Gene: GADL1

339896
ADC|CSADC|HuADC|HuCSADC
glutamate decarboxylase like 1
protein-coding
3p24.1-p23
Ensembl:ENSG00000144644 MIM:615601 Vega:OTTHUMG00000130621 UniprotKB:Q6ZQY3
NC_000003.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.734e-1 (AD)  4.921e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DPPA40.882
BMP50.864
GSDMA0.862
FMO10.86
FER1L60.854
LY90.849
CD3G0.847
MROH50.847
FOXI20.845
FCRL30.845

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC1A4-0.505
SORCS2-0.503
ASPDH-0.486
ADCY2-0.485
NTSR2-0.479
FUT9-0.475
TTYH1-0.475
HHATL-0.472
NDP-0.471
LGI1-0.469

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00114Pyridoxal PhosphateSmall Molecule54-47-7Approved|Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
C0245661,1,1-trichloroethane"1,1,1-trichloroethane results in decreased expression of GADL1 mRNA"25270620
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GADL1 mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GADL1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GADL1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GADL1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GADL1 mRNA"25510870
D052244Endocrine DisruptorsEndocrine Disruptors results in decreased expression of GADL1 mRNA25198161
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GADL1 mRNA"25510870
D010634PhenobarbitalPhenobarbital affects the methylation of GADL1 gene19233941
D012969Sodium FluorideSodium Fluoride results in increased expression of GADL1 mRNA27862939
C009495titanium dioxidetitanium dioxide results in increased phosphorylation of GADL1 protein21439344
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of GADL1 mRNA"25198161

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004068aspartate 1-decarboxylase activity-IEA-  
GO:0004782sulfinoalanine decarboxylase activity-IEA-  
GO:0016831carboxy-lyase activity-TAS-  
GO:0030170pyridoxal phosphate binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0008652cellular amino acid biosynthetic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-70614Amino acid synthesis and interconversion (transamination)TAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28355295Risk prediction of pulmonary tuberculosis using genetic and conventional risk factors in adult Korean population. (2017)Hong EPPLoS One