Gene: TMC3

342125
-
transmembrane channel like 3
protein-coding
15q25.1
Ensembl:ENSG00000188869 MIM:617196 Vega:OTTHUMG00000172314 UniprotKB:Q7Z5M5
NG_054935.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.886e-1 (AD)  2.521e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RYR20.705
FGFR1OP0.697
EML60.697
ADAM190.694
FMN10.694
SIDT10.691
HERC10.69
ADTRP0.688
ZNF385B0.687
COL12A10.687

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MDFI-0.512
RAB13-0.466
RHOD-0.438
ASB4-0.424
YES1-0.42
AQP5-0.419
DOK1-0.419
CCDC102A-0.405
LRAT-0.402
NUPR1-0.402

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of TMC3 gene27153756
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to TMC3 promoter]19654925
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of TMC3 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of TMC3 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of TMC3 mRNA26079696
D010936Plant ExtractsPlant Extracts results in decreased expression of TMC3 mRNA23557933
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of TMC3 mRNA26496021
D014635Valproic AcidValproic Acid results in decreased methylation of TMC3 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TMC3 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005216ion channel activity-IBA21873635  
GO:0008381mechanosensitive ion channel activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006811ion transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005887integral component of plasma membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24983941Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function. (2014)Tang WPLoS One