Gene info: ID 3398

Gene: ID2

GENE ID: 3398

Synonyms: GIG8|ID2A|ID2H|bHLHb26

Description: inhibitor of DNA binding 2

Gene type: protein-coding

Location: 2p25.1

dbXrefs: Ensembl:ENSG00000115738 MIM:600386 Vega:OTTHUMG00000112454 UniprotKB:Q02363

RefSeq: NC_000002.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 4.608e-1 (AD) 9.115e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg14984257	chr2:8822600	ID2	Promoter	1.796e-4	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RHEB	0.819
GOLM1	0.812
GPM6A	0.811
CXXC5	0.809
SLC25A5	0.805
HSPA9	0.804
GNAS	0.801
KIAA1191	0.796
POLDIP2	0.796
ATP6V1G1	0.796

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.74
OR4F29	-0.692
AMBN	-0.328
GPR101	-0.321
ZBED2	-0.318
DGKK	-0.317
ENTHD1	-0.315
SAG	-0.31
LHX8	-0.31
SLC18A3	-0.307

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of ID2 mRNA"	16269432
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in increased expression of ID2 mRNA"	19114083
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ID2 mRNA"	28433925
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of ID2 mRNA"	21346803
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ID2 mRNA"	15215175
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ID2 mRNA"	23196670
C025160	3-aminobenzamide	3-aminobenzamide results in decreased expression of ID2 mRNA	15670817
C473484	4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine	4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine results in increased expression of ID2 mRNA	14610520
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ID2 mRNA"	27188386
C517041	(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of ID2 mRNA"	19561079
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ID2 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of ID2 mRNA	29067470
D000082	Acetaminophen	Acetaminophen results in increased expression of ID2 mRNA	22230336
D000082	Acetaminophen	Acetaminophen affects the expression of ID2 mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in decreased expression of ID2 mRNA	17585979
D000108	Acetylcarnitine	[Acetylcarnitine co-treated with NGF protein] results in increased expression of ID2 mRNA	14654561
D000111	Acetylcysteine	Acetylcysteine results in decreased expression of ID2 mRNA	16084531
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of ID2 mRNA	28522335
D013196	Dihydrotestosterone	Dihydrotestosterone results in increased expression of ID2 mRNA	16541417
D000638	Amiodarone	Amiodarone results in increased expression of ID2 mRNA	23397585
D000640	Amitrole	Amitrole results in decreased expression of ID2 mRNA	23397585
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of ID2 mRNA	16483693
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of ID2 mRNA	24449571
D001151	Arsenic	Arsenic results in decreased expression of ID2 mRNA	16835338
C006632	arsenic trioxide	arsenic trioxide affects the expression of ID2 mRNA	25076250
C006632	arsenic trioxide	arsenic trioxide affects the expression of ID2 protein	25076250
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of ID2 mRNA	15761015
C006632	arsenic trioxide	arsenic trioxide results in increased expression of ID2 mRNA	24356939
C006632	arsenic trioxide	[Tretinoin co-treated with arsenic trioxide] results in increased expression of ID2 mRNA	15894607
C006632	arsenic trioxide	arsenic trioxide results in increased expression of ID2 mRNA	21921037
C015001	arsenite	arsenite results in increased methylation of ID2 promoter	23974009
D001241	Aspirin	Aspirin affects the expression of ID2 mRNA	12800193
D001554	Benzene	[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of ID2 mRNA	17905399
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of ID2 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene metabolite results in decreased expression of ID2 mRNA	24356939
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ID2 mRNA	21569818
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ID2 mRNA	22228805
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of ID2 mRNA"	19150397
D004958	Estradiol	EGF protein inhibits the reaction [Estradiol results in decreased expression of ID2 mRNA]	24758408
D004958	Estradiol	[Estradiol binds to ESR2 protein] which results in increased expression of ID2 mRNA	20404318
D004958	Estradiol	[Estradiol co-treated with Progesterone] results in decreased expression of ID2 mRNA	20660070
D004958	Estradiol	Estradiol results in decreased expression of ID2 mRNA	20106945\|2339758
D004958	Estradiol	ESR1 protein promotes the reaction [Estradiol results in decreased expression of ID2 mRNA]	25210133
D004958	Estradiol	Estradiol results in decreased expression of ID2 mRNA	23144751\|2521013
D001622	Betaine	Betaine results in increased expression of ID2 mRNA	26391144
C044887	beta-methylcholine	beta-methylcholine affects the expression of ID2 mRNA	21179406
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ID2 mRNA	28628672
C006780	bisphenol A	bisphenol A results in increased expression of ID2 mRNA	22576693\|2927551
C006780	bisphenol A	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ID2 mRNA"	28433925
C006780	bisphenol A	bisphenol A affects the expression of ID2 mRNA	25181051
C006780	bisphenol A	bisphenol A results in decreased expression of ID2 mRNA	24988533
C006780	bisphenol A	bisphenol A results in increased methylation of ID2 gene	28505145
D020122	tert-Butylhydroperoxide	[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ID2 mRNA	20847119
D020122	tert-Butylhydroperoxide	pioglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ID2 mRNA]	20847119
D020122	tert-Butylhydroperoxide	[rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ID2 mRNA	20847119
D020122	tert-Butylhydroperoxide	rosiglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ID2 mRNA]	20847119
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of ID2 mRNA	20847119
D020122	tert-Butylhydroperoxide	[troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ID2 mRNA	20847119
D020122	tert-Butylhydroperoxide	troglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ID2 mRNA]	20847119
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of ID2 mRNA	14729362\|1500399
C018475	butyraldehyde	butyraldehyde results in increased expression of ID2 mRNA	26079696
D002087	Butyrates	Butyrates results in increased expression of ID2 mRNA	14674679
D020148	Butyric Acid	Butyric Acid results in increased expression of ID2 mRNA	12800193
C584509	C646 compound	C646 compound results in decreased expression of ID2 mRNA	26191083
D019256	Cadmium Chloride	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of ID2 mRNA	12634122
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of ID2 mRNA	18804290
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of ID2 mRNA	18636176
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of ID2 mRNA	27339419
C030583	ceric oxide	ceric oxide analog results in decreased expression of ID2 mRNA	24821434
D002706	Chlordan	Chlordan results in decreased expression of ID2 mRNA	23153324
D002713	Chlorine	Chlorine results in decreased expression of ID2 mRNA	18636392
D002713	Chlorine	[Ozone co-treated with Chlorine] affects the expression of ID2 mRNA	18636392
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of ID2 mRNA	16934159
D002737	Chloroprene	Chloroprene results in decreased expression of ID2 mRNA	23125180
D002737	Chloroprene	Chloroprene results in increased expression of ID2 mRNA	23125180
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ID2 mRNA	20938992
C023600	chromic oxide	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of ID2 mRNA	12634122
C017133	chromous chloride	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of ID2 mRNA	12634122
D002922	Ciguatoxins	Ciguatoxins affects the expression of ID2 mRNA	18353800
D003024	Clozapine	Clozapine results in increased expression of ID2 mRNA	12437575
D003300	Copper	[Disulfiram binds to Copper] which results in decreased expression of ID2 mRNA	24690739
D003300	Copper	[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of ID2 mRNA	15467011
D003300	Copper	Copper results in decreased expression of ID2 mRNA	22465980
D019327	Copper Sulfate	Copper Sulfate results in increased expression of ID2 mRNA	19549813
C029892	cupric chloride	cupric chloride affects the expression of ID2 mRNA	17211630
D003474	Curcumin	Curcumin results in decreased expression of ID2 mRNA	21594647
C009160	cyclonite	cyclonite results in increased expression of ID2 mRNA	25559034
D003520	Cyclophosphamide	Cyclophosphamide metabolite results in decreased expression of ID2 mRNA	24356939
D016572	Cyclosporine	Cyclosporine results in decreased expression of ID2 mRNA	20106945\|2798913
D016572	Cyclosporine	Cyclosporine results in decreased expression of ID2 mRNA	19770486
C014347	decitabine	[decitabine co-treated with vorinostat] affects the expression of ID2 mRNA	17330099
C014347	decitabine	decitabine results in increased expression of ID2 mRNA	19194470
D013759	Dronabinol	Dronabinol results in increased expression of ID2 mRNA	18454173
D003703	Demecolcine	Demecolcine results in increased expression of ID2 mRNA	23649840
D003907	Dexamethasone	Dexamethasone results in decreased expression of ID2 mRNA	22048647\|2504701
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ID2 mRNA	28628672
D003907	Dexamethasone	Dexamethasone results in decreased expression of ID2 mRNA	22733784
D003976	Diazinon	Diazinon affects the expression of ID2 mRNA	22546817
C041517	dibenzo(a,l)pyrene	"dibenzo(a,l)pyrene results in increased expression of ID2 mRNA"	16269432
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of ID2 mRNA	21266533
D002945	Cisplatin	Cisplatin results in increased expression of ID2 mRNA	19561079\|2160359
D004008	Diclofenac	Diclofenac results in increased expression of ID2 mRNA	26934552
D004026	Dieldrin	Dieldrin affects the expression of ID2 mRNA	22546817
D004041	Dietary Fats	[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of ID2 mRNA	28433925
D004041	Dietary Fats	Dietary Fats results in decreased expression of ID2 mRNA	18042831
D004041	Dietary Fats	Dietary Fats results in increased expression of ID2 mRNA	18042831
D019422	Dietary Sucrose	[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of ID2 mRNA	28433925
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of ID2 mRNA	19850644
D004051	Diethylhexyl Phthalate	PPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of ID2 mRNA]	19850644
D004051	Diethylhexyl Phthalate	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ID2 mRNA"	28433925
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of ID2 mRNA	21922642
D002117	Calcitriol	Calcitriol results in decreased expression of ID2 mRNA	16002434\|2648566
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in decreased expression of ID2 mRNA	27638505
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of ID2 mRNA"	22485181
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of ID2 mRNA	20146380
D004221	Disulfiram	[Disulfiram binds to Copper] which results in decreased expression of ID2 mRNA	24690739
D004317	Doxorubicin	ID2 protein affects the susceptibility to Doxorubicin	16217747
D004317	Doxorubicin	Doxorubicin affects the expression of ID2 mRNA	12187937
D004785	Environmental Pollutants	Environmental Pollutants results in increased expression of ID2 mRNA	20064776
C038939	enzacamene	enzacamene results in decreased expression of ID2 mRNA	23397585
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased expression of ID2 mRNA	16084531
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of ID2 mRNA	17475347
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of ID2 mRNA	17555576\|1794274
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of ID2 mRNA	12655037\|1583489
D011345	Fenofibrate	Fenofibrate results in decreased expression of ID2 mRNA	11798191
C006012	fenofibric acid	[fenofibric acid binds to PPARA protein] which results in increased expression of ID2 mRNA	16197558
C017690	fenvalerate	fenvalerate results in increased expression of ID2 mRNA	23397585
D005472	Fluorouracil	Fluorouracil results in decreased expression of ID2 protein	15352031
D005472	Fluorouracil	Fluorouracil results in increased expression of ID2 mRNA	16557594
D005472	Fluorouracil	ID2 protein affects the susceptibility to Fluorouracil	15352031
D005472	Fluorouracil	TP53 protein promotes the reaction [Fluorouracil results in increased expression of ID2 mRNA]	16557594
D005472	Fluorouracil	Fluorouracil results in increased expression of ID2 mRNA	25178657
D005472	Fluorouracil	ID2 protein affects the susceptibility to Fluorouracil	15016739
C061365	flusilazole	flusilazole affects the expression of ID2 mRNA	21195148
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ID2 mRNA	20938992
D005557	Formaldehyde	Formaldehyde results in increased expression of ID2 mRNA	20655997\|2364984
C039281	furan	furan results in decreased expression of ID2 mRNA	26194646
D005839	Gentamicins	Gentamicins results in increased expression of ID2 mRNA	22061828
D005897	Glafenine	Glafenine results in decreased expression of ID2 mRNA	24136188
D005944	Glucosamine	Glucosamine results in increased expression of ID2 mRNA	17178593
D005947	Glucose	[INS protein co-treated with Glucose] results in decreased expression of ID2 mRNA	22634610
D006220	Haloperidol	Haloperidol results in decreased expression of ID2 mRNA	12437575
D006220	Haloperidol	Haloperidol results in increased expression of ID2 mRNA	12437575
D006247	Harmine	Harmine inhibits the reaction [WNT3A protein results in decreased expression of ID2 mRNA]	20519739
C409722	hexaconazole	hexaconazole affects the expression of ID2 mRNA	21195148
D017313	Fenretinide	Fenretinide results in increased expression of ID2 mRNA	28973697
D006851	Hydrochloric Acid	Hydrochloric Acid results in increased expression of ID2 mRNA	15046208
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of ID2 mRNA	20044591
C492448	ICG 001	ICG 001 results in decreased expression of ID2 mRNA	26191083
D000068877	Imatinib Mesylate	Imatinib Mesylate results in increased expression of ID2 mRNA	21536647
D000068877	Imatinib Mesylate	Imatinib Mesylate results in increased expression of ID2 protein	21536647
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ID2 mRNA	28628672
D019807	Iodoacetic Acid	Iodoacetic Acid results in decreased expression of ID2 mRNA	23397585
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of ID2 mRNA	25613284
C051890	irinotecan	irinotecan metabolite results in decreased expression of ID2 mRNA	15956246
C051890	irinotecan	irinotecan results in decreased expression of ID2 mRNA	15956246
D058085	Iron Compounds	Iron Compounds results in decreased expression of ID2 mRNA	28483490
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of ID2 mRNA	28628672
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of ID2 mRNA	23086925
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of ID2 mRNA	27432991
C008261	lead acetate	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of ID2 mRNA	12634122
C045463	leflunomide	leflunomide results in increased expression of ID2 mRNA	28988120
C018584	linalool	linalool results in increased expression of ID2 mRNA	19922762
D001556	Lindane	Lindane results in increased expression of ID2 mRNA	18804290
C482199	lipopolysaccharide, E coli O55-B5	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of ID2 mRNA"	18930950
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of ID2 protein	21110107
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of ID2 mRNA	16415329
D008070	Lipopolysaccharides	Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of ID2 mRNA]	16415329
D058185	Magnetite Nanoparticles	[Magnetite Nanoparticles co-treated with Succimer] affects the expression of ID2 mRNA	25522732
D058185	Magnetite Nanoparticles	[Magnetite Nanoparticles co-treated with Succimer] affects the expression of ID2 mRNA	25522732
D008345	Manganese	Manganese results in increased expression of ID2 mRNA	17175027
C025340	manganese chloride	manganese chloride results in increased expression of ID2 mRNA	17175027
D008713	Methimazole	Methimazole results in increased expression of ID2 mRNA	23397585
D008713	Methimazole	Methimazole results in decreased expression of ID2 mRNA	17403546
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of ID2 mRNA	20938992
C005219	methyl cellosolve	methyl cellosolve results in decreased expression of ID2 mRNA	19643169
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of ID2 mRNA	23397585
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of ID2 mRNA	20713471
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of ID2 mRNA	18804290
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of ID2 mRNA	28001369
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of ID2 mRNA	28001369
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of ID2 mRNA	23397585
C030957	methylmercury II	[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of ID2 mRNA	17905399
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of ID2 mRNA	23649840
C008493	methylselenic acid	methylselenic acid affects the expression of ID2 mRNA	14617803
D008803	Mianserin	Mianserin results in decreased expression of ID2 mRNA	24154490
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of ID2 mRNA	23876855
C437683	motexafin gadolinium	motexafin gadolinium results in increased expression of ID2 mRNA	16357179
C437683	motexafin gadolinium	[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of ID2 mRNA	16357179
C523799	MRK 003	ID2 results in increased susceptibility to MRK 003	19903844
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of ID2 mRNA"	29244179
C064769	N-acetylsphingosine	N-acetylsphingosine results in decreased expression of ID2 mRNA	18270325
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of ID2 mRNA"	23634900\|2438911
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of ID2 mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of ID2 mRNA"	25620056
C017096	n-butoxyethanol	n-butoxyethanol results in increased expression of ID2 mRNA	19812364
C029938	nickel sulfate	nickel sulfate results in increased expression of ID2 mRNA	16780908\|2014638
D009538	Nicotine	Nicotine results in increased splicing of ID2 mRNA alternative form	23825647
D005996	Nitroglycerin	Nitroglycerin results in increased expression of ID2 mRNA	12102619
C464660	obeticholic acid	obeticholic acid results in decreased expression of ID2 mRNA	27939613
C025589	ochratoxin A	ochratoxin A results in decreased expression of ID2 mRNA	24356939
C025589	ochratoxin A	ochratoxin A results in decreased expression of ID2 mRNA	14994279
C507134	ON 01910	ON 01910 results in increased expression of ID2 mRNA	22351695
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of ID2 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of ID2 mRNA	25729387
D010100	Oxygen	Oxygen deficiency results in increased expression of ID2 mRNA	17175027
D010100	Oxygen	Oxygen deficiency results in increased expression of ID2 mRNA	26476374
D010100	Oxygen	Quercetin inhibits the reaction [Oxygen deficiency results in increased expression of ID2 mRNA]	26476374
D010126	Ozone	[Ozone co-treated with Chlorine] affects the expression of ID2 mRNA	18636392
D000073878	Palm Oil	Palm Oil results in decreased expression of ID2 mRNA	18042831
D000073878	Palm Oil	Palm Oil results in increased expression of ID2 mRNA	18042831
C055778	panaxydol	panaxydol results in decreased expression of ID2 mRNA	19450571
C016030	pantogab	pantogab results in decreased expression of ID2 mRNA	17379144
D052638	Particulate Matter	Particulate Matter results in decreased expression of ID2 mRNA	22178795\|2308503
C568608	PCI 5002	[PCI 5002 co-treated with Zinc] results in increased expression of ID2 mRNA	18593933
C494474	perchlorate	perchlorate results in decreased expression of ID2 mRNA	17403546
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid affects the expression of ID2 mRNA	19429403
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of ID2 mRNA	19429403
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of ID2 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in decreased expression of ID2 mRNA	19482888
D010634	Phenobarbital	Phenobarbital results in decreased expression of ID2 mRNA	19162173
C049032	pinosylvin	[pinosylvin affects the localization of and results in decreased activity of CTNNB1 protein] which results in decreased expression of ID2 mRNA	23333577
C049032	pinosylvin	pinosylvin results in decreased expression of ID2 mRNA	23333577
C060836	pioglitazone	[pioglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ID2 mRNA	20847119
C060836	pioglitazone	pioglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ID2 mRNA]	20847119
C006253	pirinixic acid	pirinixic acid results in decreased expression of ID2 mRNA	11798191\|1844570
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in decreased expression of ID2 mRNA]	20059764
D010938	Plant Oils	Plant Oils results in increased expression of ID2 mRNA	23370395
C467566	pomalidomide	pomalidomide results in increased expression of ID2 mRNA	15292067
C027373	potassium chromate(VI)	potassium chromate(VI) results in increased expression of ID2 mRNA	22714537
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in decreased expression of ID2 mRNA	19162173
D011374	Progesterone	ID2 protein promotes the reaction [FSHB protein results in increased abundance of Progesterone]	18325989
D011374	Progesterone	LHB protein promotes the reaction [ID2 protein promotes the reaction [FSHB protein results in increased abundance of Progesterone]]	18325989
D011374	Progesterone	[Estradiol co-treated with Progesterone] results in decreased expression of ID2 mRNA	20660070
D011374	Progesterone	Progesterone results in increased expression of ID2 mRNA	18037150
C045950	propiconazole	propiconazole results in decreased expression of ID2 mRNA	21278054
D011435	Propyl Gallate	Propyl Gallate affects the expression of ID2 mRNA	18539377
D011441	Propylthiouracil	Propylthiouracil results in increased expression of ID2 mRNA	23397585
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of ID2 mRNA	17403546
D015237	Dinoprost	Dinoprost results in decreased expression of ID2 mRNA	11517196
D011794	Quercetin	Quercetin affects the expression of ID2 mRNA	21632981
D011794	Quercetin	Quercetin inhibits the reaction [Oxygen deficiency results in increased expression of ID2 mRNA]	26476374
D011899	Ranitidine	Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of ID2 mRNA]	16415329
C488333	Ro 65-7199	Ro 65-7199 affects the expression of ID2 mRNA	14610520
C089730	rosiglitazone	[rosiglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ID2 mRNA	20847119
C089730	rosiglitazone	rosiglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ID2 mRNA]	20847119
D012643	Selenium	Selenium results in decreased expression of ID2 mRNA	19244175
C009250	sevoflurane	sevoflurane affects the expression of ID2 mRNA	15967596
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of ID2 mRNA	19073995
D012835	Silver Nitrate	Silver Nitrate results in decreased expression of ID2 mRNA	22727896
D012906	Smoke	Smoke results in decreased expression of ID2 mRNA	21095227
C009277	sodium arsenate	sodium arsenate results in decreased expression of ID2 mRNA	12727804
C017947	sodium arsenite	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromic oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of ID2 mRNA	12634122
C017947	sodium arsenite	sodium arsenite results in decreased expression of ID2 mRNA	12727804
C017947	sodium arsenite	sodium arsenite results in increased expression of ID2 mRNA	16966095\|2587980
C016104	sodium bichromate	sodium bichromate results in increased expression of ID2 mRNA	12325037
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of ID2 mRNA	27257137
D013311	Streptozocin	Streptozocin results in decreased expression of ID2 mRNA	25905778
D010042	Ouabain	Ouabain results in increased expression of ID2 mRNA	28795476
D004113	Succimer	[Magnetite Nanoparticles co-treated with Succimer] affects the expression of ID2 mRNA	25522732
D004113	Succimer	[Magnetite Nanoparticles co-treated with Succimer] affects the expression of ID2 mRNA	25522732
D014284	Triiodothyronine	Triiodothyronine results in increased expression of ID2 mRNA	17403546
D016559	Tacrolimus	Tacrolimus results in increased expression of ID2 mRNA	25270620
D013629	Tamoxifen	Tamoxifen affects the expression of ID2 mRNA	17555576\|2093736
C021751	tanshinone	tanshinone results in increased expression of ID2 mRNA	15849732
C045037	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate	testosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in decreased expression of ID2 mRNA	20189893
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in increased expression of ID2 mRNA	25172293
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ID2 mRNA	11489354\|2010694
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ID2 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ID2 mRNA"	28433925
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ID2 mRNA	19933214
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ID2 mRNA	17949056
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ID2 mRNA	22298810
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of ID2 mRNA	25613284
D019284	Thapsigargin	Thapsigargin results in increased expression of ID2 mRNA	22378314
D013853	Thioacetamide	Thioacetamide results in decreased expression of ID2 mRNA	16297948
D013974	Thyroxine	Thyroxine results in decreased expression of ID2 mRNA	17403546
D013974	Thyroxine	Thyroxine results in increased expression of ID2 mRNA	17403546
C009495	titanium dioxide	titanium dioxide results in increased expression of ID2 mRNA	23557971
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of ID2 mRNA	28065790
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of ID2 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of ID2 mRNA	25729387
D014212	Tretinoin	Tretinoin affects the expression of ID2 mRNA	16054129
D014212	Tretinoin	[Tretinoin co-treated with arsenic trioxide] results in increased expression of ID2 mRNA	15894607
D014212	Tretinoin	Tretinoin results in decreased expression of ID2 mRNA	17310985
D014212	Tretinoin	Tretinoin results in increased expression of ID2 mRNA	15894607\|1612912
C032910	triadimefon	triadimefon affects the expression of ID2 mRNA	21195148
D014241	Trichloroethylene	[Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in increased expression of ID2 mRNA	17905399
C012589	trichostatin A	trichostatin A results in increased expression of ID2 mRNA	24935251
C057693	troglitazone	[troglitazone co-treated with tert-Butylhydroperoxide] results in increased expression of ID2 mRNA	20847119
C057693	troglitazone	troglitazone inhibits the reaction [tert-Butylhydroperoxide results in increased expression of ID2 mRNA]	20847119
C080163	trovafloxacin	"[trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of ID2 mRNA"	18930950
C101044	tyrphostin AG 1478	tyrphostin AG 1478 results in increased expression of ID2 mRNA	18325989
C113580	U 0126	U 0126 results in increased expression of ID2 mRNA	18325989
D014501	Uranium	Uranium affects the expression of ID2 mRNA	15672453
C005460	uranyl acetate	uranyl acetate affects the expression of ID2 mRNA	15672453
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ID2 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of ID2 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of ID2 mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of ID2 mRNA	23179753\|2627250
D014635	Valproic Acid	Valproic Acid affects the expression of ID2 mRNA	17292431
D014635	Valproic Acid	Valproic Acid results in increased expression of ID2 mRNA	21427059
D000068756	Valsartan	Valsartan inhibits the reaction [AGT protein results in decreased expression of ID2 mRNA]	19225232
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of ID2 gene	25560391
D014747	Vinblastine	ID2 protein affects the susceptibility to Vinblastine	16217747
C025643	vinclozolin	vinclozolin results in increased expression of ID2 mRNA	23034163
D014750	Vincristine	Vincristine results in increased expression of ID2 mRNA	23649840
D014810	Vitamin E	Vitamin E results in decreased expression of ID2 mRNA	19244175
C111237	vorinostat	[decitabine co-treated with vorinostat] affects the expression of ID2 mRNA	17330099
D015032	Zinc	[PCI 5002 co-treated with Zinc] results in increased expression of ID2 mRNA	18593933
D019345	Zinc Acetate	[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of ID2 mRNA	16357179
D019345	Zinc Acetate	Zinc Acetate results in increased expression of ID2 mRNA	16357179
D015034	Zinc Oxide	Zinc Oxide analog results in decreased expression of ID2 mRNA	27215404

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0001085	RNA polymerase II transcription factor binding	-	IBA	21873635
GO:0001191	transcriptional repressor activity, RNA polymerase II transcription factor binding	-	IBA	21873635
GO:0003700	DNA-binding transcription factor activity	-	IBA	21873635
GO:0005515	protein binding	-	IPI	10915743 14752053 16311606 16549780 19321746 20861012 22453338 27107014
GO:0008134	transcription factor binding	-	IBA	21873635
GO:0044325	ion channel binding	-	IPI	16311606
GO:0046983	protein dimerization activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	-
GO:0001656	metanephros development	-	IEA	-
GO:0001779	natural killer cell differentiation	-	IEA	-
GO:0001966	thigmotaxis	-	IEA	-
GO:0003149	membranous septum morphogenesis	-	IEA	-
GO:0003166	bundle of His development	-	IEA	-
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0007275	multicellular organism development	-	TAS	1741406
GO:0007623	circadian rhythm	-	IBA	21873635
GO:0008344	adult locomotory behavior	-	IEA	-
GO:0010628	positive regulation of gene expression	-	ISS	-
GO:0010629	negative regulation of gene expression	-	ISS	-
GO:0014003	oligodendrocyte development	-	IEA	-
GO:0019216	regulation of lipid metabolic process	-	ISS	-
GO:0021772	olfactory bulb development	-	IEA	-
GO:0030182	neuron differentiation	-	IBA	21873635
GO:0032922	circadian regulation of gene expression	-	ISS	-
GO:0033598	mammary gland epithelial cell proliferation	-	ISS	-
GO:0042752	regulation of circadian rhythm	-	ISS	-
GO:0043153	entrainment of circadian clock by photoperiod	-	ISS	-
GO:0043353	enucleate erythrocyte differentiation	-	IEA	-
GO:0043392	negative regulation of DNA binding	-	IBA	21873635
GO:0043392	negative regulation of DNA binding	-	IEA	-
GO:0043433	negative regulation of DNA-binding transcription factor activity	-	IDA	14627819
GO:0045475	locomotor rhythm	-	ISS	-
GO:0045578	negative regulation of B cell differentiation	-	IEA	-
GO:0045600	positive regulation of fat cell differentiation	-	IEA	-
GO:0045648	positive regulation of erythrocyte differentiation	-	IEA	-
GO:0045651	positive regulation of macrophage differentiation	-	IEA	-
GO:0045665	negative regulation of neuron differentiation	-	IBA	21873635
GO:0045665	negative regulation of neuron differentiation	-	ISS	-
GO:0045668	negative regulation of osteoblast differentiation	-	IEA	-
GO:0045777	positive regulation of blood pressure	-	ISS	-
GO:0045892	negative regulation of transcription, DNA-templated	-	IDA	14627819
GO:0045893	positive regulation of transcription, DNA-templated	-	ISS	-
GO:0048469	cell maturation	-	IEA	-
GO:0048541	Peyer's patch development	-	IEA	-
GO:0048557	embryonic digestive tract morphogenesis	-	ISS	-
GO:0048661	positive regulation of smooth muscle cell proliferation	-	ISS	-
GO:0048663	neuron fate commitment	-	ISS	-
GO:0048667	cell morphogenesis involved in neuron differentiation	-	IEA	-
GO:0048711	positive regulation of astrocyte differentiation	-	IEA	-
GO:0048715	negative regulation of oligodendrocyte differentiation	-	IEA	-
GO:0051726	regulation of cell cycle	-	IBA	21873635
GO:0060612	adipose tissue development	-	IEA	-
GO:0060749	mammary gland alveolus development	-	ISS	-
GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development	-	ISS	-
GO:0061031	endodermal digestive tract morphogenesis	-	ISS	-
GO:0071158	positive regulation of cell cycle arrest	-	ISS	-
GO:0071285	cellular response to lithium ion	-	IEA	-
GO:0071931	positive regulation of transcription involved in G1/S transition of mitotic cell cycle	-	IC	16311606
GO:0090398	cellular senescence	-	ISS	-
GO:2000045	regulation of G1/S transition of mitotic cell cycle	-	IMP	16311606
GO:2000178	negative regulation of neural precursor cell proliferation	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IDA	16311606
GO:0005737	cytoplasm	COLOCALIZES_WITH	IBA	21873635
GO:0005737	cytoplasm	-	IDA	20861012
GO:0005737	cytoplasm	colocalizes_with	IDA	16311606
GO:0005829	cytosol	-	IDA	16311606
GO:0032991	protein-containing complex	-	ISS	-

KEGG ID	KEGG Term
hsa04350	TGF-beta signaling pathway

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26927796	POU2AF1 Functions in the Human Airway Epithelium To Regulate Expression of Host Defense Genes. (2016 Apr 1)	Zhou H	J Immunol
20422711	Benzo(a)pyrene causes PRKAA1/2-dependent ID2 loss in trophoblast stem cells. (2010 Jun)	Xie Y	Mol Reprod Dev