Gene: SP110

3431
IFI41|IFI75|IPR1|VODI
SP110 nuclear body protein
protein-coding
2q37.1
Ensembl:ENSG00000135899 MIM:604457 Vega:OTTHUMG00000133204 UniprotKB:Q9HB58
NG_008295.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.429e-1 (AD)  2.878e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NMI0.919
DTX3L0.901
MYD880.9
PARP90.897
PSMB80.896
TRIM50.896
NLRC50.896
PSMB90.893
APOL60.888
TRIM210.871

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC7A4-0.539
ABCC12-0.537
MARCH4-0.534
EXTL1-0.516
CHRNB2-0.515
NEUROD6-0.515
KCNIP3-0.514
CALHM1-0.514
ADRA1D-0.507
KCNB2-0.5

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of SP110 mRNA"23829299
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SP110 mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SP110 mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of SP110 mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SP110 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SP110 mRNA21420995
D001151ArsenicArsenic affects the methylation of SP110 gene25304211
C006632arsenic trioxide[Tretinoin co-treated with arsenic trioxide] results in increased expression of SP110 mRNA15894607
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SP110 mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SP110 mRNA21569818
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of SP110 mRNA19619570
D004958EstradiolEstradiol results in increased expression of SP110 mRNA19619570|2118537
C006780bisphenol Abisphenol A results in increased expression of SP110 mRNA25181051
D019256Cadmium Chloridezinc chloride inhibits the reaction [Cadmium Chloride inhibits the reaction [SP110 protein binds to and affects the expression of SLC5A2 promoter]]20060848
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of SP110 mRNA28472532
D002994ClofibrateClofibrate results in decreased expression of SP110 mRNA17585979
D019327Copper SulfateCopper Sulfate results in increased expression of SP110 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of SP110 mRNA26577399|2752363
D016572CyclosporineCyclosporine results in increased expression of SP110 mRNA22147139
D003630DaunorubicinSP110 affects the susceptibility to Daunorubicin17545624
C014347decitabinedecitabine results in increased expression of SP110 mRNA21856257
D002945CisplatinSP110 protein results in decreased susceptibility to Cisplatin16734730
D004041Dietary FatsDietary Fats results in increased expression of SP110 mRNA25016146
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SP110 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SP110 mRNA23086925
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SP110 mRNA25982114
C008261lead acetatelead acetate results in increased expression of SP110 mRNA20542052
D008727MethotrexateMethotrexate results in decreased expression of SP110 mRNA24449571
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of SP110 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog affects the expression of SP110 mRNA"25554681
D009532NickelNickel results in increased expression of SP110 mRNA24768652|2558310
D011374ProgesteroneProgesterone results in increased expression of SP110 mRNA19690047
D012999SomanSoman results in increased expression of SP110 mRNA19281266
C004648testosterone enanthatetestosterone enanthate affects the expression of SP110 mRNA17440010
C020806tetrabromobisphenol Atetrabromobisphenol A results in increased expression of SP110 mRNA27914987
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of SP110 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SP110 mRNA19619570
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of SP110 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of SP110 mRNA23557971
D014212Tretinoin[Tretinoin co-treated with arsenic trioxide] results in increased expression of SP110 mRNA15894607
C012589trichostatin Atrichostatin A results in increased expression of SP110 mRNA24935251
C057693troglitazonetroglitazone results in decreased expression of SP110 mRNA17569031
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SP110 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of SP110 mRNA23179753|2627250
C025643vinclozolinvinclozolin affects the expression of SP110 mRNA19015723
C016837zinc chloridezinc chloride inhibits the reaction [Cadmium Chloride inhibits the reaction [SP110 protein binds to and affects the expression of SLC5A2 promoter]]20060848

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0003677DNA binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0016032viral process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21033425[Study on relation between Sp110 gene polymorphism and tuberculosis genetic susceptibility of Chongqing Han People]. (2010 Sep)Cong JWei Sheng Yan Jiu