Gene: IDH3B

3420
RP46
isocitrate dehydrogenase 3 (NAD(+)) beta
protein-coding
20p13
Ensembl:ENSG00000101365 MIM:604526 Vega:OTTHUMG00000031699 UniprotKB:O43837
NG_012149.1
PubMed
0   ANCO-SNPs
ND
2   
3.472e-1 (AD)  2.702e-1 (ND)   (Frontal_Cortex)
3.868e-1 (AD)  7.841e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DCTN20.976
LRRC470.975
MDH20.974
USP50.971
AP2M10.97
ABCF30.97
NDUFA100.97
NDUFS20.969
ATP6V1E10.968
PSMD30.967

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.71
OR4F29-0.665
MTRNR2L6-0.406
MTRNR2L9-0.392
MTRNR2L10-0.37
KCNJ15-0.361
KLRB1-0.356
CXCR2-0.354
TFPI2-0.352
RAI14-0.349

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of IDH3B mRNA"20206263
C5756314-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile"4-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile affects the expression of IDH3B mRNA"21218783
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of IDH3B mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of IDH3B mRNA25704631|2906747
D000082AcetaminophenAcetaminophen affects the expression of IDH3B mRNA17562736
C027696acipimoxacipimox results in decreased expression of IDH3B mRNA25352640
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of IDH3B gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of IDH3B mRNA16483693
C023650anilineaniline results in increased expression of IDH3B mRNA22016648
C006780bisphenol Abisphenol A affects the expression of IDH3B mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of IDH3B mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of IDH3B gene28505145
D019256Cadmium ChlorideCadmium Chloride results in increased expression of IDH3B protein24527689
C055494caffeic acid phenethyl ester[caffeic acid phenethyl ester co-treated with Dietary Fats] results in increased expression of IDH3B mRNA28223344
C055494caffeic acid phenethyl esterNR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in increased expression of IDH3B mRNA]28223344
D002994ClofibrateClofibrate results in decreased expression of IDH3B mRNA22300585
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of IDH3B mRNA15467011
C010902decabromobiphenyl etherdecabromobiphenyl ether affects the expression of IDH3B mRNA24834073
D064730DexrazoxaneDexrazoxane results in decreased expression of IDH3B mRNA26873546
D003976DiazinonDiazinon affects the expression of IDH3B mRNA22546817
C016366dibenzothiophenedibenzothiophene results in decreased expression of IDH3B mRNA23656968
D004026DieldrinDieldrin affects the expression of IDH3B mRNA22546817
D004041Dietary Fats[caffeic acid phenethyl ester co-treated with Dietary Fats] results in increased expression of IDH3B mRNA28223344
D004041Dietary FatsDietary Fats results in decreased expression of IDH3B mRNA18042831
D004041Dietary FatsNR1H4 protein affects the reaction [[caffeic acid phenethyl ester co-treated with Dietary Fats] results in increased expression of IDH3B mRNA]28223344
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of IDH3B mRNA"22485181
D004317DoxorubicinDoxorubicin results in decreased expression of IDH3B mRNA26873546
D004317DoxorubicinDoxorubicin results in increased expression of IDH3B mRNA22016648
D005419FlavonoidsFlavonoids results in decreased expression of IDH3B mRNA18035473
D005485FlutamideFlutamide results in increased expression of IDH3B mRNA24136188
D005632FructoseFructose results in decreased expression of IDH3B protein26930160
C069837fullerene C60fullerene C60 results in decreased expression of IDH3B mRNA19167457
D005839GentamicinsGentamicins results in decreased expression of IDH3B protein22061828
D005839GentamicinsGentamicins results in increased expression of IDH3B mRNA22061828
C010974glyphosateglyphosate results in decreased expression of IDH3B mRNA26302742
C410337K 7174K 7174 results in decreased expression of IDH3B mRNA24086573
D007854LeadLead results in decreased expression of IDH3B mRNA19921347
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of IDH3B mRNA26011545
D009020MorphineMorphine deficiency affects the reaction [Morphine results in decreased expression of IDH3B protein]23056601
D009020MorphineMorphine results in decreased expression of IDH3B protein23056601
C022838nickel chloridenickel chloride affects the expression of IDH3B mRNA22546817
C028007nickel monoxidenickel monoxide results in decreased expression of IDH3B mRNA19167457
C029938nickel sulfatenickel sulfate results in decreased expression of IDH3B mRNA22714537
C025589ochratoxin Aochratoxin A results in decreased expression of IDH3B mRNA19287073
D000073878Palm OilPalm Oil results in decreased expression of IDH3B mRNA18042831
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of IDH3B protein26879310
D010695PhlorhizinPhlorhizin results in decreased expression of IDH3B mRNA22538082
D011794QuercetinQuercetin results in decreased expression of IDH3B protein14750173
C059514resveratrolresveratrol results in increased expression of IDH3B mRNA22610192
C059514resveratrolresveratrol results in increased expression of IDH3B protein25505154
C089730rosiglitazonerosiglitazone affects the expression of IDH3B mRNA22013433
C089730rosiglitazonerosiglitazone results in increased expression of IDH3B mRNA15520860
D012402RotenoneRotenone results in increased expression of IDH3B mRNA22016648
D012643SeleniumSelenium results in increased expression of IDH3B mRNA19244175
D053260SootSoot results in increased expression of IDH3B mRNA26551751
D012460SulfasalazineSulfasalazine results in increased expression of IDH3B mRNA22016648
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IDH3B mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IDH3B mRNA21215274
C009495titanium dioxidetitanium dioxide results in decreased expression of IDH3B mRNA23557971
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of IDH3B gene25560391
D014810Vitamin EVitamin E results in increased expression of IDH3B mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000287magnesium ion binding-IEA-  
GO:0004449isocitrate dehydrogenase (NAD+) activity-IEA-  
GO:0009055electron transfer activity-TAS10601238  
GO:0051287NAD binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006099tricarboxylic acid cycle-IEA-  
GO:0006102isocitrate metabolic process-TAS10601238  
GO:0022900electron transport chain-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-HDA21630459  
GO:0005739mitochondrion-IDA-  
GO:0005759mitochondrial matrix-TAS-  
KEGG ID KEGG Term
hsa00020Citrate cycle (TCA cycle)
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-71403Citric acid cycle (TCA cycle)TAS
R-HSA-71406Pyruvate metabolism and Citric Acid (TCA) cycleTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23688726Genetic variation in antioxidant enzymes, cigarette smoking, and longitudinal change in lung function. (2013 Oct)Tang WFree Radic Biol Med
22387199Genetic variation in antioxidant enzymes and lung function. (2012 May 1)Bentley ARFree Radic Biol Med