Gene: GLDN

342035
CLOM|COLM|CRG-L2|CRGL2|LCCS11|UNC-112
gliomedin
protein-coding
15q21.2
Ensembl:ENSG00000186417 MIM:608603 Vega:OTTHUMG00000131746 UniprotKB:Q6ZMI3
NG_054933.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.782e-1 (AD)  3.134e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM1440.865
SGK20.864
CYB5R20.86
FOLH10.856
MOG0.855
RBP70.845
SH3TC20.844
HHIP0.844
LDB30.843
PDE8A0.843

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WTIP-0.446
LTK-0.396
CUX2-0.383
CCDC85C-0.382
GPR153-0.381
HGFAC-0.38
SLC29A4-0.377
EPPIN-0.369
PRTN3-0.366
ZNF469-0.366

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of GLDN mRNA"26377693
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GLDN mRNA"19114083
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of GLDN mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLDN mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLDN mRNA"27188386
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GLDN mRNA16483693
D001151ArsenicArsenic affects the methylation of GLDN gene25304211
C487081belinostatbelinostat results in increased expression of GLDN mRNA27188386
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of GLDN mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased methylation of GLDN promoter28329817
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to GLDN promoter]19654925
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GLDN mRNA22228805
C006780bisphenol Abisphenol A affects the expression of GLDN mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of GLDN mRNA27685785
C006780bisphenol Abisphenol A results in decreased expression of GLDN mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GLDN gene28505145
D002220CarbamazepineCarbamazepine affects the expression of GLDN mRNA25979313
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of GLDN mRNA24763279
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GLDN mRNA20938992
D003471CuprizoneCuprizone results in decreased expression of GLDN mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of GLDN mRNA27989131
D016572CyclosporineCyclosporine results in increased methylation of GLDN promoter27989131
C041517dibenzo(a,l)pyrene"dibenzo(a,l)pyrene results in decreased expression of GLDN mRNA"25908611
C013484diethylene glycolGLDN gene SNP affects the susceptibility to diethylene glycol analog25622337
C118739entinostatentinostat results in increased expression of GLDN mRNA27188386
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GLDN mRNA20938992
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of GLDN mRNA24763279
C008261lead acetatelead acetate results in increased expression of GLDN mRNA22641619
D008345ManganeseManganese results in decreased expression of GLDN mRNA26745496
C025340manganese chloridemanganese chloride results in decreased expression of GLDN mRNA26745496
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of GLDN mRNA20938992
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of GLDN mRNA27935865
C570897NSC668394NSC668394 results in increased expression of GLDN mRNA27137931
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GLDN mRNA"27188386
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of GLDN mRNA27935865
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GLDN mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GLDN mRNA21570461
D014635Valproic AcidValproic Acid results in decreased expression of GLDN mRNA28001369
C111237vorinostatvorinostat results in increased expression of GLDN mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0086080protein binding involved in heterotypic cell-cell adhesion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0032528microvillus organization-IEA-  
GO:0034113heterotypic cell-cell adhesion-IEA-  
GO:0045162clustering of voltage-gated sodium channels-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005581collagen trimer-IEA-  
GO:0005615extracellular space-IEA-  
GO:0005886plasma membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
GO:0030424axon-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24890784Exon microarray analysis of human dorsolateral prefrontal cortex in alcoholism. (2014 Jun)Manzardo AMAlcohol Clin Exp Res