Gene: KCNT2

343450
EIEE57|KCa4.2|SLICK|SLO2.1
potassium sodium-activated channel subfamily T member 2
protein-coding
1q31.3
Ensembl:ENSG00000162687 MIM:610044 Vega:OTTHUMG00000035611 UniprotKB:Q6UVM3
NC_000001.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.221e-1 (AD)  4.322e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC25A400.892
OXR10.892
TRHDE0.889
RASAL20.887
TRUB10.885
FAM102B0.884
PRKAA20.883
SLC4A100.883
CNTN40.881
EPHA50.88

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RHOD-0.494
MYOM1-0.48
ROM1-0.472
S100A1-0.468
RAB13-0.466
STON2-0.459
ASB4-0.456
LRAT-0.449
COPZ2-0.448
IMPA2-0.448

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KCNT2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KCNT2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of KCNT2 mRNA21420995
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of KCNT2 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of KCNT2 gene27153756
D000393Air PollutantsAir Pollutants analog results in decreased expression of KCNT2 mRNA21757418
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of KCNT2 protein26597043
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of KCNT2 mRNA24449571
D001152ArsenicalsArsenicals results in increased methylation of KCNT2 promoter26039340
C015001arsenitearsenite results in increased methylation of KCNT2 promoter23974009
C447119bazedoxifenebazedoxifene results in increased expression of KCNT2 mRNA19914376
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of KCNT2 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of KCNT2 mRNA19770486
C018475butyraldehydebutyraldehyde results in decreased expression of KCNT2 mRNA26079696
C055494caffeic acid phenethyl estercaffeic acid phenethyl ester results in decreased expression of KCNT2 mRNA26100633
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of KCNT2 mRNA24763279
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of KCNT2 mRNA20971185
D003471CuprizoneCuprizone results in decreased expression of KCNT2 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of KCNT2 mRNA20106945
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of KCNT2 mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of KCNT2 mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of KCNT2 mRNA18164116
D002117CalcitriolCalcitriol results in increased expression of KCNT2 mRNA16002434
C118739entinostatentinostat results in decreased expression of KCNT2 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KCNT2 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of KCNT2 mRNA17557909
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of KCNT2 mRNA24763279
D007545IsoproterenolIsoproterenol results in increased expression of KCNT2 mRNA20003209
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of KCNT2 mRNA24810058
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of KCNT2 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of KCNT2 mRNA"25620056
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of KCNT2 mRNA20971185
D010100OxygenOxygen deficiency results in increased expression of KCNT2 mRNA26100633
C016030pantogabpantogab results in increased expression of KCNT2 mRNA17379144
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of KCNT2 mRNA27153767
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of KCNT2 mRNA24535843
D011374ProgesteroneProgesterone results in increased expression of KCNT2 mRNA21795739
D011441PropylthiouracilPropylthiouracil results in increased expression of KCNT2 mRNA24780913
C009250sevofluranesevoflurane results in decreased expression of KCNT2 mRNA26206149
C017947sodium arsenitesodium arsenite results in increased expression of KCNT2 mRNA22714537
C012589trichostatin Atrichostatin A results in increased expression of KCNT2 mRNA24935251
D014415TunicamycinTunicamycin results in increased expression of KCNT2 mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of KCNT2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of KCNT2 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased methylation of KCNT2 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of KCNT2 mRNA24935251|2670570

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005228intracellular sodium activated potassium channel activity-IBA21873635  
GO:0005524ATP binding-IEA-  
GO:0015271outward rectifier potassium channel activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0042391regulation of membrane potential-IBA21873635  
GO:0071805potassium ion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0016021integral component of membrane-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27023175Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium. (2016 Mar 29)Stringer STransl Psychiatry