Gene info: ID 341

Gene: APOC1

GENE ID: 341

Synonyms: Apo-CI|ApoC-I|apo-CIB|apoC-IB

Description: apolipoprotein C1

Gene type: protein-coding

Location: 19q13.32

dbXrefs: Ensembl:ENSG00000130208 MIM:107710 Vega:OTTHUMG00000180844 UniprotKB:P02654

RefSeq: NG_012859.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.082e-1 (AD) 6.614e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
RPL22L1	0.725
MDFI	0.682
ECEL1	0.663
S100A16	0.655
EGFLAM	0.65
FABP5	0.646
BCL7C	0.625
VAMP8	0.622
VAMP5	0.62
DIRAS3	0.618

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
FBXO40	-0.473
TBR1	-0.441
NEUROD2	-0.437
MLIP	-0.432
SATB2	-0.43
TESPA1	-0.425
ZNF385B	-0.424
ADCY1	-0.424
PRSS16	-0.422
KCNS1	-0.419

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C036423	1-aminomethylphosphonic acid	"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of APOC1 mRNA"	20566314
C036423	1-aminomethylphosphonic acid	[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of APOC1 mRNA	20566314
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether affects the expression of APOC1 mRNA"	23962555
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of APOC1 mRNA"	19114083
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of APOC1 mRNA"	28973690
C020738	9,10-dihydro-9,10-dihydroxybenzo(a)pyrene	"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of APOC1 mRNA"	26238291
D000082	Acetaminophen	Acetaminophen results in decreased expression of APOC1 mRNA	29067470
C043377	acetochlor	"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of APOC1 mRNA"	20566314
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of APOC1 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of APOC1 mRNA	27153756
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of APOC1 mRNA	19770486
C040534	alpha-hexachlorocyclohexane	alpha-hexachlorocyclohexane results in decreased expression of APOC1 mRNA	16940010
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of APOC1 mRNA	16483693
D016718	Arachidonic Acid	Arachidonic Acid results in decreased expression of APOC1 mRNA	16623957
D001241	Aspirin	Aspirin inhibits the reaction [APOC1 results in increased abundance of Triglycerides]	21862721
C487081	belinostat	belinostat results in decreased expression of APOC1 mRNA	27188386
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of APOC1 mRNA	26001963
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of APOC1 mRNA	22316170\|2623829
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of APOC1 mRNA	22228805
C095105	bexarotene	bexarotene results in decreased expression of APOC1 mRNA	16648578
C006780	bisphenol A	bisphenol A results in decreased expression of APOC1 mRNA	12075121\|2518105
C006780	bisphenol A	bisphenol A results in increased expression of APOC1 mRNA	24768697
C018475	butyraldehyde	butyraldehyde results in increased expression of APOC1 mRNA	26079696
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of APOC1 mRNA	18804290
D002110	Caffeine	[Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in increased expression of APOC1 protein	16324916
D002110	Caffeine	Caffeine results in decreased expression of APOC1 mRNA	25868845
D002211	Capsaicin	Capsaicin results in decreased expression of APOC1 mRNA	18533110
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of APOC1 mRNA	15963342
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of APOC1 mRNA	16239168
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of APOC1 mRNA	18804290
D004390	Chlorpyrifos	[Copper co-treated with Chlorpyrifos] results in increased expression of APOC1 mRNA	21356183
D002994	Clofibrate	Clofibrate results in decreased expression of APOC1 mRNA	11328961
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of APOC1 mRNA	24386269
D003300	Copper	[Copper co-treated with Chlorpyrifos] results in increased expression of APOC1 mRNA	21356183
D003300	Copper	Copper results in increased expression of APOC1 mRNA	21356183
D003300	Copper	Copper results in decreased expression of APOC1 mRNA	20875833
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of APOC1 mRNA	19549813
D003471	Cuprizone	Cuprizone results in decreased expression of APOC1 mRNA	26577399\|2752363
D016572	Cyclosporine	Cyclosporine results in decreased expression of APOC1 mRNA	20106945
D015084	2,4-Dichlorophenoxyacetic Acid	"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of APOC1 mRNA"	20566314
C014347	decitabine	decitabine affects the expression of APOC1 mRNA	23300844
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of APOC1 mRNA]	27941970
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of APOC1 mRNA	28628672
D002945	Cisplatin	Cisplatin affects the expression of APOC1 mRNA	23300844
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of APOC1 mRNA	27392435
C121718	dicyclanil	dicyclanil results in increased expression of APOC1 mRNA	15664270
D004041	Dietary Fats	Dietary Fats results in decreased expression of APOC1 mRNA	18042831\|2501614
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene affects the expression of APOC1 mRNA"	21785161
D004809	Ephedrine	[Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in increased expression of APOC1 protein	16324916
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of APOC1 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of APOC1 mRNA	16174780
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of APOC1 mRNA	17351261
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of APOC1 mRNA	12075121\|1617478
D005472	Fluorouracil	APOC1 protein affects the susceptibility to Fluorouracil	16217747
D005485	Flutamide	Flutamide results in increased expression of APOC1 mRNA	24793618
C039281	furan	furan results in decreased expression of APOC1 mRNA	15120968\|2553966
D019833	Genistein	Genistein results in decreased expression of APOC1 mRNA	12075121
C010974	glyphosate	glyphosate results in increased expression of APOC1 mRNA	16532367
D006540	Herbicides	"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of APOC1 mRNA"	20566314
D006540	Herbicides	[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of APOC1 mRNA	20566314
D017313	Fenretinide	Fenretinide results in increased expression of APOC1 mRNA	28973697
C029424	hydrazine	hydrazine results in decreased expression of APOC1 mRNA	15370871
C492448	ICG 001	ICG 001 results in increased expression of APOC1 mRNA	26191083
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of APOC1 mRNA	28628672
D007213	Indomethacin	Indomethacin results in decreased expression of APOC1 mRNA	25972201
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of APOC1 mRNA	28628672
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of APOC1 mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of APOC1 mRNA	27392435
D008095	Lithocholic Acid	Lithocholic Acid results in decreased expression of APOC1 mRNA	20359477
C008340	mecoprop	"[Herbicides co-treated with 1-aminomethylphosphonic acid co-treated with mecoprop co-treated with acetochlor co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of APOC1 mRNA"	20566314
D008701	Methapyrilene	Methapyrilene results in decreased expression of APOC1 mRNA	15120968
D008748	Methylcholanthrene	Methylcholanthrene results in decreased expression of APOC1 mRNA	11328961
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of APOC1 mRNA	23179753
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of APOC1 mRNA"	26251327
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased methylation of APOC1 promoter"	26251327
D015735	Mifepristone	Mifepristone results in decreased expression of APOC1 mRNA	17584828
D015735	Mifepristone	Mifepristone results in decreased expression of APOC1 mRNA	25972201
D009532	Nickel	Nickel results in decreased expression of APOC1 mRNA	24768652
C025589	ochratoxin A	ochratoxin A results in decreased expression of APOC1 mRNA	12700408
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"PON1 gene polymorphism affects the susceptibility to [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of APOC1 mRNA]"	21673326
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of APOC1 mRNA"	21673326
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in decreased expression of APOC1 mRNA]"	21673326
D000073878	Palm Oil	Palm Oil results in decreased expression of APOC1 mRNA	18042831
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of APOC1 mRNA	21705711
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of APOC1 protein	26879310
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of APOC1 mRNA	18804290
D010578	Petroleum	Petroleum affects the expression of APOC1 mRNA	25208076
C060836	pioglitazone	[Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in increased expression of APOC1 protein	16324916
C006253	pirinixic acid	pirinixic acid results in decreased expression of APOC1 mRNA	20813756
D011441	Propylthiouracil	Propylthiouracil results in increased expression of APOC1 mRNA	24780913
D011794	Quercetin	Quercetin results in decreased expression of APOC1 mRNA	21632981
C059514	resveratrol	resveratrol results in increased expression of APOC1 mRNA	25888808
D015474	Isotretinoin	Isotretinoin results in decreased expression of APOC1 mRNA	20436886
C089730	rosiglitazone	rosiglitazone results in increased expression of APOC1 mRNA	26670611
D017632	Asbestos, Serpentine	"Asbestos, Serpentine results in decreased expression of APOC1 mRNA"	21148743
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of APOC1 mRNA	23806026
D019821	Simvastatin	Simvastatin results in decreased expression of APOC1 mRNA	25055962
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of APOC1 mRNA	27862939
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of APOC1 protein	28918527
D013629	Tamoxifen	Tamoxifen affects the expression of APOC1 mRNA	17555576
C021751	tanshinone	tanshinone results in increased expression of APOC1 mRNA	15849732
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of APOC1 mRNA	11489354\|2010694
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of APOC1 mRNA	26377647
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of APOC1 mRNA	15703262\|1626733
D013750	Tetrachloroethylene	Tetrachloroethylene results in decreased expression of APOC1 mRNA	28973375
D013752	Tetracycline	Tetracycline results in decreased expression of APOC1 mRNA	16917069
C009495	titanium dioxide	titanium dioxide affects the expression of APOC1 mRNA	23557971
D014050	Toluene	Toluene results in decreased expression of APOC1 mRNA	22967744
D014280	Triglycerides	APOC1 results in increased abundance of Triglycerides	21862721
D014280	Triglycerides	Aspirin inhibits the reaction [APOC1 results in increased abundance of Triglycerides]	21862721
D014520	Urethane	Urethane results in decreased expression of APOC1 mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of APOC1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of APOC1 mRNA	23179753\|2718838
C029297	vinylidene chloride	vinylidene chloride results in increased expression of APOC1 mRNA	26682919
C111237	vorinostat	vorinostat results in decreased expression of APOC1 mRNA	27188386
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical affects the expression of APOC1 mRNA"	25208076

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004859	phospholipase inhibitor activity	-	IDA	2302419
GO:0005504	fatty acid binding	-	IDA	17339654
GO:0031210	phosphatidylcholine binding	-	TAS	2302419
GO:0055102	lipase inhibitor activity	-	IDA	182536 15576844
GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity	-	TAS	18992221

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006629	lipid metabolic process	-	TAS	2897845
GO:0006641	triglyceride metabolic process	-	IEA	-
GO:0008203	cholesterol metabolic process	-	IEA	-
GO:0010873	positive regulation of cholesterol esterification	-	TAS	18992221
GO:0010900	negative regulation of phosphatidylcholine catabolic process	-	IDA	2302419
GO:0010916	negative regulation of very-low-density lipoprotein particle clearance	-	IDA	1917954
GO:0032374	regulation of cholesterol transport	-	IC	15576844
GO:0032375	negative regulation of cholesterol transport	-	IDA	10978346
GO:0033344	cholesterol efflux	-	IDA	11162594
GO:0033700	phospholipid efflux	-	IDA	11162594
GO:0034369	plasma lipoprotein particle remodeling	-	IDA	10978346
GO:0034375	high-density lipoprotein particle remodeling	-	TAS	18992221
GO:0034379	very-low-density lipoprotein particle assembly	-	TAS	18992221
GO:0034382	chylomicron remnant clearance	-	IDA	4020294
GO:0034447	very-low-density lipoprotein particle clearance	-	IGI	15576844
GO:0034447	very-low-density lipoprotein particle clearance	-	TAS	-
GO:0042157	lipoprotein metabolic process	-	IEA	-
GO:0043085	positive regulation of catalytic activity	-	IEA	-
GO:0045717	negative regulation of fatty acid biosynthetic process	-	IDA	15576844
GO:0045833	negative regulation of lipid metabolic process	-	IDA	182536
GO:0048261	negative regulation of receptor-mediated endocytosis	-	IDA	1917954
GO:0050995	negative regulation of lipid catabolic process	-	IDA	15576844
GO:0051005	negative regulation of lipoprotein lipase activity	-	IDA	15576844

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005783	endoplasmic reticulum	-	IDA	-
GO:0034361	very-low-density lipoprotein particle	-	IDA	15576844
GO:0034364	high-density lipoprotein particle	-	IDA	15576844
GO:0042627	chylomicron	-	TAS	18992221

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-174824	Plasma lipoprotein assembly, remodeling, and clearance	TAS
R-HSA-174824	Plasma lipoprotein assembly, remodeling, and clearance	IEA
R-HSA-382551	Transport of small molecules	TAS
R-HSA-382551	Transport of small molecules	IEA
R-HSA-8866423	VLDL assembly	TAS
R-HSA-8963898	Plasma lipoprotein assembly	TAS
R-HSA-8964043	Plasma lipoprotein clearance	IEA
R-HSA-8964043	Plasma lipoprotein clearance	TAS
R-HSA-8964046	VLDL clearance	IEA
R-HSA-8964046	VLDL clearance	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
20442857	Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study. (2010 Apr 29)	Suchindran S	PLoS Genet
22003152	Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies. (2012 Jan)	Grallert H	Eur Heart J
20675872	[Risk factors for Alzheimer's disease]. (2010 Jul)	Ikeda T	Brain Nerve
27827461	Association and interaction of APOA5, BUD13, CETP, LIPA and health-related behavior with metabolic syndrome in a Taiwanese population. (2016 Nov 9)	Lin E	Sci Rep