Gene: NANOS1

340719
EC_Rep1a|NOS-1|NOS1|SPGF12|ZC2HC12A
nanos C2HC-type zinc finger 1
protein-coding
10q26.11
Ensembl:ENSG00000188613 MIM:608226 Vega:OTTHUMG00000019141 UniprotKB:Q8WY41
NG_050764.1
PubMed|SNP Mapped
0   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.721e-1 (AD)  6.776e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg15539330chr10:120788373NANOS1Promoter1.645e-4Alcohol use disorders26763658
cg23089913chr10:120788366NANOS1Promoter3.337e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GTF3C60.693
SMIM200.689
BCCIP0.677
LIN7C0.675
SERP10.673
RHOQ0.67
ANAPC160.669
PRDX10.669
SMIM150.668
PCBD10.666

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.514
OR4F29-0.491
PCDHAC1-0.255
DCC-0.253
PROKR2-0.245
TRPC5-0.23
PLEKHD1-0.23
KCNH7-0.23
CCDC68-0.227
SYT2-0.227

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of NANOS1 mRNA"20453058
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"2,3-bis(3'-hydroxybenzyl)butyrolactone results in decreased expression of NANOS1 mRNA"19167446
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of NANOS1 mRNA"19167446
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of NANOS1 mRNA16788091
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NANOS1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NANOS1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NANOS1 mRNA"27188386
C0343434-aminobenzhydrazide4-aminobenzhydrazide inhibits the reaction [hydroxyhydroquinone results in decreased expression of NANOS1 mRNA]24530881
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NANOS1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NANOS1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NANOS1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of NANOS1 mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 affects the expression of NANOS1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NANOS1 mRNA21632981
D000638AmiodaroneAmiodarone results in increased expression of NANOS1 mRNA19774075
D001280AtrazineAtrazine results in decreased expression of NANOS1 mRNA25929836
C487081belinostatbelinostat results in decreased expression of NANOS1 mRNA27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NANOS1 mRNA20106945
D004958EstradiolEstradiol results in decreased expression of NANOS1 mRNA19167446
C006780bisphenol Abisphenol A results in increased expression of NANOS1 mRNA26364221
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NANOS1 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of NANOS1 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of NANOS1 mRNA22079614
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of NANOS1 mRNA20971185
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of NANOS1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of NANOS1 mRNA19167446
D003375CoumestrolCoumestrol results in decreased expression of NANOS1 mRNA19167446
D003474CurcuminCurcumin results in decreased expression of NANOS1 mRNA17999991
D003520CyclophosphamideCyclophosphamide metabolite results in increased expression of NANOS1 mRNA24356939
D016572CyclosporineCyclosporine results in decreased expression of NANOS1 mRNA25562108|2798913
D016572CyclosporineCyclosporine results in increased expression of NANOS1 mRNA20106945
D003907DexamethasoneDexamethasone results in increased expression of NANOS1 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NANOS1 mRNA28628672
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of NANOS1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of NANOS1 mRNA27392435
C013038hydroxyhydroquinone4-aminobenzhydrazide inhibits the reaction [hydroxyhydroquinone results in decreased expression of NANOS1 mRNA]24530881
C013038hydroxyhydroquinonehydroxyhydroquinone results in decreased expression of NANOS1 mRNA24530881
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NANOS1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NANOS1 mRNA28628672
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of NANOS1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of NANOS1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NANOS1 mRNA24231268
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of NANOS1 mRNA27432991
D007854LeadLead affects the expression of NANOS1 mRNA28903495
D001556LindaneLindane results in decreased expression of NANOS1 mRNA24356939
D008777MethyltestosteroneMethyltestosterone results in increased expression of NANOS1 mRNA29191790
D009173Mycophenolic AcidMycophenolic Acid results in increased expression of NANOS1 mRNA24356939
C028007nickel monoxidenickel monoxide results in decreased expression of NANOS1 mRNA19167457
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of NANOS1 mRNA20971185
C025589ochratoxin Aochratoxin A metabolite results in decreased expression of NANOS1 mRNA24356939
C025589ochratoxin Aochratoxin A results in decreased expression of NANOS1 mRNA24356939
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NANOS1 mRNA"27188386
C496932panobinostatpanobinostat results in decreased expression of NANOS1 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of NANOS1 mRNA19710929
D011374ProgesteroneProgesterone results in decreased expression of NANOS1 mRNA18037150
C005556propionaldehydepropionaldehyde results in increased expression of NANOS1 mRNA26079696
C031389resorcinolresorcinol results in increased expression of NANOS1 mRNA22623647
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of NANOS1 mRNA19167446
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NANOS1 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NANOS1 mRNA21632981
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NANOS1 mRNA21570461
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of NANOS1 mRNA17494027
D014212TretinoinTretinoin results in decreased expression of NANOS1 mRNA21934132
D014212TretinoinTretinoin results in increased expression of NANOS1 mRNA23724009
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NANOS1 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of NANOS1 mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in increased expression of NANOS1 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of NANOS1 mRNA"26179874
D014520UrethaneUrethane results in decreased expression of NANOS1 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of NANOS1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of NANOS1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of NANOS1 mRNA26272509
D014635Valproic AcidValproic Acid results in increased expression of NANOS1 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased methylation of NANOS1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of NANOS1 gene25560391
C111237vorinostatvorinostat results in decreased expression of NANOS1 mRNA27188386
C088658zoledronic acidzoledronic acid results in increased expression of NANOS1 mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-IEA-  
GO:0005515protein binding-IPI17047063  19168546  21800163  24736845  
GO:0008270zinc ion binding-IEA-  
GO:0030371translation repressor activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001558regulation of cell growth-IEA-  
GO:0001894tissue homeostasis-IEA-  
GO:0010608posttranscriptional regulation of gene expression-IDA25100735  
GO:0010631epithelial cell migration-IDA17047063  
GO:0016477cell migration-IDA18223680  
GO:0017148negative regulation of translation-IDA24736845  
GO:0098749cerebellar neuron development-IEA-  
GO:1900153positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay-IDA24736845  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IDA12690449  17047063  
GO:0048471perinuclear region of cytoplasm-IDA17047063  19168546  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal