Gene: RSPO4

343637
C20orf182|CRISTIN4
R-spondin 4
protein-coding
20p13
Ensembl:ENSG00000101282 MIM:610573 Vega:OTTHUMG00000031651 UniprotKB:Q2I0M5
NG_013043.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.301e-1 (AD)  1.738e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg03569404chr20:981673RSPO4Gene body2.045e-5Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TBC1D10C0.603
NTRK10.58
KCNJ10.572
DACT20.571
SPAG170.555
TRAIP0.552
SGSH0.551
PABPC1L0.551
GOLT1A0.549
DRD20.546

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SP8-0.265
NEK2-0.258
OR4F5-0.252
BEND4-0.248
OR4F29-0.244
VIP-0.239
CHRNA2-0.238
SERPINC1-0.237
G0S2-0.23
WFDC13-0.226

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D001151ArsenicArsenic affects the methylation of RSPO4 gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of RSPO4 mRNA22228805
C006780bisphenol Abisphenol A results in increased methylation of RSPO4 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of RSPO4 mRNA25181051
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in increased expression of RSPO4 mRNA17183730
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of RSPO4 mRNA"24972896
D008727MethotrexateMethotrexate results in decreased expression of RSPO4 mRNA24449571
D010936Plant ExtractsPlant Extracts results in decreased expression of RSPO4 mRNA23557933
D011441PropylthiouracilPropylthiouracil results in decreased expression of RSPO4 mRNA24780913
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in increased expression of RSPO4 mRNA17183730

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005109frizzled binding-IBA21873635  
GO:0008201heparin binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016055Wnt signaling pathway-IEA-  
GO:0030177positive regulation of Wnt signaling pathway-NAS24431302  
GO:0035878nail development-IMP17805348  
GO:0048856anatomical structure development-IBA21873635  
GO:0090263positive regulation of canonical Wnt signaling pathway-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-NAS24431302  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-195721Signaling by WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-4641263Regulation of FZD by ubiquitinationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19472401The presence of aberrant DNA methylation in noncancerous esophageal mucosae in association with smoking history: a target for risk diagnosis and prevention of esophageal cancers. (2009 Aug 1)Oka DCancer