Gene: IDH2

3418
D2HGA2|ICD-M|IDH|IDHM|IDP|IDPM|mNADP-IDH
isocitrate dehydrogenase (NADP(+)) 2, mitochondrial
protein-coding
15q26.1
Ensembl:ENSG00000182054 MIM:147650 Vega:OTTHUMG00000149815 UniprotKB:P48735
NG_023302.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.531e-1 (AD)  5.430e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MED290.87
LDHD0.868
G6PC30.866
TMEM1290.858
TTYH10.854
PTPMT10.853
IVD0.853
GLUD10.852
ALDOC0.849
ITM2C0.846

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.692
OR4F29-0.66
RAX2-0.301
SULT1E1-0.292
FER1L6-0.29
GADL1-0.29
FCER2-0.285
C17orf112-0.283
CETP-0.279
SPRR4-0.277

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of IDH2 mRNA"19162173
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of IDH2 mRNA"16984957
C0072572'-deoxyguanosine 5'-phosphateIDH2 protein mutant form results in increased abundance of 2'-deoxyguanosine 5'-phosphate27469509
C0072572'-deoxyguanosine 5'-phosphateTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of 2'-deoxyguanosine 5'-phosphate]27469509
C0230353,4,5,3',4'-pentachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of IDH2 mRNA"16984957
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of IDH2 mRNA"16984957
C1039303-dehydrocarnitineIDH2 protein mutant form results in increased abundance of 3-dehydrocarnitine27469509
C1039303-dehydrocarnitineTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of 3-dehydrocarnitine]27469509
C0051563-phosphoglycerateIDH2 protein mutant form results in increased abundance of 3-phosphoglycerate27469509
C0051563-phosphoglycerateTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of 3-phosphoglycerate]27469509
C0118655-hydroxymethylcytosineIDH2 protein mutant form results in decreased abundance of 5-hydroxymethylcytosine27469509
C0085005'-methylthioadenosineIDH2 protein mutant form results in increased abundance of 5'-methylthioadenosine27469509
C0085005'-methylthioadenosineTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of 5'-methylthioadenosine]27469509
C0088846-phosphogluconic acidIDH2 protein mutant form results in increased abundance of 6-phosphogluconic acid27469509
C0088846-phosphogluconic acidTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of 6-phosphogluconic acid]27469509
D000082AcetaminophenAcetaminophen results in increased expression of IDH2 mRNA25704631
D000108AcetylcarnitineIDH2 protein mutant form results in increased abundance of Acetylcarnitine27469509
D000108AcetylcarnitineTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Acetylcarnitine]27469509
D000156Aconitic AcidIDH2 protein mutant form results in increased abundance of Aconitic Acid27469509
D000156Aconitic AcidTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Aconitic Acid]27469509
D000241AdenosineIDH2 protein mutant form results in increased abundance of Adenosine27469509
D000241AdenosineTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Adenosine]27469509
D000242Cyclic AMPIDH2 protein mutant form results in increased abundance of Cyclic AMP27469509
D000242Cyclic AMPTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Cyclic AMP]27469509
D000244Adenosine DiphosphateIDH2 protein mutant form results in increased abundance of Adenosine Diphosphate27469509
D000244Adenosine DiphosphateTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Adenosine Diphosphate]27469509
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of IDH2 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of IDH2 mRNA19770486
C581155AGI-6780AGI-6780 binds to and results in decreased activity of IDH2 protein25391653
D000409AlanineIDH2 protein mutant form results in decreased abundance of Alanine27469509
D000409AlanineTriazines inhibits the reaction [IDH2 protein mutant form results in decreased abundance of Alanine]27469509
D019386AlendronateAlendronate affects the expression of IDH2 mRNA16079270
C029620alpha-glycerophosphoric acidIDH2 protein mutant form results in increased abundance of alpha-glycerophosphoric acid27469509
C029620alpha-glycerophosphoric acidTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of alpha-glycerophosphoric acid]27469509
C019417alpha-hydroxyglutarateIDH2 protein mutant form results in increased abundance of alpha-hydroxyglutarate27469509
C019417alpha-hydroxyglutarateTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of alpha-hydroxyglutarate]27469509
C019417alpha-hydroxyglutarateIDH2 protein mutant form results in increased abundance of alpha-hydroxyglutarate25895133
C029743alpha-ketoglutaric acidIDH2 protein results in increased carboxylation of alpha-ketoglutaric acid23504317
D000535AluminumAluminum results in decreased activity of IDH2 protein15486972
D000638AmiodaroneAmiodarone results in increased expression of IDH2 mRNA24489787
D001125Argininosuccinic AcidIDH2 protein mutant form results in decreased abundance of Argininosuccinic Acid27469509
D001125Argininosuccinic AcidTriazines inhibits the reaction [IDH2 protein mutant form results in decreased abundance of Argininosuccinic Acid]27469509
D001151ArsenicArsenic affects the methylation of IDH2 gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of IDH2 protein25419056
C547126AZM551248AZM551248 results in increased expression of IDH2 mRNA22323515
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of IDH2 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IDH2 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IDH2 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of IDH2 mRNA"19150397
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of IDH2 mRNA26496021
D001622BetaineIDH2 protein mutant form results in increased abundance of Betaine27469509
D001622BetaineTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Betaine]27469509
D001663BilirubinBilirubin results in decreased expression of IDH2 mRNA20196124
C006780bisphenol Abisphenol A results in increased expression of IDH2 mRNA28159858
C006780bisphenol Abisphenol A affects the expression of IDH2 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of IDH2 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of IDH2 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of IDH2 mRNA26496021
C423844BL 11282BL 11282 results in increased expression of IDH2 protein17458497
D001761BleomycinBleomycin results in decreased expression of IDH2 protein25933445
D020122tert-Butylhydroperoxideresveratrol inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of IDH2 protein]25522270
D020122tert-ButylhydroperoxideSIRT3 mutant form inhibits the reaction [resveratrol inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of IDH2 protein]]25522270
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased activity of IDH2 protein25522270
C427065butyrylcarnitineIDH2 protein mutant form results in increased abundance of butyrylcarnitine27469509
C427065butyrylcarnitineTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of butyrylcarnitine]27469509
C584509C646 compoundC646 compound results in increased expression of IDH2 mRNA26191083
D002104CadmiumCadmium affects the folding of IDH2 protein16785314
D002104CadmiumCadmium binds to IDH2 protein16785314
D002104CadmiumCadmium results in decreased activity of IDH2 protein16785314
D002104CadmiumDithiothreitol inhibits the reaction [Cadmium results in decreased activity of IDH2 protein]16785314
D002104CadmiumGlutathione inhibits the reaction [Cadmium results in decreased activity of IDH2 protein]16785314
D002104CadmiumIDH2 protein inhibits the reaction [Cadmium results in decreased activity of GLRX protein]16785314
D002104CadmiumIDH2 protein results in decreased susceptibility to Cadmium16785314
D002104Cadmium[oxalomalic acid results in decreased activity of IDH2 protein] which results in increased susceptibility to Cadmium16785314
D019256Cadmium ChlorideCadmium Chloride affects the folding of IDH2 protein16785314
D019256Cadmium ChlorideCadmium Chloride binds to IDH2 protein16785314
D019256Cadmium ChlorideCadmium Chloride results in decreased activity of IDH2 protein16785314
D019256Cadmium ChlorideDithiothreitol inhibits the reaction [Cadmium Chloride results in decreased activity of IDH2 protein]16785314
D019256Cadmium ChlorideGlutathione inhibits the reaction [Cadmium Chloride results in decreased activity of IDH2 protein]16785314
D019256Cadmium ChlorideIDH2 protein inhibits the reaction [Cadmium Chloride results in decreased activity of GLRX protein]16785314
D019256Cadmium ChlorideIDH2 protein results in decreased susceptibility to Cadmium Chloride16785314
D019256Cadmium Chloride[oxalomalic acid results in decreased activity of IDH2 protein] which results in increased susceptibility to Cadmium Chloride16785314
D002331CarnitineIDH2 protein mutant form results in increased abundance of Carnitine27469509
D002331CarnitineTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Carnitine]27469509
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of IDH2 gene20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of IDH2 mRNA28472532
C018021cobaltous chloridecobaltous chloride results in decreased expression of IDH2 mRNA19320972|1937684
D009243NADIDH2 protein mutant form results in increased abundance of NAD27469509
D009243NADIDH2 protein mutant form results in increased abundance of NAD metabolite27469509
D009243NADTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of NAD]27469509
D009243NADTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of NAD metabolite]27469509
D009249NADPIDH2 protein mutant form results in increased abundance of NADP27469509
D009249NADPTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of NADP]27469509
D019327Copper SulfateCopper Sulfate results in decreased expression of IDH2 mRNA19549813
D003404CreatinineIDH2 protein mutant form results in increased abundance of Creatinine27469509
D003404CreatinineTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Creatinine]27469509
C029892cupric chloridecupric chloride results in decreased expression of IDH2 protein21641295
C009160cyclonitecyclonite results in increased expression of IDH2 mRNA20965580
D016572CyclosporineCyclosporine results in decreased expression of IDH2 mRNA20106945|2556210
D003562CytidineIDH2 protein mutant form results in increased abundance of Cytidine27469509
D003562CytidineTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Cytidine]27469509
D003843Deoxycytidine MonophosphateIDH2 protein mutant form results in increased abundance of Deoxycytidine Monophosphate27469509
D003843Deoxycytidine MonophosphateTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Deoxycytidine Monophosphate]27469509
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of IDH2 mRNA]27941970
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of IDH2 mRNA27392435
D002945CisplatinCisplatin results in increased expression of IDH2 mRNA27392435|2759478
D004008DiclofenacDiclofenac results in decreased expression of IDH2 mRNA26934552
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in increased expression of IDH2 mRNA18313992
D004041Dietary FatsDietary Fats results in increased expression of IDH2 mRNA18042831
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in decreased expression of IDH2 mRNA21852083
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of IDH2 mRNA21318169
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of IDH2 mRNA17854601
D004052DiethylnitrosamineRB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of IDH2 mRNA]17854601
D004099Dihydroxyacetone PhosphateIDH2 protein mutant form results in increased abundance of Dihydroxyacetone Phosphate27469509
D004099Dihydroxyacetone PhosphateTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Dihydroxyacetone Phosphate]27469509
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of IDH2 mRNA"22485181
D004147DioxinsDioxins affects the expression of IDH2 mRNA20463971
D004229DithiothreitolDithiothreitol inhibits the reaction [Cadmium Chloride results in decreased activity of IDH2 protein]16785314
D004229DithiothreitolDithiothreitol inhibits the reaction [Cadmium results in decreased activity of IDH2 protein]16785314
D004237DiuronDiuron results in increased expression of IDH2 mRNA21551480
C067311docetaxel[docetaxel co-treated with Doxorubicin] results in decreased expression of IDH2 protein20457137
D004317Doxorubicin[docetaxel co-treated with Doxorubicin] results in decreased expression of IDH2 protein20457137
D004317DoxorubicinDoxorubicin results in decreased expression of IDH2 mRNA26873546
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of IDH2 mRNA24534155
D004837Epinephrine[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of IDH2 protein19464573
D004837EpinephrineEpinephrine results in decreased expression of IDH2 protein19464573
C026959erythrose 4-phosphateIDH2 protein mutant form results in increased abundance of erythrose 4-phosphate27469509
C026959erythrose 4-phosphateTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of erythrose 4-phosphate]27469509
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of IDH2 mRNA16079270
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of IDH2 mRNA17557909
D005486Flavin MononucleotideIDH2 protein mutant form results in increased abundance of Flavin Mononucleotide27469509
D005486Flavin MononucleotideTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Flavin Mononucleotide]27469509
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of IDH2 gene20938992
C029063fructose-1,6-diphosphate"IDH2 protein mutant form results in increased abundance of fructose-1,6-diphosphate"27469509
C029063fructose-1,6-diphosphate"Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of fructose-1,6-diphosphate]"27469509
C002889gamma-butyrobetaineIDH2 protein mutant form results in increased abundance of gamma-butyrobetaine27469509
C002889gamma-butyrobetaineTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of gamma-butyrobetaine]27469509
C001293glucosamine 6-phosphateIDH2 protein mutant form results in increased abundance of glucosamine 6-phosphate27469509
C001293glucosamine 6-phosphateTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of glucosamine 6-phosphate]27469509
C031590glucose-1-phosphateIDH2 protein mutant form results in increased abundance of glucose-1-phosphate27469509
C031590glucose-1-phosphateTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of glucose-1-phosphate]27469509
D005978GlutathioneIDH2 protein mutant form results in increased abundance of Glutathione27469509
D005978GlutathioneTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Glutathione]27469509
D005978GlutathioneGlutathione inhibits the reaction [Cadmium Chloride results in decreased activity of IDH2 protein]16785314
D005978GlutathioneGlutathione inhibits the reaction [Cadmium results in decreased activity of IDH2 protein]16785314
C042971glyceric acidIDH2 protein mutant form results in increased abundance of glyceric acid27469509
C042971glyceric acidTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of glyceric acid]27469509
C071834glycidamideglycidamide results in decreased expression of IDH2 mRNA17822822
D006147GuanineIDH2 protein mutant form results in increased abundance of Guanine27469509
D006147GuanineTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Guanine]27469509
C100085guanosine diphosphate glucoseIDH2 protein mutant form results in increased abundance of guanosine diphosphate glucose27469509
C100085guanosine diphosphate glucoseTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of guanosine diphosphate glucose]27469509
D006820Hyaluronic AcidHyaluronic Acid analog results in decreased expression of IDH2 protein23178681
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of IDH2 protein23178681
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IDH2 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of IDH2 mRNA27392435
C544151jinfukangjinfukang results in increased expression of IDH2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IDH2 mRNA23086925
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of IDH2 mRNA24332044
C410337K 7174K 7174 results in decreased expression of IDH2 mRNA24086573
D007657Ketone BodiesKetone Bodies results in increased expression of IDH2 mRNA16807920
D019344Lactic AcidIDH2 protein mutant form results in increased abundance of Lactic Acid27469509
D019344Lactic AcidTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Lactic Acid]27469509
C052901lemongrass oillemongrass oil affects the expression of IDH2 mRNA25976427
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of IDH2 mRNA"24972896
C030298malic acidIDH2 protein mutant form results in decreased abundance of malic acid27469509
C030298malic acidTriazines inhibits the reaction [IDH2 protein mutant form results in decreased abundance of malic acid]27469509
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of IDH2 gene20938992
D008748MethylcholanthreneMethylcholanthrene promotes the reaction [AHR protein binds to IDH2 promoter]20348232
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of IDH2 mRNA16966085
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of IDH2 mRNA"20188158
D008777MethyltestosteroneMethyltestosterone results in increased expression of IDH2 mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of IDH2 mRNA"25620056
C022838nickel chloridenickel chloride results in increased activity of IDH2 protein17018869
C008472N-methylnicotinamideIDH2 protein mutant form results in increased abundance of N-methylnicotinamide27469509
C008472N-methylnicotinamideTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of N-methylnicotinamide]27469509
C015407oxalomalic acidoxalomalic acid results in decreased activity of IDH2 protein16785314
C015407oxalomalic acid[oxalomalic acid results in decreased activity of IDH2 protein] which results in increased susceptibility to Cadmium16785314
C015407oxalomalic acid[oxalomalic acid results in decreased activity of IDH2 protein] which results in increased susceptibility to Cadmium Chloride16785314
D017239PaclitaxelIDH2 protein affects the susceptibility to Paclitaxel16217747
D017239PaclitaxelPaclitaxel results in decreased expression of IDH2 mRNA15000894
D000073878Palm OilPalm Oil results in increased expression of IDH2 mRNA18042831
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of IDH2 mRNA23948077
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of IDH2 mRNA23427857
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of IDH2 mRNA19162173
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of IDH2 mRNA17097637
D010578PetroleumPetroleum affects the expression of IDH2 mRNA25208076
D010634PhenobarbitalPhenobarbital affects the expression of IDH2 mRNA19159669
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of IDH2 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of IDH2 mRNA19482888
D010634PhenobarbitalPhenobarbital results in increased expression of IDH2 mRNA19162173
D010695PhlorhizinPhlorhizin results in increased expression of IDH2 mRNA22538082
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of IDH2 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of IDH2 mRNA21318169
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of IDH2 mRNA]21318169
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of IDH2 mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of IDH2 mRNA28903501
C100573prostaglandin A1prostaglandin A1 analog results in increased metabolism of IDH2 protein19800325
C513428pyrachlostrobinpyrachlostrobin results in increased expression of IDH2 mRNA27029645
D019289Pyruvic AcidIDH2 protein mutant form results in increased abundance of Pyruvic Acid27469509
D019289Pyruvic AcidTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Pyruvic Acid]27469509
D020849Raloxifene HydrochlorideESR1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of IDH2 mRNA]14699072
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of IDH2 mRNA14699072
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of IDH2 mRNA19059307
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of IDH2 mRNA16079270
C059514resveratrolresveratrol inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of IDH2 protein]25522270
C059514resveratrolSIRT3 mutant form inhibits the reaction [resveratrol inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of IDH2 protein]]25522270
C059514resveratrolresveratrol results in increased expression of IDH2 protein25505154
C059514resveratrolresveratrol results in increased expression of IDH2 mRNA25905778
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in decreased expression of IDH2 mRNA21852083
C022079sedoheptulose 1,7-bisphosphate"IDH2 protein mutant form results in increased abundance of sedoheptulose 1,7-bisphosphate"27469509
C022079sedoheptulose 1,7-bisphosphate"Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of sedoheptulose 1,7-bisphosphate]"27469509
D012715Sesame OilSesame Oil results in decreased expression of IDH2 mRNA29191790
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of IDH2 mRNA25895662
C017947sodium arsenitesodium arsenite results in decreased expression of and affects the splicing of IDH2 mRNA25879800
D012969Sodium FluorideSodium Fluoride results in decreased expression of IDH2 mRNA27862939
D012969Sodium FluorideSodium Fluoride results in decreased expression of IDH2 protein27548804
D012999SomanSoman results in decreased expression of IDH2 mRNA19281266
D013096SpermineIDH2 protein mutant form results in increased abundance of Spermine27469509
D013096SpermineTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Spermine]27469509
D013311StreptozocinStreptozocin affects the expression of IDH2 mRNA18583417
D013629TamoxifenTamoxifen affects the expression of IDH2 mRNA14699072
D013629Tamoxifen[Tamoxifen co-treated with ESR1 protein] results in increased expression of IDH2 mRNA19059307
D013654TaurineIDH2 protein mutant form results in increased abundance of Taurine27469509
D013654TaurineTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Taurine]27469509
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IDH2 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IDH2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IDH2 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IDH2 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IDH2 mRNA25613284
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of IDH2 protein"25852303
D013938Thymidine MonophosphateIDH2 protein mutant form results in increased abundance of Thymidine Monophosphate27469509
D013938Thymidine MonophosphateTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Thymidine Monophosphate]27469509
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of IDH2 mRNA28065790
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased abundance of Alanine]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased abundance of Argininosuccinic Acid]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased abundance of malic acid]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of AQP4 mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of AS3MT mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of ASB5 mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of CENPF mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of CHRM2 mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of CLU mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of CNTN2 mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of DBH mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of DOC2G mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of FGF16 mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of GNMT mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of GSTK1 mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of HK1 mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of HOPX mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of IRX5 mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of KBTBD13 mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of KCNE1 mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of LAMB3 mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of LGI1 mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of MTR mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of NAPRT mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of RANGRF mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of RPL3L mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of SEC31B mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of SLC17A7 mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of SLC38A4 mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of SLC47A1 mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of SLC7A1 mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of THBS4 mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of TMOD4 mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in decreased expression of WFIKKN2 mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of 2'-deoxyguanosine 5'-phosphate]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of 3-dehydrocarnitine]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of 3-phosphoglycerate]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of 5'-methylthioadenosine]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of 6-phosphogluconic acid]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Acetylcarnitine]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Aconitic Acid]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Adenosine]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Adenosine Diphosphate]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of alpha-glycerophosphoric acid]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of alpha-hydroxyglutarate]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Betaine]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of butyrylcarnitine]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Carnitine]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Creatinine]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Cyclic AMP]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Cytidine]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Deoxycytidine Monophosphate]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Dihydroxyacetone Phosphate]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of erythrose 4-phosphate]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Flavin Mononucleotide]27469509
D014227Triazines"Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of fructose-1,6-diphosphate]"27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of gamma-butyrobetaine]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of glucosamine 6-phosphate]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of glucose-1-phosphate]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Glutathione]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of glyceric acid]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Guanine]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of guanosine diphosphate glucose]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Lactic Acid]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of NAD]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of NAD metabolite]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of NADP]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of N-methylnicotinamide]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Pantothenic Acid]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Pyruvic Acid]27469509
D014227Triazines"Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of sedoheptulose 1,7-bisphosphate]"27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Spermine]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Taurine]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Thymidine Monophosphate]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Uridine]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Uridine Diphosphate]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Uridine Diphosphate N-Acetylglucosamine]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased expression of ACACA mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased expression of ACTA1 mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased expression of CAMK2B mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased expression of CAR3 mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased expression of CDH4 mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased expression of EPHB2 mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased expression of GDPD3 mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased expression of GSTA1 mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased expression of GSTA2 mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased expression of HDDC3 mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased expression of HSPA1A mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased expression of HSPA1B mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased expression of MET mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased expression of MTTP mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased expression of MYH4 mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased expression of NMRK2 mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased expression of PDE3B mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased expression of SIX1 mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased expression of SNTB1 mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased expression of TNNC2 mRNA]27469509
D014227TriazinesTriazines inhibits the reaction [IDH2 protein mutant form results in increased expression of WISP2 mRNA]27469509
C080163trovafloxacintrovafloxacin results in decreased expression of IDH2 mRNA24136188
D014415TunicamycinTunicamycin results in decreased expression of IDH2 mRNA20196124
D014529UridineIDH2 protein mutant form results in increased abundance of Uridine27469509
D014529UridineTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Uridine]27469509
D014530Uridine DiphosphateIDH2 protein mutant form results in increased abundance of Uridine Diphosphate27469509
D014530Uridine DiphosphateTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Uridine Diphosphate]27469509
D014537Uridine Diphosphate N-AcetylglucosamineIDH2 protein mutant form results in increased abundance of Uridine Diphosphate N-Acetylglucosamine27469509
D014537Uridine Diphosphate N-AcetylglucosamineTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Uridine Diphosphate N-Acetylglucosamine]27469509
D014635Valproic AcidValproic Acid results in decreased expression of IDH2 mRNA19101580|2915479
D014635Valproic AcidValproic Acid results in increased expression of IDH2 mRNA24383497
D014638VanadatesVanadates results in increased expression of IDH2 mRNA22714537
D014747VinblastineIDH2 protein affects the susceptibility to Vinblastine16217747
D010205Pantothenic AcidIDH2 protein mutant form results in increased abundance of Pantothenic Acid27469509
D010205Pantothenic AcidTriazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Pantothenic Acid]27469509
C009680VXVX results in decreased activity of IDH2 protein28267914
D014874Water Pollutants, Chemical"Water Pollutants, Chemical affects the expression of IDH2 mRNA"25208076
D019820Xanthine[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of IDH2 protein19464573
D019820Xanthine[Xanthine co-treated with XDH protein] results in decreased expression of IDH2 protein19464573
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in increased expression of IDH2 mRNA18313992
C088658zoledronic acidzoledronic acid results in decreased expression of IDH2 mRNA24714768
C088658zoledronic acidzoledronic acid results in increased expression of IDH2 protein28871336

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-ISS-  
GO:0004450isocitrate dehydrogenase (NADP+) activity-EXP18806796  
GO:0004450isocitrate dehydrogenase (NADP+) activity-IDA23226729  
GO:0004450isocitrate dehydrogenase (NADP+) activity-ISS-  
GO:0051287NAD binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005975carbohydrate metabolic process-NAS8954790  
GO:0006097glyoxylate cycle-IEA-  
GO:0006099tricarboxylic acid cycle-TAS-  
GO:0006102isocitrate metabolic process-ISS-  
GO:00061032-oxoglutarate metabolic process-ISS-  
GO:0006741NADP biosynthetic process-IEA-  
GO:0060253negative regulation of glial cell proliferation-IEA-  
GO:1903976negative regulation of glial cell migration-IEA-  
GO:1904465negative regulation of matrix metallopeptidase secretion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-HDA20833797  
GO:0005739mitochondrion-IDA-  
GO:0005759mitochondrial matrix-TAS-  
GO:0005777peroxisome-IEA-  
GO:0005829cytosol-IEA-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa00020Citrate cycle (TCA cycle)
hsa00480Glutathione metabolism
hsa01100Metabolic pathways
hsa04146Peroxisome
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-1592230Mitochondrial biogenesisTAS
R-HSA-1852241Organelle biogenesis and maintenanceTAS
R-HSA-2151201Transcriptional activation of mitochondrial biogenesisTAS
R-HSA-71403Citric acid cycle (TCA cycle)TAS
R-HSA-71406Pyruvate metabolism and Citric Acid (TCA) cycleTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29723602Non-small cell lung cancers with Isocitrate dehydrogenase 1 or 2 (IDH1/2) mutations. (2018 Apr 30)Toth LNHum Pathol
22387199Genetic variation in antioxidant enzymes and lung function. (2012 May 1)Bentley ARFree Radic Biol Med