Gene: CFI

3426
AHUS3|ARMD13|C3BINA|C3b-INA|FI|IF|KAF
complement factor I
protein-coding
4q25
Ensembl:ENSG00000205403 MIM:217030 Vega:OTTHUMG00000161109 UniprotKB:P05156
NG_007569.1
PubMed
0   ANCO-SNPs
CD|OD|ND|AD
19   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.029e-1 (AD)  4.593e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CFH0.891
FLI10.859
CP0.856
CFB0.853
MECOM0.849
MYOF0.849
PROS10.849
IL13RA10.845
KDELC20.832
RNF144B0.832

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNIP3-0.578
CHRNA4-0.558
EXTL1-0.552
NEUROD6-0.55
MARCH4-0.547
FLRT1-0.543
BCL11A-0.54
SLC7A4-0.537
ABCC12-0.537
HAS1-0.53

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CFI mRNA"21346803
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in increased expression of CFI mRNA25088246
D000082AcetaminophenAcetaminophen results in decreased expression of CFI mRNA29067470
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of CFI mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CFI mRNA]17585979
D000393Air PollutantsAir Pollutants analog results in decreased expression of CFI mRNA21757418
D000447AldehydesAldehydes results in decreased expression of CFI mRNA25014914
D000638AmiodaroneAmiodarone affects the expression of CFI mRNA19483382
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of CFI mRNA"22863853
D001280AtrazineAtrazine results in increased expression of CFI mRNA22378314
D001379AzathioprineAzathioprine results in decreased expression of CFI mRNA22623647
D001553BenzbromaroneBenzbromarone affects the expression of CFI mRNA19483382
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CFI mRNA"19150397
D004958EstradiolEstradiol affects the expression of CFI mRNA15598610
D004958EstradiolEstradiol results in increased expression of CFI mRNA15289156
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of CFI mRNA27685785
C006780bisphenol Abisphenol A results in decreased expression of CFI mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of CFI gene28505145
D002084Butylated HydroxytolueneButylated Hydroxytoluene results in increased expression of CFI mRNA19925653
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of CFI mRNA15336504
C018475butyraldehydebutyraldehyde results in decreased expression of CFI mRNA26079696
D002104CadmiumCFI protein binds to Cadmium23896426
D019256Cadmium ChlorideCadmium Chloride affects the expression of CFI mRNA18804290
D019256Cadmium ChlorideCadmium Chloride affects the expression of CFI mRNA22110744
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of CFI promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of CFI mRNA12734012
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of CFI mRNA18804290
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of CFI mRNA28472532
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of CFI mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of CFI mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CFI mRNA]17585979
D002994ClofibrateClofibrate affects the expression of CFI mRNA19483382
D002994ClofibrateClofibrate results in decreased expression of CFI mRNA12851107
C018021cobaltous chloridecobaltous chloride results in decreased expression of CFI mRNA19320972
C018021cobaltous chloridecobaltous chloride results in decreased expression of CFI mRNA24386269
D003300CopperCFI protein binds to Copper23896426
D019327Copper SulfateCopper Sulfate results in decreased expression of CFI mRNA19549813
D003520CyclophosphamideCFI protein affects the susceptibility to Cyclophosphamide16217747
D016572CyclosporineCyclosporine results in decreased expression of CFI mRNA20106945|2383089
D016572CyclosporineCyclosporine results in decreased expression of CFI mRNA23830897
D016572CyclosporineCyclosporine results in increased expression of CFI mRNA21865292
C089595cylindrospermopsincylindrospermopsin results in decreased expression of CFI mRNA24921660
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of CFI mRNA28962523
C000944dicrotophosdicrotophos results in decreased expression of CFI mRNA28302478
D004026DieldrinDieldrin results in increased expression of CFI mRNA20438755
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of CFI mRNA15289156
D002117CalcitriolCalcitriol results in decreased expression of CFI mRNA26485663
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased methylation of CFI promoter27415467
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CFI mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CFI mRNA15834898|1755790
D005001EthionineEthionine affects the expression of CFI mRNA19483382
D015025ZearalenoneZearalenone results in increased expression of CFI mRNA17557909
D005485FlutamideFlutamide results in decreased expression of CFI mRNA24793618
C039281furanfuran results in decreased expression of CFI mRNA25539665|2619464
D019833GenisteinGenistein results in decreased expression of CFI mRNA26865667
D019833GenisteinGenistein results in increased expression of CFI mRNA15289156
D005839GentamicinsGentamicins results in increased expression of CFI mRNA21081137|2206182
D017313FenretinideFenretinide results in increased expression of CFI mRNA28973697
C082770IMM 125IMM 125 results in increased expression of CFI mRNA21081137
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of CFI mRNA24796395
C410337K 7174K 7174 results in decreased expression of CFI mRNA24086573
D064747LansoprazoleLansoprazole results in decreased expression of CFI mRNA25626140
D007854LeadLead affects the expression of CFI mRNA28903495
D001556LindaneLindane results in increased expression of CFI mRNA18804290
C043243methyl tert-butyl ethermethyl tert-butyl ether affects the expression of CFI mRNA24128854
C523799MRK 003MRK 003 results in decreased expression of CFI mRNA21169257
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of CFI mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of CFI mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of CFI mRNA"19836432
D009532NickelCFI protein binds to Nickel23896426
C028007nickel monoxidenickel monoxide results in increased expression of CFI mRNA19167457
D009853OmeprazoleOmeprazole affects the expression of CFI mRNA19483382
D009853OmeprazoleOmeprazole results in decreased expression of CFI mRNA25626140
D010047Ovalbumin[Ovalbumin affects the susceptibility to Particulate Matter] which results in decreased expression of CFI mRNA19176365
C064276pantoprazolepantoprazole results in decreased expression of CFI mRNA25626140
D052638Particulate Matter[Ovalbumin affects the susceptibility to Particulate Matter] which results in decreased expression of CFI mRNA19176365
C046012pentanalpentanal results in decreased expression of CFI mRNA26079696
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of CFI mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CFI protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of CFI mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CFI mRNA18467677
C023036perfluorooctanoic acidPPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of CFI mRNA]18467677
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CFI mRNA18804290
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of CFI mRNA26794494
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of CFI mRNA19710929
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of CFI mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of CFI mRNA20813756
C006253pirinixic acidpirinixic acid affects the expression of CFI mRNA19483382
D028321Plant PreparationsPlant Preparations results in decreased expression of CFI protein28284660
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of CFI mRNA27989595
D011192Potassium DichromatePotassium Dichromate affects the expression of CFI mRNA23608068
D011374ProgesteroneProgesterone results in decreased expression of CFI mRNA22238285
C005556propionaldehydepropionaldehyde results in decreased expression of CFI mRNA26079696
D011441PropylthiouracilPropylthiouracil affects the expression of CFI mRNA19483382
D054328Proton Pump InhibitorsProton Pump Inhibitors results in decreased expression of CFI mRNA25626140
D011791QuartzQuartz results in increased expression of CFI mRNA19836432
D011794QuercetinQuercetin results in decreased expression of CFI mRNA21632981
D064750RabeprazoleRabeprazole results in decreased expression of CFI mRNA25626140
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CFI mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in increased expression of CFI mRNA22431001
D016559TacrolimusTacrolimus results in increased expression of CFI mRNA21865292
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CFI mRNA17942748
D013853ThioacetamideThioacetamide affects the expression of CFI mRNA19483382
C009495titanium dioxidetitanium dioxide results in increased expression of CFI mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of CFI mRNA20133372
D014212TretinoinTretinoin results in increased expression of CFI mRNA23830798
D014241TrichloroethyleneTrichloroethylene results in increased methylation of CFI gene27618143
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of CFI mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CFI mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of CFI mRNA29024780
D014635Valproic AcidValproic Acid results in decreased expression of CFI mRNA29154799
D014635Valproic AcidValproic Acid results in increased expression of CFI mRNA23179753|2718838
D014635Valproic AcidValproic Acid affects the expression of CFI mRNA17963808
D014640VancomycinVancomycin results in decreased expression of CFI mRNA18930951
C025643vinclozolinvinclozolin results in decreased expression of CFI mRNA23034163
C029297vinylidene chloridevinylidene chloride results in decreased expression of CFI mRNA26682919
D015032ZincCFI protein binds to Zinc23896426
D015032ZincZinc deficiency results in increased expression of CFI mRNA20857495

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-TAS-  
GO:0005044scavenger receptor activity-IEA-  
GO:0005515protein binding-IPI16237761  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IEA-  
GO:0006898receptor-mediated endocytosis-IEA-  
GO:0006958complement activation, classical pathway-IEA-  
GO:0030449regulation of complement activation-TAS-  
GO:0045087innate immune response-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-HDA16502470  
GO:0016020membrane-IEA-  
GO:0070062extracellular exosome-HDA19056867  23533145  
KEGG ID KEGG Term
hsa04610Complement and coagulation cascades
hsa05150Staphylococcus aureus infection
Reactome ID Reactome Term Evidence
R-HSA-166658Complement cascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-977606Regulation of Complement cascadeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22815349Genetic, behavioral, and sociodemographic risk factors for second eye progression in age-related macular degeneration. (2012 Aug 24)Lechanteur YTInvest Ophthalmol Vis Sci
23941100Scales of smoking-related self-efficacy, beliefs, and intention: assessing measurement invariance among intermittent and daily high school smokers. (2014 May-Jun)Sterling KLAm J Health Promot
21139980Associations of smoking, body mass index, dietary lutein, and the LIPC gene variant rs10468017 with advanced age-related macular degeneration. (2010 Nov 17)Seddon JMMol Vis
19661236Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes. (2009 Dec)Reynolds RInvest Ophthalmol Vis Sci
15993545Psychometric properties of the 'Processes of Change' scale for alcohol misuse and its short form (POC-20). (2006 May)Freyer JAddict Behav
2221580Inactivation of chemotactic factor inactivator by cigarette smoke. A potential mechanism of modulating neutrophil recruitment to the lung. (1990 Oct)Robbins RAAm Rev Respir Dis
15061046Outcome of critical foot ischaemia in longstanding diabetic patients: a retrospective cohort study in a specialised tertiary care centre. (2004 Feb)Volaco AVasa
22833236Mediators of the effect of neighborhood poverty on physical functioning among breast cancer survivors: a longitudinal study. (2012 Sep)Pruitt SLCancer Causes Control
21152851[Smoking-related self-efficacy and smoking intention in young people: Factorial validity and structural association]. (2010)Palacios Delgado JRAdicciones
25893111Association of OCT derived drusen measurements with AMD associated-genotypic SNPs in Amish population. (2015)Chavali VRJ Clin Med
25394898Tag SNPs of CFI contributed to the susceptibility for non-small cell lung cancer in Chinese population. (2015 Mar)Liu YTumour Biol
21447678Association of variants in the LIPC and ABCA1 genes with intermediate and large drusen and advanced age-related macular degeneration. (2011 Jun 28)Yu YInvest Ophthalmol Vis Sci
28545471Decisional Balance Inventory (DBI) Adolescent Form for Smoking: Psychometric Properties of the Persian Version. (2017 May 25)Khazaee-Pool MBMC Public Health
24859123[A structural model for health risk behavior of late adolescents: based on 2010 Korea Adolescent Health Survey]. (2014 Apr)Jee YJJ Korean Acad Nurs
25478207Age-related macular degeneration: insights into inflammatory genes. (2014)Cascella RJ Ophthalmol
23481534Dietary omega-3 fatty acids, other fat intake, genetic susceptibility, and progression to incident geographic atrophy. (2013 May)Reynolds ROphthalmology
16412579Psychometric evaluation of the smoking cessation Processes of Change scale in an adolescent sample. (2006 Aug)Hoeppner BBAddict Behav
29353298Development and Validation of the Marijuana Motives Measure Short Form. (2018 Jan 15)Mezquita LAdicciones
26312598Association between vitamin D status and age-related macular degeneration by genetic risk. (2015 Oct)Millen AEJAMA Ophthalmol