Gene: CPLX4

339302
CPX-IV|CPXIV
complexin 4
protein-coding
18q21.32
Ensembl:ENSG00000166569 MIM:609586 Vega:OTTHUMG00000132756 UniprotKB:Q7Z7G2
NC_000018.10
PubMed
0   ANCO-SNPs
CD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.507e-1 (AD)  3.969e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
POM121L120.839
DAOA0.829
OR4C50.827
OR12D20.822
TAAR20.819
OR4D60.815
KRTAP27-10.811
OR4C120.811
KRTAP6-20.811
OR5T20.811

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM221-0.292
OMG-0.283
FUT9-0.283
NDP-0.282
SFTPC-0.276
HHATL-0.272
DBP-0.266
BDH1-0.265
DNAI1-0.262
C19orf73-0.261

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C006780bisphenol A[bisphenol A co-treated with Butter] affects the expression of CPLX4 mRNA28487351
C006780bisphenol Abisphenol A results in decreased expression of CPLX4 mRNA25181051
D002079Butter[bisphenol A co-treated with Butter] affects the expression of CPLX4 mRNA28487351
D007854LeadLead affects the expression of CPLX4 mRNA28903495
C008261lead acetatelead acetate results in decreased expression of CPLX4 mRNA22641619
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of CPLX4 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000149SNARE binding-IBA21873635  
GO:0019905syntaxin binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006836neurotransmitter transport-IEA-  
GO:0006887exocytosis-IEA-  
GO:0016079synaptic vesicle exocytosis-IBA21873635  
GO:0046928regulation of neurotransmitter secretion-IBA21873635  
GO:0046928regulation of neurotransmitter secretion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016020membrane-IEA-  
GO:0030054cell junction-IEA-  
GO:0031201SNARE complex-IBA21873635  
GO:0043195terminal bouton-IBA21873635  
GO:0045202synapse-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21426264Candidate pathway association study in cocaine dependence: the control of neurotransmitter release. (2012 Feb)Fernandez-Castillo NWorld J Biol Psychiatry