Gene: IARS

3376
GRIDHH|IARS1|ILERS|ILRS|IRS|PRO0785
isoleucyl-tRNA synthetase
protein-coding
9q22.31
Ensembl:ENSG00000196305 MIM:600709 Vega:OTTHUMG00000020219 UniprotKB:P41252
NG_051498.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.823e-1 (AD)  8.309e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs556155chr9:92223355 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SDAD10.951
UBQLN10.947
UBP10.944
UBFD10.943
HCCS0.942
CLTC0.942
B4GALT50.941
FOXJ30.94
ATP2A20.939
RNMT0.938

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.496
OR4F29-0.449
MYOM1-0.419
MYL3-0.412
ASB4-0.408
COPZ2-0.397
HEY2-0.394
CSAG1-0.378
ROM1-0.373
STON2-0.37

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of IARS mRNA25596134
C0326681-nitropyrene1-nitropyrene results in increased expression of IARS mRNA19041380
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of IARS mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of IARS mRNA"20406850
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of IARS mRNA"21346803
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of IARS mRNA"21346803
D000082AcetaminophenAcetaminophen results in increased expression of IARS mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of IARS mRNA27153756
C006632arsenic trioxidearsenic trioxide results in decreased expression of IARS mRNA19128835
C006632arsenic trioxidearsenic trioxide results in increased expression of IARS mRNA20458559
C015001arsenitearsenite results in decreased methylation of IARS promoter23974009
D001205Ascorbic AcidAscorbic Acid results in decreased expression of IARS mRNA19197388
D001241AspirinAspirin results in decreased expression of IARS mRNA11906190
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IARS mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IARS mRNA21569818|2222880
C006780bisphenol Abisphenol A results in increased expression of IARS mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of IARS mRNA26512966
C006780bisphenol Abisphenol A results in increased expression of IARS mRNA25181051
D002065BuspironeBuspirone results in decreased expression of IARS mRNA24136188
D019256Cadmium ChlorideCadmium Chloride results in increased expression of IARS mRNA25596134|2647268
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of IARS promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of IARS mRNA27339419
C004656chloroacetaldehydechloroacetaldehyde affects the expression of IARS mRNA25596134
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of IARS mRNA28472532
C059262cidofovircidofovir results in increased expression of IARS mRNA25596134
D004002Clodronic AcidClodronic Acid affects the expression of IARS mRNA25596134
C018021cobaltous chloridecobaltous chloride results in decreased expression of IARS mRNA19320972
D003471CuprizoneCuprizone results in increased expression of IARS mRNA26577399
D016572CyclosporineCyclosporine affects the expression of IARS mRNA25562108
D016572CyclosporineCyclosporine results in increased expression of IARS mRNA20106945|2559613
D016572CyclosporineCyclosporine results in increased expression of IARS mRNA25596134
D013759DronabinolDronabinol results in increased expression of IARS mRNA18454173
D002945CisplatinCisplatin results in increased expression of IARS mRNA25596134
D004026DieldrinDieldrin results in decreased expression of IARS protein20584760
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of IARS protein23301498
D011345FenofibrateFenofibrate results in increased expression of IARS mRNA25596134
D011345FenofibrateFenofibrate results in increased expression of IARS mRNA25596134
D005485FlutamideFlutamide results in decreased expression of IARS mRNA24793618
D005485FlutamideFlutamide results in increased expression of IARS mRNA24136188
D005839GentamicinsGentamicins results in increased expression of IARS mRNA22061828
D007052IbuprofenIbuprofen results in increased expression of IARS mRNA25596134
D007052IbuprofenIbuprofen results in decreased expression of IARS mRNA25596134
C492448ICG 001ICG 001 results in increased expression of IARS mRNA26191083
D007069IfosfamideIfosfamide results in increased expression of IARS mRNA25596134
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IARS mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IARS mRNA22904298
D007854LeadLead affects the splicing of IARS mRNA28903495
C008261lead acetatelead acetate results in increased expression of IARS mRNA11578147
D008627Mercuric ChlorideMercuric Chloride results in increased expression of IARS mRNA16507785
D008687MetforminMetformin results in increased expression of IARS mRNA25596134
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of IARS mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of IARS mRNA23649840
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of IARS mRNA24810058
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of IARS protein"23026733
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of IARS mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of IARS mRNA"25554681|2562005
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of IARS mRNA20551477
C051752nefazodonenefazodone results in increased expression of IARS mRNA24136188
D010100OxygenOxygen deficiency results in decreased expression of IARS mRNA25596134
C031181phenanthrenephenanthrene results in increased expression of IARS mRNA19457238
D010936Plant ExtractsPlant Extracts results in increased expression of IARS mRNA23557933
D011794QuercetinQuercetin results in decreased expression of IARS mRNA21632981
C089730rosiglitazonerosiglitazone results in increased expression of IARS mRNA25572481
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of IARS mRNA19244175
D012643SeleniumSelenium results in decreased expression of IARS mRNA19244175
C017947sodium arsenitesodium arsenite results in decreased expression of IARS mRNA28595984
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IARS mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IARS mRNA21570461|2468072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IARS mRNA23238561
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IARS mRNA23238561
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of IARS mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IARS mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of IARS mRNA28065790
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of IARS mRNA19042947
D014520UrethaneUrethane results in decreased expression of IARS mRNA28818685
D014635Valproic AcidValproic Acid results in increased expression of IARS mRNA29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of IARS gene25560391
C025643vinclozolinvinclozolin results in decreased expression of IARS mRNA23034163
C025643vinclozolinvinclozolin results in increased expression of IARS mRNA22570695
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of IARS mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of IARS mRNA19244175
D024483Vitamin K 3Vitamin K 3 affects the expression of IARS mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000049tRNA binding-IEA-  
GO:0002161aminoacyl-tRNA editing activity-IEA-  
GO:0004822isoleucine-tRNA ligase activity-IBA21873635  
GO:0004822isoleucine-tRNA ligase activity-IDA8052601  
GO:0004822isoleucine-tRNA ligase activity-TAS-  
GO:0005515protein binding-IPI9556618  10913161  11142386  
GO:0005524ATP binding-IEA-  
GO:0051020GTPase binding-IPI24337748  
GO ID GO Term Qualifier Evidence PubMed
GO:0001649osteoblast differentiation-HDA16210410  
GO:0006418tRNA aminoacylation for protein translation-TAS-  
GO:0006428isoleucyl-tRNA aminoacylation-IBA21873635  
GO:0006428isoleucyl-tRNA aminoacylation-IDA8052601  
GO:0106074aminoacyl-tRNA metabolism involved in translational fidelity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA22424946  
GO:0005829cytosol-IDA19289464  
GO:0005829cytosol-TAS-  
GO:0016020membrane-HDA16210410  19946888  
GO:0017101aminoacyl-tRNA synthetase multienzyme complex-IDA19131329  
GO:0070062extracellular exosome-HDA20458337  
KEGG ID KEGG Term
hsa00290Valine, leucine and isoleucine biosynthesis
hsa00970Aminoacyl-tRNA biosynthesis
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismIEA
R-HSA-2408517SeMet incorporation into proteinsIEA
R-HSA-2408522Selenoamino acid metabolismIEA
R-HSA-379716Cytosolic tRNA aminoacylationTAS
R-HSA-379724tRNA AminoacylationTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-71291Metabolism of amino acids and derivativesIEA
R-HSA-72766TranslationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21280466Rationale, design & preliminary findings of the Indian Atherosclerosis Research Study. (2010 Jul-Aug)Shanker JIndian Heart J