Gene: HTR5A

3361
5-HT5A
5-hydroxytryptamine receptor 5A
protein-coding
7q36.2
Ensembl:ENSG00000157219 MIM:601305 Vega:OTTHUMG00000151327 UniprotKB:P47898
NG_044997.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.680e-1 (AD)  2.404e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg10538202chr7:154863338HTR5APromoter1.969e-5Alcohol use disorders26763658
cg03024742chr7:154863244HTR5APromoter2.706e-5Alcohol use disorders26763658
cg11298960chr7:154862548HTR5APromoter8.920e-5Alcohol use disorders26763658
cg20967585chr7:154862524HTR5APromoter3.716e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GABRG20.963
NELL20.959
FAXC0.959
RBFOX10.959
AMPH0.959
FBXL20.958
PCSK20.958
MAGEE10.957
SH3GL20.956
ATP2B30.956

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAI14-0.586
HEY2-0.585
YES1-0.584
FZD10-0.579
REST-0.572
TFPI2-0.572
RNF135-0.564
WWTR1-0.561
MYL3-0.557
CSAG1-0.55

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00334OlanzapineSmall Molecule132539-06-1Approved|InvestigationalTarget
DB00408LoxapineSmall Molecule1977-10-2ApprovedTarget
DB06216AsenapineSmall Molecule65576-45-6ApprovedTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of HTR5A mRNA"25614096
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of HTR5A mRNA"19114083
C0087454,4'-bisphenol F"4,4'-bisphenol F results in decreased expression of HTR5A mRNA"26186136
D000082AcetaminophenAcetaminophen results in decreased expression of HTR5A mRNA26690555
D019386AlendronateAlendronate affects the expression of HTR5A mRNA16079270
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of HTR5A mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HTR5A mRNA16483693
D003913DextroamphetamineDextroamphetamine results in increased expression of HTR5A mRNA16715494
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of HTR5A mRNA"19446018
D001554BenzeneBenzene results in decreased expression of HTR5A mRNA21843810
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to HTR5A promoter]19654925
C006780bisphenol Abisphenol A affects the expression of HTR5A mRNA23557687
C006780bisphenol Abisphenol A results in decreased expression of HTR5A mRNA25181051
D001761BleomycinBleomycin results in decreased expression of HTR5A mRNA15808516
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of HTR5A promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of HTR5A mRNA16644059
D004390ChlorpyrifosChlorpyrifos results in decreased expression of HTR5A mRNA17452286
D004390ChlorpyrifosChlorpyrifos results in increased expression of HTR5A mRNA18835401
D002994ClofibrateClofibrate results in decreased expression of HTR5A mRNA17585979
D003976DiazinonDiazinon affects the expression of HTR5A mRNA17452286
D004026DieldrinDieldrin results in increased expression of HTR5A mRNA18835401
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of HTR5A mRNA16079270
D005557FormaldehydeFormaldehyde results in increased expression of HTR5A mRNA12679049
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of HTR5A mRNA21782745
D007854LeadLead affects the expression of HTR5A mRNA28903495
C008261lead acetatelead acetate results in increased expression of HTR5A mRNA20542052
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of HTR5A mRNA21782745
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of HTR5A mRNA16079270
C057693troglitazonetroglitazone results in increased expression of HTR5A mRNA28973697
D014635Valproic AcidValproic Acid results in increased methylation of HTR5A gene29154799
D019287Zinc SulfateZinc Sulfate results in increased expression of HTR5A mRNA27504894

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0004993G-protein coupled serotonin receptor activity-IBA21873635  
GO:0004993G-protein coupled serotonin receptor activity-IDA7988681  
GO:0030594neurotransmitter receptor activity-IBA21873635  
GO:0051378serotonin binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger-IBA21873635  
GO:0007198adenylate cyclase-inhibiting serotonin receptor signaling pathway-IBA21873635  
GO:0007268chemical synaptic transmission-IBA21873635  
GO:0019933cAMP-mediated signaling-IEA-  
GO:0021766hippocampus development-IEA-  
GO:0032355response to estradiol-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005791rough endoplasmic reticulum-IEA-  
GO:0005794Golgi apparatus-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IEA-  
GO:0030425dendrite-IBA21873635  
GO:0030425dendrite-IEA-  
GO:0043204perikaryon-IEA-  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375280Amine ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-390666Serotonin receptorsTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
11134668Pharmacogenetics and the serotonin system: initial studies and future directions. (2000 Dec 27)Veenstra-VanderWeele JEur J Pharmacol