Gene: IDS

3423
MPS2|SIDS
iduronate 2-sulfatase
protein-coding
Xq28
Ensembl:ENSG00000010404 MIM:300823 Vega:OTTHUMG00000022615 UniprotKB:P22304
NG_011900.3
PubMed
0   ANCO-SNPs
CD|ND|AD
8   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GNB10.952
TTC7B0.943
CALM10.941
TNPO20.938
SEPT30.936
HPCAL40.93
CCNY0.928
MAP20.926
CBX60.925
WSB20.922

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.724
OR4F29-0.692
CSAG1-0.327
SPINK8-0.326
SNHG18-0.309
ANXA13-0.305
FFAR2-0.303
S100A12-0.303
SH2D2A-0.3
SGMS2-0.299

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09301Chondroitin sulfateSmall Molecule24967-93-9Approved|Investigational|NutraceuticalEnzyme
ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of IDS mRNA"19167446
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDS mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDS mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDS mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDS mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDS mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDS mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of IDS mRNA21641981|2715375
C006632arsenic trioxidearsenic trioxide results in increased expression of IDS mRNA15761015
D004958EstradiolEstradiol results in decreased expression of IDS mRNA16202921
C044887beta-methylcholinebeta-methylcholine affects the expression of IDS mRNA21179406
C006780bisphenol Abisphenol A affects the expression of IDS mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of IDS mRNA29097150
D002104CadmiumCadmium results in increased expression of IDS mRNA23369406
D019256Cadmium ChlorideCadmium Chloride results in increased expression of IDS mRNA25596134
D002220CarbamazepineCarbamazepine affects the expression of IDS mRNA25979313
D002330CarmustineCarmustine results in decreased expression of IDS mRNA15980968
C004656chloroacetaldehydechloroacetaldehyde results in increased expression of IDS mRNA25596134
C059262cidofovircidofovir results in decreased expression of IDS mRNA25596134
D004002Clodronic AcidClodronic Acid results in decreased expression of IDS mRNA25596134
C018021cobaltous chloridecobaltous chloride results in increased expression of IDS mRNA19376846
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of IDS mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of IDS mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of IDS mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of IDS mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of IDS mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in decreased expression of IDS mRNA19167446
D016572CyclosporineCyclosporine results in increased expression of IDS mRNA25562108
D003703DemecolcineDemecolcine results in increased expression of IDS mRNA23649840
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of IDS mRNA21266533
D002945CisplatinCisplatin results in decreased expression of IDS mRNA25596134
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of IDS mRNA"22485181
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of IDS mRNA29097150
D005557FormaldehydeFormaldehyde results in decreased expression of IDS mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of IDS mRNA27664576
D007052IbuprofenIbuprofen results in increased expression of IDS mRNA25596134
D007069IfosfamideIfosfamide results in decreased expression of IDS mRNA25596134
D007854LeadLead affects the expression of IDS mRNA28903495
D018021Lithium ChlorideLithium Chloride results in increased expression of IDS mRNA23527032
D008345ManganeseManganese results in increased expression of IDS mRNA18284614
C042720mercuric bromidemercuric bromide results in increased expression of IDS mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDS mRNA"27188386
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of IDS mRNA23179753|2627250
C004925methylmercuric chloride"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDS mRNA"27188386
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of IDS mRNA"20188158
C008493methylselenic acidmethylselenic acid results in increased expression of IDS mRNA18548127
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of IDS mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of IDS mRNA"25554681
C029938nickel sulfatenickel sulfate results in decreased expression of IDS mRNA22714537
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of IDS mRNA20971185
D010100OxygenOxygen deficiency affects the expression of IDS mRNA25596134
D010126OzoneOzone results in increased expression of IDS mRNA19555225
D010634PhenobarbitalPhenobarbital affects the expression of IDS mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDS mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of IDS mRNA26272509
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of IDS mRNA22714537
C059514resveratrol[Coumestrol co-treated with resveratrol] results in decreased expression of IDS mRNA19167446
D012524SarinSarin results in decreased expression of IDS mRNA19522546
D012822Silicon DioxideSilicon Dioxide results in increased expression of IDS mRNA25351596
C017947sodium arsenitesodium arsenite affects the expression of IDS mRNA20816728
C004648testosterone enanthatetestosterone enanthate affects the expression of IDS mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IDS mRNA21570461
C009495titanium dioxidetitanium dioxide results in increased expression of IDS mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of IDS mRNA28065790
D014212TretinoinTretinoin results in decreased expression of IDS mRNA23724009
D014212TretinoinTretinoin results in increased expression of IDS mRNA23830798
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDS mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of IDS mRNA24935251|2627250
D014520UrethaneUrethane results in increased expression of IDS mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IDS mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of IDS mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of IDS mRNA23179753|2352703
D014635Valproic AcidValproic Acid affects the expression of IDS mRNA17292431
D014638VanadatesVanadates results in increased expression of IDS mRNA22714537
D014810Vitamin EVitamin E results in increased expression of IDS mRNA19244175
C111237vorinostatvorinostat results in decreased expression of IDS mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004423iduronate-2-sulfatase activity-IBA21873635  
GO:0004423iduronate-2-sulfatase activity-TAS-  
GO:0008484sulfuric ester hydrolase activity-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006027glycosaminoglycan catabolic process-TAS-  
GO:0030207chondroitin sulfate catabolic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0043202lysosomal lumen-TAS-  
KEGG ID KEGG Term
hsa00531Glycosaminoglycan degradation
hsa01100Metabolic pathways
hsa04142Lysosome
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1630316Glycosaminoglycan metabolismTAS
R-HSA-1638091Heparan sulfate/heparin (HS-GAG) metabolismTAS
R-HSA-1643685DiseaseTAS
R-HSA-1793185Chondroitin sulfate/dermatan sulfate metabolismTAS
R-HSA-2024096HS-GAG degradationTAS
R-HSA-2024101CS/DS degradationTAS
R-HSA-2206281MucopolysaccharidosesTAS
R-HSA-2206296MPS II - Hunter syndromeTAS
R-HSA-5663084Diseases of carbohydrate metabolismTAS
R-HSA-5668914Diseases of metabolismTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27020076The inflammatory marker GDF-15 is not independently associated with late-life depression. (2016 Apr)Teunissen CEJ Psychosom Res
29763572Determinants of Response to Roflumilast in Severe COPD: Pooled Analysis of Two Randomized Trials. (2018 May 15)Martinez FJAm J Respir Crit Care Med
29098320Iatrogenic Vessel Dissection in Endovascular Treatment of Acute Ischemic Stroke. (2017 Nov 2)Goeggel Simonetti BClin Neuroradiol
22419026Expression of the RNA-binding protein HuR and its clinical significance in human stage I and II lung adenocarcinoma. (2012 May)Lauriola LHistol Histopathol
28566009Health and Health-Care Utilization of the Older Population of Ireland: Comparing the Intellectual Disability Population and the General Population. (2017 Jul)McCarron MRes Aging
11980276One-year mortality in elderly stable patients with COPD. (2001 Dec)Ranieri PMonaldi Arch Chest Dis
20479012Effect of smoking on the serum levels of 25-hydroxyvitamin D depends on the assay employed. (2010 Aug)Grimnes GEur J Endocrinol
8387617Psychometric evaluation of a short form of the inventory of drinking situations. (1993 May)Isenhart CEJ Stud Alcohol