Gene: NANOS2

339345
NOS2|ZC2HC12B
nanos C2HC-type zinc finger 2
protein-coding
19q13.32
Ensembl:ENSG00000188425 MIM:608228 Vega:OTTHUMG00000182487 UniprotKB:P60321
NC_000019.10
PubMed
0   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.044e-1 (AD)  6.487e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NPC1L10.734
C9orf1520.709
PPEF20.663
CNTD20.646
RAX20.629
IFNA50.623
ESPNL0.623
LTA0.622
NPIPB60.616
MISP0.615

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM86A-0.369
WDR31-0.367
HAPLN1-0.356
CDCA7-0.345
SLC25A15-0.345
MDH1B-0.342
ERBB4-0.337
HYKK-0.334
CARF-0.328
ZNF843-0.326

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NANOS2 mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of NANOS2 mRNA"28712647
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NANOS2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NANOS2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NANOS2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NANOS2 mRNA"25510870
C547126AZM551248AZM551248 results in increased expression of NANOS2 mRNA22323515
C006780bisphenol Abisphenol A results in decreased expression of NANOS2 mRNA25181051
D002066BusulfanBusulfan results in decreased expression of NANOS2 mRNA26524245
D002066BusulfanBusulfan results in decreased expression of NANOS2 protein26524245
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of NANOS2 mRNA"25510870
D010936Plant ExtractsPlant Extracts results in decreased expression of NANOS2 mRNA23557933
D012834SilverSilver results in increased expression of NANOS2 mRNA27131904
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in increased expression of NANOS2 mRNA20189893
D013853ThioacetamideThioacetamide results in decreased expression of NANOS2 mRNA23411599
D014635Valproic AcidValproic Acid results in increased methylation of NANOS2 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003729mRNA binding-IEA-  
GO:0005515protein binding-IPI24736845  25416956  
GO:0008270zinc ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006402mRNA catabolic process-ISS-  
GO:0007275multicellular organism development-IEA-  
GO:0007283spermatogenesis-ISS-  
GO:0017148negative regulation of translation-IDA24736845  
GO:0030154cell differentiation-IEA-  
GO:0030718germ-line stem cell population maintenance-ISS-  
GO:0045835negative regulation of meiotic nuclear division-ISS-  
GO:1900153positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay-IDA24736845  
GO ID GO Term Qualifier Evidence PubMed
GO:0000932P-body-ISS-  
GO:0005634nucleus-IDA22899867  
GO:0005737cytoplasm-IDA19168545  
GO:0048471perinuclear region of cytoplasm-IDA19168545  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal