Gene: ZNF284

342909
ZNF284L
zinc finger protein 284
protein-coding
19q13.31
Ensembl:ENSG00000186026 Vega:OTTHUMG00000182312 UniprotKB:Q2VY69
NC_000019.10
SNP Mapped
7   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.351e-2 (AD)  7.788e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs8113487chr19:44087401 (GRCh38.p7)G>A / G>Calcohol dependenceSNV(Single Nucleotide Variation)
rs8113249chr19:44087207 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs57895932chr19:44076605 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs4550576chr19:44074294 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs7252213chr19:44072710 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs11666432chr19:44072149 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs9646633chr19:44070874 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRDM150.82
PRR14L0.817
TBCK0.815
KLHL30.807
ZNF780B0.802
ORC20.797
GIT20.796
OGT0.796
DIDO10.796
GAPVD10.796

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.389
OR4F29-0.355
AQP5-0.344
ENDOU-0.328
LRAT-0.328
S100A14-0.287
CNBD2-0.286
WNT7B-0.278
S100A1-0.273
TNNT1-0.272

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0127962-butenal2-butenal results in decreased expression of ZNF284 mRNA20471460
C018475butyraldehydebutyraldehyde results in increased expression of ZNF284 mRNA26079696
C045463leflunomideleflunomide results in decreased expression of ZNF284 mRNA28988120
C005556propionaldehydepropionaldehyde results in increased expression of ZNF284 mRNA26079696
C012589trichostatin Atrichostatin A results in increased expression of ZNF284 mRNA24935251
D014635Valproic AcidValproic Acid results in increased expression of ZNF284 mRNA24935251

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0003677DNA binding-IBA21873635  
GO:0003700DNA-binding transcription factor activity-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-IBA21873635  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal