Gene info: ID 3362

Gene: HTR6

GENE ID: 3362

Synonyms: 5-HT6|5-HT6R

Description: 5-hydroxytryptamine receptor 6

Gene type: protein-coding

Location: 1p36.13

dbXrefs: Ensembl:ENSG00000158748 MIM:601109 Vega:OTTHUMG00000002713 UniprotKB:P50406

RefSeq: NC_000001.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 3.023e-1 (AD) 8.998e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CHRM4	0.896
SPTB	0.884
EPHA10	0.872
CHRNB2	0.871
FADS6	0.866
SLC1A6	0.863
GRIN2B	0.862
SEZ6	0.86
P2RX5	0.858
PCDHGC5	0.855

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
YES1	-0.645
RAB13	-0.628
COPZ2	-0.619
ROM1	-0.609
MYL3	-0.608
REST	-0.597
HEBP2	-0.593
WWTR1	-0.59
RNF135	-0.59
TGIF1	-0.576

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00246	Ziprasidone	Small Molecule	146939-27-7	Approved	Target
DB00321	Amitriptyline	Small Molecule	50-48-6	Approved	Target
DB00334	Olanzapine	Small Molecule	132539-06-1	Approved\|Investigational	Target
DB00363	Clozapine	Small Molecule	5786-21-0	Approved	Target
DB00408	Loxapine	Small Molecule	1977-10-2	Approved	Target
DB00458	Imipramine	Small Molecule	50-49-7	Approved	Target
DB00477	Chlorpromazine	Small Molecule	50-53-3	Approved\|Investigational	Target
DB00540	Nortriptyline	Small Molecule	72-69-5	Approved	Target
DB00543	Amoxapine	Small Molecule	14028-44-5	Approved	Target
DB01142	Doxepin	Small Molecule	1668-19-5	Approved\|Investigational	Target
DB01224	Quetiapine	Small Molecule	111974-69-7	Approved	Target
DB01238	Aripiprazole	Small Molecule	129722-12-9	Approved\|Investigational	Target
DB01488	Dimethyltryptamine	Small Molecule	61-50-7	Experimental\|Illicit	Target
DB04829	Lysergic Acid Diethylamide	Small Molecule	50-37-3	Illicit\|Investigational\|Withdrawn	Target
DB04946	Iloperidone	Small Molecule	133454-47-4	Approved	Target
DB05042	SGS518	Small Molecule	-	Investigational	Target
DB05993	PRX-07034	Small Molecule	903580-39-2	Investigational	Target
DB06140	SUVN-502	Small Molecule	701205-60-9	Investigational	Target
DB06144	Sertindole	Small Molecule	106516-24-9	Approved\|Investigational\|Withdrawn	Target
DB06148	Mianserin	Small Molecule	24219-97-4	Approved\|Investigational	Target
DB06216	Asenapine	Small Molecule	65576-45-6	Approved	Target
DB09225	Zotepine	Small Molecule	26615-21-4	Approved\|Investigational\|Withdrawn	Target
DB01049	Ergoloid mesylate	Small Molecule	8067-24-1	Approved	Target
DB09304	Setiptiline	Small Molecule	57262-94-9	Approved	Target
DB13025	Tiapride	Small Molecule	51012-32-9	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C568612	(2-(6-fluoro-1H-indol-3-yl)-ethyl)-(3-(2,2,3,3-tetrafluoropropoxy)benzyl)amine	"(2-(6-fluoro-1H-indol-3-yl)-ethyl)-(3-(2,2,3,3-tetrafluoropropoxy)benzyl)amine binds to and results in decreased activity of HTR6 protein"	22029285
C548140	3-benzenesulfonyl-8-piperazin-1-ylquinoline	3-benzenesulfonyl-8-piperazin-1-ylquinoline binds to and results in decreased activity of HTR6 protein	22029285
C473484	4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine	4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine binds to and results in decreased activity of HTR6 protein	14610520
C008745	4,4'-bisphenol F	"4,4'-bisphenol F results in decreased expression of HTR6 mRNA"	26186136
C534240	5-chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole	"5-chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole binds to and results in increased activity of HTR6 protein"	21864673
D000082	Acetaminophen	Acetaminophen affects the expression of HTR6 mRNA	17562736
D020106	Acrylamide	Acrylamide results in decreased expression of HTR6 mRNA	28959563
D000242	Cyclic AMP	HTR6 protein results in increased abundance of Cyclic AMP	11406289
D000242	Cyclic AMP	Serotonin promotes the reaction [HTR6 protein results in increased abundance of Cyclic AMP]	11406289
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of HTR6 mRNA	16483693
D001058	Apomorphine	HTR6 protein results in increased susceptibility to Apomorphine	17920665
D001058	Apomorphine	Ro4368554 inhibits the reaction [HTR6 protein results in increased susceptibility to Apomorphine]	17920665
C006780	bisphenol A	bisphenol A results in decreased methylation of HTR6 promoter	27312807
C006780	bisphenol A	bisphenol A results in decreased expression of HTR6 mRNA	25181051
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of HTR6 mRNA	17805973
D002713	Chlorine	[Ozone co-treated with Chlorine] results in increased expression of HTR6 mRNA	18636392
D004390	Chlorpyrifos	Chlorpyrifos affects the expression of HTR6 mRNA	17452286\|1883540
D003024	Clozapine	Clozapine binds to HTR6 protein	16983399
D003024	Clozapine	Clozapine binds to and results in decreased activity of HTR6 protein	11406289
D003024	Clozapine	Clozapine binds to and results in decreased activity of HTR6 protein	10199625
D003042	Cocaine	[Ro 4-6790 binds to and results in decreased activity of HTR6 protein] which results in decreased susceptibility to Cocaine	20426879
D003042	Cocaine	[SB 271046 binds to and results in decreased activity of HTR6 protein] which results in decreased susceptibility to Cocaine	20426879
D003300	Copper	[Copper co-treated with Dietary Sucrose] results in increased expression of HTR6 mRNA	26033743
D003300	Copper	Copper deficiency results in increased expression of HTR6 mRNA	26033743
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of HTR6 mRNA	23640034\|2391405
D003976	Diazinon	Diazinon affects the expression of HTR6 mRNA	17452286
D004026	Dieldrin	Dieldrin affects the expression of HTR6 mRNA	18835401
D019422	Dietary Sucrose	[Copper co-treated with Dietary Sucrose] results in increased expression of HTR6 mRNA	26033743
D019422	Dietary Sucrose	Dietary Sucrose results in increased expression of HTR6 mRNA	26033743
D004052	Diethylnitrosamine	[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of HTR6 gene	23968726
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of HTR6 mRNA	23649840
D005557	Formaldehyde	Formaldehyde results in decreased expression of HTR6 mRNA	23649840
D012701	Serotonin	HTR6 protein affects the reaction [Serotonin affects the phosphorylation of PPP1R1B protein]	11880652
D012701	Serotonin	Serotonin promotes the reaction [HTR6 protein results in increased abundance of Cyclic AMP]	11406289
D007854	Lead	Lead results in increased expression of HTR6 mRNA	19921347
D008238	Lysergic Acid Diethylamide	Lysergic Acid Diethylamide binds to HTR6 protein	21866910
D008694	Methamphetamine	HTR6 gene SNP results in increased susceptibility to Methamphetamine	20705401
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of HTR6 mRNA	23649840
C076029	olanzapine	olanzapine binds to HTR6 protein	16983399
D010126	Ozone	[Ozone co-treated with Chlorine] results in increased expression of HTR6 mRNA	18636392
D052638	Particulate Matter	Particulate Matter results in increased methylation of HTR6 gene	28495853
C000593032	PGW5 compound	PGW5 compound binds to HTR6 protein	24389121
D010852	Picrotoxin	Picrotoxin results in increased expression of HTR6 mRNA	15170462
D010882	Piperonyl Butoxide	[Piperonyl Butoxide co-treated with Diethylnitrosamine] affects the methylation of HTR6 gene	23968726
C006253	pirinixic acid	NCF1 protein promotes the reaction [pirinixic acid results in decreased expression of HTR6 mRNA]	17950772
C006253	pirinixic acid	pirinixic acid results in decreased expression of HTR6 mRNA	17950772
D010936	Plant Extracts	Plant Extracts results in decreased expression of HTR6 mRNA	23557933
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of HTR6 mRNA	23608068
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of HTR6 mRNA	24780913
D018967	Risperidone	HTR6 gene polymorphism affects the reaction [Risperidone results in increased expression of PRL protein]	19997080
C507242	Ro4368554	Ro4368554 binds to and results in decreased activity of HTR6 protein	17920665
C507242	Ro4368554	Ro4368554 inhibits the reaction [HTR6 protein results in increased susceptibility to Apomorphine]	17920665
C507242	Ro4368554	Ro4368554 binds to and results in decreased activity of HTR6 protein	15957009
C114163	Ro 4-6790	[Ro 4-6790 binds to and results in decreased activity of HTR6 protein] which results in decreased susceptibility to Cocaine	20426879
C114163	Ro 4-6790	Ro 4-6790 binds to and results in decreased activity of HTR6 protein	20426879\|9884085
C488333	Ro 65-7199	Ro 65-7199 binds to and results in decreased activity of HTR6 protein	14610520
C581984	SAM-531	SAM-531 binds to and results in decreased activity of HTR6 protein	22029285
C418570	SB 258585	SB 258585 binds to HTR6 protein	12112397
C418570	SB 258585	SB 258585 binds to HTR6 protein	12112397
C418570	SB 258585	SB 258585 binds to and results in decreased activity of HTR6 protein	21864673
C117443	SB 271046	SB 271046 binds to and results in decreased activity of HTR6 protein	14571256
C117443	SB 271046	[SB 271046 binds to and results in decreased activity of HTR6 protein] which results in decreased susceptibility to Cocaine	20426879
C117443	SB 271046	SB 271046 binds to and results in decreased activity of HTR6 protein	20426879
C503990	SB 399885	SB 399885 results in increased expression of HTR6 mRNA	19733250
C503990	SB 399885	SB 399885 binds to and results in decreased activity of HTR6 protein	18570192
D012601	Scopolamine Hydrobromide	Scopolamine Hydrobromide results in decreased expression of HTR6 mRNA	19733250
C017947	sodium arsenite	sodium arsenite affects the methylation of HTR6 gene	28589171
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of HTR6 gene	27618143
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of HTR6 gene	28495853

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004930	G-protein coupled receptor activity	-	IBA	21873635
GO:0004969	histamine receptor activity	-	TAS	8522988
GO:0004993	G-protein coupled serotonin receptor activity	-	IBA	21873635
GO:0005515	protein binding	-	IPI	17189269 23027611
GO:0030594	neurotransmitter receptor activity	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007186	G-protein coupled receptor signaling pathway	-	TAS	-
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	-	IBA	21873635
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	-	TAS	8522988
GO:0007268	chemical synaptic transmission	-	IBA	21873635
GO:0007268	chemical synaptic transmission	-	TAS	8522988
GO:0021795	cerebral cortex cell migration	-	ISS	-
GO:0032008	positive regulation of TOR signaling	-	IDA	23027611
GO:0098664	G-protein coupled serotonin receptor signaling pathway	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005887	integral component of plasma membrane	-	TAS	8522988
GO:0005929	cilium	-	IEA	-
GO:0030425	dendrite	-	IBA	21873635

KEGG ID	KEGG Term
hsa04020	Calcium signaling pathway
hsa04080	Neuroactive ligand-receptor interaction

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-372790	Signaling by GPCR	TAS
R-HSA-373076	Class A/1 (Rhodopsin-like receptors)	TAS
R-HSA-375280	Amine ligand-binding receptors	TAS
R-HSA-388396	GPCR downstream signalling	TAS
R-HSA-390666	Serotonin receptors	TAS
R-HSA-418555	G alpha (s) signalling events	TAS
R-HSA-500792	GPCR ligand binding	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
16770336	Why do young women smoke? II. Role of traumatic life experience, psychological characteristics and serotonergic genes. (2006 Aug)	Lerer E	Mol Psychiatry