Gene info: ID 3360

Gene: HTR4

GENE ID: 3360

Synonyms: 5-HT4|5-HT4R

Description: 5-hydroxytryptamine receptor 4

Gene type: protein-coding

Location: 5q32

dbXrefs: Ensembl:ENSG00000164270 MIM:602164 Vega:OTTHUMG00000129931 UniprotKB:Q13639

RefSeq: NG_029052.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.721e-2 (AD) 8.547e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
GPR52	0.857
KCNA4	0.84
C4orf50	0.833
RNF150	0.827
ANO3	0.816
WNT1	0.812
STRIP2	0.806
GPR88	0.801
KIAA1324	0.8
NCR3LG1	0.799

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MYL3	-0.535
ROM1	-0.506
CDKN2C	-0.499
COPZ2	-0.495
RAB13	-0.494
S100A1	-0.476
CSAG1	-0.469
PPP1R14B	-0.463
TSPO	-0.457
C1QTNF5	-0.454

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00604	Cisapride	Small Molecule	81098-60-4	Approved\|Investigational\|Withdrawn	Target
DB00904	Ondansetron	Small Molecule	99614-02-5	Approved	Target
DB01079	Tegaserod	Small Molecule	145158-71-0	Approved\|Investigational\|Withdrawn	Target
DB01233	Metoclopramide	Small Molecule	364-62-5	Approved\|Investigational	Target
DB04873	Piboserod	Small Molecule	152811-62-6	Investigational	Target
DB04917	Renzapride	Small Molecule	112727-80-7	Investigational	Target
DB05542	Naronapride	Small Molecule	860174-12-5	Investigational	Target
DB05905	TD-2749	Small Molecule	-	Investigational	Target
DB06422	Ticalopride	Small Molecule	202590-69-0	Investigational	Target
DB06480	Prucalopride	Small Molecule	179474-81-8	Approved	Target
DB08810	Cinitapride	Small Molecule	66564-14-5	Approved\|Investigational	Target
DB12702	Velusetrag	Small Molecule	866933-46-2	Investigational	Target
DB01049	Ergoloid mesylate	Small Molecule	8067-24-1	Approved	Target
DB09304	Setiptiline	Small Molecule	57262-94-9	Approved	Target
DB13025	Tiapride	Small Molecule	51012-32-9	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of HTR4 mRNA"	19162173
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of HTR4 mRNA"	25510870
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of HTR4 mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of HTR4 mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of HTR4 mRNA"	25510870
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of HTR4 mRNA"	25510870
C072790	2-methoxy-4-amino-5-chlorobenzoic acid 2-(diethylamino)ethyl ester	2-methoxy-4-amino-5-chlorobenzoic acid 2-(diethylamino)ethyl ester binds to and results in decreased activity of HTR4 protein	10490917
C117947	2-piperidinoethyl 4-amino-5-chloro-2-methoxybenzoate	2-piperidinoethyl 4-amino-5-chloro-2-methoxybenzoate binds to and results in increased activity of HTR4 protein	11020291
C008745	4,4'-bisphenol F	"4,4'-bisphenol F results in increased expression of HTR4 mRNA"	26186136
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of HTR4 gene	27153756
D001280	Atrazine	Atrazine results in decreased expression of HTR4 mRNA	25929836
C447119	bazedoxifene	bazedoxifene results in increased expression of HTR4 mRNA	19914376
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of HTR4 mRNA	22228805
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of HTR4 mRNA	26186136
C006780	bisphenol A	bisphenol A results in decreased expression of HTR4 mRNA	25181051
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of HTR4 mRNA	23741332
D002220	Carbamazepine	[Fluoxetine co-treated with Venlafaxine Hydrochloride co-treated with Carbamazepine] results in decreased expression of HTR4 mRNA	22701549
D020117	Cisapride	Cisapride binds to and results in increased activity of HTR4 protein	15115163\|1894837
D003042	Cocaine	HTR4 protein affects the susceptibility to Cocaine	9806222
D003300	Copper	Copper deficiency results in increased expression of HTR4 mRNA	26033743
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of HTR4 mRNA	15620428
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of HTR4 mRNA	26033743
D004237	Diuron	Diuron results in increased expression of HTR4 mRNA	21551480\|2515243
C070187	(endo-N-8-methyl-8-azabicyclo(3.2.1)oct-3-yl)-2,3-dihydro-3-ethyl-2-oxo-1H-benzimidazol-1-carboxamide	"(endo-N-8-methyl-8-azabicyclo(3.2.1)oct-3-yl)-2,3-dihydro-3-ethyl-2-oxo-1H-benzimidazol-1-carboxamide binds to and results in increased activity of HTR4 protein"	12736770
D005047	Etoposide	HTR4 protein affects the susceptibility to Etoposide	16217747
D005473	Fluoxetine	[Fluoxetine co-treated with Venlafaxine Hydrochloride co-treated with Carbamazepine] results in decreased expression of HTR4 mRNA	22701549
D005492	Folic Acid	Folic Acid results in decreased expression of HTR4 mRNA	25006883
C082871	GR 113808	GR 113808 binds to HTR4 protein	12502367
C082871	GR 113808	GR 113808 binds to HTR4 protein	11020291
C082871	GR 113808	GR 113808 binds to and results in decreased activity of HTR4 protein	12736770
C082871	GR 113808	GR 113808 binds to and results in decreased activity of HTR4 protein	15236628
C082871	GR 113808	GR 113808 binds to and results in decreased activity of HTR4 protein	11888554\|1511516
D012701	Serotonin	HTR4 protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]	11880652
D008070	Lipopolysaccharides	HTR4 protein inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]	15802305
D008070	Lipopolysaccharides	HTR4 protein promotes the reaction [Lipopolysaccharides results in increased secretion of CXCL8 protein]	15802305
D008070	Lipopolysaccharides	HTR4 protein promotes the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]	15802305
D008070	Lipopolysaccharides	HTR4 protein promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]	15802305
D008070	Lipopolysaccharides	HTR4 protein promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]	15802305
D008787	Metoclopramide	Metoclopramide binds to and results in increased activity of HTR4 protein	18948374
C062720	mosapride	mosapride binds to and results in increased activity of HTR4 protein	23330973
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of HTR4 mRNA"	29244179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of HTR4 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of HTR4 mRNA"	25554681
D009287	Naphthyridines	Naphthyridines analog binds to and affects the activity of HTR4 protein	12502367
C025589	ochratoxin A	ochratoxin A results in decreased methylation of HTR4 gene	26431795
C025589	ochratoxin A	ochratoxin A results in increased expression of HTR4 mRNA	27346841
D010126	Ozone	Ozone results in increased expression of HTR4 protein	23570994
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of HTR4 mRNA"	25510870
C000593032	PGW5 compound	PGW5 compound binds to HTR4 protein	24389121
D010617	Phenanthridines	Phenanthridines analog binds to and affects the activity of HTR4 protein	12502367
D010879	Piperazines	Piperazines analog binds to and results in decreased activity of HTR4 protein	11020291
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of HTR4 mRNA	23608068
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of HTR4 mRNA	19162173
C406662	prucalopride	prucalopride binds to and results in increased activity of HTR4 protein	18061284
D011719	Pyrazines	Pyrazines analog binds to and results in decreased activity of HTR4 protein	19261477
D011804	Quinolines	Quinolines analog binds to and affects the activity of HTR4 protein	12502367
C475107	RS 39604	RS 39604 binds to and results in decreased activity of HTR4 protein	15146954
C107826	RS 67333	RS 67333 binds to and results in increased activity of HTR4 protein	12736770\|1806128
C107826	RS 67333	RS 67333 binds to and affects the activity of HTR4 protein	10490917
D012643	Selenium	Selenium results in increased expression of HTR4 mRNA	19244175
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of HTR4 mRNA	23806026
C017947	sodium arsenite	sodium arsenite affects the methylation of HTR4 gene	28589171
D012999	Soman	Soman results in increased expression of HTR4 mRNA	19281266
C105050	tegaserod	tegaserod binds to and results in increased activity of HTR4 protein	15238200\|1596198
C105050	tegaserod	tegaserod binds to and results in increased activity of HTR4 protein	11560869
D014635	Valproic Acid	Valproic Acid results in decreased methylation of HTR4 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of HTR4 mRNA	19101580
D014635	Valproic Acid	Valproic Acid affects the expression of HTR4 mRNA	17963808
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of HTR4 gene	25560391
D000069470	Venlafaxine Hydrochloride	[Fluoxetine co-treated with Venlafaxine Hydrochloride co-treated with Carbamazepine] results in decreased expression of HTR4 mRNA	22701549
C055971	zacopride	zacopride results in increased activity of HTR4 protein	8577400
C088658	zoledronic acid	zoledronic acid results in increased expression of HTR4 mRNA	20977926

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004930	G-protein coupled receptor activity	-	IBA	21873635
GO:0004993	G-protein coupled serotonin receptor activity	-	IBA	21873635
GO:0004993	G-protein coupled serotonin receptor activity	-	IDA	16102731
GO:0030594	neurotransmitter receptor activity	-	IBA	21873635
GO:0042802	identical protein binding	-	IPI	15896782

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	-	IBA	21873635
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	-	TAS	9603189
GO:0007268	chemical synaptic transmission	-	IBA	21873635
GO:0007268	chemical synaptic transmission	-	IEA	-
GO:0032098	regulation of appetite	-	IEA	-
GO:0098664	G-protein coupled serotonin receptor signaling pathway	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IDA	15925089
GO:0005768	endosome	-	IEA	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	IEA	-
GO:0016020	membrane	-	IDA	16102731
GO:0030425	dendrite	-	IBA	21873635

KEGG ID	KEGG Term
hsa04020	Calcium signaling pathway
hsa04080	Neuroactive ligand-receptor interaction

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375280	Amine ligand-binding receptors	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-390666	Serotonin receptors	TAS
R-HSA-418555	G alpha (s) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22837378	Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. (2012 Oct 1)	Wilk JB	Am J Respir Crit Care Med
24163739	Genetic susceptibility to lung cancer and co-morbidities. (2013 Oct)	Yang IA	J Thorac Dis
28900078	[Polymorphic Variants of Glutamate Receptor (GRIK5, GRIN2B) and Serotonin Receptor (HTR2A) Genes Are Associated with Chronic Obstructive Pulmonary Disease]. (2017 Jul-Aug)	Korytina GF	Mol Biol (Mosk)