Gene: IRF8

3394
H-ICSBP|ICSBP|ICSBP1|IMD32A|IMD32B|IRF-8
interferon regulatory factor 8
protein-coding
16q24.1
Ensembl:ENSG00000140968 MIM:601565 Vega:OTTHUMG00000137648 UniprotKB:Q02556
NG_029333.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.550e-1 (AD)  3.879e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYK0.951
APBB1IP0.938
NCKAP1L0.934
ITGB20.932
PARVG0.93
TLR70.924
LAIR10.924
ITGAM0.921
IKZF10.92
CYTH40.919

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP2C2-0.435
HES5-0.414
ST6GAL2-0.398
KREMEN2-0.397
KCNIP3-0.395
ZSCAN1-0.392
MAGIX-0.383
ANKRD55-0.377
WNT7A-0.375
C9orf24-0.368

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IRF8 mRNA]"21851831
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of IRF8 mRNA"25380136
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of IRF8 mRNA19191707
D000082AcetaminophenAcetaminophen results in increased expression of IRF8 mRNA26690555|2906747
D000082AcetaminophenAcetaminophen affects the expression of IRF8 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of IRF8 mRNA22100608
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of IRF8 mRNA24449571
C004984apocarotenalapocarotenal results in increased expression of IRF8 mRNA17034753
D001151ArsenicArsenic results in increased methylation of IRF8 gene27838757
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of IRF8 mRNA"24160326
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IRF8 mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IRF8 mRNA22228805
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of IRF8 protein15837792
D019207beta Carotenebeta Carotene results in increased expression of IRF8 mRNA17034753
D004958EstradiolEstradiol affects the expression of IRF8 mRNA15598610
C006780bisphenol Abisphenol A results in decreased expression of IRF8 mRNA25181051
D001966BromineBromine results in increased expression of IRF8 mRNA21391292
C018475butyraldehydebutyraldehyde results in increased expression of IRF8 mRNA26079696
D000001Calcimycinfulvic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IRF8 mRNA]21331654
D000001Calcimycin[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IRF8 mRNA21331654
D002248Carbon MonoxideCarbon Monoxide results in decreased activity of IRF8 protein16365149
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of IRF8 mRNA27339419
D002737ChloropreneChloroprene results in decreased expression of IRF8 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IRF8 mRNA20938992
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of IRF8 mRNA24690739
D003471CuprizoneCuprizone results in increased expression of IRF8 mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of IRF8 mRNA27989131
C014347decitabine[decitabine affects the methylation of IRF8 promoter] which affects the expression of IRF8 protein18922617|1892261
C014347decitabinetrichostatin A affects the reaction [[decitabine affects the methylation of IRF8 promoter] which affects the expression of IRF8 protein]18922617|1892261
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of IRF8 mRNA]27941970
D003907Dexamethasone[Dexamethasone results in increased phosphorylation of and results in increased activity of NR3C1 protein] which results in increased expression of IRF8 mRNA18483179
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of IRF8 mRNA21266533
D004041Dietary FatsDietary Fats results in decreased expression of IRF8 mRNA18042831
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of IRF8 mRNA25380136
D004147DioxinsDioxins affects the expression of IRF8 mRNA20463971
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of IRF8 mRNA24690739
C061365flusilazoleflusilazole results in decreased expression of IRF8 mRNA22382673
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IRF8 mRNA20938992
D004397FonofosFonofos results in increased methylation of IRF8 promoter22847954
C005023fulvic acidfulvic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IRF8 mRNA]21331654
C546771gardiquimodgardiquimod results in increased expression of IRF8 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of IRF8 mRNA]28003376
D005839GentamicinsGentamicins results in increased expression of IRF8 mRNA22061828
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IRF8 mRNA25613284
D007501IronIron deficiency results in decreased expression of IRF8 mRNA20368581
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [BRD4 protein binds to IRF8 enhancer]24332044
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IRF8 mRNA24332044
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IRF8 protein24332044
C561695(+)-JQ1 compound(+)-JQ1 compound affects the expression of IRF8 mRNA25656449
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [[Lipopolysaccharides co-treated with IL4 protein] results in increased expression of IRF8 protein]25656449
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of IRF8 mRNA]26582142
D007854LeadLead results in increased expression of IRF8 protein28973681
D007854LeadLead results in increased expression of IRF8 protein28973681
D008070Lipopolysaccharides(+)-JQ1 compound inhibits the reaction [[Lipopolysaccharides co-treated with IL4 protein] results in increased expression of IRF8 protein]25656449
D008070Lipopolysaccharides(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of IRF8 mRNA]26582142
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IRF8 mRNA10415056
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with IL4 protein] results in increased expression of IRF8 protein25656449
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IRF8 mRNA11123339|2658214
D008070LipopolysaccharidesTLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of IRF8 mRNA]11123339
D008627Mercuric ChlorideIFNG gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF8 mRNA]28453771
D008627Mercuric ChlorideIL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF8 mRNA]28453771
D008627Mercuric Chloride[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF8 mRNA28453771
D008628MercuryIFNG gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF8 mRNA]28453771
D008628MercuryIL6 gene mutant form inhibits the reaction [[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF8 mRNA]28453771
D008628Mercury[Mercuric Chloride results in increased abundance of Mercury] which results in increased expression of IRF8 mRNA28453771
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of IRF8 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of IRF8 mRNA23458150
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of IRF8 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of IRF8 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of IRF8 mRNA"25554681
D009532NickelNickel results in increased expression of IRF8 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in increased expression of IRF8 mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of IRF8 mRNA22714537
D009538NicotineNicotine results in decreased expression of IRF8 mRNA17456735
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of IRF8 mRNA25729387
D017239PaclitaxelPaclitaxel results in increased expression of IRF8 mRNA11123339
D017239PaclitaxelTLR4 protein affects the reaction [Paclitaxel results in increased expression of IRF8 mRNA]11123339
D000073878Palm OilPalm Oil results in decreased expression of IRF8 mRNA18042831
D010278ParathionParathion results in increased methylation of IRF8 promoter22847954
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of IRF8 mRNA23948077
C046012pentanalpentanal results in increased expression of IRF8 mRNA26079696
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of IRF8 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of IRF8 mRNA17426115
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of IRF8 mRNA]28003376
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of IRF8 mRNA"24160326
C016766sulforafansulforafan results in decreased expression of IRF8 mRNA26833863
C012568terbufosterbufos results in increased methylation of IRF8 promoter22847954
D013749Tetrachlorodibenzodioxin"2,4,5,2',4',5'-hexachlorobiphenyl inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IRF8 mRNA]"21851831
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IRF8 mRNA21570461|2405805
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IRF8 mRNA21851831
D013755Tetradecanoylphorbol Acetatefulvic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IRF8 mRNA]21331654
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IRF8 mRNA21331654
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IRF8 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of IRF8 mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of IRF8 mRNA22363418
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of IRF8 mRNA20133372
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of IRF8 mRNA28111298
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of IRF8 mRNA25729387
D014212TretinoinSTAT1 protein affects the reaction [Tretinoin results in increased expression of IRF8 protein]16918696
C012589trichostatin Atrichostatin A affects the reaction [[decitabine affects the methylation of IRF8 promoter] which affects the expression of IRF8 protein]18922617|1892261
D014635Valproic AcidValproic Acid results in increased expression of IRF8 mRNA29154799
D014640VancomycinVancomycin results in decreased expression of IRF8 mRNA18930951
C025643vinclozolinvinclozolin results in increased expression of IRF8 mRNA23034163
C088658zoledronic acidzoledronic acid results in decreased expression of IRF8 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IDA1460054  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IDA1460054  
GO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-TAS1460054  
GO:0005515protein binding-IPI21903422  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA1460054  25122610  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006909phagocytosis-IEA-  
GO:0006955immune response-TAS8861914  
GO:0030099myeloid cell differentiation-IEA-  
GO:0032729positive regulation of interferon-gamma production-IEA-  
GO:0032735positive regulation of interleukin-12 production-IEA-  
GO:0042742defense response to bacterium-IEA-  
GO:0042832defense response to protozoan-IEA-  
GO:0044130negative regulation of growth of symbiont in host-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IDA25122610  
GO:0060261positive regulation of transcription initiation from RNA polymerase II promoter-IEA-  
GO:0060333interferon-gamma-mediated signaling pathway-TAS-  
GO:0060337type I interferon signaling pathway-TAS-  
GO:0071222cellular response to lipopolysaccharide-IEA-  
GO:0071346cellular response to interferon-gamma-IDA25122610  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA25122610  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IDA25122610  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-168256Immune SystemTAS
R-HSA-877300Interferon gamma signalingTAS
R-HSA-909733Interferon alpha/beta signalingTAS
R-HSA-913531Interferon SignalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28193307Heritability and GWAS Studies for Monocyte-Lymphocyte Ratio. (2017 Apr)Lin BDTwin Res Hum Genet
21859832Interferon-signaling pathway: associations with colon and rectal cancer risk and subsequent survival. (2011 Nov)Slattery MLCarcinogenesis