Gene: FFAR4

338557
BMIQ10|GPR120|GPR129|GT01|O3FAR1|PGR4
free fatty acid receptor 4
protein-coding
10q23.33
Ensembl:ENSG00000186188 MIM:609044 Vega:OTTHUMG00000034409 UniprotKB:Q5NUL3
NG_032670.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.910e-1 (AD)  3.127e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IGSF30.851
PCDH80.847
FAM163A0.842
LRRTM40.842
RHOV0.838
LINGO20.838
ASB20.834
NDST30.832
KCNN20.831
RTP10.83

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEY2-0.59
YES1-0.571
TGFB3-0.553
RAI14-0.546
REST-0.538
FAM114A1-0.536
SEPT10-0.53
ROM1-0.525
CPM-0.524
SNHG18-0.521

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB05532BMS-488043Small Molecule452296-83-2InvestigationalTarget
DB05793PRO-542BiotechDrug-InvestigationalTarget
ID Drug Name Action PubMed
C547126AZM551248AZM551248 results in decreased expression of FFAR4 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of FFAR4 mRNA19770486
C006780bisphenol Abisphenol A results in decreased expression of FFAR4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of FFAR4 gene28505145
D002737ChloropreneChloroprene results in increased expression of FFAR4 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FFAR4 mRNA20938992
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of FFAR4 mRNA28962523
D004041Dietary FatsDietary Fats results in decreased expression of FFAR4 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of FFAR4 mRNA25016146
D005395Fish OilsFish Oils inhibits the reaction [Ozone results in increased expression of FFAR4 mRNA]29329427
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FFAR4 mRNA20938992
C039281furanfuran results in increased expression of FFAR4 mRNA27387713
D019833GenisteinGenistein results in increased methylation of FFAR4 gene28505145
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of FFAR4 mRNA20938992
C523799MRK 003FFAR4 results in decreased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of FFAR4 mRNA"25620056
D010126OzoneFish Oils inhibits the reaction [Ozone results in increased expression of FFAR4 mRNA]29329427
D010126OzoneOzone results in increased expression of FFAR4 mRNA29329427
D000073878Palm OilPalm Oil results in decreased expression of FFAR4 mRNA18042831
C006253pirinixic acidpirinixic acid results in increased expression of FFAR4 mRNA18301758
D011441PropylthiouracilPropylthiouracil results in increased expression of FFAR4 mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of FFAR4 mRNA25895662
D053260SootSoot results in decreased expression of FFAR4 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of FFAR4 mRNA19770486
C009495titanium dioxidetitanium dioxide results in decreased expression of FFAR4 mRNA23557971
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of FFAR4 mRNA19042947

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0005504fatty acid binding-IBA21873635  
GO:0005504fatty acid binding-ISS-  
GO:0008527taste receptor activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007166cell surface receptor signaling pathway-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0010827regulation of glucose transmembrane transport-ISS-  
GO:0043066negative regulation of apoptotic process-ISS-  
GO:0045444fat cell differentiation-IEA-  
GO:0046879hormone secretion-IBA21873635  
GO:0050710negative regulation of cytokine secretion-ISS-  
GO:0050728negative regulation of inflammatory response-ISS-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-ISS-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0030139endocytic vesicle-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-2980736Peptide hormone metabolismTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-372790Signaling by GPCRIEA
R-HSA-373076Class A/1 (Rhodopsin-like receptors)IEA
R-HSA-381771Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-400508Incretin synthesis, secretion, and inactivationTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-444209Free fatty acid receptorsIEA
R-HSA-500792GPCR ligand bindingIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25644374Informed genome-wide association analysis with family history as a secondary phenotype identifies novel loci of lung cancer. (2015 Mar)Poirier JGGenet Epidemiol