Gene: EVX2

344191
EVX-2
even-skipped homeobox 2
protein-coding
2q31.1
Ensembl:ENSG00000174279 MIM:142991 Vega:OTTHUMG00000154173 UniprotKB:Q03828
NG_012893.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.184e-1 (AD)  6.655e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR9G40.661
RPTN0.661
OR8B20.653
OR5A20.645
UGT1A60.633
OR6K60.632
OR51S10.627
SPINK60.626
LINC004300.625
USP260.62

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NTSR2-0.306
HPR-0.273
CRB2-0.269
EYA2-0.255
GDPD2-0.254
SLC22A6-0.253
HHATL-0.253
ABHD1-0.248
PLXNB1-0.248
RABGEF1-0.247

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of EVX2 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of EVX2 mRNA21298039
D001151ArsenicArsenic affects the methylation of EVX2 gene25304211
C006780bisphenol Abisphenol A affects the methylation of EVX2 promoter27334623
C006780bisphenol Abisphenol A results in decreased expression of EVX2 mRNA17706920
C006780bisphenol ALHB protein affects the reaction [bisphenol A results in decreased expression of EVX2 mRNA]17706920
C006780bisphenol Abisphenol A results in decreased expression of EVX2 mRNA25181051
D053260SootSoot results in decreased expression of EVX2 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EVX2 mRNA24058054

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0043565sequence-specific DNA binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0008150biological_process-ND-  
GO:0035108limb morphogenesis-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21507233Highly frequent promoter methylation and PIK3CA amplification in non-small cell lung cancer (NSCLC). (2011 Apr 20)Ji MBMC Cancer