Gene: ID4

3400
IDB4|bHLHb27
inhibitor of DNA binding 4, HLH protein
protein-coding
6p22.3
Ensembl:ENSG00000172201 MIM:600581 Vega:OTTHUMG00000014333 UniprotKB:P47928
NC_000006.12
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.147e-1 (AD)  1.974e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SOX20.904
GJA10.891
PBXIP10.886
METTL7A0.877
SDC20.877
AQP40.872
PON20.871
EZR0.866
SLC1A30.865
STOX10.864

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.431
TYRP1-0.415
OR4F29-0.402
IL12RB2-0.39
DUSP27-0.386
GABRG3-0.383
ZNF860-0.381
KLHL38-0.367
RHO-0.366
ADTRP-0.366

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of ID4 mRNA19933214
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ID4 mRNA"19114083
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ID4 mRNA"14633621
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of ID4 protein"14633621
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of ID4 mRNA"20206263
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ID4 mRNA"23196670
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of ID4 mRNA21983209
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of ID4 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ID4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ID4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ID4 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ID4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ID4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ID4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ID4 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ID4 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ID4 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of ID4 mRNA17562736
C006418adrenocorticotropin zincadrenocorticotropin zinc results in increased expression of ID4 mRNA19920212
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ID4 gene27153756
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of ID4 mRNA16541417
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ID4 mRNA16483693
C006632arsenic trioxide[arsenic trioxide results in decreased methylation of ID4 promoter] which results in increased expression of ID4 mRNA21223739|2122373
C487081belinostatbelinostat results in increased expression of ID4 mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ID4 mRNA"27188386
D001554BenzeneBenzene results in decreased expression of ID4 mRNA17905399
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ID4 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ID4 mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ID4 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ID4 mRNA21839799
C038328BEP protocolBEP protocol results in decreased expression of ID4 mRNA18987330
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of ID4 mRNA20660070
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of ID4 mRNA26496021
C006780bisphenol Abisphenol A affects the expression of ID4 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of ID4 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of ID4 mRNA26496021
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of ID4 mRNA25270620
D019256Cadmium ChlorideCadmium Chloride results in increased expression of ID4 mRNA26472689
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of ID4 promoter22457795
D002737ChloropreneChloroprene results in decreased expression of ID4 mRNA23125180
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of ID4 mRNA28472532
C018021cobaltous chloridecobaltous chloride results in decreased expression of ID4 mRNA19376846
C018021cobaltous chloridecobaltous chloride results in decreased expression of ID4 mRNA24386269
D003300CopperCopper results in decreased expression of ID4 mRNA22465980
D019327Copper SulfateCopper Sulfate results in decreased expression of ID4 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of ID4 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of ID4 mRNA27989131
D003609DactinomycinDactinomycin inhibits the reaction [BTC protein results in increased expression of ID4 mRNA]18325989
C014347decitabinedecitabine results in increased expression of ID4 mRNA16367923
D002945CisplatinID4 protein affects the susceptibility to Cisplatin16217747
D004041Dietary FatsDietary Fats results in increased expression of ID4 mRNA18042831|2501614
C014476diethyl maleatediethyl maleate results in decreased expression of ID4 mRNA25270620
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ID4 mRNA18164116
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of ID4 mRNA19638242
C015835dimethyl-4-toluidinedimethyl-4-toluidine affects the expression of ID4 mRNA27638505
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of ID4 mRNA27638505
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of ID4 mRNA25380136
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of ID4 mRNA20064776
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ID4 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ID4 mRNA17557909
D005485FlutamideFlutamide results in decreased expression of ID4 mRNA24136188
D005557FormaldehydeFormaldehyde results in increased expression of ID4 mRNA20655997
C039281furanfuran results in decreased expression of ID4 mRNA25539665|2619464
D019833GenisteinGenistein results in increased expression of ID4 mRNA22228119
D005897GlafenineGlafenine results in decreased expression of ID4 mRNA24136188
C412815GW 4064GW 4064 results in decreased expression of ID4 mRNA26655953
D017313FenretinideFenretinide results in increased expression of ID4 mRNA28973697
C045463leflunomideleflunomide results in decreased expression of ID4 mRNA19751817
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of ID4 mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of ID4 mRNA16415329
D008070LipopolysaccharidesRanitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of ID4 mRNA]16415329
D058185Magnetite Nanoparticles[Magnetite Nanoparticles co-treated with Succimer] affects the expression of ID4 mRNA25522732
D058185Magnetite Nanoparticles[Magnetite Nanoparticles co-treated with Succimer] affects the expression of ID4 mRNA25522732
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of ID4 mRNA"20188158
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of ID4 mRNA24810058
D016685MitomycinID4 protein affects the susceptibility to Mitomycin16217747
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ID4 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ID4 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of ID4 mRNA25380136
C051752nefazodonenefazodone results in decreased expression of ID4 mRNA24136188
D009532NickelNickel results in decreased expression of ID4 mRNA24768652
C028007nickel monoxidenickel monoxide results in decreased expression of ID4 mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of ID4 mRNA22714537
C012655nimesulidenimesulide results in decreased expression of ID4 mRNA24136188
C025589ochratoxin Aochratoxin A results in decreased expression of ID4 mRNA23358140
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of ID4 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of ID4 mRNA25729387
D000073878Palm OilPalm Oil results in increased expression of ID4 mRNA18042831
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ID4 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of ID4 mRNA26272509
D052638Particulate MatterParticulate Matter results in decreased expression of ID4 mRNA22178795
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of ID4 mRNA18593933
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in increased expression of ID4 mRNA28973697
D010634PhenobarbitalPhenobarbital results in decreased expression of ID4 mRNA23091169
D010656PhenylephrinePhenylephrine results in increased expression of ID4 mRNA18158353
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ID4 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of ID4 mRNA26272509
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of ID4 mRNA24583197
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of ID4 mRNA20660070
D011374ProgesteroneProgesterone results in increased expression of ID4 mRNA20864642
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of ID4 mRNA19059307
D011899RanitidineRanitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of ID4 mRNA]16415329
C059514resveratrolresveratrol results in decreased expression of ID4 mRNA25905778
C089730rosiglitazonerosiglitazone results in decreased expression of ID4 mRNA21515302
D012834SilverSilver results in decreased expression of ID4 mRNA27131904
C017947sodium arsenitesodium arsenite results in increased expression of ID4 mRNA22714537
D004113Succimer[Magnetite Nanoparticles co-treated with Succimer] affects the expression of ID4 mRNA25522732
D004113Succimer[Magnetite Nanoparticles co-treated with Succimer] affects the expression of ID4 mRNA25522732
D013501Surface-Active AgentsSurface-Active Agents results in decreased expression of ID4 mRNA22467014
D016559TacrolimusTacrolimus results in increased expression of ID4 mRNA25270620
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in increased expression of ID4 mRNA19059307
D013629TamoxifenTamoxifen affects the expression of ID4 mRNA17555576|2093736
C501413tesaglitazartesaglitazar results in decreased expression of ID4 mRNA21515302
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of ID4 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ID4 mRNA21296121
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ID4 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ID4 mRNA18691609|1993321
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ID4 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ID4 mRNA19490992|2121527
D013853ThioacetamideThioacetamide results in decreased expression of ID4 mRNA23411599
C009495titanium dioxidetitanium dioxide results in decreased expression of ID4 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of ID4 mRNA25729387
D019772TopotecanTopotecan results in increased expression of ID4 mRNA25729387
C483909torcetrapibtorcetrapib results in increased expression of ID4 mRNA23228038
D014241TrichloroethyleneTrichloroethylene results in increased expression of ID4 mRNA28973375
C012589trichostatin Atrichostatin A results in increased expression of ID4 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of ID4 mRNA19042947
C057693troglitazonetroglitazone results in decreased expression of ID4 mRNA21515302
C101044tyrphostin AG 1478tyrphostin AG 1478 results in decreased expression of ID4 mRNA18325989
C113580U 0126U 0126 results in decreased expression of ID4 mRNA18325989
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ID4 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ID4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of ID4 mRNA23179753|2519280
D014635Valproic AcidValproic Acid results in increased expression of ID4 mRNA23179753|2438349
D014640VancomycinVancomycin results in increased expression of ID4 mRNA18930951
C025643vinclozolinvinclozolin affects the expression of ID4 mRNA19015723
C029297vinylidene chloridevinylidene chloride results in decreased expression of ID4 mRNA26682919
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of ID4 mRNA18593933
C088658zoledronic acidzoledronic acid results in increased expression of ID4 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0001085RNA polymerase II transcription factor binding-IBA21873635  
GO:0001085RNA polymerase II transcription factor binding-IEA-  
GO:0001191transcriptional repressor activity, RNA polymerase II transcription factor binding-IBA21873635  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0003714transcription corepressor activity-TAS7665172  
GO:0005515protein binding-IPI17474147  
GO:0008134transcription factor binding-IBA21873635  
GO:0046983protein dimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000082G1/S transition of mitotic cell cycle-IEA-  
GO:0000122negative regulation of transcription by RNA polymerase II-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-TAS7665172  
GO:0007405neuroblast proliferation-IEA-  
GO:0007623circadian rhythm-IBA21873635  
GO:0007623circadian rhythm-IEA-  
GO:0008284positive regulation of cell proliferation-IEA-  
GO:0021766hippocampus development-IEA-  
GO:0021895cerebral cortex neuron differentiation-IEA-  
GO:0022010central nervous system myelination-IEA-  
GO:0030182neuron differentiation-IBA21873635  
GO:0034613cellular protein localization-IEA-  
GO:0043392negative regulation of DNA binding-IBA21873635  
GO:0045444fat cell differentiation-IEA-  
GO:0045599negative regulation of fat cell differentiation-IEA-  
GO:0045665negative regulation of neuron differentiation-IBA21873635  
GO:0045665negative regulation of neuron differentiation-IEA-  
GO:0045669positive regulation of osteoblast differentiation-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-IDA11136250  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0048712negative regulation of astrocyte differentiation-IEA-  
GO:0048715negative regulation of oligodendrocyte differentiation-IEA-  
GO:0051726regulation of cell cycle-IBA21873635  
GO:0060740prostate gland epithelium morphogenesis-IEA-  
GO:0060741prostate gland stromal morphogenesis-IEA-  
GO:0061682seminal vesicle morphogenesis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IC11136250  
GO:0005634nucleus-IDA-  
GO:0005737cytoplasmCOLOCALIZES_WITHIBA21873635  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
hsa04350TGF-beta signaling pathway
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11. (2010 May)Edenberg HJAlcohol Clin Exp Res