Gene: IDH3A

3419
-
isocitrate dehydrogenase 3 (NAD(+)) alpha
protein-coding
15q25.1
Ensembl:ENSG00000166411 MIM:601149 Vega:OTTHUMG00000143732 UniprotKB:P50213
NC_000015.10
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.253e-1 (AD)  3.118e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FTO0.939
TBRG10.938
PITPNB0.935
USP320.935
FBXO110.932
BECN10.921
MTPN0.916
SMAP10.906
ZFYVE90.904
G3BP20.902

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.439
OR4F5-0.439
CSAG1-0.401
STON2-0.397
AKR1C3-0.393
RNF135-0.386
OLAH-0.369
MTRNR2L10-0.368
FXYD3-0.365
HIST1H1C-0.363

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of IDH3A mRNA"26377693
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of IDH3A mRNA"20453058
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of IDH3A mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of IDH3A mRNA"21346803
C0158022,6-dichloro-4-nitrophenol"2,6-dichloro-4-nitrophenol results in decreased expression of IDH3A mRNA"11227219
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of IDH3A mRNA"21346803
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of IDH3A mRNA]"19467301
C5756314-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile"4-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile affects the expression of IDH3A mRNA"21218783
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDH3A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDH3A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDH3A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDH3A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDH3A mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDH3A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDH3A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDH3A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDH3A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDH3A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDH3A mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDH3A mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of IDH3A mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of IDH3A mRNA17562736
C027696acipimoxacipimox results in increased expression of IDH3A mRNA25352640
D020106AcrylamideAcrylamide results in increased expression of IDH3A mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of IDH3A mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of IDH3A protein24211421
D000643Ammonium ChlorideAmmonium Chloride affects the expression of IDH3A mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of IDH3A mRNA24449571
D047310ApigeninApigenin results in decreased expression of IDH3A mRNA22359648
D001151ArsenicArsenic affects the methylation of IDH3A gene25304211
C487081belinostatbelinostat results in increased expression of IDH3A mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDH3A mRNA"27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IDH3A mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of IDH3A gene25435355
D001564Benzo(a)pyrene[Soot co-treated with Benzo(a)pyrene] results in decreased expression of IDH3A protein24464499
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of IDH3A mRNA]22228805
D004958EstradiolEstradiol promotes the reaction [IDH3A protein binds to ESR1 protein]27156127
D004958EstradiolEstradiol results in decreased expression of IDH3A mRNA19484750
C006780bisphenol Abisphenol A affects the expression of IDH3A mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of IDH3A mRNA26063408
C006780bisphenol Abisphenol A results in increased expression of IDH3A protein24909818
C006780bisphenol Abisphenol A results in decreased expression of IDH3A mRNA25181051
C025703bleomycetinbleomycetin results in decreased expression of IDH3A mRNA21040473
C013418bromfenacoumbromfenacoum results in increased expression of IDH3A protein28903499
C055494caffeic acid phenethyl ester[caffeic acid phenethyl ester co-treated with Dietary Fats] results in increased expression of IDH3A mRNA28223344
C055494caffeic acid phenethyl esterNR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in increased expression of IDH3A mRNA]28223344
D002220CarbamazepineCarbamazepine affects the expression of IDH3A mRNA25979313
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of IDH3A mRNA23650126
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of IDH3A mRNA18804290
D002994ClofibrateClofibrate results in increased expression of IDH3A protein16470657
D003042CocaineCocaine affects the expression of IDH3A mRNA20187946
D003300CopperIDH3A protein binds to Copper15359738
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of IDH3A mRNA20971185
D003300CopperCopper deficiency results in increased expression of IDH3A protein18993053
C017160cypermethrincypermethrin results in decreased expression of IDH3A protein21561882
D003907Dexamethasone[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of IDH3A mRNA23428407
D064730Dexrazoxane[Doxorubicin co-treated with Dexrazoxane] results in increased expression of IDH3A mRNA26873546
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in increased expression of IDH3A mRNA18313992
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of IDH3A mRNA]"19467301
D004041Dietary Fats[caffeic acid phenethyl ester co-treated with Dietary Fats] results in increased expression of IDH3A mRNA28223344
D004041Dietary FatsDietary Fats results in increased expression of IDH3A mRNA19467301
D004041Dietary FatsNR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in increased expression of IDH3A mRNA]28223344
D004147DioxinsDioxins affects the expression of IDH3A mRNA20463971
D007980Levodopa"Levodopa inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IDH3A protein]"23562983
D007980LevodopaLevodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IDH3A protein]23562983
D004317Doxorubicin[Doxorubicin co-treated with Dexrazoxane] results in increased expression of IDH3A mRNA26873546
D004317DoxorubicinDoxorubicin results in decreased expression of IDH3A mRNA26873546
D004317DoxorubicinDoxorubicin results in decreased expression of IDH3A protein26873546
D004317DoxorubicinDoxorubicin results in increased expression of IDH3A protein21251210
D004317Doxorubicinsodium nitrate inhibits the reaction [Doxorubicin results in increased expression of IDH3A protein]21251210
C118739entinostatentinostat results in increased expression of IDH3A mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDH3A mRNA"27188386
D000431EthanolEthanol results in decreased expression of IDH3A mRNA24355176
D015025ZearalenoneZearalenone results in increased expression of IDH3A protein25058043
D005419FlavonoidsFlavonoids results in decreased expression of IDH3A mRNA18035473
D005485FlutamideFlutamide results in decreased expression of IDH3A mRNA24793618
D005485FlutamideFlutamide results in increased expression of IDH3A mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of IDH3A mRNA23649840
C039281furanfuran results in increased methylation of IDH3A gene22079235
D017313FenretinideFenretinide results in decreased expression of IDH3A mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of IDH3A protein24211421
C503753Indolinone AIndolinone A results in increased phosphorylation of IDH3A protein15838870
D0150561-Methyl-3-isobutylxanthine[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of IDH3A mRNA23428407
D007854LeadLead affects the expression of IDH3A mRNA28903495
C052901lemongrass oillemongrass oil affects the expression of IDH3A mRNA25976427
D008344ManebLevodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IDH3A protein]23562983
D008344Maneb[Maneb co-treated with Paraquat] results in increased expression of IDH3A protein23562983
D008344Manebtetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IDH3A protein]23562983
D008345ManganeseManganese binds to IDH3A protein16737955
C042720mercuric bromidemercuric bromide results in increased expression of IDH3A mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDH3A mRNA"27188386
D008694MethamphetamineMethamphetamine results in decreased expression of IDH3A protein19826936
D008727MethotrexateMethotrexate affects the expression of IDH3A mRNA18502557
D008748MethylcholanthreneMethylcholanthrene results in increased expression of IDH3A mRNA18804290
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of IDH3A mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of IDH3A mRNA23649840
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IDH3A protein"23562983
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Levodopa inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IDH3A protein]"23562983
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IDH3A protein]"23562983
D008777MethyltestosteroneMethyltestosterone results in decreased expression of IDH3A mRNA29191790
C063855microcystin RRmicrocystin RR results in increased expression of IDH3A protein19111056
D008942MitoxantroneIDH3A protein affects the susceptibility to Mitoxantrone16217747
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of IDH3A mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of IDH3A mRNA"25554681|2562005
D009532NickelNickel results in decreased expression of IDH3A mRNA25583101
D009532NickelNickel results in decreased expression of IDH3A mRNA24084258
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of IDH3A mRNA17616710
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of IDH3A mRNA20971185
D016627OxidopamineOxidopamine results in decreased expression of IDH3A mRNA19763263
D010126OzoneOzone results in increased expression of IDH3A mRNA25838073
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDH3A mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of IDH3A mRNA26272509
D010269ParaquatLevodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IDH3A protein]23562983
D010269Paraquat[Maneb co-treated with Paraquat] results in increased expression of IDH3A protein23562983
D010269Paraquattetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IDH3A protein]23562983
D010416PentachlorophenolPentachlorophenol results in increased expression of IDH3A mRNA23892564
D010426Pentosan Sulfuric PolyesterPentosan Sulfuric Polyester results in decreased expression of IDH3A mRNA28973697
C522391perfluorododecanoic acidperfluorododecanoic acid results in decreased expression of IDH3A protein26168851
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of IDH3A protein26879310
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDH3A mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of IDH3A mRNA26272509
D010695PhlorhizinPhlorhizin results in decreased expression of IDH3A mRNA22538082
C006253pirinixic acidpirinixic acid results in increased expression of IDH3A mRNA18301758
D010894PiroxicamPiroxicam results in decreased expression of IDH3A mRNA21858171
C015586propiverinepropiverine binds to IDH3A protein29273565
C059514resveratrolresveratrol results in increased expression of IDH3A protein25505154
C089730rosiglitazonerosiglitazone affects the expression of IDH3A mRNA22013433
C089730rosiglitazonerosiglitazone results in increased expression of IDH3A mRNA19201733
D012402RotenoneRotenone results in decreased expression of IDH3A protein19763263
D012402RotenoneRotenone results in increased expression of IDH3A protein19763263
C080703SK&F 83959SK&F 83959 affects the expression of IDH3A protein25852303
D012969Sodium FluorideSodium Fluoride results in decreased expression of IDH3A protein27548804
C031618sodium nitratesodium nitrate inhibits the reaction [Doxorubicin results in increased expression of IDH3A protein]21251210
D053260Soot[Soot co-treated with Benzo(a)pyrene] results in decreased expression of IDH3A protein24464499
D013605T-2 ToxinT-2 Toxin affects the expression of IDH3A protein26141394
D013739TestosteroneTestosterone deficiency results in decreased expression of IDH3A mRNA21045173
D013739TestosteroneTestosterone inhibits the reaction [Testosterone deficiency results in decreased expression of IDH3A mRNA]21045173
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of IDH3A mRNA25975270
D013749TetrachlorodibenzodioxinAHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of IDH3A mRNA]21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IDH3A mRNA21215274
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine affects the expression of IDH3A protein"25852303
C050950tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex"tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IDH3A protein]"23562983
C050950tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complextetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IDH3A protein]23562983
D019284ThapsigarginThapsigargin results in increased expression of IDH3A mRNA22378314
C011559tributyltinIDH3A protein affects the reaction [tributyltin results in decreased expression of CCNB1 protein]26961604
C011559tributyltinIDH3A protein affects the reaction [tributyltin results in decreased expression of CDC25C protein]26961604
C011559tributyltintributyltin results in increased expression of IDH3A mRNA23428407
C012589trichostatin Atrichostatin A affects the expression of IDH3A mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of IDH3A mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of IDH3A mRNA19042947
D014415TunicamycinTunicamycin results in increased expression of IDH3A mRNA22378314
C501517UCF 101UCF 101 results in increased expression of IDH3A protein19763263
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDH3A mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of IDH3A mRNA23179753|2438349
D014635Valproic AcidValproic Acid affects the expression of IDH3A mRNA17292431|1796380
C111237vorinostatvorinostat results in increased expression of IDH3A protein17593366
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in increased expression of IDH3A mRNA18313992

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IDA28098230  
GO:0004449isocitrate dehydrogenase (NAD+) activity-IDA28098230  
GO:0051287NAD binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005975carbohydrate metabolic process-NAS8833160  
GO:0006099tricarboxylic acid cycle-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-HDA21630459  
GO:0005739mitochondrion-IDA-  
GO:0005759mitochondrial matrix-TAS-  
GO:0043209myelin sheath-IEA-  
KEGG ID KEGG Term
hsa00020Citrate cycle (TCA cycle)
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-71403Citric acid cycle (TCA cycle)TAS
R-HSA-71406Pyruvate metabolism and Citric Acid (TCA) cycleTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22387199Genetic variation in antioxidant enzymes and lung function. (2012 May 1)Bentley ARFree Radic Biol Med