Gene: NLRP10

338322
CLR11.1|NALP10|NOD8|PAN5|PYNOD
NLR family pyrin domain containing 10
protein-coding
11p15.4
Ensembl:ENSG00000182261 MIM:609662 Vega:OTTHUMG00000165673 UniprotKB:Q86W26
NG_046899.1
PubMed
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.493e-3 (AD)  1.687e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DUXA0.8
OR52K10.79
OR2W50.78
INSL40.772
IL17A0.758
OR7G10.757
MYF50.756
OR4C110.752
OR2AP10.748
TAAR10.748

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OMG-0.205
NDP-0.192
CRYBA2-0.175
HHATL-0.174
MMP15-0.171
ATP6AP1L-0.171
MYOG-0.169
SFTPC-0.168
NKAIN4-0.166
DEFA5-0.166

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of NLRP10 mRNA19191707
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of NLRP10 mRNA21298039
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of NLRP10 mRNA26377693
C006780bisphenol Abisphenol A results in decreased expression of NLRP10 mRNA29275510
C006780bisphenol Abisphenol A results in decreased expression of NLRP10 mRNA25181051
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of NLRP10 mRNA28962523
D019833GenisteinGenistein results in increased expression of NLRP10 mRNA24967385
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of NLRP10 mRNA21641980
C029938nickel sulfatenickel sulfate results in decreased expression of NLRP10 mRNA22714537
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of NLRP10 mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of NLRP10 mRNA20813756
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of NLRP10 mRNA22714537
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of NLRP10 mRNA21641980
C029297vinylidene chloridevinylidene chloride results in increased expression of NLRP10 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003924GTPase activity-IDA23861819  
GO:0005524ATP binding-IEA-  
GO:0016887ATPase activity-IDA23861819  
GO ID GO Term Qualifier Evidence PubMed
GO:0002250adaptive immune response-IEA-  
GO:0002827positive regulation of T-helper 1 type immune response-ISS-  
GO:0006954inflammatory response-IEA-  
GO:0009617response to bacterium-IBA21873635  
GO:0045087innate immune response-IEA-  
GO:0050717positive regulation of interleukin-1 alpha secretion-IMP28766990  
GO:0050729positive regulation of inflammatory response-ISS-  
GO:0050829defense response to Gram-negative bacterium-IMP22672233  
GO:0050832defense response to fungus-ISS-  
GO:1900426positive regulation of defense response to bacterium-IMP28766990  
GO:2000318positive regulation of T-helper 17 type immune response-ISS-  
GO:2000484positive regulation of interleukin-8 secretion-IMP22672233  
GO:2000778positive regulation of interleukin-6 secretion-IMP22672233  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA22672233  
GO:0019897extrinsic component of plasma membrane-IDA22672233  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29623357Membrane microdomains regulate NLRP10- and NLRP12-dependent signalling in A549 cells challenged with cigarette smoke extract. (2018 May)Singh DPArch Toxicol
29501574Cigarette smoke-induced inflammation: NLRP10-mediated mechanisms. (2018 Apr 1)Kaur GToxicology