Gene info: ID 3428

Gene: IFI16

GENE ID: 3428

Synonyms: IFNGIP1|PYHIN2

Description: interferon gamma inducible protein 16

Gene type: protein-coding

Location: 1q23.1

dbXrefs: Ensembl:ENSG00000163565 MIM:147586 Vega:OTTHUMG00000037108 UniprotKB:Q16666

RefSeq: NG_029141.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 2

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.883e-1 (AD) 8.233e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
PLSCR1	0.902
CASP4	0.895
CLIC1	0.894
SERPINB1	0.889
S100A11	0.888
STAT5A	0.884
IFI30	0.883
MYD88	0.881
DRAM1	0.879
DTX3L	0.879

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MARCH4	-0.556
NEUROD6	-0.551
EXTL1	-0.54
MYADML2	-0.539
LRTM2	-0.539
ABCC12	-0.539
SCRT1	-0.532
KCNQ4	-0.528
CALHM1	-0.526
KCNIP3	-0.525

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane affects the expression of IFI16 mRNA"	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IFI16 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IFI16 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IFI16 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IFI16 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IFI16 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IFI16 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IFI16 mRNA"	27188386
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of IFI16 mRNA	19191707
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IFI16 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IFI16 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IFI16 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IFI16 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IFI16 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IFI16 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IFI16 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of IFI16 mRNA	21420995
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of IFI16 protein	20106945
D000395	Air Pollutants, Occupational	"Air Pollutants, Occupational results in decreased expression of IFI16 mRNA"	23195993
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of IFI16 mRNA	24449571
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of IFI16 mRNA	15761015
C006632	arsenic trioxide	arsenic trioxide results in increased expression of IFI16 protein	25419056
C006632	arsenic trioxide	IFI16 protein results in increased susceptibility to arsenic trioxide	20707922
C006632	arsenic trioxide	[Tretinoin co-treated with arsenic trioxide] results in increased expression of IFI16 mRNA	15894607
C487081	belinostat	belinostat results in increased expression of IFI16 mRNA	26272509
C487081	belinostat	"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IFI16 mRNA"	27188386
D004958	Estradiol	Estradiol affects the expression of IFI16 mRNA	22574217
D004958	Estradiol	Estradiol results in increased expression of IFI16 mRNA	23373633
C006780	bisphenol A	bisphenol A results in increased expression of IFI16 mRNA	29275510
C028031	cadmium acetate	cadmium acetate results in decreased expression of IFI16 mRNA	18155341
D002220	Carbamazepine	Carbamazepine affects the expression of IFI16 mRNA	25979313
D003300	Copper	[NSC 689534 binds to Copper] which results in increased expression of IFI16 mRNA	20971185
D016572	Cyclosporine	Cyclosporine results in increased expression of IFI16 mRNA	20106945\|2798913
D003703	Demecolcine	Demecolcine results in increased expression of IFI16 mRNA	23649840
D002945	Cisplatin	Cisplatin results in increased expression of IFI16 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of IFI16 mRNA	21151649
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of IFI16 mRNA	23649840
D005472	Fluorouracil	TP53 protein affects the reaction [Fluorouracil results in decreased expression of IFI16 mRNA]	15016801
D005557	Formaldehyde	Formaldehyde results in increased expression of IFI16 mRNA	23649840
D017313	Fenretinide	Fenretinide results in decreased expression of IFI16 mRNA	28973697
D017313	Fenretinide	Fenretinide results in increased expression of IFI16 mRNA	28973697
D058185	Magnetite Nanoparticles	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of IFI16 mRNA	26378955
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IFI16 mRNA"	27188386
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of IFI16 mRNA	23179753\|2627250
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of IFI16 mRNA	28001369
C004925	methylmercuric chloride	"[NOG protein co-treated with methylmercuric chloride co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of IFI16 mRNA"	27188386
C008493	methylselenic acid	methylselenic acid results in increased expression of IFI16 mRNA	18548127
D009532	Nickel	Nickel results in decreased expression of IFI16 mRNA	23195993
D009532	Nickel	Nickel results in increased expression of IFI16 mRNA	24768652\|2558310
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in increased expression of IFI16 mRNA	20971185
C025589	ochratoxin A	ochratoxin A results in decreased acetylation of IFI16 promoter	29098329
C025589	ochratoxin A	[ochratoxin A results in decreased acetylation of IFI16 promoter] which results in decreased expression of IFI16 mRNA	29098329\|2909832
C025589	ochratoxin A	ochratoxin A results in decreased expression of IFI16 mRNA	29098329
C496932	panobinostat	"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IFI16 mRNA"	27188386
C496932	panobinostat	panobinostat results in increased expression of IFI16 mRNA	26272509
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IFI16 mRNA"	27188386
D011374	Progesterone	Progesterone results in decreased expression of IFI16 mRNA	20631399
D011374	Progesterone	Progesterone results in increased expression of IFI16 mRNA	19690047
D012524	Sarin	Sarin results in increased expression of IFI16 mRNA	19522546
C017947	sodium arsenite	sodium arsenite results in increased expression of IFI16 mRNA	25199682
D004113	Succimer	[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of IFI16 mRNA	26378955
C061133	tamibarotene	tamibarotene results in increased expression of IFI16 mRNA	15498508
C004648	testosterone enanthate	testosterone enanthate affects the expression of IFI16 mRNA	17440010
D013849	Thimerosal	Thimerosal results in decreased expression of IFI16 mRNA	27188386
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of IFI16 mRNA	28111298
C483909	torcetrapib	torcetrapib results in increased expression of IFI16 mRNA	23228038
D014212	Tretinoin	Tretinoin affects the expression of IFI16 mRNA	15498508
D014212	Tretinoin	[Tretinoin co-treated with arsenic trioxide] results in increased expression of IFI16 mRNA	15894607
D014212	Tretinoin	Tretinoin results in increased expression of IFI16 mRNA	21934132
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IFI16 mRNA"	27188386
C012589	trichostatin A	trichostatin A results in increased expression of IFI16 mRNA	24935251\|2627250
D014635	Valproic Acid	Valproic Acid affects the expression of IFI16 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of IFI16 mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in decreased methylation of IFI16 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of IFI16 mRNA	24383497\|2493525
D014635	Valproic Acid	Valproic Acid affects the expression of IFI16 mRNA	17292431
C111237	vorinostat	"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IFI16 mRNA"	27188386
C111237	vorinostat	vorinostat results in increased expression of IFI16 mRNA	26272509

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IDA	24413532
GO:0001078	transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding	-	IDA	24413532
GO:0003690	double-stranded DNA binding	-	IDA	7536752
GO:0003723	RNA binding	-	HDA	22658674
GO:0005515	protein binding	-	IPI	11146555 14654789 16494870 20890285 21397192 24413532
GO:0008134	transcription factor binding	-	IDA	12894224 22291595

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IDA	12894224 24413532
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IMP	22046441
GO:0001819	positive regulation of cytokine production	-	TAS	22046441
GO:0002218	activation of innate immune response	-	IDA	21575908
GO:0006351	transcription, DNA-templated	-	IEA	-
GO:0006914	autophagy	-	IEA	-
GO:0006954	inflammatory response	-	IEA	-
GO:0008283	cell proliferation	-	NAS	9766636
GO:0010506	regulation of autophagy	-	IEP	21573174
GO:0030097	hemopoiesis	-	NAS	9766636
GO:0030099	myeloid cell differentiation	-	NAS	7536752
GO:0030224	monocyte differentiation	-	IDA	9766636
GO:0032481	positive regulation of type I interferon production	-	TAS	-
GO:0032731	positive regulation of interleukin-1 beta production	-	IDA	21575908
GO:0040029	regulation of gene expression, epigenetic	-	IMP	24413532
GO:0042149	cellular response to glucose starvation	-	IDA	21573174
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	-	IDA	14654789
GO:0043392	negative regulation of DNA binding	-	IDA	22291595
GO:0045071	negative regulation of viral genome replication	-	IDA	22291595
GO:0045087	innate immune response	-	IEA	-
GO:0045824	negative regulation of innate immune response	-	IDA	22046441
GO:0045892	negative regulation of transcription, DNA-templated	-	IDA	9642285
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IDA	11146555
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IMP	21575908
GO:0051607	defense response to virus	-	IDA	21478870
GO:0051607	defense response to virus	-	IMP	21575908
GO:0071479	cellular response to ionizing radiation	-	IDA	14654789
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	-	IMP	21573174
GO:0097202	activation of cysteine-type endopeptidase activity	-	IMP	21575908
GO:2000117	negative regulation of cysteine-type endopeptidase activity	-	IDA	22046441

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	IDA	7536752 19158679 24413532
GO:0005654	nucleoplasm	-	IDA	14654789
GO:0005730	nucleolus	-	IDA	14654789
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0016020	membrane	-	HDA	19946888
GO:0016607	nuclear speck	-	IDA	19158679

KEGG ID	KEGG Term

Reactome ID	Reactome Term	Evidence
R-HSA-168249	Innate Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-1834941	STING mediated induction of host immune responses	TAS
R-HSA-1834949	Cytosolic sensors of pathogen-associated DNA	TAS
R-HSA-3270619	IRF3-mediated induction of type I IFN	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
29341486	Rheumatoid arthritis and periodontal disease: What are the similarities and differences? (2017 Dec)	Li R	Int J Rheum Dis
26316393	Circulating Interferon-Inducible Protein IFI16 Correlates With Clinical and Serological Features in Rheumatoid Arthritis. (2016 Apr)	Alunno A	Arthritis Care Res (Hoboken)