Gene: IFNAR1

3454
AVP|IFN-alpha-REC|IFNAR|IFNBR|IFRC
interferon alpha and beta receptor subunit 1
protein-coding
21q22.11
Ensembl:ENSG00000142166 MIM:107450 Vega:OTTHUMG00000065126 UniprotKB:P17181
NC_000021.9
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.174e-2 (AD)  1.404e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COPB20.911
CLINT10.909
DHX150.907
TRIP120.9
CSNK1A10.899
CRK0.897
SEC24B0.895
SON0.894
PBRM10.894
YTHDF30.892

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.657
OR4F29-0.619
HES5-0.198
TNFRSF13B-0.194
APOA4-0.18
SOX3-0.175
TPPP2-0.173
NANOGNB-0.171
TCL1A-0.171
VCX3A-0.17

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00008Peginterferon alfa-2aBiotechDrug198153-51-4Approved|InvestigationalTarget
DB00011Interferon alfa-n1BiotechDrug74899-72-2Approved|InvestigationalTarget
DB00018Interferon alfa-n3BiotechDrug-Approved|InvestigationalTarget
DB00022Peginterferon alfa-2bBiotechDrug215647-85-1ApprovedTarget
DB00034Interferon Alfa-2a, RecombinantBiotechDrug76543-88-9Approved|InvestigationalTarget
DB00060Interferon beta-1aBiotechDrug145258-61-3Approved|InvestigationalTarget
DB00068Interferon beta-1bBiotechDrug145155-23-3ApprovedTarget
DB00069Interferon alfacon-1BiotechDrug118390-30-0Approved|InvestigationalTarget
DB00105Interferon Alfa-2b, RecombinantBiotechDrug98530-12-2ApprovedTarget
DB05258Natural alpha interferonBiotechDrug-Approved|InvestigationalTarget
DB05472omega interferonSmall Molecule-InvestigationalTarget
ID Drug Name Action PubMed
C0413987,7'-dimethoxy-(4,4'-bi-1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester"7,7'-dimethoxy-(4,4'-bi-1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester affects the expression of IFNAR1 mRNA"16756086
D000082AcetaminophenAcetaminophen results in decreased expression of IFNAR1 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of IFNAR1 mRNA17562736
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of IFNAR1 mRNA"23195993
D000547AmantadineAmantadine affects the expression of IFNAR1 mRNA16756086
D0150812-Naphthylamine2-Naphthylamine results in decreased expression of IFNAR1 mRNA18247414
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of IFNAR1 mRNA24449571
C547126AZM551248AZM551248 results in increased expression of IFNAR1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IFNAR1 mRNA18247414
C006780bisphenol Abisphenol A results in increased expression of IFNAR1 mRNA25181051
D002994ClofibrateClofibrate results in decreased expression of IFNAR1 mRNA17585979
D003474CurcuminCurcumin promotes the reaction [IFNA1 protein results in increased expression of IFNAR1 protein]17979888
D003474CurcuminCurcumin promotes the reaction [IFNB1 protein results in increased expression of IFNAR1 protein]17979888
D016572CyclosporineCyclosporine results in decreased expression of IFNAR1 mRNA25562108
C007262deoxynivalenoldeoxynivalenol results in decreased expression of IFNAR1 mRNA17090620
D018120FinasterideFinasteride results in decreased expression of IFNAR1 mRNA24136188
D005472FluorouracilFluorouracil results in increased expression of IFNAR1 mRNA17088986
D005472FluorouracilFluorouracil results in increased expression of IFNAR1 protein17088986
D005485FlutamideFlutamide results in decreased expression of IFNAR1 mRNA24136188
D019833GenisteinGenistein results in decreased expression of IFNAR1 mRNA22228119
D005839GentamicinsGentamicins results in decreased expression of IFNAR1 mRNA22061828
D005839GentamicinsGentamicins results in increased expression of IFNAR1 mRNA22061828
D017313FenretinideFenretinide results in increased expression of IFNAR1 mRNA28973697
C492448ICG 001ICG 001 results in increased expression of IFNAR1 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IFNAR1 mRNA25613284
D008070LipopolysaccharidesIFNAR1 protein affects the reaction [Lipopolysaccharides results in increased activity of STAT3 protein]21586572
C027451methylaminemethylamine inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of IFNAR1 protein]18722370
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of IFNAR1 mRNA28001369
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of IFNAR1 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of IFNAR1 mRNA"25554681
D009532NickelNickel results in decreased expression of IFNAR1 mRNA23195993
D009538NicotineNicotine results in decreased expression of IFNAR1 mRNA18247414
D011794QuercetinQuercetin results in decreased expression of IFNAR1 mRNA21632981
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of IFNAR1 mRNA21427059
C009277sodium arsenatesodium arsenate results in increased expression of IFNAR1 mRNA21795629
D013467SulindacSulindac results in decreased expression of IFNAR1 mRNA24136188
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IFNAR1 mRNA25613284
D014028Tobacco Smoke Pollutionmethylamine inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of IFNAR1 protein]18722370
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of IFNAR1 protein18722370
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased ubiquitination of and results in increased degradation of IFNAR1 protein modified form18722370
D014635Valproic AcidValproic Acid results in increased expression of IFNAR1 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of IFNAR1 mRNA21427059
C025643vinclozolinvinclozolin results in increased expression of IFNAR1 mRNA20566332
D015032ZincZinc results in decreased expression of IFNAR1 mRNA18316168

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004896cytokine receptor activity-IBA21873635  
GO:0004905type I interferon receptor activity-IDA7665574  
GO:0005515protein binding-IPI7665574  8605876  9121453  9677371  12220192  14532120  
GO:0019962type I interferon binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007259JAK-STAT cascade-TAS7665574  
GO:0009615response to virus-TAS2153461  
GO:0019221cytokine-mediated signaling pathway-IBA21873635  
GO:0032496response to lipopolysaccharide-ISS-  
GO:0035457cellular response to interferon-alpha-ISS-  
GO:0060337type I interferon signaling pathway-IDA7665574  
GO:0060337type I interferon signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005764lysosome-IEA-  
GO:0005770late endosome-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IDA14532120  
GO:0016021integral component of membrane-IBA21873635  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04380Osteoclast differentiation
hsa04620Toll-like receptor signaling pathway
hsa04630Jak-STAT signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa05160Hepatitis C
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-909733Interferon alpha/beta signalingTAS
R-HSA-909733Interferon alpha/beta signalingIEA
R-HSA-912694Regulation of IFNA signalingTAS
R-HSA-912694Regulation of IFNA signalingIEA
R-HSA-913531Interferon SignalingTAS
R-HSA-913531Interferon SignalingIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
18722370Cigarette smoking products suppress anti-viral effects of Type I interferon via phosphorylation-dependent downregulation of its receptor. (2008 Sep 22)HuangFu WCFEBS Lett
27980621Analysis of gene expression to predict dynamics of future hypertension incidence in type 2 diabetic patients. (2016)Radkowski PBMC Proc