Gene info: ID 345611

Gene: IRGM

GENE ID: 345611

Synonyms: IFI1|IRGM1|LRG-47|LRG47

Description: immunity related GTPase M

Gene type: protein-coding

Location: 5q33.1

dbXrefs: Ensembl:ENSG00000237693 MIM:608212 Vega:OTTHUMG00000163647 UniprotKB:A1A4Y4

RefSeq: NG_027809.2

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 5

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.539e-3 (AD) 9.743e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
MROH9	0.656
KRT73	0.655
GPR18	0.65
IGF2BP3	0.647
OR51I2	0.647
TPO	0.623
IYD	0.605
CSRP3	0.584
TTN	0.575
FOXE1	0.574

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
WFDC1	-0.343
TMEM221	-0.326
WIF1	-0.326
HDDC3	-0.324
CYP46A1	-0.311
C9orf24	-0.308
CYS1	-0.308
ASPDH	-0.3
NTSR2	-0.293
TBC1D10A	-0.286

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C046760	15-acetyldeoxynivalenol	15-acetyldeoxynivalenol results in increased expression of IRGM mRNA	23792671
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of IRGM mRNA"	21346803
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of IRGM mRNA"	21346803
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in decreased expression of IRGM mRNA	19191707
C029370	4-toluidine	4-toluidine results in decreased expression of IRGM mRNA	27638505
D000082	Acetaminophen	Acetaminophen affects the expression of IRGM mRNA	17562736
D020106	Acrylamide	Acrylamide results in increased expression of IRGM mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of IRGM mRNA	19770486
D019324	beta-Naphthoflavone	AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of IRGM mRNA]	22234961
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in decreased expression of IRGM mRNA	22234961
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of IRGM mRNA	19770486
C006780	bisphenol A	bisphenol A results in increased expression of IRGM mRNA	25181051
D002065	Buspirone	Buspirone results in decreased expression of IRGM mRNA	24136188
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of IRGM mRNA	14729362\|1500399
C018475	butyraldehyde	butyraldehyde results in increased expression of IRGM mRNA	26079696
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of IRGM mRNA	25993096
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of IRGM mRNA	23650126
D002737	Chloroprene	Chloroprene results in decreased expression of IRGM mRNA	23125180
D002922	Ciguatoxins	Ciguatoxins affects the expression of IRGM mRNA	18353800
D003471	Cuprizone	Cuprizone results in increased expression of IRGM mRNA	26577399\|2752363
D016572	Cyclosporine	Cyclosporine results in decreased expression of IRGM mRNA	19770486
C014476	diethyl maleate	diethyl maleate results in decreased expression of IRGM mRNA	21161181
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide affects the expression of IRGM mRNA	24834073
D005485	Flutamide	Flutamide results in decreased expression of IRGM mRNA	24793618
D005839	Gentamicins	Gentamicins results in increased expression of IRGM mRNA	22061828
C049864	ginsenoside Re	ginsenoside Re results in decreased expression of IRGM protein	20230918
D017313	Fenretinide	Fenretinide results in increased expression of IRGM mRNA	28973697
C016517	indole-3-carbinol	indole-3-carbinol affects the expression of IRGM mRNA	21396975
C523799	MRK 003	IRGM results in decreased susceptibility to MRK 003	19903844
C051752	nefazodone	nefazodone results in decreased expression of IRGM mRNA	24136188
D019829	Nevirapine	Nevirapine results in decreased expression of IRGM mRNA	23947594
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of IRGM mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of IRGM mRNA	25729387
D010081	Oxazolone	Oxazolone results in increased expression of IRGM mRNA	21893156
C006253	pirinixic acid	pirinixic acid results in decreased expression of IRGM mRNA	18445702
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of IRGM mRNA	23608068
C045950	propiconazole	propiconazole results in increased expression of IRGM mRNA	21278054
C005556	propionaldehyde	propionaldehyde results in increased expression of IRGM mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in increased expression of IRGM mRNA	24780913
D012999	Soman	Soman results in increased expression of IRGM mRNA	19281266
D013629	Tamoxifen	Tamoxifen affects the expression of IRGM mRNA	20937368
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in increased expression of IRGM mRNA	28970181
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of IRGM mRNA	22808131
C009495	titanium dioxide	titanium dioxide results in decreased expression of IRGM mRNA	27760801
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of IRGM mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of IRGM mRNA	25729387
C012589	trichostatin A	trichostatin A affects the expression of IRGM mRNA	28542535
C015559	trimellitic anhydride	trimellitic anhydride results in increased expression of IRGM mRNA	21893156
D014635	Valproic Acid	Valproic Acid results in increased methylation of IRGM gene	29154799
D014640	Vancomycin	Vancomycin results in decreased expression of IRGM mRNA	18930951
C025643	vinclozolin	vinclozolin results in increased expression of IRGM mRNA	22570695

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003924	GTPase activity	-	IBA	21873635
GO:0005515	protein binding	-	IPI	25891078
GO:0005525	GTP binding	-	IEA	-
GO:0016787	hydrolase activity	-	IEA	-
GO:0019901	protein kinase binding	-	IPI	25891078
GO:0043539	protein serine/threonine kinase activator activity	-	IMP	28389568
GO:0050700	CARD domain binding	-	IMP	25891078
GO:0051434	BH3 domain binding	-	IMP	25891078

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000045	autophagosome assembly	-	IMP	16888103
GO:0001934	positive regulation of protein phosphorylation	-	IMP	28389568
GO:0006952	defense response	-	IBA	21873635
GO:0006954	inflammatory response	-	IEA	-
GO:0010508	positive regulation of autophagy	-	IMP	25891078
GO:0010800	positive regulation of peptidyl-threonine phosphorylation	-	IMP	25891078
GO:0031648	protein destabilization	-	IMP	25891078
GO:0033138	positive regulation of peptidyl-serine phosphorylation	-	IMP	25891078
GO:0035458	cellular response to interferon-beta	-	IBA	21873635
GO:0042742	defense response to bacterium	-	IMP	16888103
GO:0043254	regulation of protein complex assembly	-	IMP	25891078
GO:0045087	innate immune response	-	IMP	16888103
GO:0050821	protein stabilization	-	IMP	25891078
GO:0050829	defense response to Gram-negative bacterium	-	IMP	25891078
GO:0060335	positive regulation of interferon-gamma-mediated signaling pathway	-	IMP	16888103
GO:0061635	regulation of protein complex stability	-	IMP	25891078
GO:0061739	protein lipidation involved in autophagosome assembly	-	IMP	28389568
GO:0061762	CAMKK-AMPK signaling cascade	-	IMP	25891078
GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	-	IMP	25891078
GO:0071222	cellular response to lipopolysaccharide	-	IMP	25891078
GO:0071902	positive regulation of protein serine/threonine kinase activity	-	IMP	28389568
GO:0075044	autophagy of host cells involved in interaction with symbiont	-	IMP	16888103 28389568
GO:0098586	cellular response to virus	-	IMP	28389568
GO:1901098	positive regulation of autophagosome maturation	-	IMP	16888103

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000139	Golgi membrane	-	IDA	28389568
GO:0000421	autophagosome membrane	-	IEA	-
GO:0001891	phagocytic cup	-	IEA	-
GO:0005739	mitochondrion	-	IDA	25891078 28389568
GO:0005789	endoplasmic reticulum membrane	-	IBA	21873635
GO:0005794	Golgi apparatus	-	IDA	28389568
GO:0005829	cytosol	-	IDA	25891078
GO:0030670	phagocytic vesicle membrane	-	IEA	-
GO:0042995	cell projection	-	IEA	-

KEGG ID	KEGG Term
hsa05145	Toxoplasmosis

Reactome ID	Reactome Term	Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22228152	Mutations in IRGM are associated with more frequent need for surgery in patients with ileocolonic Crohn's disease. (2012 Feb)	Sehgal R	Dis Colon Rectum
19953089	Differences in genetic background between active smokers, passive smokers, and non-smokers with Crohn's disease. (2010 May)	van der Heide F	Am J Gastroenterol
28983640	A haplotypic variant at the IRGM locus and rs11747270 are related to the susceptibility for chronic periodontitis. (2018 Feb)	Folwaczny M	Inflamm Res
22158027	Clinical and genetic risk factors for perianal Crohn's disease in a population-based cohort. (2012 Apr)	Eglinton TW	Am J Gastroenterol
29434451	Impaired granulocyte-macrophage colony-stimulating factor bioactivity accelerates surgical recurrence in ileal Crohn's disease. (2018 Feb 7)	Gathungu G	World J Gastroenterol