Gene: ID2

3398
GIG8|ID2A|ID2H|bHLHb26
inhibitor of DNA binding 2
protein-coding
2p25.1
Ensembl:ENSG00000115738 MIM:600386 Vega:OTTHUMG00000112454 UniprotKB:Q02363
NC_000002.12
PubMed
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.608e-1 (AD)  9.115e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg14984257chr2:8822600ID2Promoter1.796e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RHEB0.819
GOLM10.812
GPM6A0.811
CXXC50.809
SLC25A50.805
HSPA90.804
GNAS0.801
KIAA11910.796
POLDIP20.796
ATP6V1G10.796

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.74
OR4F29-0.692
AMBN-0.328
GPR101-0.321
ZBED2-0.318
DGKK-0.317
ENTHD1-0.315
SAG-0.31
LHX8-0.31
SLC18A3-0.307

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of ID2 mRNA"16269432
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in increased expression of ID2 mRNA"19114083
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ID2 mRNA"28433925
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ID2 mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ID2 mRNA"15215175
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ID2 mRNA"23196670
C0251603-aminobenzamide3-aminobenzamide results in decreased expression of ID2 mRNA15670817
C4734844-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine results in increased expression of ID2 mRNA14610520
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ID2 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of ID2 mRNA"19561079
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ID2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ID2 mRNA29067470
D000082AcetaminophenAcetaminophen results in increased expression of ID2 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of ID2 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of ID2 mRNA17585979
D000108Acetylcarnitine[Acetylcarnitine co-treated with NGF protein] results in increased expression of ID2 mRNA14654561
D000111AcetylcysteineAcetylcysteine results in decreased expression of ID2 mRNA16084531
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of ID2 mRNA28522335
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of ID2 mRNA16541417
D000638AmiodaroneAmiodarone results in increased expression of ID2 mRNA23397585
D000640AmitroleAmitrole results in decreased expression of ID2 mRNA23397585
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ID2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ID2 mRNA24449571
D001151ArsenicArsenic results in decreased expression of ID2 mRNA16835338
C006632arsenic trioxidearsenic trioxide affects the expression of ID2 mRNA25076250
C006632arsenic trioxidearsenic trioxide affects the expression of ID2 protein25076250
C006632arsenic trioxidearsenic trioxide results in decreased expression of ID2 mRNA15761015
C006632arsenic trioxidearsenic trioxide results in increased expression of ID2 mRNA24356939
C006632arsenic trioxide[Tretinoin co-treated with arsenic trioxide] results in increased expression of ID2 mRNA15894607
C006632arsenic trioxidearsenic trioxide results in increased expression of ID2 mRNA21921037
C015001arsenitearsenite results in increased methylation of ID2 promoter23974009
D001241AspirinAspirin affects the expression of ID2 mRNA12800193
D001554Benzene[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of ID2 mRNA17905399
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of ID2 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene metabolite results in decreased expression of ID2 mRNA24356939
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ID2 mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ID2 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ID2 mRNA"19150397
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in decreased expression of ID2 mRNA]24758408
D004958Estradiol[Estradiol binds to ESR2 protein] which results in increased expression of ID2 mRNA20404318
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of ID2 mRNA20660070
D004958EstradiolEstradiol results in decreased expression of ID2 mRNA20106945|2339758
D004958EstradiolESR1 protein promotes the reaction [Estradiol results in decreased expression of ID2 mRNA]25210133
D004958EstradiolEstradiol results in decreased expression of ID2 mRNA23144751|2521013
D001622BetaineBetaine results in increased expression of ID2 mRNA26391144
C044887beta-methylcholinebeta-methylcholine affects the expression of ID2 mRNA21179406
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ID2 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of ID2 mRNA22576693|2927551
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ID2 mRNA"28433925
C006780bisphenol Abisphenol A affects the expression of ID2 mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of ID2 mRNA24988533
C006780bisphenol Abisphenol A results in increased methylation of ID2 gene28505145
D020122tert-Butylhydroperoxide[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ID2 mRNA20847119
D020122tert-Butylhydroperoxidepioglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ID2 mRNA]20847119
D020122tert-Butylhydroperoxide[rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ID2 mRNA20847119
D020122tert-Butylhydroperoxiderosiglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ID2 mRNA]20847119
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of ID2 mRNA20847119
D020122tert-Butylhydroperoxide[troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ID2 mRNA20847119
D020122tert-Butylhydroperoxidetroglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ID2 mRNA]20847119
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of ID2 mRNA14729362|1500399
C018475butyraldehydebutyraldehyde results in increased expression of ID2 mRNA26079696
D002087ButyratesButyrates results in increased expression of ID2 mRNA14674679
D020148Butyric AcidButyric Acid results in increased expression of ID2 mRNA12800193
C584509C646 compoundC646 compound results in decreased expression of ID2 mRNA26191083
D019256Cadmium Chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of ID2 mRNA12634122
D019256Cadmium ChlorideCadmium Chloride affects the expression of ID2 mRNA18804290
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ID2 mRNA18636176
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ID2 mRNA27339419
C030583ceric oxideceric oxide analog results in decreased expression of ID2 mRNA24821434
D002706ChlordanChlordan results in decreased expression of ID2 mRNA23153324
D002713ChlorineChlorine results in decreased expression of ID2 mRNA18636392
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of ID2 mRNA18636392
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of ID2 mRNA16934159
D002737ChloropreneChloroprene results in decreased expression of ID2 mRNA23125180
D002737ChloropreneChloroprene results in increased expression of ID2 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ID2 mRNA20938992
C023600chromic oxide[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of ID2 mRNA12634122
C017133chromous chloride[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of ID2 mRNA12634122
D002922CiguatoxinsCiguatoxins affects the expression of ID2 mRNA18353800
D003024ClozapineClozapine results in increased expression of ID2 mRNA12437575
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of ID2 mRNA24690739
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of ID2 mRNA15467011
D003300CopperCopper results in decreased expression of ID2 mRNA22465980
D019327Copper SulfateCopper Sulfate results in increased expression of ID2 mRNA19549813
C029892cupric chloridecupric chloride affects the expression of ID2 mRNA17211630
D003474CurcuminCurcumin results in decreased expression of ID2 mRNA21594647
C009160cyclonitecyclonite results in increased expression of ID2 mRNA25559034
D003520CyclophosphamideCyclophosphamide metabolite results in decreased expression of ID2 mRNA24356939
D016572CyclosporineCyclosporine results in decreased expression of ID2 mRNA20106945|2798913
D016572CyclosporineCyclosporine results in decreased expression of ID2 mRNA19770486
C014347decitabine[decitabine co-treated with vorinostat] affects the expression of ID2 mRNA17330099
C014347decitabinedecitabine results in increased expression of ID2 mRNA19194470
D013759DronabinolDronabinol results in increased expression of ID2 mRNA18454173
D003703DemecolcineDemecolcine results in increased expression of ID2 mRNA23649840
D003907DexamethasoneDexamethasone results in decreased expression of ID2 mRNA22048647|2504701
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ID2 mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of ID2 mRNA22733784
D003976DiazinonDiazinon affects the expression of ID2 mRNA22546817
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in increased expression of ID2 mRNA"16269432
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ID2 mRNA21266533
D002945CisplatinCisplatin results in increased expression of ID2 mRNA19561079|2160359
D004008DiclofenacDiclofenac results in increased expression of ID2 mRNA26934552
D004026DieldrinDieldrin affects the expression of ID2 mRNA22546817
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of ID2 mRNA28433925
D004041Dietary FatsDietary Fats results in decreased expression of ID2 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of ID2 mRNA18042831
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of ID2 mRNA28433925
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of ID2 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of ID2 mRNA]19850644
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ID2 mRNA"28433925
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of ID2 mRNA21922642
D002117CalcitriolCalcitriol results in decreased expression of ID2 mRNA16002434|2648566
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of ID2 mRNA27638505
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of ID2 mRNA"22485181
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of ID2 mRNA20146380
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of ID2 mRNA24690739
D004317DoxorubicinID2 protein affects the susceptibility to Doxorubicin16217747
D004317DoxorubicinDoxorubicin affects the expression of ID2 mRNA12187937
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of ID2 mRNA20064776
C038939enzacameneenzacamene results in decreased expression of ID2 mRNA23397585
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of ID2 mRNA16084531
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ID2 mRNA17475347
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ID2 mRNA17555576|1794274
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ID2 mRNA12655037|1583489
D011345FenofibrateFenofibrate results in decreased expression of ID2 mRNA11798191
C006012fenofibric acid[fenofibric acid binds to PPARA protein] which results in increased expression of ID2 mRNA16197558
C017690fenvaleratefenvalerate results in increased expression of ID2 mRNA23397585
D005472FluorouracilFluorouracil results in decreased expression of ID2 protein15352031
D005472FluorouracilFluorouracil results in increased expression of ID2 mRNA16557594
D005472FluorouracilID2 protein affects the susceptibility to Fluorouracil15352031
D005472FluorouracilTP53 protein promotes the reaction [Fluorouracil results in increased expression of ID2 mRNA]16557594
D005472FluorouracilFluorouracil results in increased expression of ID2 mRNA25178657
D005472FluorouracilID2 protein affects the susceptibility to Fluorouracil15016739
C061365flusilazoleflusilazole affects the expression of ID2 mRNA21195148
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ID2 mRNA20938992
D005557FormaldehydeFormaldehyde results in increased expression of ID2 mRNA20655997|2364984
C039281furanfuran results in decreased expression of ID2 mRNA26194646
D005839GentamicinsGentamicins results in increased expression of ID2 mRNA22061828
D005897GlafenineGlafenine results in decreased expression of ID2 mRNA24136188
D005944GlucosamineGlucosamine results in increased expression of ID2 mRNA17178593
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of ID2 mRNA22634610
D006220HaloperidolHaloperidol results in decreased expression of ID2 mRNA12437575
D006220HaloperidolHaloperidol results in increased expression of ID2 mRNA12437575
D006247HarmineHarmine inhibits the reaction [WNT3A protein results in decreased expression of ID2 mRNA]20519739
C409722hexaconazolehexaconazole affects the expression of ID2 mRNA21195148
D017313FenretinideFenretinide results in increased expression of ID2 mRNA28973697
D006851Hydrochloric AcidHydrochloric Acid results in increased expression of ID2 mRNA15046208
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of ID2 mRNA20044591
C492448ICG 001ICG 001 results in decreased expression of ID2 mRNA26191083
D000068877Imatinib MesylateImatinib Mesylate results in increased expression of ID2 mRNA21536647
D000068877Imatinib MesylateImatinib Mesylate results in increased expression of ID2 protein21536647
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ID2 mRNA28628672
D019807Iodoacetic AcidIodoacetic Acid results in decreased expression of ID2 mRNA23397585
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of ID2 mRNA25613284
C051890irinotecanirinotecan metabolite results in decreased expression of ID2 mRNA15956246
C051890irinotecanirinotecan results in decreased expression of ID2 mRNA15956246
D058085Iron CompoundsIron Compounds results in decreased expression of ID2 mRNA28483490
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ID2 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ID2 mRNA23086925
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of ID2 mRNA27432991
C008261lead acetate[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of ID2 mRNA12634122
C045463leflunomideleflunomide results in increased expression of ID2 mRNA28988120
C018584linaloollinalool results in increased expression of ID2 mRNA19922762
D001556LindaneLindane results in increased expression of ID2 mRNA18804290
C482199lipopolysaccharide, E coli O55-B5"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of ID2 mRNA"18930950
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of ID2 protein21110107
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of ID2 mRNA16415329
D008070LipopolysaccharidesRanitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of ID2 mRNA]16415329
D058185Magnetite Nanoparticles[Magnetite Nanoparticles co-treated with Succimer] affects the expression of ID2 mRNA25522732
D058185Magnetite Nanoparticles[Magnetite Nanoparticles co-treated with Succimer] affects the expression of ID2 mRNA25522732
D008345ManganeseManganese results in increased expression of ID2 mRNA17175027
C025340manganese chloridemanganese chloride results in increased expression of ID2 mRNA17175027
D008713MethimazoleMethimazole results in increased expression of ID2 mRNA23397585
D008713MethimazoleMethimazole results in decreased expression of ID2 mRNA17403546
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ID2 mRNA20938992
C005219methyl cellosolvemethyl cellosolve results in decreased expression of ID2 mRNA19643169
D008748MethylcholanthreneMethylcholanthrene results in increased expression of ID2 mRNA23397585
D008748MethylcholanthreneMethylcholanthrene results in increased expression of ID2 mRNA20713471
D008748MethylcholanthreneMethylcholanthrene results in increased expression of ID2 mRNA18804290
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ID2 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ID2 mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of ID2 mRNA23397585
C030957methylmercury II[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of ID2 mRNA17905399
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ID2 mRNA23649840
C008493methylselenic acidmethylselenic acid affects the expression of ID2 mRNA14617803
D008803MianserinMianserin results in decreased expression of ID2 mRNA24154490
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of ID2 mRNA23876855
C437683motexafin gadoliniummotexafin gadolinium results in increased expression of ID2 mRNA16357179
C437683motexafin gadolinium[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of ID2 mRNA16357179
C523799MRK 003ID2 results in increased susceptibility to MRK 00319903844
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of ID2 mRNA"29244179
C064769N-acetylsphingosineN-acetylsphingosine results in decreased expression of ID2 mRNA18270325
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ID2 mRNA"23634900|2438911
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ID2 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ID2 mRNA"25620056
C017096n-butoxyethanoln-butoxyethanol results in increased expression of ID2 mRNA19812364
C029938nickel sulfatenickel sulfate results in increased expression of ID2 mRNA16780908|2014638
D009538NicotineNicotine results in increased splicing of ID2 mRNA alternative form23825647
D005996NitroglycerinNitroglycerin results in increased expression of ID2 mRNA12102619
C464660obeticholic acidobeticholic acid results in decreased expression of ID2 mRNA27939613
C025589ochratoxin Aochratoxin A results in decreased expression of ID2 mRNA24356939
C025589ochratoxin Aochratoxin A results in decreased expression of ID2 mRNA14994279
C507134ON 01910ON 01910 results in increased expression of ID2 mRNA22351695
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of ID2 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of ID2 mRNA25729387
D010100OxygenOxygen deficiency results in increased expression of ID2 mRNA17175027
D010100OxygenOxygen deficiency results in increased expression of ID2 mRNA26476374
D010100OxygenQuercetin inhibits the reaction [Oxygen deficiency results in increased expression of ID2 mRNA]26476374
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of ID2 mRNA18636392
D000073878Palm OilPalm Oil results in decreased expression of ID2 mRNA18042831
D000073878Palm OilPalm Oil results in increased expression of ID2 mRNA18042831
C055778panaxydolpanaxydol results in decreased expression of ID2 mRNA19450571
C016030pantogabpantogab results in decreased expression of ID2 mRNA17379144
D052638Particulate MatterParticulate Matter results in decreased expression of ID2 mRNA22178795|2308503
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of ID2 mRNA18593933
C494474perchlorateperchlorate results in decreased expression of ID2 mRNA17403546
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of ID2 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of ID2 mRNA19429403
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of ID2 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of ID2 mRNA19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of ID2 mRNA19162173
C049032pinosylvin[pinosylvin affects the localization of and results in decreased activity of CTNNB1 protein] which results in decreased expression of ID2 mRNA23333577
C049032pinosylvinpinosylvin results in decreased expression of ID2 mRNA23333577
C060836pioglitazone[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ID2 mRNA20847119
C060836pioglitazonepioglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ID2 mRNA]20847119
C006253pirinixic acidpirinixic acid results in decreased expression of ID2 mRNA11798191|1844570
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of ID2 mRNA]20059764
D010938Plant OilsPlant Oils results in increased expression of ID2 mRNA23370395
C467566pomalidomidepomalidomide results in increased expression of ID2 mRNA15292067
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of ID2 mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of ID2 mRNA19162173
D011374ProgesteroneID2 protein promotes the reaction [FSHB protein results in increased abundance of Progesterone]18325989
D011374ProgesteroneLHB protein promotes the reaction [ID2 protein promotes the reaction [FSHB protein results in increased abundance of Progesterone]]18325989
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of ID2 mRNA20660070
D011374ProgesteroneProgesterone results in increased expression of ID2 mRNA18037150
C045950propiconazolepropiconazole results in decreased expression of ID2 mRNA21278054
D011435Propyl GallatePropyl Gallate affects the expression of ID2 mRNA18539377
D011441PropylthiouracilPropylthiouracil results in increased expression of ID2 mRNA23397585
D011441PropylthiouracilPropylthiouracil results in decreased expression of ID2 mRNA17403546
D015237DinoprostDinoprost results in decreased expression of ID2 mRNA11517196
D011794QuercetinQuercetin affects the expression of ID2 mRNA21632981
D011794QuercetinQuercetin inhibits the reaction [Oxygen deficiency results in increased expression of ID2 mRNA]26476374
D011899RanitidineRanitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of ID2 mRNA]16415329
C488333Ro 65-7199Ro 65-7199 affects the expression of ID2 mRNA14610520
C089730rosiglitazone[rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ID2 mRNA20847119
C089730rosiglitazonerosiglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ID2 mRNA]20847119
D012643SeleniumSelenium results in decreased expression of ID2 mRNA19244175
C009250sevofluranesevoflurane affects the expression of ID2 mRNA15967596
D012822Silicon DioxideSilicon Dioxide results in increased expression of ID2 mRNA19073995
D012835Silver NitrateSilver Nitrate results in decreased expression of ID2 mRNA22727896
D012906SmokeSmoke results in decreased expression of ID2 mRNA21095227
C009277sodium arsenatesodium arsenate results in decreased expression of ID2 mRNA12727804
C017947sodium arsenite[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of ID2 mRNA12634122
C017947sodium arsenitesodium arsenite results in decreased expression of ID2 mRNA12727804
C017947sodium arsenitesodium arsenite results in increased expression of ID2 mRNA16966095|2587980
C016104sodium bichromatesodium bichromate results in increased expression of ID2 mRNA12325037
D012969Sodium FluorideSodium Fluoride results in decreased expression of ID2 mRNA27257137
D013311StreptozocinStreptozocin results in decreased expression of ID2 mRNA25905778
D010042OuabainOuabain results in increased expression of ID2 mRNA28795476
D004113Succimer[Magnetite Nanoparticles co-treated with Succimer] affects the expression of ID2 mRNA25522732
D004113Succimer[Magnetite Nanoparticles co-treated with Succimer] affects the expression of ID2 mRNA25522732
D014284TriiodothyronineTriiodothyronine results in increased expression of ID2 mRNA17403546
D016559TacrolimusTacrolimus results in increased expression of ID2 mRNA25270620
D013629TamoxifenTamoxifen affects the expression of ID2 mRNA17555576|2093736
C021751tanshinonetanshinone results in increased expression of ID2 mRNA15849732
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in decreased expression of ID2 mRNA20189893
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of ID2 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ID2 mRNA11489354|2010694
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ID2 mRNA21570461
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ID2 mRNA"28433925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ID2 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ID2 mRNA17949056
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ID2 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of ID2 mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of ID2 mRNA22378314
D013853ThioacetamideThioacetamide results in decreased expression of ID2 mRNA16297948
D013974ThyroxineThyroxine results in decreased expression of ID2 mRNA17403546
D013974ThyroxineThyroxine results in increased expression of ID2 mRNA17403546
C009495titanium dioxidetitanium dioxide results in increased expression of ID2 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ID2 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of ID2 mRNA25729387
D019772TopotecanTopotecan results in increased expression of ID2 mRNA25729387
D014212TretinoinTretinoin affects the expression of ID2 mRNA16054129
D014212Tretinoin[Tretinoin co-treated with arsenic trioxide] results in increased expression of ID2 mRNA15894607
D014212TretinoinTretinoin results in decreased expression of ID2 mRNA17310985
D014212TretinoinTretinoin results in increased expression of ID2 mRNA15894607|1612912
C032910triadimefontriadimefon affects the expression of ID2 mRNA21195148
D014241Trichloroethylene[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of ID2 mRNA17905399
C012589trichostatin Atrichostatin A results in increased expression of ID2 mRNA24935251
C057693troglitazone[troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ID2 mRNA20847119
C057693troglitazonetroglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ID2 mRNA]20847119
C080163trovafloxacin"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of ID2 mRNA"18930950
C101044tyrphostin AG 1478tyrphostin AG 1478 results in increased expression of ID2 mRNA18325989
C113580U 0126U 0126 results in increased expression of ID2 mRNA18325989
D014501UraniumUranium affects the expression of ID2 mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of ID2 mRNA15672453
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ID2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ID2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ID2 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of ID2 mRNA23179753|2627250
D014635Valproic AcidValproic Acid affects the expression of ID2 mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of ID2 mRNA21427059
D000068756ValsartanValsartan inhibits the reaction [AGT protein results in decreased expression of ID2 mRNA]19225232
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ID2 gene25560391
D014747VinblastineID2 protein affects the susceptibility to Vinblastine16217747
C025643vinclozolinvinclozolin results in increased expression of ID2 mRNA23034163
D014750VincristineVincristine results in increased expression of ID2 mRNA23649840
D014810Vitamin EVitamin E results in decreased expression of ID2 mRNA19244175
C111237vorinostat[decitabine co-treated with vorinostat] affects the expression of ID2 mRNA17330099
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of ID2 mRNA18593933
D019345Zinc Acetate[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of ID2 mRNA16357179
D019345Zinc AcetateZinc Acetate results in increased expression of ID2 mRNA16357179
D015034Zinc OxideZinc Oxide analog results in decreased expression of ID2 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001085RNA polymerase II transcription factor binding-IBA21873635  
GO:0001191transcriptional repressor activity, RNA polymerase II transcription factor binding-IBA21873635  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0005515protein binding-IPI10915743  14752053  16311606  16549780  19321746  20861012  
22453338  27107014  
GO:0008134transcription factor binding-IBA21873635  
GO:0044325ion channel binding-IPI16311606  
GO:0046983protein dimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0001656metanephros development-IEA-  
GO:0001779natural killer cell differentiation-IEA-  
GO:0001966thigmotaxis-IEA-  
GO:0003149membranous septum morphogenesis-IEA-  
GO:0003166bundle of His development-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007275multicellular organism development-TAS1741406  
GO:0007623circadian rhythm-IBA21873635  
GO:0008344adult locomotory behavior-IEA-  
GO:0010628positive regulation of gene expression-ISS-  
GO:0010629negative regulation of gene expression-ISS-  
GO:0014003oligodendrocyte development-IEA-  
GO:0019216regulation of lipid metabolic process-ISS-  
GO:0021772olfactory bulb development-IEA-  
GO:0030182neuron differentiation-IBA21873635  
GO:0032922circadian regulation of gene expression-ISS-  
GO:0033598mammary gland epithelial cell proliferation-ISS-  
GO:0042752regulation of circadian rhythm-ISS-  
GO:0043153entrainment of circadian clock by photoperiod-ISS-  
GO:0043353enucleate erythrocyte differentiation-IEA-  
GO:0043392negative regulation of DNA binding-IBA21873635  
GO:0043392negative regulation of DNA binding-IEA-  
GO:0043433negative regulation of DNA-binding transcription factor activity-IDA14627819  
GO:0045475locomotor rhythm-ISS-  
GO:0045578negative regulation of B cell differentiation-IEA-  
GO:0045600positive regulation of fat cell differentiation-IEA-  
GO:0045648positive regulation of erythrocyte differentiation-IEA-  
GO:0045651positive regulation of macrophage differentiation-IEA-  
GO:0045665negative regulation of neuron differentiation-IBA21873635  
GO:0045665negative regulation of neuron differentiation-ISS-  
GO:0045668negative regulation of osteoblast differentiation-IEA-  
GO:0045777positive regulation of blood pressure-ISS-  
GO:0045892negative regulation of transcription, DNA-templated-IDA14627819  
GO:0045893positive regulation of transcription, DNA-templated-ISS-  
GO:0048469cell maturation-IEA-  
GO:0048541Peyer's patch development-IEA-  
GO:0048557embryonic digestive tract morphogenesis-ISS-  
GO:0048661positive regulation of smooth muscle cell proliferation-ISS-  
GO:0048663neuron fate commitment-ISS-  
GO:0048667cell morphogenesis involved in neuron differentiation-IEA-  
GO:0048711positive regulation of astrocyte differentiation-IEA-  
GO:0048715negative regulation of oligodendrocyte differentiation-IEA-  
GO:0051726regulation of cell cycle-IBA21873635  
GO:0060612adipose tissue development-IEA-  
GO:0060749mammary gland alveolus development-ISS-  
GO:0061030epithelial cell differentiation involved in mammary gland alveolus development-ISS-  
GO:0061031endodermal digestive tract morphogenesis-ISS-  
GO:0071158positive regulation of cell cycle arrest-ISS-  
GO:0071285cellular response to lithium ion-IEA-  
GO:0071931positive regulation of transcription involved in G1/S transition of mitotic cell cycle-IC16311606  
GO:0090398cellular senescence-ISS-  
GO:2000045regulation of G1/S transition of mitotic cell cycle-IMP16311606  
GO:2000178negative regulation of neural precursor cell proliferation-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA16311606  
GO:0005737cytoplasmCOLOCALIZES_WITHIBA21873635  
GO:0005737cytoplasm-IDA20861012  
GO:0005737cytoplasmcolocalizes_withIDA16311606  
GO:0005829cytosol-IDA16311606  
GO:0032991protein-containing complex-ISS-  
KEGG ID KEGG Term
hsa04350TGF-beta signaling pathway
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26927796POU2AF1 Functions in the Human Airway Epithelium To Regulate Expression of Host Defense Genes. (2016 Apr 1)Zhou HJ Immunol
20422711Benzo(a)pyrene causes PRKAA1/2-dependent ID2 loss in trophoblast stem cells. (2010 Jun)Xie YMol Reprod Dev