Gene: ID3

3399
HEIR-1|bHLHb25
inhibitor of DNA binding 3, HLH protein
protein-coding
1p36.12
Ensembl:ENSG00000117318 MIM:600277 UniprotKB:Q02535
NC_000001.11
PubMed
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.297e-1 (AD)  6.134e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg02343604chr1:23884703ID35.750e-8Alcohol consumption der day27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EMP30.811
MYL12A0.802
RRAS0.792
TAGLN20.791
TSPO0.784
KANK20.783
VAMP50.782
CARD80.78
FLT3LG0.779
PSMB80.776

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ABCC12-0.55
TPBGL-0.537
PPEF1-0.536
KCNB2-0.527
NEUROD6-0.527
MARCH4-0.524
SLC7A4-0.515
CHRNB2-0.51
BCL11A-0.501
GRIN2B-0.5

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4327471,1-dimethylbutyl-1-deoxy-Delta(9)-THC"1,1-dimethylbutyl-1-deoxy-Delta(9)-THC results in decreased expression of ID3 mRNA"15313899
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of ID3 mRNA"19162173
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ID3 mRNA19933214
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ID3 mRNA"19167446
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ID3 mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of ID3 mRNA"12376462
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ID3 mRNA"15059925
C0144643,4-dichloroaniline"3,4-dichloroaniline results in decreased expression of ID3 mRNA"24172598
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of ID3 mRNA"25912373
D000082AcetaminophenAcetaminophen affects the expression of ID3 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of ID3 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ID3 mRNA]17585979
D000108Acetylcarnitine[Acetylcarnitine co-treated with NGF protein] results in increased expression of ID3 mRNA14654561
C096064acteinactein affects the expression of ID3 mRNA19527300
C016601afimoxifeneafimoxifene inhibits the reaction [Estrogens results in decreased expression of ID3 mRNA]21233418
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ID3 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ID3 mRNA22100608|2715375
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of ID3 mRNA28522335
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of ID3 mRNA16541417
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of ID3 mRNA21298039
D000640AmitroleAmitrole results in decreased expression of ID3 mRNA23397585
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ID3 mRNA16483693
D016718Arachidonic AcidArachidonic Acid results in decreased expression of ID3 mRNA16704987
C519728archazolid Barchazolid B results in decreased expression of ID3 mRNA25218289
C015001arseniteID3 protein results in decreased susceptibility to arsenite23523789
D001374AzacitidineAzacitidine results in increased expression of ID3 mRNA19194470
D001379AzathioprineAzathioprine results in increased expression of ID3 mRNA19192274
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ID3 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ID3 mRNA19770486|2156981
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ID3 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ID3 mRNA"19150397
D004958EstradiolEstradiol results in decreased expression of ID3 mRNA16474171|1916744
C044887beta-methylcholinebeta-methylcholine affects the expression of ID3 mRNA21179406
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of ID3 mRNA25912373
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in increased expression of ID3 mRNA15912405
C006780bisphenol Abisphenol A results in decreased expression of ID3 mRNA16474171
C006780bisphenol Abisphenol A results in increased expression of ID3 mRNA25912373
C006780bisphenol Abisphenol A results in decreased expression of ID3 mRNA25270620
C006780bisphenol Abisphenol A results in increased methylation of ID3 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of ID3 mRNA25181051|2698221
C006780bisphenol Abisphenol A results in increased expression of ID3 mRNA27178563
C006780bisphenol Aindole-3-carbinol promotes the reaction [bisphenol A results in increased expression of ID3 mRNA]27178563
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of ID3 mRNA15003993
C584509C646 compoundC646 compound results in decreased expression of ID3 mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ID3 mRNA23397585
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ID3 mRNA18636176
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of ID3 mRNA]16221973
D002110CaffeineCaffeine results in increased expression of ID3 mRNA20864626
C059041calyculin Acalyculin A results in decreased expression of ID3 mRNA25270620
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ID3 mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of ID3 mRNA12734012
C100187chloropicrinchloropicrin results in increased expression of ID3 mRNA26352163
D002922CiguatoxinsCiguatoxins affects the expression of ID3 mRNA18353800
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of ID3 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ID3 mRNA]17585979
D002996ClomipheneClomiphene results in increased expression of ID3 mRNA26865669
C018021cobaltous chloridecobaltous chloride results in decreased expression of ID3 mRNA19320972
D003078ColchicineColchicine results in decreased expression of ID3 mRNA24211769
D003300CopperCopper deficiency results in decreased expression of ID3 mRNA26033743
D019327Copper SulfateCopper Sulfate results in increased expression of ID3 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of ID3 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of ID3 mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of ID3 mRNA19167446
D003471CuprizoneCuprizone affects the expression of ID3 mRNA26577399|2752363
D003474CurcuminCurcumin results in decreased expression of ID3 mRNA21594647
C000541cyclopaminecyclopamine results in decreased expression of ID3 mRNA21703336
D016572CyclosporineCyclosporine results in decreased expression of ID3 mRNA21632981|2798913
D003609DactinomycinDactinomycin inhibits the reaction [BTC protein results in increased expression of ID3 mRNA]18325989
C014347decitabinedecitabine affects the expression of ID3 mRNA23300844
C014347decitabinedecitabine results in increased expression of ID3 mRNA19194470
D003907DexamethasoneDexamethasone results in decreased expression of ID3 mRNA25047013
D002945CisplatinCisplatin affects the expression of ID3 mRNA23300844
D002945CisplatinCisplatin results in decreased expression of ID3 mRNA24211769
D002945CisplatinCisplatin results in decreased expression of ID3 mRNA22023808
D004008DiclofenacDiclofenac results in increased expression of ID3 mRNA26934552
D004041Dietary FatsDietary Fats results in increased expression of ID3 mRNA18042831|2501614
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of ID3 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of ID3 mRNA]19850644
C014476diethyl maleatediethyl maleate results in decreased expression of ID3 mRNA25270620
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of ID3 mRNA17942915
D004052DiethylnitrosamineMET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ID3 mRNA]17942915
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of ID3 mRNA26865669
D004117DimethoateDimethoate results in decreased expression of ID3 mRNA23397585
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of ID3 mRNA"12376462
D004237DiuronDiuron metabolite results in decreased expression of ID3 mRNA24172598
D004237DiuronDiuron results in increased expression of ID3 mRNA25152437
D004317DoxorubicinDoxorubicin results in increased expression of ID3 mRNA15205334
C118739entinostatentinostat results in increased expression of ID3 mRNA27188386
D004967Estrogensafimoxifene inhibits the reaction [Estrogens results in decreased expression of ID3 mRNA]21233418
D004967EstrogensEstrogens results in decreased expression of ID3 mRNA21233418
D004970EstroneEstrone results in decreased expression of ID3 mRNA26865669
D004997Ethinyl EstradiolEthinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of ID3 mRNA]12072388
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ID3 mRNA12655037|1557682
D008656MestranolMestranol results in decreased expression of ID3 mRNA26865669
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of ID3 mRNA24211769
D005038EthylnitrosoureaEthylnitrosourea results in increased expression of ID3 mRNA15954086
C000499ferric oxideferric oxide analog results in increased expression of ID3 mRNA24525745
D005419FlavonoidsFlavonoids results in increased expression of ID3 mRNA18035473
D005472FluorouracilFluorouracil results in increased expression of ID3 mRNA15205334|1655759
D005485FlutamideFlutamide results in increased expression of ID3 mRNA21126777
D005485FlutamideFlutamide results in decreased expression of ID3 mRNA24793618
D005557FormaldehydeFormaldehyde results in decreased expression of ID3 mRNA27664576
C070081fulvestrantfulvestrant results in increased expression of ID3 mRNA26865669
C039281furanfuran results in increased methylation of ID3 gene22079235
D005665FurosemideFurosemide results in decreased expression of ID3 mRNA16526316
D019833GenisteinGenistein results in decreased expression of ID3 mRNA16474171|2686566
D019833GenisteinGenistein results in increased expression of ID3 mRNA22228119
D005944GlucosamineGlucosamine results in increased expression of ID3 mRNA17178593
D005947GlucoseGlucose results in increased expression of ID3 mRNA17178593
C004312glycidolglycidol results in decreased expression of ID3 mRNA24915197
D006589HexestrolHexestrol results in decreased expression of ID3 mRNA26865669
D017313FenretinideFenretinide results in increased expression of ID3 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of ID3 mRNA20044591
C492448ICG 001ICG 001 results in decreased expression of ID3 mRNA26191083
D000068877Imatinib MesylateImatinib Mesylate results in decreased expression of ID3 mRNA21536647
C016517indole-3-carbinolindole-3-carbinol promotes the reaction [bisphenol A results in increased expression of ID3 mRNA]27178563
D019807Iodoacetic AcidIodoacetic Acid results in decreased expression of ID3 mRNA23397585
D007480Iopanoic AcidIopanoic Acid results in decreased expression of ID3 mRNA23397585
D058085Iron CompoundsIron Compounds results in decreased expression of ID3 mRNA28483490
C008261lead acetatelead acetate results in decreased expression of ID3 mRNA25270620
C045463leflunomideleflunomide results in increased expression of ID3 mRNA28988120
C038753leptomycin Bleptomycin B inhibits the reaction [sodium arsenite affects the localization of ID3 protein]23523789
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of ID3 mRNA"11578593
D018021Lithium ChlorideLithium Chloride results in decreased expression of ID3 mRNA15711924
D058185Magnetite Nanoparticles[Magnetite Nanoparticles co-treated with Succimer] results in decreased expression of ID3 mRNA25522732
D058185Magnetite Nanoparticles[Magnetite Nanoparticles co-treated with Succimer] results in decreased expression of ID3 mRNA25522732
D058185Magnetite NanoparticlesMagnetite Nanoparticles results in increased expression of ID3 mRNA24525745
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of ID3 mRNA21641980
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ID3 mRNA26378955
D008694MethamphetamineMethamphetamine results in decreased expression of ID3 mRNA28619521
D008713MethimazoleMethimazole results in increased expression of ID3 mRNA23397585
D008727MethotrexateMethotrexate results in decreased expression of ID3 mRNA17400583
D008727MethotrexateMethotrexate results in increased expression of ID3 mRNA19192274
C013598methoxyacetic acidmethoxyacetic acid results in increased expression of ID3 mRNA20864626
D008731MethoxychlorMethoxychlor results in decreased expression of ID3 mRNA23397585
D008748MethylcholanthreneMethylcholanthrene results in increased expression of ID3 mRNA23397585
D008752Methylene ChlorideMethylene Chloride results in decreased expression of ID3 mRNA28392392
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ID3 mRNA20864626
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of ID3 mRNA23397585
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ID3 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ID3 mRNA24211769
D008770MethylnitrosoureaMethylnitrosourea results in decreased expression of ID3 mRNA25270620
D008775MethylprednisoloneMethylprednisolone results in increased expression of ID3 mRNA19192274
C008493methylselenic acidmethylselenic acid results in decreased expression of ID3 mRNA12517777
C008493methylselenic acidmethylselenic acid results in increased expression of ID3 mRNA18548127
C028577monobutyl phthalatemonobutyl phthalate results in increased expression of ID3 mRNA20864626
C523799MRK 003ID3 results in decreased susceptibility to MRK 00319903844
D009151Mustard GasMustard Gas results in increased expression of ID3 mRNA15674844
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of ID3 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ID3 mRNA"24389112
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ID3 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ID3 mRNA"25620056
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of ID3 mRNA19812364
C029938nickel sulfatenickel sulfate results in increased expression of ID3 mRNA22714537
D009538NicotineNicotine results in decreased expression of ID3 mRNA17456735
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of ID3 mRNA17616710
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of ID3 mRNA19716841
C570897NSC668394NSC668394 results in decreased expression of ID3 mRNA27137931
C025589ochratoxin Aochratoxin A results in decreased expression of ID3 mRNA21703336
C118580octylmethoxycinnamateoctylmethoxycinnamate results in decreased expression of ID3 mRNA23397585
D009966OrphenadrineOrphenadrine affects the expression of ID3 mRNA23665939
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of ID3 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of ID3 mRNA25729387
C029341oxophenylarsineoxophenylarsine binds to ID3 protein23523789
D000073878Palm OilPalm Oil results in increased expression of ID3 mRNA18042831
C084656paricalcitol[Phosphorus co-treated with paricalcitol] results in increased expression of ID3 mRNA17715259
D052638Particulate MatterParticulate Matter results in decreased expression of ID3 mRNA22178795|2476925
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in decreased expression of ID3 mRNA28973697
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of ID3 mRNA27153767
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ID3 mRNA19162173
D010634PhenobarbitalPhenobarbital affects the expression of ID3 mRNA19159669
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of ID3 mRNA]19482888
D010634PhenobarbitalPhenobarbital affects the expression of ID3 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of ID3 mRNA19270015|1948288
D019800PhenolPhenol results in increased expression of ID3 mRNA17547211
D010758Phosphorus[Phosphorus co-treated with paricalcitol] results in increased expression of ID3 mRNA17715259
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ID3 mRNA19710929
C006253pirinixic acidpirinixic acid affects the expression of ID3 mRNA18445702
C006253pirinixic acidpirinixic acid results in decreased expression of ID3 mRNA20813756|2381119
D010938Plant OilsPlant Oils results in increased expression of ID3 mRNA23370395
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in decreased expression of ID3 mRNA16474171
D011239PrednisolonePrednisolone results in increased expression of ID3 mRNA19192274
D011374ProgesteroneProgesterone results in increased expression of ID3 mRNA18037150|2086464
C045950propiconazolepropiconazole results in decreased expression of ID3 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in increased expression of ID3 mRNA23397585
D011441PropylthiouracilPropylthiouracil results in increased expression of ID3 mRNA24780913
D015237DinoprostDinoprost results in decreased expression of ID3 mRNA11517196
D011794QuercetinQuercetin affects the expression of ID3 mRNA21632981
D015125OxyquinolineOxyquinoline results in decreased expression of ID3 mRNA21632981
C031389resorcinolresorcinol results in decreased expression of ID3 mRNA22623647
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of ID3 mRNA19167446
C009166retinol acetateretinol acetate results in increased expression of ID3 mRNA16772331
D012715Sesame OilSesame Oil results in decreased expression of ID3 mRNA29191790
C009277sodium arsenatesodium arsenate results in decreased expression of ID3 mRNA12727804
C017947sodium arsenitesodium arsenite results in decreased expression of ID3 mRNA12727804
C017947sodium arsenitesodium arsenite results in increased expression of ID3 mRNA12760830|1696609
C017947sodium arseniteID3 protein inhibits the reaction [sodium arsenite results in increased expression of EGR1 mRNA]23523789
C017947sodium arseniteleptomycin B inhibits the reaction [sodium arsenite affects the localization of ID3 protein]23523789
C017947sodium arsenitesodium arsenite affects the localization of ID3 protein23523789
C017947sodium arsenitesodium arsenite binds to ID3 protein23523789
C017947sodium arsenite[sodium arsenite binds to ID3 protein] promotes the reaction [XPO1 protein affects the localization of ID3 protein]23523789
C017947sodium arsenitesodium arsenite results in decreased expression of ID3 mRNA16014739
C041711St. Thomas' Hospital cardioplegic solutionSt. Thomas' Hospital cardioplegic solution results in decreased expression of ID3 mRNA16214533
D004113Succimer[Magnetite Nanoparticles co-treated with Succimer] results in decreased expression of ID3 mRNA25522732
D004113Succimer[Magnetite Nanoparticles co-treated with Succimer] results in decreased expression of ID3 mRNA25522732
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of ID3 mRNA21641980
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ID3 mRNA26378955
D013629TamoxifenTamoxifen affects the expression of ID3 mRNA20937368
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ID3 mRNA17257637|1968428
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ID3 mRNA19684285|2149626
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ID3 mRNA16611356|2157046
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of ID3 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ID3 mRNA19684285|1993321
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ID3 mRNA15591033|1794274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ID3 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ID3 mRNA21496263|2323856
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of ID3 mRNA28973375
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of ID3 mRNA28973375
C009495titanium dioxidetitanium dioxide results in decreased expression of ID3 mRNA19486931
C009495titanium dioxidetitanium dioxide results in decreased expression of ID3 mRNA23557971
C009495titanium dioxidetitanium dioxide results in increased expression of ID3 mRNA23131501
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ID3 mRNA27404394|2786577
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of ID3 mRNA25729387
D019772TopotecanTopotecan results in increased expression of ID3 mRNA25729387
D014212TretinoinTretinoin results in increased expression of ID3 mRNA20530235
D014212TretinoinTretinoin affects the expression of ID3 mRNA16054129
D014212TretinoinTretinoin results in increased expression of ID3 mRNA16494909|1713896
C034613triacsin Ctriacsin C results in decreased expression of ID3 mRNA16704987
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of ID3 mRNA29024780
C057693troglitazonetroglitazone results in decreased expression of ID3 mRNA19140230
C101044tyrphostin AG 1478tyrphostin AG 1478 results in decreased expression of ID3 mRNA18325989
C113580U 0126U 0126 results in decreased expression of ID3 mRNA18325989
D014635Valproic AcidValproic Acid affects the expression of ID3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ID3 mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of ID3 mRNA27188386
D014635Valproic AcidValproic Acid results in decreased expression of ID3 mRNA20546886
C034028vanadyl sulfatevanadyl sulfate results in decreased expression of ID3 mRNA16330358
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ID3 gene25560391
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of ID3 mRNA19165385
C025643vinclozolinvinclozolin results in increased expression of ID3 mRNA23034163
D014750VincristineID3 gene SNP results in increased susceptibility to Vincristine21245421
D000225AdenineAdenine results in decreased expression of ID3 mRNA24211769
D010205Pantothenic AcidPantothenic Acid results in increased expression of ID3 mRNA19397697
D002762CholecalciferolCholecalciferol results in decreased expression of ID3 mRNA16508948
D015032ZincZinc affects the expression of ID3 mRNA16979875
C088658zoledronic acidzoledronic acid results in increased expression of ID3 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001085RNA polymerase II transcription factor binding-IBA21873635  
GO:0001191transcriptional repressor activity, RNA polymerase II transcription factor binding-IBA21873635  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0003714transcription corepressor activity-TAS8437843  
GO:0005515protein binding-IPI20861012  25416956  25609649  
GO:0008134transcription factor binding-IBA21873635  
GO:0008134transcription factor binding-IEA-  
GO:0019904protein domain specific binding-IEA-  
GO:0046983protein dimerization activity-IEA-  
GO:1901707leptomycin B binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0001656metanephros development-IEA-  
GO:0006275regulation of DNA replication-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007275multicellular organism development-TAS1628620  
GO:0007417central nervous system development-IEA-  
GO:0007507heart development-IEA-  
GO:0007517muscle organ development-IEA-  
GO:0007623circadian rhythm-IBA21873635  
GO:0007623circadian rhythm-IEA-  
GO:0009611response to wounding-IEA-  
GO:0030182neuron differentiation-IBA21873635  
GO:0030182neuron differentiation-IEA-  
GO:0030855epithelial cell differentiation-IEA-  
GO:0030903notochord development-IEA-  
GO:0042476odontogenesis-IEA-  
GO:0043065positive regulation of apoptotic process-IEA-  
GO:0043392negative regulation of DNA binding-IBA21873635  
GO:0043433negative regulation of DNA-binding transcription factor activity-IDA14627819  
GO:0045662negative regulation of myoblast differentiation-IEA-  
GO:0045665negative regulation of neuron differentiation-IBA21873635  
GO:0045668negative regulation of osteoblast differentiation-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-IDA14627819  
GO:0051726regulation of cell cycle-IBA21873635  
GO:0051726regulation of cell cycle-IEA-  
GO:0072750cellular response to leptomycin B-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IEA-  
GO:0005737cytoplasmCOLOCALIZES_WITHIBA21873635  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
hsa04350TGF-beta signaling pathway
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26614807Identification of gene expression signature for cigarette smoke exposure response--from man to mouse. (2015 Dec)Martin FHum Exp Toxicol
26927796POU2AF1 Functions in the Human Airway Epithelium To Regulate Expression of Host Defense Genes. (2016 Apr 1)Zhou HJ Immunol