Gene: ICAM4

3386
CD242|LW
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
protein-coding
19p13.2
Ensembl:ENSG00000105371 MIM:614088 Vega:OTTHUMG00000180405 UniprotKB:Q14773
NG_007728.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.404e-1 (AD)  6.794e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ICAM4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ICAM4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of ICAM4 mRNA22230336
D000082AcetaminophenAcetaminophen results in decreased expression of ICAM4 mRNA17942131
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ICAM4 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ICAM4 mRNA21632981|2164198
C547126AZM551248AZM551248 results in decreased expression of ICAM4 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ICAM4 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ICAM4 mRNA17942131
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ICAM4 mRNA"20382639
C006780bisphenol Abisphenol A results in increased expression of ICAM4 mRNA29275510
C006780bisphenol Abisphenol A results in increased methylation of ICAM4 gene28505145
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of ICAM4 mRNA17942131
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of ICAM4 mRNA18958704
C018475butyraldehydebutyraldehyde results in increased expression of ICAM4 mRNA26079696
D016572CyclosporineCyclosporine results in decreased expression of ICAM4 mRNA21632981|2556210
D016572CyclosporineCyclosporine results in increased expression of ICAM4 mRNA20106945
D016572CyclosporineCyclosporine results in decreased expression of ICAM4 mRNA17942131
D003703DemecolcineDemecolcine results in increased expression of ICAM4 mRNA23649840
C000944dicrotophosdicrotophos results in decreased expression of ICAM4 mRNA28302478
C118739entinostatentinostat results in increased expression of ICAM4 mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ICAM4 mRNA"27188386
D005557FormaldehydeFormaldehyde results in increased expression of ICAM4 mRNA23649840
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ICAM4 protein18951874
C005556propionaldehydepropionaldehyde results in increased expression of ICAM4 mRNA26079696
D011794QuercetinQuercetin results in increased expression of ICAM4 mRNA21632981
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of ICAM4 mRNA23806026
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ICAM4 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ICAM4 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ICAM4 mRNA21570461
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of ICAM4 protein18951874
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ICAM4 mRNA28065790
D014118Toxins, Biological"Toxins, Biological affects the expression of ICAM4 mRNA"19682533
D014635Valproic AcidValproic Acid affects the expression of ICAM4 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ICAM4 mRNA24383497|2800136
D014635Valproic AcidValproic Acid results in increased methylation of ICAM4 gene29154799
D014639VanadiumVanadium results in decreased expression of ICAM4 mRNA19000753
D014750VincristineVincristine results in increased expression of ICAM4 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005178integrin binding-IBA21873635  
GO:0005178integrin binding-TAS8566017  
GO ID GO Term Qualifier Evidence PubMed
GO:0007155cell adhesion-IBA21873635  
GO:0030198extracellular matrix organization-TAS-  
GO:0050776regulation of immune response-TAS-  
GO:0098609cell-cell adhesion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0016021integral component of membrane-TAS6431896  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-168256Immune SystemTAS
R-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellTAS
R-HSA-216083Integrin cell surface interactionsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27616475Gene variants as risk factors for gastroschisis. (2016 Nov)Padula AMAm J Med Genet A