Gene info: ID 3416

Gene: IDE

GENE ID: 3416

Synonyms: INSULYSIN

Description: insulin degrading enzyme

Gene type: protein-coding

Location: 10q23.33

dbXrefs: Ensembl:ENSG00000119912 MIM:146680 Vega:OTTHUMG00000018759 UniprotKB:P14735

RefSeq: NG_013012.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 7

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 9.256e-1 (AD) 6.937e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ZMYM6	0.886
COPB1	0.871
PRPF4B	0.868
SLC30A7	0.865
SMCHD1	0.864
SCYL2	0.863
XRN2	0.863
CNOT2	0.859
SEC24B	0.858
NUP205	0.857

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.512
OR4F29	-0.476
HES5	-0.217
LCN1	-0.201
SPRR2A	-0.187
REN	-0.18
APOA4	-0.174
AADAC	-0.174
TSPY2	-0.172
BTBD17	-0.172

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00030	Insulin Human	BiotechDrug	11061-68-0	Approved\|Investigational	Target
DB00071	Insulin Pork	BiotechDrug	12584-58-6	Approved	Target
DB00626	Bacitracin	Small Molecule	1405-87-4	Approved	Target

ID	Drug Name	Action	PubMed
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of IDE mRNA"	21346803
C457499	2-chloro-5-nitrobenzanilide	2-chloro-5-nitrobenzanilide inhibits the reaction [rosiglitazone results in increased expression of IDE mRNA]	21765445
C457499	2-chloro-5-nitrobenzanilide	2-chloro-5-nitrobenzanilide inhibits the reaction [notoginsenoside R1 results in increased expression of IDE]	25714973
C019499	2-nitrofluorene	2-nitrofluorene results in increased expression of IDE mRNA	15890375
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane affects the expression of IDE mRNA"	18648102
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of IDE mRNA"	21346803
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of IDE mRNA	15890375
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of IDE mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of IDE mRNA]	17585979
D000082	Acetaminophen	Acetaminophen results in increased expression of IDE protein	16538041
D020106	Acrylamide	Acrylamide results in increased expression of IDE mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of IDE mRNA	15890375
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin analog results in decreased expression of IDE protein	26072098
D000535	Aluminum	[APP protein modified form binds to Aluminum] which results in increased expression of IDE mRNA	21298039
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of IDE mRNA	16483693
C015001	arsenite	arsenite results in increased expression of IDE mRNA	18191166
D001280	Atrazine	Atrazine results in decreased expression of IDE mRNA	22378314
C547126	AZM551248	AZM551248 results in decreased expression of IDE mRNA	22323515
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in decreased expression of IDE mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of IDE mRNA	22228805
C006780	bisphenol A	bisphenol A affects the expression of IDE mRNA	21786754
C006780	bisphenol A	bisphenol A affects the expression of IDE mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased expression of IDE mRNA	25181051
D000069286	Bortezomib	Bortezomib results in increased expression of IDE mRNA	20977926
D002211	Capsaicin	Capsaicin affects the expression of IDE protein	22150557
D002211	Capsaicin	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of IDE protein]	22150557
D002211	Capsaicin	Naproxen inhibits the reaction [Capsaicin affects the expression of IDE protein]	22150557
D002211	Capsaicin	Sumatriptan inhibits the reaction [Capsaicin affects the expression of IDE protein]	22150557
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of IDE mRNA	23650126
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of IDE mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of IDE mRNA]	17585979
D003300	Copper	Copper affects the reaction [IDE protein affects the degradation of IAPP protein]	24719342
D003300	Copper	Copper affects the reaction [IDE protein affects the degradation of IAPP protein]	24719342
D003300	Copper	Copper affects the activity of IDE protein	22819648
D003300	Copper	Copper results in decreased activity of IDE protein	24719342
D016572	Cyclosporine	Cyclosporine results in increased expression of IDE mRNA	20106945\|2556210
D003634	DDT	DDT results in decreased activity of IDE protein	25720399
C014347	decitabine	decitabine affects the expression of IDE mRNA	23300844
D003907	Dexamethasone	Dexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of IDE mRNA]	27941970
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of IDE mRNA	21266533
D002945	Cisplatin	Cisplatin affects the expression of IDE mRNA	23300844
D004041	Dietary Fats	Dietary Fats results in decreased expression of IDE mRNA	18042831
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of IDE mRNA	15890375
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of IDE mRNA"	22485181
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of IDE mRNA	15890375
C076126	disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate	"disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate results in increased expression of IDE mRNA"	20184727
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of IDE mRNA	22079256
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IDE mRNA	17942748
D018120	Finasteride	Finasteride results in increased expression of IDE mRNA	24136188
D005419	Flavonoids	Flavonoids results in increased expression of IDE mRNA	18035473
D005485	Flutamide	Flutamide results in decreased expression of IDE mRNA	24793618
D005485	Flutamide	Flutamide results in increased expression of IDE mRNA	24136188
D005947	Glucose	Glucose results in decreased expression of IDE mRNA	17178593
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of IDE mRNA	25613284
C544151	jinfukang	jinfukang results in decreased expression of IDE mRNA	27392435
D048628	Ketolides	Ketolides analog results in decreased expression of IDE mRNA	24967691
C045463	leflunomide	leflunomide results in increased expression of IDE mRNA	24136188
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of IDE mRNA	26378955
D008701	Methapyrilene	Methapyrilene results in increased expression of IDE mRNA	15890375
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of IDE mRNA"	20188158
D015741	Metribolone	Metribolone results in increased expression of IDE protein	17152098
D009288	Naproxen	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of IDE protein]	22150557
D009288	Naproxen	Naproxen inhibits the reaction [Capsaicin affects the expression of IDE protein]	22150557
C051752	nefazodone	nefazodone results in increased expression of IDE mRNA	24136188
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of IDE mRNA	17616710
C072936	notoginsenoside R1	2-chloro-5-nitrobenzanilide inhibits the reaction [notoginsenoside R1 results in increased expression of IDE]	25714973
C072936	notoginsenoside R1	notoginsenoside R1 results in increased expression of IDE	25714973
C108709	oleoyl-estrone	oleoyl-estrone results in decreased expression of IDE mRNA	20184727
D010100	Oxygen	Oxygen deficiency results in increased expression of IDE mRNA	24205000
D010126	Ozone	Ozone results in decreased expression of IDE mRNA	16183385
D000073878	Palm Oil	Palm Oil results in decreased expression of IDE mRNA	18042831
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of IDE mRNA	23892564
D010426	Pentosan Sulfuric Polyester	Pentosan Sulfuric Polyester results in increased expression of IDE mRNA	28973697
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of IDE mRNA	24667235
C031181	phenanthrene	phenanthrene results in increased expression of IDE mRNA	19457238
D010634	Phenobarbital	Phenobarbital affects the expression of IDE mRNA	23091169
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of IDE mRNA	15890375
C006253	pirinixic acid	pirinixic acid results in increased expression of IDE mRNA	23811191
C006253	pirinixic acid	pirinixic acid results in increased expression of IDE mRNA	15890375\|1916217
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of IDE mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of IDE mRNA	22079256
C059514	resveratrol	resveratrol inhibits the reaction [APP protein modified form results in decreased expression of IDE protein]	25654502
C089730	rosiglitazone	2-chloro-5-nitrobenzanilide inhibits the reaction [rosiglitazone results in increased expression of IDE mRNA]	21765445
C089730	rosiglitazone	rosiglitazone results in increased expression of IDE	21765445
C009277	sodium arsenate	sodium arsenate results in increased expression of IDE mRNA	23922661
C009277	sodium arsenate	sodium arsenate results in increased expression of IDE mRNA	21795629
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of IDE mRNA	26378955
D018170	Sumatriptan	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin affects the expression of IDE protein]	22150557
D018170	Sumatriptan	Sumatriptan inhibits the reaction [Capsaicin affects the expression of IDE protein]	22150557
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of IDE mRNA	20044593
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of IDE mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IDE mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of IDE mRNA	20044593
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of IDE mRNA	25613284
D014241	Trichloroethylene	Trichloroethylene results in increased expression of IDE mRNA	19448997
D014241	Trichloroethylene	Trichloroethylene results in increased expression of IDE mRNA	19448997
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of IDE mRNA	19042947
C080163	trovafloxacin	trovafloxacin results in decreased expression of IDE mRNA	24136188
D014415	Tunicamycin	Tunicamycin results in increased expression of IDE mRNA	22378314
D014520	Urethane	Urethane results in decreased expression of IDE mRNA	28818685
C406224	valdecoxib	valdecoxib results in increased expression of IDE mRNA	24136188
D014635	Valproic Acid	Valproic Acid affects the expression of IDE mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased methylation of IDE gene	29154799
D015032	Zinc	Zinc affects the reaction [IDE protein affects the degradation of IAPP protein]	24719342
D015032	Zinc	Zinc affects the reaction [IDE protein affects the degradation of IAPP protein]	24719342
D015032	Zinc	Zinc results in decreased activity of IDE protein	24719342

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0001540	amyloid-beta binding	-	IEA	-
GO:0001618	virus receptor activity	-	IEA	-
GO:0004222	metalloendopeptidase activity	-	IDA	17051221 17613531
GO:0005102	signaling receptor binding	-	IPI	20178365
GO:0005515	protein binding	-	IPI	17055432 17715127 20959807
GO:0005524	ATP binding	-	IDA	17613531
GO:0008270	zinc ion binding	-	IDA	17613531
GO:0016887	ATPase activity	-	IEA	-
GO:0031626	beta-endorphin binding	-	IEA	-
GO:0042277	peptide binding	-	IPI	20082125
GO:0042803	protein homodimerization activity	-	IPI	17613531
GO:0043559	insulin binding	-	IDA	17051221
GO:0043559	insulin binding	-	IPI	20082125
GO:0140036	ubiquitin-dependent protein binding	-	IPI	21185309

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006508	proteolysis	-	IDA	20082125 21185309
GO:0006625	protein targeting to peroxisome	-	TAS	-
GO:0008286	insulin receptor signaling pathway	-	NAS	3059494
GO:0008340	determination of adult lifespan	-	IDA	18448515
GO:0010815	bradykinin catabolic process	-	IDA	17613531 21185309
GO:0010992	ubiquitin recycling	-	IDA	21185309
GO:0032461	positive regulation of protein oligomerization	-	IDA	9830016
GO:0042447	hormone catabolic process	-	IBA	21873635
GO:0042447	hormone catabolic process	-	IEA	-
GO:0043171	peptide catabolic process	-	IBA	21873635
GO:0045732	positive regulation of protein catabolic process	-	TAS	22383525
GO:0045861	negative regulation of proteolysis	-	IEA	-
GO:0046718	viral entry into host cell	-	IEA	-
GO:0050435	amyloid-beta metabolic process	-	IBA	21873635
GO:0050435	amyloid-beta metabolic process	-	IDA	9830016 17613531
GO:0051260	protein homooligomerization	-	IDA	17051221
GO:0051289	protein homotetramerization	-	IEA	-
GO:0051291	protein heterooligomerization	-	IEA	-
GO:0051603	proteolysis involved in cellular protein catabolic process	-	IBA	21873635
GO:0051603	proteolysis involved in cellular protein catabolic process	-	IDA	9830016
GO:0097242	amyloid-beta clearance	-	ISS	-
GO:1901142	insulin metabolic process	-	IDA	18448515
GO:1901143	insulin catabolic process	-	IDA	9231799 9830016

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005615	extracellular space	-	IDA	9830016
GO:0005634	nucleus	-	IDA	9231799 15285718
GO:0005634	nucleus	NOT	IDA	18226493
GO:0005737	cytoplasm	-	IDA	9231799 9830016 18226493
GO:0005739	mitochondrion	-	IBA	21873635
GO:0005739	mitochondrion	-	IDA	15285718
GO:0005777	peroxisome	-	IDA	9231799
GO:0005782	peroxisomal matrix	-	IBA	21873635
GO:0005782	peroxisomal matrix	-	TAS	-
GO:0005829	cytosol	-	IDA	9830016 15285718
GO:0005829	cytosol	-	TAS	-
GO:0005886	plasma membrane	-	IEA	-
GO:0009986	cell surface	-	IDA	17055432
GO:0031597	cytosolic proteasome complex	-	IEA	-

KEGG ID	KEGG Term
hsa05010	Alzheimer's disease

Reactome ID	Reactome Term	Evidence
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-392499	Metabolism of proteins	IEA
R-HSA-5688426	Deubiquitination	TAS
R-HSA-5689880	Ub-specific processing proteases	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-9033241	Peroxisomal protein import	TAS
R-HSA-9033241	Peroxisomal protein import	IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24239421	Re: impact of smoking status on bladder tumor recurrence after radical nephroureterectomy for upper tract urothelial carcinoma: M. Hagiwara, E. Kikuchi, N. Tanaka, K. Matsumoto, H. Ide, A. Miyajima, T. Masuda, S. Nakamura and M. Oya J Urol 2013; 189: 2062-2068. (2014 Feb)	Crivelli JJ	J Urol
27806189	Effect of the Interplay Between Genetic and Behavioral Risks on Survival After Age 75. (2016 Dec)	Rizzuto D	J Am Geriatr Soc
16413443	MOS short form 36 and Oswestry Disability Index outcomes in lumbar fusion: a multicenter experience. (2006 Jan-Feb)	Glassman S	Spine J
17047540	Clinical outcomes and fusion success at 2 years of single-level instrumented posterolateral fusions with recombinant human bone morphogenetic protein-2/compression resistant matrix versus iliac crest bone graft. (2006 Oct 15)	Dimar JR	Spine (Phila Pa 1976)
23384375	Relationships among independent major depressions, alcohol use, and other substance use and related problems over 30 years in 397 families. (2013 Mar)	Schuckit MA	J Stud Alcohol Drugs
17621221	The efficacy of rhBMP-2 for posterolateral lumbar fusion in smokers. (2007 Jul 1)	Glassman SD	Spine (Phila Pa 1976)
28707319	Tenofovir disoproxil fumarate significantly decreases serum lipoprotein levels compared with entecavir nucleos(t)ide analogue therapy in chronic hepatitis B carriers. (2017 Sep)	Shaheen AA	Aliment Pharmacol Ther