Gene: APOC2

344
APO-CII|APOC-II
apolipoprotein C2
protein-coding
19q13.32
Ensembl:ENSG00000234906 MIM:608083 Vega:OTTHUMG00000180847 UniprotKB:P02655
NG_008837.1
PubMed
0   ANCO-SNPs
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.739e-1 (AD)  9.446e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PARVG0.856
WAS0.842
MSLN0.835
IL10RA0.833
MYO1F0.833
PTPN60.825
RHBDF20.823
DEF60.822
LAIR10.822
ABI30.819

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NEUROD6-0.45
CALHM1-0.406
FUT9-0.406
B3GALT2-0.405
CPLX3-0.394
WNT7A-0.391
KCNIP3-0.388
ST6GAL2-0.386
EXTL1-0.381
KCNA2-0.38

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0364231-aminomethylphosphonic acid[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of APOC2 mRNA20566314
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of APOC2 mRNA"15215175
C5756314-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile"4-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile affects the expression of APOC2 mRNA"21218783
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of APOC2 mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of APOC2 mRNA17562736
D000638AmiodaroneAmiodarone results in increased expression of APOC2 mRNA24489787
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of APOC2 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of APOC2 mRNA16488489
D001629BezafibrateBezafibrate results in decreased expression of APOC2 mRNA12782154
D001629BezafibratePPARA protein affects the reaction [Bezafibrate results in decreased expression of APOC2 mRNA]12782154
D001629BezafibratePPARD protein affects the reaction [Bezafibrate results in decreased expression of APOC2 mRNA]12782154
C006780bisphenol Abisphenol A results in increased expression of APOC2 mRNA26364221
C006780bisphenol Abisphenol A results in decreased expression of APOC2 mRNA27502578
C006780bisphenol Abisphenol A results in decreased expression of APOC2 mRNA25181051
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of APOC2 mRNA18804290
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of APOC2 mRNA24982889
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of APOC2 mRNA18804290
D002110Caffeine[Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in decreased expression of APOC2 protein16324916
D002110CaffeineCaffeine results in decreased expression of APOC2 mRNA25868845
D000074262Canola OilCanola Oil affects the expression of APOC2 mRNA16177195
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of APOC2 mRNA27339419
D002509CephaloridineCephaloridine results in increased expression of APOC2 mRNA18500788
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of APOC2 mRNA18804290
D002737ChloropreneChloroprene results in decreased expression of APOC2 mRNA23125180
D002793Cholic Acids[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of APOC2 mRNA27344345
D002793Cholic Acids[Cyclosporine co-treated with Cholic Acids] affects the expression of APOC2 mRNA27344345
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of APOC2 mRNA16488489
D003300CopperAPOC2 protein binds to Copper23896426
D019327Copper SulfateCopper Sulfate results in decreased expression of APOC2 mRNA19549813
D016572Cyclosporine[Cyclosporine co-treated with Cholic Acids] affects the expression of APOC2 mRNA27344345
D016572CyclosporineCyclosporine results in decreased expression of APOC2 mRNA25562108
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of APOC2 mRNA]27941970
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of APOC2 mRNA28962523
D004041Dietary FatsDietary Fats results in increased expression of APOC2 mRNA15238619|1845759
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of APOC2 mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of APOC2 mRNA19638242
D052244Endocrine DisruptorsEndocrine Disruptors results in decreased expression of APOC2 mRNA25198161
D004809Ephedrine[Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in decreased expression of APOC2 protein16324916
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of APOC2 mRNA12072388|1497612
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of APOC2 mRNA16488489
C039281furanfuran results in decreased expression of APOC2 mRNA26194646
C039281furanfuran results in increased methylation of APOC2 gene22079235
D015248GemfibrozilGemfibrozil results in decreased expression of APOC2 protein8847480
D015248Gemfibrozil[Gemfibrozil results in decreased expression of APOC2 protein] which results in decreased abundance of Triglycerides8847480
D006540Herbicides[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of APOC2 mRNA20566314
C410337K 7174K 7174 results in decreased expression of APOC2 mRNA24086573
C008261lead acetatelead acetate results in increased expression of APOC2 mRNA22609695
D001556LindaneLindane results in decreased expression of APOC2 mRNA18804290
D044243Linoleic Acids, Conjugated"Linoleic Acids, Conjugated results in increased expression of APOC2 mRNA"17322064
D008095Lithocholic AcidLithocholic Acid results in increased expression of APOC2 mRNA20359477
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of APOC2 mRNA26378955
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of APOC2 mRNA18804290
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of APOC2 mRNA27544571
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of APOC2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of APOC2 mRNA"25554681
C031721naphthalenenaphthalene results in increased expression of APOC2 mRNA18978301
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of APOC2 mRNA27344345
D009532NickelAPOC2 protein binds to Nickel23896426
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of APOC2 mRNA27935865
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of APOC2 mRNA27935865
C464660obeticholic acidobeticholic acid results in increased expression of APOC2 mRNA27939613
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of APOC2 mRNA21705711
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of APOC2 mRNA18804290
D010634PhenobarbitalPhenobarbital results in increased expression of APOC2 mRNA12082028
C060836pioglitazone[Ephedrine co-treated with Caffeine co-treated with pioglitazone] results in decreased expression of APOC2 protein16324916
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of APOC2 mRNA27935865
D028321Plant PreparationsPlant Preparations results in increased expression of APOC2 mRNA26945725
D011794QuercetinQuercetin results in decreased expression of APOC2 mRNA21632981
D053260SootSoot results in decreased expression of APOC2 mRNA26551751
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of APOC2 mRNA26378955
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of APOC2 mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to APOC2 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of APOC2 mRNA21724226
D013752TetracyclineTetracycline results in decreased expression of APOC2 mRNA16917069|2448978
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of APOC2 mRNA28943392
C066340tolcaponetolcapone results in decreased expression of APOC2 mRNA24136188
D014280Triglycerides[Gemfibrozil results in decreased expression of APOC2 protein] which results in decreased abundance of Triglycerides8847480
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of APOC2 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of APOC2 mRNA29024780
D014415TunicamycinTunicamycin results in decreased expression of APOC2 mRNA17127020|2241438
C029297vinylidene chloridevinylidene chloride results in increased expression of APOC2 mRNA26682919
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in decreased expression of APOC2 mRNA"25198161
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in increased expression of APOC2 mRNA27935865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008289lipid binding-IBA21873635  
GO:0008289lipid binding-IDA10727238  
GO:0016004phospholipase activator activity-IBA21873635  
GO:0016004phospholipase activator activity-IDA10727238  
GO:0042803protein homodimerization activity-IMP8245722  
GO:0043274phospholipase binding-IBA21873635  
GO:0043274phospholipase binding-IPI10727238  
GO:0055102lipase inhibitor activity-IDA182536  
GO:0060230lipoprotein lipase activator activity-IBA21873635  
GO:0060230lipoprotein lipase activator activity-IDA270715  10727238  
GO ID GO Term Qualifier Evidence PubMed
GO:0001523retinoid metabolic process-TAS-  
GO:0010518positive regulation of phospholipase activity-IBA21873635  
GO:0010518positive regulation of phospholipase activity-IDA10727238  
GO:0010898positive regulation of triglyceride catabolic process-IDA10727238  
GO:0010902positive regulation of very-low-density lipoprotein particle remodeling-IC10727238  
GO:0010916negative regulation of very-low-density lipoprotein particle clearance-IBA21873635  
GO:0010916negative regulation of very-low-density lipoprotein particle clearance-IDA1917954  
GO:0016042lipid catabolic process-IEA-  
GO:0032375negative regulation of cholesterol transport-IMP15778093  
GO:0033344cholesterol efflux-IDA11162594  
GO:0033700phospholipid efflux-IDA11162594  
GO:0034370triglyceride-rich lipoprotein particle remodeling-TAS17018885  
GO:0034371chylomicron remodeling-IC10727238  
GO:0034371chylomicron remodeling-TAS-  
GO:0034372very-low-density lipoprotein particle remodeling-TAS15778093  
GO:0034375high-density lipoprotein particle remodeling-TAS-  
GO:0034378chylomicron assembly-TAS-  
GO:0034382chylomicron remnant clearance-IBA21873635  
GO:0034382chylomicron remnant clearance-IDA4020294  
GO:0034384high-density lipoprotein particle clearance-IBA21873635  
GO:0034384high-density lipoprotein particle clearance-IMP15778093  
GO:0042159lipoprotein catabolic process-IBA21873635  
GO:0042493response to drug-IEA-  
GO:0042632cholesterol homeostasis-IC15778093  
GO:0042953lipoprotein transport-IEA-  
GO:0043086negative regulation of catalytic activity-IEA-  
GO:0043691reverse cholesterol transport-IC15778093  
GO:0045723positive regulation of fatty acid biosynthetic process-IDA10727238  
GO:0045833negative regulation of lipid metabolic process-IDA182536  
GO:0048261negative regulation of receptor-mediated endocytosis-IDA1917954  
GO:0051006positive regulation of lipoprotein lipase activity-IBA21873635  
GO:0051006positive regulation of lipoprotein lipase activity-IDA10727238  15878877  
GO:0060697positive regulation of phospholipid catabolic process-IBA21873635  
GO:0060697positive regulation of phospholipid catabolic process-IDA10727238  
GO:0070328triglyceride homeostasis-IMP17018885  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-NAS14718574  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA10727238  
GO:0005769early endosome-TAS-  
GO:0034361very-low-density lipoprotein particle-IBA21873635  
GO:0034361very-low-density lipoprotein particle-IDA8245722  
GO:0034362low-density lipoprotein particle-IBA21873635  
GO:0034362low-density lipoprotein particle-IDA8245722  
GO:0034363intermediate-density lipoprotein particle-IBA21873635  
GO:0034363intermediate-density lipoprotein particle-IDA17336988  
GO:0034366spherical high-density lipoprotein particle-IBA21873635  
GO:0034366spherical high-density lipoprotein particle-IDA16682745  
GO:0042627chylomicron-IBA21873635  
GO:0042627chylomicron-IDA8245722  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1430728MetabolismIEA
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-174824Plasma lipoprotein assembly, remodeling, and clearanceTAS
R-HSA-174824Plasma lipoprotein assembly, remodeling, and clearanceIEA
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsIEA
R-HSA-2187338Visual phototransductionTAS
R-HSA-2187338Visual phototransductionIEA
R-HSA-372790Signaling by GPCRTAS
R-HSA-372790Signaling by GPCRIEA
R-HSA-382551Transport of small moleculesTAS
R-HSA-382551Transport of small moleculesIEA
R-HSA-388396GPCR downstream signallingTAS
R-HSA-388396GPCR downstream signallingIEA
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-418594G alpha (i) signalling eventsIEA
R-HSA-6806667Metabolism of fat-soluble vitaminsTAS
R-HSA-6806667Metabolism of fat-soluble vitaminsIEA
R-HSA-8963888Chylomicron assemblyTAS
R-HSA-8963889Assembly of active LPL and LIPC lipase complexesIEA
R-HSA-8963898Plasma lipoprotein assemblyTAS
R-HSA-8963899Plasma lipoprotein remodelingTAS
R-HSA-8963899Plasma lipoprotein remodelingIEA
R-HSA-8963901Chylomicron remodelingTAS
R-HSA-8964058HDL remodelingTAS
R-HSA-975634Retinoid metabolism and transportTAS
R-HSA-975634Retinoid metabolism and transportIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29132311Weighted gene co-expression network analysis of expression data of monozygotic twins identifies specific modules and hub genes related to BMI. (2017 Nov 13)Wang WBMC Genomics
22003152Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies. (2012 Jan)Grallert HEur Heart J
19878569Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis. (2009 Oct 30)Chen SNBMC Med Genet
11286640Genetic determinants of plasma triglycerides: impact of rare and common mutations. (2001 May)Talmud PJCurr Atheroscler Rep