Gene: TNC

3371
150-225|DFNA56|GMEM|GP|HXB|JI|TN|TN-C
tenascin C
protein-coding
9q33.1
Ensembl:ENSG00000041982 MIM:187380 Vega:OTTHUMG00000021010 UniprotKB:P24821
NG_029637.1
PubMed
0   ANCO-SNPs
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.778e-1 (AD)  5.708e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CD440.729
SERPINB80.719
PIRT0.713
SPOCD10.701
MATN20.671
CDKN2B0.665
RBBP80.661
BMP20.66
PDPN0.653
RDH100.65

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SCRT1-0.424
RASL10B-0.412
KCNQ4-0.392
DBP-0.387
PANX2-0.383
EIF4E1B-0.379
EMX1-0.37
DBH-0.368
KCNN1-0.363
NKX6-3-0.362

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0389831,3-dimethylthiourea"1,3-dimethylthiourea inhibits the reaction [Monocrotaline results in increased expression of TNC mRNA]"9251245
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of TNC mRNA"25614096
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of TNC mRNA"19114083
C0131862,3-pentanedione"2,3-pentanedione results in increased expression of TNC mRNA"25710175
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TNC mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TNC mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNC mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNC mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TNC mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TNC mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNC mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNC mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of TNC mRNA26690555
D000082AcetaminophenAcetaminophen results in increased expression of TNC mRNA29067470
D020106AcrylamideAcrylamide affects the expression of TNC mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of TNC mRNA27153756
C000188alachloralachlor results in increased expression of TNC mRNA12419858
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of TNC mRNA"22863853
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TNC mRNA24449571
D001151ArsenicArsenic affects the methylation of TNC gene25304211
C015001arsenitearsenite results in decreased expression of TNC mRNA18929588
C015001arseniteTRP53 protein affects the reaction [arsenite results in decreased expression of TNC mRNA]18929588
D001280AtrazineAtrazine results in decreased expression of TNC mRNA25929836
D001374AzacitidineAzacitidine results in decreased expression of TNC mRNA20823114
C487081belinostatbelinostat results in decreased expression of TNC mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TNC mRNA"27188386
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of TNC mRNA26377693
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of TNC mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of TNC mRNA27858113
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TNC mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TNC mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TNC mRNA20064835
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of TNC mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TNC mRNA15034205|2071347
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TNC mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TNC mRNA"20382639
D004958Estradiol[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of TNC mRNA20823114
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of TNC mRNA20660070
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of TNC mRNA20226447
C044887beta-methylcholinebeta-methylcholine affects the expression of TNC mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of TNC mRNA26364221
C006780bisphenol Abisphenol A results in decreased expression of TNC mRNA27685785
C006780bisphenol Abisphenol A results in decreased expression of TNC mRNA23704952
C006780bisphenol Abisphenol A results in decreased expression of TNC protein23704952
C006780bisphenol Abisphenol A affects the expression of TNC mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of TNC mRNA25181051
D001761BleomycinBleomycin results in increased expression of TNC mRNA26345256
D001761BleomycinBleomycin results in increased expression of TNC protein26345256
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of TNC mRNA20147733
D0151248-Bromo Cyclic Adenosine Monophosphate[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of TNC mRNA16997883
D003931DiacetylDiacetyl results in increased expression of TNC protein21464978
D002084Butylated HydroxytolueneButylated Hydroxytoluene results in increased expression of TNC mRNA19925653
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of TNC mRNA15336504
C018475butyraldehydebutyraldehyde results in increased expression of TNC mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of TNC mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of TNC mRNA17484886
D002251Carbon TetrachloridePPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of TNC mRNA]18038451
D002330CarmustineTNC mRNA affects the susceptibility to Carmustine16365179
D002737ChloropreneChloroprene results in decreased expression of TNC mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TNC mRNA20938992
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of TNC mRNA27858113
D003300CopperCopper results in decreased expression of TNC mRNA26293553
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of TNC mRNA15467011
D003345CorticosteroneCorticosterone results in decreased expression of TNC mRNA15755911
D003471CuprizoneCuprizone results in increased expression of TNC mRNA26577399
D003474CurcuminCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNC mRNA]18200517
D016572CyclosporineCyclosporine results in decreased expression of TNC mRNA22147139|2798913
D016572CyclosporineCyclosporine results in increased expression of TNC mRNA20106945
C014347decitabinedecitabine affects the expression of TNC mRNA23300844
C014347decitabinedecitabine results in increased expression of TNC mRNA15251184|2791501
C014347decitabine[Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of TNC mRNA15251184
D003907Dexamethasone[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of TNC mRNA16997883
D003907DexamethasoneDexamethasone results in decreased expression of TNC mRNA22733784
D003975DiazepamDiazepam results in decreased expression of TNC mRNA19114084
D003994Bucladesine[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of TNC mRNA20823114
D002945CisplatinCisplatin affects the expression of TNC mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of TNC mRNA27392435
D002945Cisplatin[Cisplatin co-treated with Paclitaxel] affects the expression of TNC mRNA20705681
D002945CisplatinCisplatin results in decreased expression of TNC mRNA27392435
D002945CisplatinCisplatin results in decreased expression of TNC mRNA21151649
D002945CisplatinCisplatin results in decreased expression of TNC mRNA22023808
D002945CisplatinCisplatin results in increased expression of TNC mRNA24880025
D004041Dietary FatsDietary Fats results in increased expression of TNC mRNA18042831
C058705diethyl malatediethyl malate affects the expression of TNC mRNA24814887
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TNC mRNA18164116
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of TNC protein25242112
D002117CalcitriolCalcitriol results in decreased expression of TNC mRNA12040012
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of TNC mRNA"22485181
D004298DopamineDopamine results in increased expression of TNC mRNA21983523
D004317DoxorubicinDoxorubicin affects the expression of TNC protein29385562
D004317DoxorubicinDoxorubicin results in increased expression of TNC mRNA15033991
C118739entinostatentinostat results in decreased expression of TNC mRNA26272509
C118739entinostatentinostat results in increased expression of TNC mRNA27188386
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TNC mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of TNC mRNA17606305
D004997Ethinyl Estradiol[Ethinyl Estradiol co-treated with Megestrol Acetate] results in decreased expression of TNC mRNA22085904
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of TNC mRNA23649840
C540355fenamidonefenamidone results in increased expression of TNC mRNA27029645
D018818FenoldopamFenoldopam results in increased expression of TNC mRNA21983523
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TNC mRNA20938992
D005557FormaldehydeFormaldehyde results in decreased expression of TNC mRNA20655997
D005557FormaldehydeFormaldehyde results in increased expression of TNC mRNA23649840
C039281furanfuran results in increased expression of TNC mRNA27387713
C004312glycidolglycidol results in decreased expression of TNC mRNA24915197
D003900Desoxycorticosterone"[Desoxycorticosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TNC mRNA"21135038
D003900Desoxycorticosterone"Mineralocorticoid Receptor Antagonists inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TNC mRNA]"21135038
D003900Desoxycorticosterone"Spironolactone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TNC mRNA]"21135038
D006923HymecromoneHymecromone results in decreased expression of TNC mRNA23139787
D007052IbuprofenIbuprofen results in increased expression of TNC mRNA17070997
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of TNC mRNA16997883
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of TNC mRNA27392435
C544151jinfukangjinfukang results in decreased expression of TNC mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TNC mRNA24796395|2675264
D007854LeadLead affects the expression of TNC mRNA28903495
C008261lead acetatelead acetate results in decreased expression of TNC mRNA22613225
C008261lead acetatelead acetate results in decreased expression of TNC mRNA11578147
D018021Lithium ChlorideLithium Chloride results in increased expression of TNC mRNA15711924
D019808LosartanLosartan results in decreased expression of TNC mRNA15100363
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of TNC mRNA20823114
D019290Megestrol Acetate[Ethinyl Estradiol co-treated with Megestrol Acetate] results in decreased expression of TNC mRNA22085904
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TNC mRNA20938992
D008727MethotrexateMethotrexate results in increased expression of TNC mRNA17400583
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of TNC mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of TNC mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNC mRNA"27188386
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of TNC mRNA21628967
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of TNC mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of TNC mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TNC mRNA"20188158
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of TNC mRNA12634122
D015735MifepristoneMifepristone results in decreased expression of TNC mRNA25972201
D000451Mineralocorticoid Receptor Antagonists"Mineralocorticoid Receptor Antagonists inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TNC mRNA]"21135038
D016686Monocrotaline"1,3-dimethylthiourea inhibits the reaction [Monocrotaline results in increased expression of TNC mRNA]"9251245
D016686MonocrotalineMonocrotaline results in increased expression of TNC mRNA9251245
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of TNC mRNA22108045
D009151Mustard GasMustard Gas results in increased expression of TNC mRNA18988085
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TNC mRNA"24389112
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TNC mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TNC mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of TNC mRNA18978301
C031721naphthalenenaphthalene results in increased expression of TNC protein18978301
D009532NickelNickel results in increased expression of TNC mRNA25583101
D009532NickelNickel results in increased expression of TNC mRNA12540486
C029938nickel sulfatenickel sulfate results in decreased expression of TNC mRNA22714537
C029938nickel sulfatenickel sulfate results in increased expression of TNC mRNA16100012
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of TNC mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of TNC mRNA25729387
D010126OzoneOzone results in increased expression of TNC mRNA9533934
D010126OzoneOzone results in increased expression of TNC protein9533934
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] affects the expression of TNC mRNA25658374
D010126OzoneOzone results in increased expression of TNC mRNA19555225
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of TNC mRNA]19555225
D017239Paclitaxel[Cisplatin co-treated with Paclitaxel] affects the expression of TNC mRNA20705681
D000073878Palm OilPalm Oil results in increased expression of TNC mRNA18042831
D010269ParaquatParaquat results in increased expression of TNC mRNA26345256
D010269ParaquatParaquat results in increased expression of TNC protein26345256
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of TNC mRNA26705709
D010862PilocarpinePilocarpine results in increased expression of TNC mRNA14656328
C006253pirinixic acidpirinixic acid results in decreased expression of TNC mRNA17426115
D011374ProgesteroneProgesterone results in decreased expression of TNC mRNA23018184
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of TNC mRNA20660070
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of TNC mRNA20226447
D011374ProgesteroneProgesterone results in decreased expression of TNC mRNA18692832|2179573
D011374ProgesteroneProgesterone results in increased expression of TNC mRNA20864642
D011374ProgesteroneProgesterone results in decreased expression of TNC mRNA19690047
D011441PropylthiouracilPropylthiouracil results in increased expression of TNC mRNA24780913
C043680ptaquilosideptaquiloside results in decreased expression of TNC mRNA23274088
C513428pyrachlostrobinpyrachlostrobin results in increased expression of TNC mRNA27029645
C014175pyrazolo(3,4-d)pyrimidine"pyrazolo(3,4-d)pyrimidine analog affects the expression of TNC mRNA"21152443
C014175pyrazolo(3,4-d)pyrimidine"pyrazolo(3,4-d)pyrimidine analog affects the expression of TNC mRNA"21152443
D011794QuercetinQuercetin affects the expression of TNC mRNA18178720
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of TNC mRNA14699072
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TNC mRNA19059307
C116926rofecoxibrofecoxib results in increased expression of TNC mRNA17070997
C010327salinomycinsalinomycin results in decreased expression of TNC mRNA19682730
C078903seocalcitolseocalcitol results in decreased expression of TNC mRNA12040012
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of TNC mRNA"21514415
D017632Asbestos, Serpentine"SPP1 gene mutant form inhibits the reaction [Asbestos, Serpentine results in increased expression of TNC mRNA]"21514415
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of TNC mRNA25895662
D012822Silicon DioxideGREM1 protein inhibits the reaction [Silicon Dioxide results in increased expression of TNC mRNA]27428020
D012822Silicon DioxideSilicon Dioxide results in increased expression of TNC mRNA23221170|2634525
D012822Silicon DioxideSilicon Dioxide results in increased expression of TNC protein26345256
D012834SilverSilver results in decreased expression of TNC mRNA27131904
D019821SimvastatinSimvastatin results in decreased expression of TNC mRNA16414398
D012906SmokeSmoke affects the expression of TNC mRNA23693141
C017947sodium arsenitesodium arsenite results in decreased expression of TNC mRNA12727804
D017673Sodium Chloride, Dietary"[Desoxycorticosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TNC mRNA"21135038
D017673Sodium Chloride, Dietary"Mineralocorticoid Receptor Antagonists inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TNC mRNA]"21135038
D017673Sodium Chloride, Dietary"Spironolactone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TNC mRNA]"21135038
D012969Sodium FluorideSodium Fluoride results in increased expression of TNC protein28918527
D012999SomanSoman results in increased expression of TNC mRNA19281266
D053260SootSoot results in increased expression of TNC mRNA22461453|2655175
D013148Spironolactone"Spironolactone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TNC mRNA]"21135038
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in increased expression of TNC mRNA19059307
C047246temozolomideTNC mRNA affects the susceptibility to temozolomide16365179
D013749TetrachlorodibenzodioxinAHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of TNC mRNA]15034205
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TNC mRNA16611356|2157046
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of TNC mRNA15251184
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in increased expression of TNC mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TNC mRNA15034205|1758670
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TNC mRNA15251184|2613916
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of TNC mRNA16979875
D019284ThapsigarginThapsigargin results in decreased expression of TNC mRNA22378314
C009495titanium dioxidetitanium dioxide results in increased expression of TNC mRNA23557971|2776080
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of TNC mRNA25729387
D019772TopotecanTopotecan results in increased expression of TNC mRNA25729387
D014212TretinoinSMAD3 protein inhibits the reaction [Tretinoin results in decreased expression of TNC]24374174
D014212TretinoinTGFB3 protein inhibits the reaction [Tretinoin results in decreased expression of TNC]24374174
D014212TretinoinTretinoin results in decreased expression of TNC mRNA23724009|2437417
D014212TretinoinTretinoin results in decreased expression of TNC protein24374174
D014212TretinoinTretinoin results in increased expression of TNC mRNA21934132
C012589trichostatin Atrichostatin A results in decreased expression of TNC mRNA15901671
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TNC mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of TNC mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in decreased expression of TNC mRNA15901671
D014302Trinitrobenzenesulfonic AcidCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNC mRNA]18200517
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of TNC mRNA18200517
D014415TunicamycinTunicamycin results in decreased expression of TNC mRNA22378314
D014635Valproic AcidValproic Acid results in decreased expression of TNC mRNA15901671
D014635Valproic AcidValproic Acid results in decreased expression of TNC mRNA28001369|2915479
D014635Valproic AcidValproic Acid results in increased expression of TNC mRNA19101580|2317975
D014635Valproic AcidValproic Acid results in decreased expression of TNC mRNA15901671
D014638VanadatesVanadates results in increased expression of TNC mRNA22714537
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TNC gene25560391
D024483Vitamin K 3TNC affects the susceptibility to Vitamin K 322715409
C111237vorinostatvorinostat results in increased expression of TNC mRNA27188386
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in decreased expression of TNC mRNA20370541
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of TNC mRNA16979875
C088658zoledronic acidzoledronic acid results in increased expression of TNC mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI20979576  29150600  
GO:0045545syndecan binding-IDA8769660  
GO ID GO Term Qualifier Evidence PubMed
GO:0001649osteoblast differentiation-HDA16210410  
GO:0007155cell adhesion-IEA-  
GO:0007162negative regulation of cell adhesion-IEA-  
GO:0007528neuromuscular junction development-IEA-  
GO:0008284positive regulation of cell proliferation-IEA-  
GO:0009611response to wounding-IEP16891397  
GO:0009612response to mechanical stimulus-IEA-  
GO:0010628positive regulation of gene expression-IEA-  
GO:0014012peripheral nervous system axon regeneration-IEA-  
GO:0030198extracellular matrix organization-TAS-  
GO:0042060wound healing-IEA-  
GO:0042475odontogenesis of dentin-containing tooth-IEA-  
GO:0043687post-translational protein modification-TAS-  
GO:0044267cellular protein metabolic process-TAS-  
GO:0045471response to ethanol-IEA-  
GO:0060447bud outgrowth involved in lung branching-IEA-  
GO:0060739mesenchymal-epithelial cell signaling involved in prostate gland development-IEA-  
GO:0060740prostate gland epithelium morphogenesis-IEA-  
GO:0071300cellular response to retinoic acid-IEA-  
GO:0071305cellular response to vitamin D-IEA-  
GO:0071774response to fibroblast growth factor-IEA-  
GO:0071799cellular response to prostaglandin D stimulus-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-HDA27068509  
GO:0005576extracellular region-TAS-  
GO:0005604basement membrane-IEA-  
GO:0005614interstitial matrix-IEA-  
GO:0005615extracellular space-HDA16502470  20551380  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005925focal adhesion-HDA21423176  
GO:0016020membrane-HDA16210410  
GO:0031012extracellular matrix-HDA23658023  
GO:0062023collagen-containing extracellular matrix-HDA27559042  
GO:0062023collagen-containing extracellular matrixcolocalizes_withHDA20551380  
GO:0062023collagen-containing extracellular matrixcolocalizes_withISS22261194  
KEGG ID KEGG Term
hsa04510Focal adhesion
hsa04512ECM-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-216083Integrin cell surface interactionsTAS
R-HSA-3000170Syndecan interactionsIEA
R-HSA-3000171Non-integrin membrane-ECM interactionsIEA
R-HSA-3000178ECM proteoglycansTAS
R-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)TAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8957275Post-translational protein phosphorylationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21514415Osteopontin modulates inflammation, mucin production, and gene expression signatures after inhalation of asbestos in a murine model of fibrosis. (2011 May)Sabo-Attwood TAm J Pathol
28652369Quantitative proteomics identify Tenascin-C as a promoter of lung cancer progression and contributor to a signature prognostic of patient survival. (2017 Jul 11)Gocheva VProc Natl Acad Sci U S A
29614203Changes in the expression of matrix extracellular genes and TGFB family members in rotator cuff tears. (2018 Apr 3)Belangero PSJ Orthop Res
21071578A migration signature and plasma biomarker panel for pancreatic adenocarcinoma. (2011 Jan)Balasenthil SCancer Prev Res (Phila)