CopperCopper results in decreased expression of APOA2 mRNA21356183
D003300CopperAPOA2 protein binds to Copper23896426
D019327Copper SulfateCopper Sulfate results in decreased expression of APOA2 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of APOA2 mRNA20106945
D017373Cyproterone AcetateCyproterone Acetate affects the expression of APOA2 protein16323982
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of APOA2 mRNA]27941970
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of APOA2 mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of APOA2 mRNA19638242
C070609EMD 53998EMD 53998 analog results in decreased expression of APOA2 mRNA24977338
D004809Ephedrine[Ephedrine co-treated with Caffeine] results in decreased expression of APOA2 protein16324916
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of APOA2 protein20227414
C006012fenofibric acidfenofibric acid results in decreased expression of APOA2 mRNA7556148
D058607Fibric Acids"[[Fibric Acids results in increased expression of APOA1] co-treated with [Fibric Acids results in increased expression of APOA2]] results in increased abundance of Cholesterol, HDL"11123853
D058607Fibric AcidsFibric Acids results in increased expression of APOA211123853
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in decreased expression of APOA2 mRNA17070881
D005485FlutamideFlutamide results in decreased expression of APOA2 mRNA24136188
D005485FlutamideFlutamide results in increased expression of APOA2 mRNA24793618
D005492Folic Acid[APOE gene mutant form affects the susceptibility to Folic Acid] which results in increased expression of APOA2 protein17118406
C039281furanfuran results in decreased expression of APOA2 mRNA15120968
C039281furanfuran results in increased methylation of APOA2 gene22079235
D005897GlafenineGlafenine results in decreased expression of APOA2 mRNA24136188
C029424hydrazinehydrazine results in decreased expression of APOA2 mRNA15370871
D007545IsoproterenolIsoproterenol results in increased expression of APOA2 mRNA21335049
D007854LeadAPOA2 protein binds to Lead23896426
C095104LG 100268LG 100268 results in increased expression of APOA2 mRNA8668150
C095104LG 100268RXRA promotes the reaction [LG 100268 results in increased expression of APOA2 mRNA]8668150
C033266Menhaden oilMenhaden oil results in decreased expression of APOA2 mRNA7556148
C042720mercuric bromidemercuric bromide results in increased expression of APOA2 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APOA2 mRNA"27188386
D008628MercuryMercury affects the expression of APOA2 protein22030286
D008713MethimazoleMethimazole results in increased expression of APOA2 mRNA22504374
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of APOA2 mRNA23179753|2718838
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of APOA2 mRNA27544571
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of APOA2 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of APOA2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of APOA2"21654424
D009532NickelAPOA2 protein binds to Nickel23896426
D009543NifedipineNifedipine results in increased expression of APOA21928808
C464660obeticholic acidobeticholic acid results in increased expression of APOA2 mRNA27939613
D004369Pentetic Acid"[Butylated Hydroxytoluene co-treated with Pentetic Acid] inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA2 protein]"12576517
D004369Pentetic Acid"Pentetic Acid inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased oxidation of APOA2 protein]"12576517
C108042perfluorobutaneperfluorobutane affects the expression of APOA2 mRNA23567314
C036567perfluorodecanoic acidperfluorodecanoic acid affects the expression of APOA2 mRNA23567314
C522391perfluorododecanoic acidperfluorododecanoic acid affects the expression of APOA2 mRNA23567314
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid affects the expression of APOA2 mRNA23567314
C479228perfluorohexanoic acidperfluorohexanoic acid results in increased expression of APOA2 mRNA23567314
C101815perfluoro-n-heptanoic acidperfluoro-n-heptanoic acid results in increased expression of APOA2 mRNA23567314
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in increased expression of APOA2 mRNA23567314
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid affects the expression of APOA2 mRNA23567314
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of APOA2 mRNA23567314
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of APOA2 mRNA18692542
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of APOA2 protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of APOA2 mRNA23567314
C058216perilla seed oilperilla seed oil affects the expression of APOA2 protein10720173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of APOA2 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of APOA2 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of APOA2 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of APOA2 mRNA17426115
C006253pirinixic acidpirinixic acid results in decreased expression of APOA2 mRNA19162173
D010936Plant ExtractsPlant Extracts results in decreased expression of APOA2 mRNA23557933
D028321Plant Preparations[Estradiol co-treated with Plant Preparations] results in decreased expression of APOA2 mRNA26945725
D011192Potassium DichromatePotassium Dichromate affects the expression of APOA2 mRNA23608068
D011441PropylthiouracilPropylthiouracil results in increased expression of APOA2 mRNA22504374
D054328Proton Pump InhibitorsProton Pump Inhibitors results in decreased expression of APOA2 mRNA25626140
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in increased expression of APOA2 protein7442475
D012450Safflower OilSafflower Oil affects the expression of APOA2 protein10720173
D019821SimvastatinSimvastatin results in decreased expression of APOA2 mRNA25055962
C017947sodium arsenitesodium arsenite results in increased expression of APOA2 protein23570992
C017947sodium arsenitesodium arsenite affects the expression of APOA2 mRNA17450228
D053260SootSoot results in increased expression of APOA2 mRNA26551751
C501413tesaglitazartesaglitazar results in increased expression of APOA2 mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of APOA2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to APOA2 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of APOA2 mRNA28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of APOA2 mRNA21215274
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of APOA2 mRNA28943392
C009495titanium dioxidetitanium dioxide affects the expression of APOA2 mRNA23557971
D014212TretinoinRXRA promotes the reaction [Tretinoin results in increased expression of APOA2 mRNA]8668150
D014212TretinoinTretinoin results in increased expression of APOA2 mRNA8668150
D014212TretinoinTretinoin results in increased secretion of APOA2 protein8668150
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of APOA2 mRNA29024780
C057693troglitazonetroglitazone results in increased expression of APOA2 mRNA25572481
D014635Valproic AcidValproic Acid results in decreased expression of APOA2 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased expression of APOA2 mRNA28001369
C025643vinclozolinvinclozolin results in increased expression of APOA2 mRNA23034163
C029297vinylidene chloridevinylidene chloride results in decreased expression of APOA2 mRNA26682919
D015032ZincAPOA2 protein binds to Zinc23896426

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005319lipid transporter activity-IDA1606170  
GO:0005515protein binding-IPI11991719  17786215  25416956  
GO:0005543phospholipid binding-IDA218942  
GO:0008035high-density lipoprotein particle binding-IBA21873635  
GO:0008289lipid binding-IDA14967812  
GO:0015485cholesterol binding-IBA21873635  
GO:0015485cholesterol binding-IDA218942  
GO:0017127cholesterol transporter activityCONTRIBUTES_TOIBA21873635  
GO:0017127cholesterol transporter activitycontributes_toIDA9651324  
GO:0031072heat shock protein binding-IPI11027668  
GO:0031210phosphatidylcholine binding-IBA21873635  
GO:0031210phosphatidylcholine binding-IDA17264082  
GO:0034190apolipoprotein receptor binding-IBA21873635  
GO:0034190apolipoprotein receptor binding-IPI11162594  
GO:0042803protein homodimerization activity-IDA17264082  
GO:0046982protein heterodimerization activity-IPI7918467  8245722  
GO:0055102lipase inhibitor activity-IBA21873635  
GO:0055102lipase inhibitor activity-IDA14967812  
GO:0060228phosphatidylcholine-sterol O-acyltransferase activator activity-IDA14967812  
GO:0070653high-density lipoprotein particle receptor binding-IBA21873635  
GO:0070653high-density lipoprotein particle receptor binding-IPI10764676  
GO ID GO Term Qualifier Evidence PubMed
GO:0001523retinoid metabolic process-TAS-  
GO:0002526acute inflammatory response-IEA-  
GO:0002740negative regulation of cytokine secretion involved in immune response-IDA12458630  
GO:0006641triglyceride metabolic process-TAS11551871  
GO:0006656phosphatidylcholine biosynthetic process-IDA14967812  
GO:0008203cholesterol metabolic process-IBA21873635  
GO:0009395phospholipid catabolic process-IDA14967812  
GO:0009749response to glucose-IDA14988251  
GO:0010873positive regulation of cholesterol esterification-IDA14967812  
GO:0010903negative regulation of very-low-density lipoprotein particle remodeling-IDA14967812  
GO:0016032viral process-IEA-  
GO:0018158protein oxidation-IDA12576517  
GO:0018206peptidyl-methionine modification-IDA12576517  
GO:0019216regulation of lipid metabolic process-TAS-  
GO:0030300regulation of intestinal cholesterol absorption-IEA-  
GO:0030301cholesterol transport-IBA21873635  
GO:0031100animal organ regeneration-IEA-  
GO:0031647regulation of protein stability-IDA14967812  
GO:0032375negative regulation of cholesterol transport-IMP8636092  
GO:0033344cholesterol efflux-IDA11162594  
GO:0033700phospholipid efflux-IDA11162594  
GO:0034370triglyceride-rich lipoprotein particle remodeling-IBA21873635  
GO:0034370triglyceride-rich lipoprotein particle remodeling-IDA14967812  
GO:0034371chylomicron remodeling-TAS-  
GO:0034374low-density lipoprotein particle remodeling-IBA21873635  
GO:0034374low-density lipoprotein particle remodeling-IDA8106353  
GO:0034375high-density lipoprotein particle remodeling-IBA21873635  
GO:0034375high-density lipoprotein particle remodeling-IDA8106353  14967812  
GO:0034378chylomicron assembly-TAS-  
GO:0034380high-density lipoprotein particle assembly-IBA21873635  
GO:0034380high-density lipoprotein particle assembly-IDA218942  
GO:0034384high-density lipoprotein particle clearance-IDA10764676  
GO:0042157lipoprotein metabolic process-IBA21873635  
GO:0042493response to drug-IEA-  
GO:0042632cholesterol homeostasis-IBA21873635  
GO:0042632cholesterol homeostasis-IDA14967812  
GO:0043085positive regulation of catalytic activity-IEA-  
GO:0043627response to estrogen-IEA-  
GO:0043687post-translational protein modification-TAS-  
GO:0043691reverse cholesterol transport-IDA14967812  
GO:0044267cellular protein metabolic process-TAS-  
GO:0045416positive regulation of interleukin-8 biosynthetic process-IDA11591715  
GO:0046340diacylglycerol catabolic process-IDA14967812  
GO:0050995negative regulation of lipid catabolic process-IDA14967812  
GO:0050996positive regulation of lipid catabolic process-IDA8640403  
GO:0051384response to glucocorticoid-IEA-  
GO:0060192negative regulation of lipase activity-IBA21873635  
GO:0060192negative regulation of lipase activity-IDA14967812  
GO:0060621negative regulation of cholesterol import-IDA10764676  
GO:0060695negative regulation of cholesterol transporter activity-IDA8106353  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-NAS14718574  
GO:0005576extracellular region-TAS-  
GO:0005769early endosome-TAS-  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005829cytosol-TAS-  
GO:0034361very-low-density lipoprotein particle-IBA21873635  
GO:0034361very-low-density lipoprotein particle-IDA8245722  
GO:0034364high-density lipoprotein particle-IDA210174  3104518  17264082  
GO:0034366spherical high-density lipoprotein particle-IBA21873635  
GO:0034366spherical high-density lipoprotein particle-IDA16682745  
GO:0042627chylomicron-IBA21873635  
GO:0042627chylomicron-IDA8245722  
GO:0070062extracellular exosome-HDA19056867  19199708  23533145  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
hsa03320PPAR signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-162582Signal TransductionIEA
R-HSA-162582Signal TransductionTAS
R-HSA-174824Plasma lipoprotein assembly, remodeling, and clearanceTAS
R-HSA-196854Metabolism of vitamins and cofactorsIEA
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-2187338Visual phototransductionIEA
R-HSA-2187338Visual phototransductionTAS
R-HSA-372790Signaling by GPCRIEA
R-HSA-372790Signaling by GPCRTAS
R-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)TAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-388396GPCR downstream signallingIEA
R-HSA-388396GPCR downstream signallingTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-418594G alpha (i) signalling eventsIEA
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6806667Metabolism of fat-soluble vitaminsIEA
R-HSA-6806667Metabolism of fat-soluble vitaminsTAS
R-HSA-8957275Post-translational protein phosphorylationTAS
R-HSA-8963888Chylomicron assemblyTAS
R-HSA-8963898Plasma lipoprotein assemblyTAS
R-HSA-8963899Plasma lipoprotein remodelingTAS
R-HSA-8963901Chylomicron remodelingTAS
R-HSA-975634Retinoid metabolism and transportIEA
R-HSA-975634Retinoid metabolism and transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24895480Intercorrelations of lipoprotein subfractions and their covariation with lifestyle factors in healthy men. (2014 May)Parlesak AJ Clin Biochem Nutr
19878569Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis. (2009 Oct 30)Chen SNBMC Med Genet
18388696Why study gene-environment interactions? (2008 Apr)Ordovas JMCurr Opin Lipidol