Gene: APOA4

337
-
apolipoprotein A4
protein-coding
11q23.3
Ensembl:ENSG00000110244 MIM:107690 Vega:OTTHUMG00000046110 UniprotKB:P06727
NG_012044.1
PubMed
0   ANCO-SNPs
ND
5   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.434e-2 (AD)  3.004e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DEFA60.464
GUCA2B0.423
CLCA10.363
ASCL30.363
GUCA2A0.354
MUC20.335
PACSIN30.334
STAP20.305
FAM53A0.303
TEX120.3

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NFAT5-0.295
MYL2-0.292
ZNF778-0.292
RAPH1-0.291
MAN1A1-0.28
RPS6KA6-0.28
ZNF852-0.279
DNAH5-0.275
HRH2-0.275
SMCR8-0.275

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0810141,2-bis(2,4,6-tribromophenoxy)ethane"1,2-bis(2,4,6-tribromophenoxy)ethane results in decreased expression of APOA4 mRNA"28249227
C0122771,2-diamino-4-nitrobenzene"1,2-diamino-4-nitrobenzene results in decreased expression of APOA4 mRNA"17070881
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of APOA4 mRNA"28903501
C0353141-nitropropane1-nitropropane results in decreased expression of APOA4 mRNA17070881
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of APOA4 mRNA"21920950
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of APOA4 mRNA"19114083
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of APOA4 mRNA"28433925
C0109142,4-diaminotoluene"2,4-diaminotoluene results in decreased expression of APOA4 mRNA"17070881
C0252352,6-diaminotoluene"2,6-diaminotoluene results in decreased expression of APOA4 mRNA"17070881
C0147062-nitro-4-phenylenediamine2-nitro-4-phenylenediamine results in decreased expression of APOA4 mRNA17070881
C0166172-nitropropane2-nitropropane results in decreased expression of APOA4 mRNA17070881
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of APOA4 mRNA"20959002
C0261373-hydroxyacetanilide3-hydroxyacetanilide results in increased expression of APOA4 mRNA18544908
C4734844-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine affects the expression of APOA4 mRNA14610520
C5756314-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile"4-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile affects the expression of APOA4 mRNA"21218783
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of APOA4 mRNA"18648102
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of APOA4 mRNA"25380136
C0286764-acetylaminofluorene4-acetylaminofluorene results in decreased expression of APOA4 mRNA17070881
C0293704-toluidine4-toluidine results in decreased expression of APOA4 mRNA27638505
D000082AcetaminophenAcetaminophen results in decreased expression of APOA4 mRNA22230336|2906747
D000082AcetaminophenAcetaminophen affects the expression of APOA4 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of APOA4 mRNA11264010|1854490
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of APOA4 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of APOA4 mRNA]17585979
C006418adrenocorticotropin zincadrenocorticotropin zinc results in increased expression of APOA4 mRNA19920212
D000638AmiodaroneAmiodarone affects the expression of APOA4 mRNA18355885|1948338
D000639AmitriptylineAmitriptyline affects the expression of APOA4 mRNA18355885
D001151ArsenicArsenic affects the methylation of APOA4 gene25304211
D001553BenzbromaroneBenzbromarone affects the expression of APOA4 mRNA19483382
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of APOA4 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of APOA4 mRNA19770486
D004958EstradiolEstradiol results in decreased expression of APOA4 mRNA19484750
C452139BIRB 796BIRB 796 results in decreased expression of APOA4 mRNA21328587
C006780bisphenol Abisphenol A results in increased expression of APOA4 mRNA27322340
C006780bisphenol Abisphenol A results in decreased expression of APOA4 mRNA27502578
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of APOA4 mRNA"28433925
C006780bisphenol Abisphenol A results in decreased expression of APOA4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of APOA4 gene28505145
D002084Butylated HydroxytolueneButylated Hydroxytoluene results in increased expression of APOA4 mRNA12082028
D002104CadmiumAPOA4 protein binds to Cadmium23896426
D002104CadmiumCadmium results in increased expression of APOA4 mRNA24084258
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of APOA4 mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of APOA4 mRNA15963578
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of APOA4 mRNA15963578
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of APOA4 mRNA15963342
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of APOA4 mRNA16239168
D002509CephaloridineCephaloridine results in increased expression of APOA4 mRNA18500788
C026690cerous chloridecerous chloride affects the expression of APOA4 mRNA23139204
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in decreased expression of APOA4 mRNA27174168
D008076Cholesterol, HDL"APOA4 gene polymorphism affects the abundance of Cholesterol, HDL"16030523
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of APOA4 mRNA20938992
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of APOA4 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of APOA4 mRNA17585979|2381119
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of APOA4 mRNA]17585979
D002994ClofibrateClofibrate affects the expression of APOA4 mRNA19483382
D002994ClofibrateClofibrate results in decreased expression of APOA4 mRNA11328961|1285110
D002997ClomipramineClomipramine affects the expression of APOA4 mRNA18355885
D003300CopperAPOA4 protein binds to Copper23896426
D019327Copper SulfateCopper Sulfate results in decreased expression of APOA4 mRNA19549813
C029892cupric chloridecupric chloride results in increased expression of APOA4 mRNA21072851
C029892cupric chlorideAPOA4 protein binds to cupric chloride22699969
C029892cupric chloridecupric chloride results in increased expression of APOA4 protein22699969
D016572CyclosporineCyclosporine affects the expression of APOA4 mRNA27989131
D003907DexamethasoneDexamethasone affects the expression of APOA4 mRNA15102944
D003907DexamethasoneDexamethasone results in increased expression of APOA4 mRNA11328961
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of APOA4 mRNA28962523
D004008DiclofenacDiclofenac affects the expression of APOA4 mRNA26934552
C000944dicrotophosdicrotophos results in decreased expression of APOA4 mRNA28302478
D004041Dietary FatsDietary Fats affects the expression of APOA4 mRNA17086191|1968055
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of APOA4 mRNA28433925
D004041Dietary FatsDietary Fats results in increased expression of APOA4 mRNA15238619|1845759
D004041Dietary FatsNEIL1 affects the reaction [Dietary Fats results in increased expression of APOA4 mRNA]21285402
D004041Dietary FatsQuercetin inhibits the reaction [Dietary Fats results in increased expression of APOA4 mRNA]22447684
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats affects the expression of APOA4 mRNA]17086191
D004041Dietary FatsDietary Fats results in decreased expression of APOA4 mRNA22715380
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of APOA4 mRNA28433925
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of APOA4 mRNA19245819|1985064
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of APOA4 mRNA]19850644
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of APOA4 mRNA"28433925
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of APOA4 mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of APOA4 mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of APOA4 mRNA28943392
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in increased expression of APOA4 mRNA"27840820
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of APOA4 mRNA25380136
D052244Endocrine DisruptorsEndocrine Disruptors results in decreased expression of APOA4 mRNA25198161
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of APOA4 mRNA17555576
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with IL1B protein] results in increased expression of APOA4 mRNA12072388
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of APOA4 mRNA12072388|1497612
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of APOA4 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of APOA4 mRNA15953391
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of APOA4 mRNA12082028
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of APOA4 mRNA23550701
D005001EthionineEthionine affects the expression of APOA4 mRNA19483382
C024565ethylene dichlorideethylene dichloride results in increased expression of APOA4 mRNA28189721
D011345FenofibrateFenofibrate results in decreased expression of APOA4 mRNA11798191
D005411Flame RetardantsFlame Retardants results in decreased expression of APOA4 protein18550172
D005419FlavonoidsFlavonoids results in decreased expression of APOA4 mRNA18035473
D015725FluconazoleFluconazole results in decreased expression of APOA4 mRNA16643972
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in decreased expression of APOA4 mRNA17070881
D005492Folic Acid[APOE gene mutant form affects the susceptibility to Folic Acid] which results in increased expression of APOA4 mRNA17118406
D005492Folic Acid[APOE gene mutant form affects the susceptibility to Folic Acid] which results in increased expression of APOA4 protein17118406
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of APOA4 mRNA20938992
D005632FructoseFructose results in increased expression of APOA4 mRNA11983814
C056933fumonisin B1fumonisin B1 results in increased expression of APOA4 mRNA16221962
C039281furanfuran results in decreased expression of APOA4 mRNA25539665|2619464
D006046Gold[Gold co-treated with Polyethylene Glycols] results in decreased expression of APOA4 mRNA19695318
C029424hydrazinehydrazine results in increased expression of APOA4 mRNA15282401
C029424hydrazinehydrazine results in decreased expression of APOA4 protein15370871
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of APOA4 mRNA20044591
D007099ImipramineImipramine affects the expression of APOA4 mRNA18355885
C051140iron(II)-ascorbic acid complexiron(II)-ascorbic acid complex results in decreased expression of APOA4 protein10898742
D007538IsoniazidAPOA4 affects the susceptibility to Isoniazid24848797
C410337K 7174K 7174 results in decreased expression of APOA4 mRNA24086573
D007654KetoconazoleKetoconazole affects the expression of APOA4 mRNA18355885
C099406L 742694L 742694 affects the expression of APOA4 mRNA15102944
D054709Lecithins[Taurocholic Acid co-treated with Triolein co-treated with Lecithins] results in increased expression of APOA4 protein6631239
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of APOA4 mRNA27339419
D008095Lithocholic AcidLithocholic Acid results in increased expression of APOA4 mRNA20359477
D008627Mercuric ChlorideMercuric Chloride affects the expression of APOA4 mRNA20353558
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of APOA4 mRNA20938992
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of APOA4 mRNA11328961
C043243methyl tert-butyl ethermethyl tert-butyl ether affects the expression of APOA4 mRNA24128854
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of APOA4 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of APOA4 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased secretion of APOA4 protein"25598225
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of APOA4 mRNA25380136
C051752nefazodonenefazodone results in decreased expression of APOA4 mRNA24136188
D009532NickelAPOA4 protein binds to Nickel23896426
D009532NickelNickel analog results in decreased expression of APOA4 protein alternative form25144474
D017672Nitrogen Compounds[APOA4 protein co-treated with CBS protein] affects the abundance of Nitrogen Compounds18224302
D017672Nitrogen CompoundsSimvastatin inhibits the reaction [[APOA4 protein co-treated with CBS protein] affects the abundance of Nitrogen Compounds]18224302
C002741N-nitrosomorpholineN-nitrosomorpholine affects the expression of APOA4 protein19716841
C025589ochratoxin Aochratoxin A results in increased expression of APOA4 mRNA23358140
D019301Oleic AcidOleic Acid results in increased expression of APOA4 mRNA26739624
C076029olanzapineolanzapine affects the phosphorylation of APOA4 protein25821032
D009853OmeprazoleOmeprazole affects the expression of APOA4 mRNA19483382
C016340o,p'-DDT"o,p'-DDT affects the expression of APOA4 mRNA"18925944
D000073878Palm OilPalm Oil affects the expression of APOA4 mRNA19680557
D010269ParaquatParaquat results in increased expression of APOA4 mRNA17275934
D052638Particulate MatterParticulate Matter results in decreased expression of APOA4 protein alternative form25144474
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of APOA4 protein18550172
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of APOA4 mRNA23948077
C539348perfluorobutanesulfonic acidperfluorobutanesulfonic acid results in decreased expression of APOA4 mRNA22071372
C033094perfluorobutyric acidperfluorobutyric acid affects the expression of APOA4 mRNA22071372
C522391perfluorododecanoic acidperfluorododecanoic acid affects the expression of APOA4 mRNA22071372
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in decreased expression of APOA4 mRNA22071372
C479228perfluorohexanoic acidperfluorohexanoic acid results in increased expression of APOA4 mRNA22071372
C584865perfluorononanoic acidperfluorononanoic acid results in increased expression of APOA4 mRNA22071372
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of APOA4 mRNA23602845
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of APOA4 mRNA22071372
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of APOA4 mRNA16221955|1916217
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of APOA4 mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of APOA4 mRNA27153767
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of APOA4 mRNA25092180
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of APOA4 mRNA22071372
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of APOA4 mRNA16221955|1916217
C586085perfluoroundecanoic acidperfluoroundecanoic acid affects the expression of APOA4 mRNA22071372
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of APOA4 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of APOA4 mRNA19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of APOA4 mRNA12807726
D010634PhenobarbitalPhenobarbital results in decreased expression of APOA4 mRNA19162173
D010634PhenobarbitalPhenobarbital results in increased expression of APOA4 mRNA11328961|1208202
D010672PhenytoinPhenytoin results in increased expression of APOA4 mRNA15136057
D010882Piperonyl ButoxidePiperonyl Butoxide results in decreased expression of APOA4 mRNA22484513
C006253pirinixic acidpirinixic acid results in decreased expression of APOA4 mRNA11798191|1537516
C006253pirinixic acidpirinixic acid results in increased expression of APOA4 mRNA18445702
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of APOA4 mRNA]20059764
C006253pirinixic acidpirinixic acid affects the expression of APOA4 mRNA19483382
C006253pirinixic acidpirinixic acid results in decreased expression of APOA4 mRNA19162173|2248451
D011092Polyethylene Glycols[Gold co-treated with Polyethylene Glycols] results in decreased expression of APOA4 mRNA19695318
D011137PolystyrenesPolystyrenes analog promotes the reaction [Simvastatin results in decreased expression of APOA4 protein]8461338
D011137PolystyrenesPolystyrenes analog results in decreased expression of APOA4 protein8461338
D011137PolystyrenesSimvastatin promotes the reaction [Polystyrenes analog results in decreased expression of APOA4 protein]8461338
D011192Potassium DichromatePotassium Dichromate results in increased expression of APOA4 mRNA23608068
C045950propiconazolepropiconazole results in decreased expression of APOA4 mRNA19423681
D011441PropylthiouracilPropylthiouracil affects the expression of APOA4 mRNA19483382
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in decreased expression of APOA4 protein8412754
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in increased expression of APOA4 mRNA8412754
D011692Puromycin AminonucleosidePuromycin Aminonucleoside results in increased expression of APOA4 protein7442475
C030984pyrenepyrene results in decreased expression of APOA4 mRNA15963578
D011794QuercetinQuercetin inhibits the reaction [Dietary Fats results in increased expression of APOA4 mRNA]22447684
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats affects the expression of APOA4 mRNA]17086191
C059514resveratrolresveratrol results in decreased expression of APOA4 mRNA18930334
C059514resveratrol[resveratrol co-treated with Streptozocin] results in decreased expression of APOA4 mRNA25905778
C042734rifaximin[NR1I2 results in increased susceptibility to rifaximin] which results in increased expression of APOA4 mRNA22790967
C488333Ro 65-7199Ro 65-7199 affects the expression of APOA4 mRNA14610520
C089730rosiglitazonerosiglitazone results in decreased expression of APOA4 mRNA25572481
D019821SimvastatinSimvastatin inhibits the reaction [[APOA4 protein co-treated with CBS protein] affects the abundance of Nitrogen Compounds]18224302
D019821SimvastatinSimvastatin promotes the reaction [[APOA4 protein co-treated with CBS protein] affects the expression of CAV1 protein]18224302
D019821SimvastatinSimvastatin results in increased expression of APOA4 protein18224302
D019821SimvastatinPolystyrenes analog promotes the reaction [Simvastatin results in decreased expression of APOA4 protein]8461338
D019821SimvastatinSimvastatin promotes the reaction [Polystyrenes analog results in decreased expression of APOA4 protein]8461338
D019821SimvastatinSimvastatin results in decreased expression of APOA4 mRNA25055962|8461338
D019821SimvastatinSimvastatin results in decreased expression of APOA4 protein8289597|8461338
C017947sodium arsenitesodium arsenite affects the expression of APOA4 mRNA19590694
C017947sodium arsenitesodium arsenite results in increased expression of APOA4 protein21925251
C017947sodium arsenitesodium arsenite results in decreased expression of APOA4 mRNA17450228
D012969Sodium FluorideSodium Fluoride results in increased expression of APOA4 protein28918527
C031183stearic acidstearic acid results in increased expression of APOA4 mRNA26739624
D013311Streptozocin[resveratrol co-treated with Streptozocin] results in decreased expression of APOA4 mRNA25905778
C446685systhanesysthane results in decreased expression of APOA4 mRNA16643972|1942368
D014284TriiodothyronineTriiodothyronine results in increased expression of [APOE protein co-treated with APOA4 protein]6816881
C013698tallowtallow affects the expression of APOA4 mRNA19680557
D013629TamoxifenTamoxifen affects the expression of APOA4 mRNA17555576
D013656Taurocholic Acid[Taurocholic Acid co-treated with Triolein co-treated with Lecithins] results in increased expression of APOA4 protein6631239
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of APOA4 mRNA27914987
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of APOA4 mRNA28213091
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of APOA4 mRNA"28433925
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of APOA4 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to APOA4 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of APOA4 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of APOA4 mRNA16054898|1969266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of APOA4 mRNA15644576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of APOA4 protein15822908
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of APOA4 mRNA28943392
D013853ThioacetamideThioacetamide affects the expression of APOA4 mRNA19483382
D013853ThioacetamideThioacetamide results in decreased expression of APOA4 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of APOA4 protein19478969
D014212TretinoinTretinoin results in decreased expression of APOA4 mRNA18230668
C032910triadimefontriadimefon results in decreased expression of APOA4 mRNA16643972|1942368
D014241TrichloroethyleneTrichloroethylene results in increased expression of APOA4 mRNA19448997
D014241TrichloroethyleneTrichloroethylene results in decreased expression of APOA4 mRNA19448997
D014304Triolein[Taurocholic Acid co-treated with Triolein co-treated with Lecithins] results in increased expression of APOA4 protein6631239
C057693troglitazonetroglitazone results in decreased expression of APOA4 mRNA28973697
D014520UrethaneUrethane results in decreased expression of APOA4 mRNA28818685
C406224valdecoxibvaldecoxib results in decreased expression of APOA4 mRNA24136188
D014635Valproic AcidValproic Acid results in increased expression of APOA4 mRNA28001369
D014635Valproic AcidValproic Acid results in increased methylation of APOA4 gene29154799
D014635Valproic AcidValproic Acid affects the expression of APOA4 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of APOA4 gene25560391
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of APOA4 mRNA"25198161
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of APOA4 mRNA"23246600
D015032ZincAPOA4 protein binds to Zinc23896426

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005319lipid transporter activity-TAS3080432  
GO:0005507copper ion binding-IDA16945374  
GO:0005515protein binding-IPI24311788  
GO:0005543phospholipid binding-IBA21873635  
GO:0008289lipid binding-IMP16159879  
GO:0015485cholesterol binding-IBA21873635  
GO:0016209antioxidant activity-IDA16945374  
GO:0017127cholesterol transporter activity-IBA21873635  
GO:0017127cholesterol transporter activity-IDA1935934  
GO:0031210phosphatidylcholine binding-IBA21873635  
GO:0031210phosphatidylcholine binding-IDA1935934  11940599  
GO:0042802identical protein binding-IPI22579246  
GO:0042803protein homodimerization activity-IDA1935934  
GO:0060228phosphatidylcholine-sterol O-acyltransferase activator activity-IBA21873635  
GO:0060228phosphatidylcholine-sterol O-acyltransferase activator activity-IDA1935934  
GO ID GO Term Qualifier Evidence PubMed
GO:0001523retinoid metabolic process-TAS-  
GO:0002227innate immune response in mucosa-IDA15254593  
GO:0006695cholesterol biosynthetic process-IBA21873635  
GO:0006869lipid transport-IDA1935934  3095477  
GO:0006982response to lipid hydroperoxide-IDA16945374  
GO:0007159leukocyte cell-cell adhesion-IDA15254593  
GO:0008203cholesterol metabolic process-IDA1935934  
GO:0010873positive regulation of cholesterol esterification-IBA21873635  
GO:0010873positive regulation of cholesterol esterification-IDA1935934  
GO:0010898positive regulation of triglyceride catabolic process-IBA21873635  
GO:0010898positive regulation of triglyceride catabolic process-IDA2307668  
GO:0016042lipid catabolic process-IDA3095477  
GO:0019430removal of superoxide radicals-IDA16945374  
GO:0019433triglyceride catabolic process-IBA21873635  
GO:0030300regulation of intestinal cholesterol absorption-IBA21873635  
GO:0031102neuron projection regeneration-IBA21873635  
GO:0032374regulation of cholesterol transport-IBA21873635  
GO:0032374regulation of cholesterol transport-IDA11940599  
GO:0033344cholesterol efflux-IBA21873635  
GO:0033344cholesterol efflux-IDA1935934  11162594  
GO:0033700phospholipid efflux-IBA21873635  
GO:0033700phospholipid efflux-IDA11162594  
GO:0034371chylomicron remodeling-IC2307668  
GO:0034371chylomicron remodeling-TAS-  
GO:0034372very-low-density lipoprotein particle remodeling-IBA21873635  
GO:0034372very-low-density lipoprotein particle remodeling-IDA2307668  
GO:0034375high-density lipoprotein particle remodeling-IC1935934  
GO:0034378chylomicron assembly-TAS16159879  
GO:0034380high-density lipoprotein particle assembly-IBA21873635  
GO:0034445negative regulation of plasma lipoprotein oxidation-IDA16945374  
GO:0035634response to stilbenoid-IEA-  
GO:0042157lipoprotein metabolic process-IBA21873635  
GO:0042157lipoprotein metabolic process-IEA-  
GO:0042632cholesterol homeostasis-IBA21873635  
GO:0042632cholesterol homeostasis-IDA1935934  
GO:0042744hydrogen peroxide catabolic process-IDA16945374  
GO:0043691reverse cholesterol transport-IBA21873635  
GO:0043691reverse cholesterol transport-IDA3095477  
GO:0044267cellular protein metabolic process-TAS-  
GO:0045723positive regulation of fatty acid biosynthetic process-IBA21873635  
GO:0045723positive regulation of fatty acid biosynthetic process-IDA2307668  
GO:0046470phosphatidylcholine metabolic process-IBA21873635  
GO:0046470phosphatidylcholine metabolic process-IDA1935934  
GO:0046889positive regulation of lipid biosynthetic process-IBA21873635  
GO:0051006positive regulation of lipoprotein lipase activity-IBA21873635  
GO:0051006positive regulation of lipoprotein lipase activity-IDA2307668  
GO:0055088lipid homeostasis-IDA3095477  
GO:0065005protein-lipid complex assembly-IMP16159879  
GO:0070328triglyceride homeostasis-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-HDA27068509  
GO:0005576extracellular region-NAS14718574  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA20551380  
GO:0005615extracellular space-IDA1935934  
GO:0005769early endosome-TAS-  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005829cytosol-TAS-  
GO:0009986cell surfacecolocalizes_withIDA1935934  
GO:0034361very-low-density lipoprotein particle-IDA3095477  17154273  
GO:0034364high-density lipoprotein particle-IBA21873635  
GO:0034364high-density lipoprotein particle-IDA3095477  
GO:0042627chylomicron-IBA21873635  
GO:0042627chylomicron-IDA3095477  
GO:0062023collagen-containing extracellular matrix-HDA27559042  
GO:0070062extracellular exosome-HDA23533145  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
hsa04975Fat digestion and absorption
hsa04977Vitamin digestion and absorption
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
16421347The APOA4 Thr347->Ser347 polymorphism is not a major risk factor of obesity. (2005 Dec)Dallongeville JObes Res
26824674Interactions of Environmental Factors and APOA1-APOC3-APOA4-APOA5 Gene Cluster Gene Polymorphisms with Metabolic Syndrome. (2016)Wu YPLoS One
23096082Minor allele of the APOA4 gene T347S polymorphism predisposes to obesity in postmenopausal Turkish women. (2012 Dec)Guclu-Geyik FMol Biol Rep
17130180Candidate gene genotypes, along with conventional risk factor assessment, improve estimation of coronary heart disease risk in healthy UK men. (2007 Jan)Humphries SEClin Chem
11815309Lipoproteins, nutrition, and heart disease. (2002 Feb)Schaefer EJAm J Clin Nutr