Gene info: ID 3399

Gene: ID3

GENE ID: 3399

Synonyms: HEIR-1|bHLHb25

Description: inhibitor of DNA binding 3, HLH protein

Gene type: protein-coding

Location: 1p36.12

dbXrefs: Ensembl:ENSG00000117318 MIM:600277 UniprotKB:Q02535

RefSeq: NC_000001.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.297e-1 (AD) 6.134e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg02343604	chr1:23884703	ID3		5.750e-8	Alcohol consumption der day	27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
EMP3	0.811
MYL12A	0.802
RRAS	0.792
TAGLN2	0.791
TSPO	0.784
KANK2	0.783
VAMP5	0.782
CARD8	0.78
FLT3LG	0.779
PSMB8	0.776

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ABCC12	-0.55
TPBGL	-0.537
PPEF1	-0.536
KCNB2	-0.527
NEUROD6	-0.527
MARCH4	-0.524
SLC7A4	-0.515
CHRNB2	-0.51
BCL11A	-0.501
GRIN2B	-0.5

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C432747	1,1-dimethylbutyl-1-deoxy-Delta(9)-THC	"1,1-dimethylbutyl-1-deoxy-Delta(9)-THC results in decreased expression of ID3 mRNA"	15313899
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in decreased expression of ID3 mRNA"	19162173
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ID3 mRNA	19933214
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ID3 mRNA"	19167446
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of ID3 mRNA"	21346803
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ID3 mRNA"	12376462
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ID3 mRNA"	15059925
C014464	3,4-dichloroaniline	"3,4-dichloroaniline results in decreased expression of ID3 mRNA"	24172598
C583074	4,4'-hexafluorisopropylidene diphenol	"4,4'-hexafluorisopropylidene diphenol results in increased expression of ID3 mRNA"	25912373
D000082	Acetaminophen	Acetaminophen affects the expression of ID3 mRNA	17562736
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of ID3 mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ID3 mRNA]	17585979
D000108	Acetylcarnitine	[Acetylcarnitine co-treated with NGF protein] results in increased expression of ID3 mRNA	14654561
C096064	actein	actein affects the expression of ID3 mRNA	19527300
C016601	afimoxifene	afimoxifene inhibits the reaction [Estrogens results in decreased expression of ID3 mRNA]	21233418
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of ID3 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of ID3 mRNA	22100608\|2715375
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in decreased expression of ID3 mRNA	28522335
D013196	Dihydrotestosterone	Dihydrotestosterone results in increased expression of ID3 mRNA	16541417
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in decreased expression of ID3 mRNA	21298039
D000640	Amitrole	Amitrole results in decreased expression of ID3 mRNA	23397585
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of ID3 mRNA	16483693
D016718	Arachidonic Acid	Arachidonic Acid results in decreased expression of ID3 mRNA	16704987
C519728	archazolid B	archazolid B results in decreased expression of ID3 mRNA	25218289
C015001	arsenite	ID3 protein results in decreased susceptibility to arsenite	23523789
D001374	Azacitidine	Azacitidine results in increased expression of ID3 mRNA	19194470
D001379	Azathioprine	Azathioprine results in increased expression of ID3 mRNA	19192274
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ID3 mRNA	20064835
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of ID3 mRNA	19770486\|2156981
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of ID3 mRNA	22228805
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ID3 mRNA"	19150397
D004958	Estradiol	Estradiol results in decreased expression of ID3 mRNA	16474171\|1916744
C044887	beta-methylcholine	beta-methylcholine affects the expression of ID3 mRNA	21179406
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of ID3 mRNA	25912373
C002791	bismuth tripotassium dicitrate	bismuth tripotassium dicitrate results in increased expression of ID3 mRNA	15912405
C006780	bisphenol A	bisphenol A results in decreased expression of ID3 mRNA	16474171
C006780	bisphenol A	bisphenol A results in increased expression of ID3 mRNA	25912373
C006780	bisphenol A	bisphenol A results in decreased expression of ID3 mRNA	25270620
C006780	bisphenol A	bisphenol A results in increased methylation of ID3 promoter	27312807
C006780	bisphenol A	bisphenol A results in decreased expression of ID3 mRNA	25181051\|2698221
C006780	bisphenol A	bisphenol A results in increased expression of ID3 mRNA	27178563
C006780	bisphenol A	indole-3-carbinol promotes the reaction [bisphenol A results in increased expression of ID3 mRNA]	27178563
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of ID3 mRNA	15003993
C584509	C646 compound	C646 compound results in decreased expression of ID3 mRNA	26191083
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of ID3 mRNA	23397585
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of ID3 mRNA	18636176
C037123	cadmium sulfate	cadmium sulfate affects the reaction [MTF1 affects the expression of ID3 mRNA]	16221973
D002110	Caffeine	Caffeine results in increased expression of ID3 mRNA	20864626
C059041	calyculin A	calyculin A results in decreased expression of ID3 mRNA	25270620
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of ID3 mRNA	27339419
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of ID3 mRNA	12734012
C100187	chloropicrin	chloropicrin results in increased expression of ID3 mRNA	26352163
D002922	Ciguatoxins	Ciguatoxins affects the expression of ID3 mRNA	18353800
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of ID3 mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ID3 mRNA]	17585979
D002996	Clomiphene	Clomiphene results in increased expression of ID3 mRNA	26865669
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of ID3 mRNA	19320972
D003078	Colchicine	Colchicine results in decreased expression of ID3 mRNA	24211769
D003300	Copper	Copper deficiency results in decreased expression of ID3 mRNA	26033743
D019327	Copper Sulfate	Copper Sulfate results in increased expression of ID3 mRNA	19549813
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ID3 mRNA"	19167446
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in decreased expression of ID3 mRNA	19167446
D003375	Coumestrol	Coumestrol results in decreased expression of ID3 mRNA	19167446
D003471	Cuprizone	Cuprizone affects the expression of ID3 mRNA	26577399\|2752363
D003474	Curcumin	Curcumin results in decreased expression of ID3 mRNA	21594647
C000541	cyclopamine	cyclopamine results in decreased expression of ID3 mRNA	21703336
D016572	Cyclosporine	Cyclosporine results in decreased expression of ID3 mRNA	21632981\|2798913
D003609	Dactinomycin	Dactinomycin inhibits the reaction [BTC protein results in increased expression of ID3 mRNA]	18325989
C014347	decitabine	decitabine affects the expression of ID3 mRNA	23300844
C014347	decitabine	decitabine results in increased expression of ID3 mRNA	19194470
D003907	Dexamethasone	Dexamethasone results in decreased expression of ID3 mRNA	25047013
D002945	Cisplatin	Cisplatin affects the expression of ID3 mRNA	23300844
D002945	Cisplatin	Cisplatin results in decreased expression of ID3 mRNA	24211769
D002945	Cisplatin	Cisplatin results in decreased expression of ID3 mRNA	22023808
D004008	Diclofenac	Diclofenac results in increased expression of ID3 mRNA	26934552
D004041	Dietary Fats	Dietary Fats results in increased expression of ID3 mRNA	18042831\|2501614
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of ID3 mRNA	19850644
D004051	Diethylhexyl Phthalate	PPARA protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of ID3 mRNA]	19850644
C014476	diethyl maleate	diethyl maleate results in decreased expression of ID3 mRNA	25270620
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of ID3 mRNA	17942915
D004052	Diethylnitrosamine	MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ID3 mRNA]	17942915
D004054	Diethylstilbestrol	Diethylstilbestrol results in decreased expression of ID3 mRNA	26865669
D004117	Dimethoate	Dimethoate results in decreased expression of ID3 mRNA	23397585
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of ID3 mRNA"	12376462
D004237	Diuron	Diuron metabolite results in decreased expression of ID3 mRNA	24172598
D004237	Diuron	Diuron results in increased expression of ID3 mRNA	25152437
D004317	Doxorubicin	Doxorubicin results in increased expression of ID3 mRNA	15205334
C118739	entinostat	entinostat results in increased expression of ID3 mRNA	27188386
D004967	Estrogens	afimoxifene inhibits the reaction [Estrogens results in decreased expression of ID3 mRNA]	21233418
D004967	Estrogens	Estrogens results in decreased expression of ID3 mRNA	21233418
D004970	Estrone	Estrone results in decreased expression of ID3 mRNA	26865669
D004997	Ethinyl Estradiol	Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of ID3 mRNA]	12072388
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of ID3 mRNA	12655037\|1557682
D008656	Mestranol	Mestranol results in decreased expression of ID3 mRNA	26865669
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of ID3 mRNA	24211769
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased expression of ID3 mRNA	15954086
C000499	ferric oxide	ferric oxide analog results in increased expression of ID3 mRNA	24525745
D005419	Flavonoids	Flavonoids results in increased expression of ID3 mRNA	18035473
D005472	Fluorouracil	Fluorouracil results in increased expression of ID3 mRNA	15205334\|1655759
D005485	Flutamide	Flutamide results in increased expression of ID3 mRNA	21126777
D005485	Flutamide	Flutamide results in decreased expression of ID3 mRNA	24793618
D005557	Formaldehyde	Formaldehyde results in decreased expression of ID3 mRNA	27664576
C070081	fulvestrant	fulvestrant results in increased expression of ID3 mRNA	26865669
C039281	furan	furan results in increased methylation of ID3 gene	22079235
D005665	Furosemide	Furosemide results in decreased expression of ID3 mRNA	16526316
D019833	Genistein	Genistein results in decreased expression of ID3 mRNA	16474171\|2686566
D019833	Genistein	Genistein results in increased expression of ID3 mRNA	22228119
D005944	Glucosamine	Glucosamine results in increased expression of ID3 mRNA	17178593
D005947	Glucose	Glucose results in increased expression of ID3 mRNA	17178593
C004312	glycidol	glycidol results in decreased expression of ID3 mRNA	24915197
D006589	Hexestrol	Hexestrol results in decreased expression of ID3 mRNA	26865669
D017313	Fenretinide	Fenretinide results in increased expression of ID3 mRNA	28973697
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of ID3 mRNA	20044591
C492448	ICG 001	ICG 001 results in decreased expression of ID3 mRNA	26191083
D000068877	Imatinib Mesylate	Imatinib Mesylate results in decreased expression of ID3 mRNA	21536647
C016517	indole-3-carbinol	indole-3-carbinol promotes the reaction [bisphenol A results in increased expression of ID3 mRNA]	27178563
D019807	Iodoacetic Acid	Iodoacetic Acid results in decreased expression of ID3 mRNA	23397585
D007480	Iopanoic Acid	Iopanoic Acid results in decreased expression of ID3 mRNA	23397585
D058085	Iron Compounds	Iron Compounds results in decreased expression of ID3 mRNA	28483490
C008261	lead acetate	lead acetate results in decreased expression of ID3 mRNA	25270620
C045463	leflunomide	leflunomide results in increased expression of ID3 mRNA	28988120
C038753	leptomycin B	leptomycin B inhibits the reaction [sodium arsenite affects the localization of ID3 protein]	23523789
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of ID3 mRNA"	11578593
D018021	Lithium Chloride	Lithium Chloride results in decreased expression of ID3 mRNA	15711924
D058185	Magnetite Nanoparticles	[Magnetite Nanoparticles co-treated with Succimer] results in decreased expression of ID3 mRNA	25522732
D058185	Magnetite Nanoparticles	[Magnetite Nanoparticles co-treated with Succimer] results in decreased expression of ID3 mRNA	25522732
D058185	Magnetite Nanoparticles	Magnetite Nanoparticles results in increased expression of ID3 mRNA	24525745
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of ID3 mRNA	21641980
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ID3 mRNA	26378955
D008694	Methamphetamine	Methamphetamine results in decreased expression of ID3 mRNA	28619521
D008713	Methimazole	Methimazole results in increased expression of ID3 mRNA	23397585
D008727	Methotrexate	Methotrexate results in decreased expression of ID3 mRNA	17400583
D008727	Methotrexate	Methotrexate results in increased expression of ID3 mRNA	19192274
C013598	methoxyacetic acid	methoxyacetic acid results in increased expression of ID3 mRNA	20864626
D008731	Methoxychlor	Methoxychlor results in decreased expression of ID3 mRNA	23397585
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of ID3 mRNA	23397585
D008752	Methylene Chloride	Methylene Chloride results in decreased expression of ID3 mRNA	28392392
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of ID3 mRNA	20864626
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of ID3 mRNA	23397585
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of ID3 mRNA	26011545
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of ID3 mRNA	24211769
D008770	Methylnitrosourea	Methylnitrosourea results in decreased expression of ID3 mRNA	25270620
D008775	Methylprednisolone	Methylprednisolone results in increased expression of ID3 mRNA	19192274
C008493	methylselenic acid	methylselenic acid results in decreased expression of ID3 mRNA	12517777
C008493	methylselenic acid	methylselenic acid results in increased expression of ID3 mRNA	18548127
C028577	monobutyl phthalate	monobutyl phthalate results in increased expression of ID3 mRNA	20864626
C523799	MRK 003	ID3 results in decreased susceptibility to MRK 003	19903844
D009151	Mustard Gas	Mustard Gas results in increased expression of ID3 mRNA	15674844
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of ID3 mRNA"	29244179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of ID3 mRNA"	24389112
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of ID3 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of ID3 mRNA"	25620056
C017096	n-butoxyethanol	n-butoxyethanol results in decreased expression of ID3 mRNA	19812364
C029938	nickel sulfate	nickel sulfate results in increased expression of ID3 mRNA	22714537
D009538	Nicotine	Nicotine results in decreased expression of ID3 mRNA	17456735
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of ID3 mRNA	17616710
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in increased expression of ID3 mRNA	19716841
C570897	NSC668394	NSC668394 results in decreased expression of ID3 mRNA	27137931
C025589	ochratoxin A	ochratoxin A results in decreased expression of ID3 mRNA	21703336
C118580	octylmethoxycinnamate	octylmethoxycinnamate results in decreased expression of ID3 mRNA	23397585
D009966	Orphenadrine	Orphenadrine affects the expression of ID3 mRNA	23665939
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of ID3 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of ID3 mRNA	25729387
C029341	oxophenylarsine	oxophenylarsine binds to ID3 protein	23523789
D000073878	Palm Oil	Palm Oil results in increased expression of ID3 mRNA	18042831
C084656	paricalcitol	[Phosphorus co-treated with paricalcitol] results in increased expression of ID3 mRNA	17715259
D052638	Particulate Matter	Particulate Matter results in decreased expression of ID3 mRNA	22178795\|2476925
D010426	Pentosan Sulfuric Polyester	Pentosan Sulfuric Polyester results in decreased expression of ID3 mRNA	28973697
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of ID3 mRNA	27153767
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of ID3 mRNA	19162173
D010634	Phenobarbital	Phenobarbital affects the expression of ID3 mRNA	19159669
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of ID3 mRNA]	19482888
D010634	Phenobarbital	Phenobarbital affects the expression of ID3 mRNA	23091169
D010634	Phenobarbital	Phenobarbital results in decreased expression of ID3 mRNA	19270015\|1948288
D019800	Phenol	Phenol results in increased expression of ID3 mRNA	17547211
D010758	Phosphorus	[Phosphorus co-treated with paricalcitol] results in increased expression of ID3 mRNA	17715259
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ID3 mRNA	19710929
C006253	pirinixic acid	pirinixic acid affects the expression of ID3 mRNA	18445702
C006253	pirinixic acid	pirinixic acid results in decreased expression of ID3 mRNA	20813756\|2381119
D010938	Plant Oils	Plant Oils results in increased expression of ID3 mRNA	23370395
D011078	Polychlorinated Biphenyls	Polychlorinated Biphenyls analog results in decreased expression of ID3 mRNA	16474171
D011239	Prednisolone	Prednisolone results in increased expression of ID3 mRNA	19192274
D011374	Progesterone	Progesterone results in increased expression of ID3 mRNA	18037150\|2086464
C045950	propiconazole	propiconazole results in decreased expression of ID3 mRNA	21278054
D011441	Propylthiouracil	Propylthiouracil results in increased expression of ID3 mRNA	23397585
D011441	Propylthiouracil	Propylthiouracil results in increased expression of ID3 mRNA	24780913
D015237	Dinoprost	Dinoprost results in decreased expression of ID3 mRNA	11517196
D011794	Quercetin	Quercetin affects the expression of ID3 mRNA	21632981
D015125	Oxyquinoline	Oxyquinoline results in decreased expression of ID3 mRNA	21632981
C031389	resorcinol	resorcinol results in decreased expression of ID3 mRNA	22623647
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in decreased expression of ID3 mRNA	19167446
C009166	retinol acetate	retinol acetate results in increased expression of ID3 mRNA	16772331
D012715	Sesame Oil	Sesame Oil results in decreased expression of ID3 mRNA	29191790
C009277	sodium arsenate	sodium arsenate results in decreased expression of ID3 mRNA	12727804
C017947	sodium arsenite	sodium arsenite results in decreased expression of ID3 mRNA	12727804
C017947	sodium arsenite	sodium arsenite results in increased expression of ID3 mRNA	12760830\|1696609
C017947	sodium arsenite	ID3 protein inhibits the reaction [sodium arsenite results in increased expression of EGR1 mRNA]	23523789
C017947	sodium arsenite	leptomycin B inhibits the reaction [sodium arsenite affects the localization of ID3 protein]	23523789
C017947	sodium arsenite	sodium arsenite affects the localization of ID3 protein	23523789
C017947	sodium arsenite	sodium arsenite binds to ID3 protein	23523789
C017947	sodium arsenite	[sodium arsenite binds to ID3 protein] promotes the reaction [XPO1 protein affects the localization of ID3 protein]	23523789
C017947	sodium arsenite	sodium arsenite results in decreased expression of ID3 mRNA	16014739
C041711	St. Thomas' Hospital cardioplegic solution	St. Thomas' Hospital cardioplegic solution results in decreased expression of ID3 mRNA	16214533
D004113	Succimer	[Magnetite Nanoparticles co-treated with Succimer] results in decreased expression of ID3 mRNA	25522732
D004113	Succimer	[Magnetite Nanoparticles co-treated with Succimer] results in decreased expression of ID3 mRNA	25522732
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of ID3 mRNA	21641980
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ID3 mRNA	26378955
D013629	Tamoxifen	Tamoxifen affects the expression of ID3 mRNA	20937368
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ID3 mRNA	17257637\|1968428
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ID3 mRNA	19684285\|2149626
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ID3 mRNA	16611356\|2157046
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of ID3 mRNA	25975270
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ID3 mRNA	19684285\|1993321
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ID3 mRNA	15591033\|1794274
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of ID3 mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of ID3 mRNA	21496263\|2323856
D013750	Tetrachloroethylene	Tetrachloroethylene results in decreased expression of ID3 mRNA	28973375
D013750	Tetrachloroethylene	Tetrachloroethylene results in increased expression of ID3 mRNA	28973375
C009495	titanium dioxide	titanium dioxide results in decreased expression of ID3 mRNA	19486931
C009495	titanium dioxide	titanium dioxide results in decreased expression of ID3 mRNA	23557971
C009495	titanium dioxide	titanium dioxide results in increased expression of ID3 mRNA	23131501
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of ID3 mRNA	27404394\|2786577
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of ID3 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of ID3 mRNA	25729387
D014212	Tretinoin	Tretinoin results in increased expression of ID3 mRNA	20530235
D014212	Tretinoin	Tretinoin affects the expression of ID3 mRNA	16054129
D014212	Tretinoin	Tretinoin results in increased expression of ID3 mRNA	16494909\|1713896
C034613	triacsin C	triacsin C results in decreased expression of ID3 mRNA	16704987
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of ID3 mRNA	29024780
C057693	troglitazone	troglitazone results in decreased expression of ID3 mRNA	19140230
C101044	tyrphostin AG 1478	tyrphostin AG 1478 results in decreased expression of ID3 mRNA	18325989
C113580	U 0126	U 0126 results in decreased expression of ID3 mRNA	18325989
D014635	Valproic Acid	Valproic Acid affects the expression of ID3 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of ID3 mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of ID3 mRNA	27188386
D014635	Valproic Acid	Valproic Acid results in decreased expression of ID3 mRNA	20546886
C034028	vanadyl sulfate	vanadyl sulfate results in decreased expression of ID3 mRNA	16330358
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of ID3 gene	25560391
D001335	Vehicle Emissions	Vehicle Emissions results in decreased expression of ID3 mRNA	19165385
C025643	vinclozolin	vinclozolin results in increased expression of ID3 mRNA	23034163
D014750	Vincristine	ID3 gene SNP results in increased susceptibility to Vincristine	21245421
D000225	Adenine	Adenine results in decreased expression of ID3 mRNA	24211769
D010205	Pantothenic Acid	Pantothenic Acid results in increased expression of ID3 mRNA	19397697
D002762	Cholecalciferol	Cholecalciferol results in decreased expression of ID3 mRNA	16508948
D015032	Zinc	Zinc affects the expression of ID3 mRNA	16979875
C088658	zoledronic acid	zoledronic acid results in increased expression of ID3 mRNA	24714768

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	ISM	19274049
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding	-	NAS	19274049
GO:0001085	RNA polymerase II transcription factor binding	-	IBA	21873635
GO:0001191	transcriptional repressor activity, RNA polymerase II transcription factor binding	-	IBA	21873635
GO:0003700	DNA-binding transcription factor activity	-	IBA	21873635
GO:0003714	transcription corepressor activity	-	TAS	8437843
GO:0005515	protein binding	-	IPI	20861012 25416956 25609649
GO:0008134	transcription factor binding	-	IBA	21873635
GO:0008134	transcription factor binding	-	IEA	-
GO:0019904	protein domain specific binding	-	IEA	-
GO:0046983	protein dimerization activity	-	IEA	-
GO:1901707	leptomycin B binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	-
GO:0001656	metanephros development	-	IEA	-
GO:0006275	regulation of DNA replication	-	IEA	-
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0007275	multicellular organism development	-	TAS	1628620
GO:0007417	central nervous system development	-	IEA	-
GO:0007507	heart development	-	IEA	-
GO:0007517	muscle organ development	-	IEA	-
GO:0007623	circadian rhythm	-	IBA	21873635
GO:0007623	circadian rhythm	-	IEA	-
GO:0009611	response to wounding	-	IEA	-
GO:0030182	neuron differentiation	-	IBA	21873635
GO:0030182	neuron differentiation	-	IEA	-
GO:0030855	epithelial cell differentiation	-	IEA	-
GO:0030903	notochord development	-	IEA	-
GO:0042476	odontogenesis	-	IEA	-
GO:0043065	positive regulation of apoptotic process	-	IEA	-
GO:0043392	negative regulation of DNA binding	-	IBA	21873635
GO:0043433	negative regulation of DNA-binding transcription factor activity	-	IDA	14627819
GO:0045662	negative regulation of myoblast differentiation	-	IEA	-
GO:0045665	negative regulation of neuron differentiation	-	IBA	21873635
GO:0045668	negative regulation of osteoblast differentiation	-	IEA	-
GO:0045892	negative regulation of transcription, DNA-templated	-	IDA	14627819
GO:0051726	regulation of cell cycle	-	IBA	21873635
GO:0051726	regulation of cell cycle	-	IEA	-
GO:0072750	cellular response to leptomycin B	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IBA	21873635
GO:0005634	nucleus	-	IEA	-
GO:0005737	cytoplasm	COLOCALIZES_WITH	IBA	21873635
GO:0005737	cytoplasm	-	IEA	-

KEGG ID	KEGG Term
hsa04350	TGF-beta signaling pathway

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26614807	Identification of gene expression signature for cigarette smoke exposure response--from man to mouse. (2015 Dec)	Martin F	Hum Exp Toxicol
26927796	POU2AF1 Functions in the Human Airway Epithelium To Regulate Expression of Host Defense Genes. (2016 Apr 1)	Zhou H	J Immunol