Gene: IFNGR1

3459
CD119|IFNGR|IMD27A|IMD27B
interferon gamma receptor 1
protein-coding
6q23.3
Ensembl:ENSG00000027697 MIM:107470 Vega:OTTHUMG00000015656 UniprotKB:P15260
NG_007394.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.590e-2 (AD)  1.906e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PAK20.839
LBR0.838
GINM10.824
BNIP20.821
MCMBP0.821
PTPN120.816
CALCOCO20.815
HAT10.811
H3F3B0.808
LMAN10.808

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.55
OR4F5-0.537
OPRD1-0.325
ABCC12-0.312
WNT7A-0.309
KCNG1-0.309
LYPD8-0.304
CYP1A1-0.3
ADRA1D-0.295
MARCH4-0.285

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00033Interferon gamma-1bBiotechDrug98059-61-1Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of IFNGR1 mRNA"19162173
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of IFNGR1 mRNA19933214
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of IFNGR1 mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of IFNGR1 mRNA"25380136
D000082AcetaminophenAcetaminophen results in decreased expression of IFNGR1 mRNA27761495
D000082AcetaminophenAcetaminophen results in increased expression of IFNGR1 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of IFNGR1 mRNA17562736
D000171AcroleinAcrolein results in increased expression of IFNGR1 mRNA18515264
D020106AcrylamideAcrylamide results in increased expression of IFNGR1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of IFNGR1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of IFNGR1 mRNA27153756
D000393Air PollutantsAir Pollutants results in decreased expression of IFNGR1 protein19269302
C103303alitretinoinalitretinoin results in increased expression of IFNGR1 protein16085646
C068073Am 580Am 580 results in increased expression of IFNGR1 protein16085646
C068073Am 580Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of IFNGR1 protein]16085646
D000643Ammonium ChlorideAmmonium Chloride affects the expression of IFNGR1 mRNA16483693
D000666Amphotericin BAmphotericin B results in increased expression of IFNGR112803856
D000967Antimony Sodium GluconateAntimony Sodium Gluconate results in increased expression of IFNGR1 mRNA12803856
D000967Antimony Sodium GluconateAntimony Sodium Gluconate results in increased expression of IFNGR1 protein12803856
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of IFNGR1 mRNA25339124
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of IFNGR1 mRNA24449571
C487081belinostatbelinostat results in increased expression of IFNGR1 mRNA19606018
D001554BenzeneBenzene results in increased expression of IFNGR1 mRNA15929907
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IFNGR1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IFNGR1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of IFNGR1 mRNA"19150397
C095105bexarotenebexarotene results in increased expression of IFNGR1 mRNA16648578
C006780bisphenol Abisphenol A results in decreased expression of IFNGR1 mRNA20678512|2257669
C006780bisphenol Abisphenol A results in increased methylation of IFNGR1 gene22576693
C006780bisphenol Abisphenol A results in increased expression of IFNGR1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of IFNGR1 promoter22457795
C058667cadmium selenide[cadmium selenide co-treated with zinc sulfide] affects the expression of IFNGR1 mRNA22342292
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of IFNGR1 mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of IFNGR1 mRNA12734012
D019327Copper SulfateCopper Sulfate results in increased expression of IFNGR1 mRNA19549813
D003520CyclophosphamideCyclophosphamide results in decreased expression of IFNGR1 mRNA21041162
C007262deoxynivalenoldeoxynivalenol inhibits the reaction [IFNG protein results in increased expression of IFNGR1 protein]19549553
C007262deoxynivalenoldeoxynivalenol results in decreased expression of IFNGR1 mRNA17090620
D003907DexamethasoneDexamethasone inhibits the reaction [Lipopolysaccharides results in decreased expression of IFNGR1 mRNA]22185406
D003907DexamethasoneDexamethasone results in decreased expression of IFNGR1 mRNA21041162|2218540
C000944dicrotophosdicrotophos results in decreased expression of IFNGR1 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of IFNGR1 mRNA18042831
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of IFNGR1 mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of IFNGR1 mRNA19638242
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of IFNGR1 mRNA21041162
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of IFNGR1 mRNA25380136
D004121Dimethyl SulfoxideDimethyl Sulfoxide inhibits the reaction [IL1B protein results in increased expression of IFNGR1 mRNA]21878375
D004237DiuronDiuron results in decreased expression of IFNGR1 mRNA25152437
D004391DustDust results in decreased expression of IFNGR1 mRNA17805423
D004785Environmental PollutantsEnvironmental Pollutants affects the expression of IFNGR1 mRNA19118595
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IFNGR1 mRNA17942748
D005485FlutamideFlutamide results in decreased expression of IFNGR1 mRNA24136188
D005557FormaldehydeFormaldehyde results in decreased expression of IFNGR1 mRNA23649840
D037741FullerenesFullerenes analog results in increased expression of IFNGR1 mRNA22342292
D017313FenretinideFenretinide results in decreased expression of IFNGR1 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of IFNGR1 mRNA20044591
C492448ICG 001ICG 001 results in increased expression of IFNGR1 mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IFNGR1 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of IFNGR1 mRNA25961927
D007649KetamineKetamine results in increased expression of IFNGR1 mRNA20080153
C045463leflunomideleflunomide results in increased expression of IFNGR1 mRNA28988120
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of IFNGR1 mRNA21878375
D008070LipopolysaccharidesDexamethasone inhibits the reaction [Lipopolysaccharides results in decreased expression of IFNGR1 mRNA]22185406
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of IFNGR1 mRNA22185406
D008070LipopolysaccharidesQuercetin inhibits the reaction [Lipopolysaccharides results in decreased expression of IFNGR1 mRNA]22185406
D008070Lipopolysaccharides"tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of IFNGR1 mRNA]"22185406
D008070Lipopolysaccharides[TNF protein co-treated with IL1B protein co-treated with IFNG protein co-treated with Lipopolysaccharides] results in increased expression of IFNGR1 mRNA20816778
C018091maduramicinmaduramicin results in decreased expression of IFNGR1 mRNA29128925
D008345ManganeseManganese results in increased expression of IFNGR1 mRNA18284614
D008628MercuryIFNGR1 affects the susceptibility to Mercury22578563
D008727MethotrexateMethotrexate results in increased expression of IFNGR1 mRNA21678067
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of IFNGR1 mRNA23649840
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of IFNGR1 protein24625837
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of IFNGR1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of IFNGR1 mRNA"25554681
D009281NaphthalenesNaphthalenes results in decreased expression of IFNGR1 protein17337753
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of IFNGR1 mRNA25380136
C022838nickel chloridenickel chloride results in increased expression of IFNGR1 mRNA17312168
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of IFNGR1 mRNA"19013360
D000073878Palm OilPalm Oil results in decreased expression of IFNGR1 mRNA18042831
D010419PentamidinePentamidine results in increased expression of IFNGR1 mRNA12803856
D010419PentamidinePentamidine results in increased expression of IFNGR1 protein12803856
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of IFNGR1 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of IFNGR1 mRNA19482888
D010672PhenytoinPhenytoin results in increased expression of IFNGR1 mRNA14741686
C006253pirinixic acidpirinixic acid results in increased expression of IFNGR1 mRNA18301758
D011374ProgesteroneProgesterone results in decreased expression of IFNGR1 mRNA21540246
D011374ProgesteroneProgesterone results in increased expression of IFNGR1 mRNA18692832
C010313pseudocumenepseudocumene results in decreased expression of IFNGR1 protein17337753
D011794QuercetinQuercetin inhibits the reaction [Lipopolysaccharides results in decreased expression of IFNGR1 mRNA]22185406
D011794QuercetinQuercetin results in decreased expression of IFNGR1 mRNA22185406
C084904Ro 41-5253Ro 41-5253 inhibits the reaction [Am 580 results in increased expression of IFNGR1 protein]16085646
D012822Silicon DioxideSilicon Dioxide results in decreased expression of IFNGR1 mRNA25351596
D012834SilverSilver results in increased expression of IFNGR1 mRNA22342292
C017947sodium arsenitesodium arsenite results in increased expression of IFNGR1 mRNA12016162
D012999SomanSoman results in decreased expression of IFNGR1 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of IFNGR1 mRNA12377990
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IFNGR1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IFNGR1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of IFNGR1 mRNA19933214|2104116
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IFNGR1 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of IFNGR1 mRNA22342292
C082097tocotrienol, delta"tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of IFNGR1 mRNA]"22185406
C082097tocotrienol, delta"tocotrienol, delta results in decreased expression of IFNGR1 mRNA"22185406
D014212TretinoinTretinoin results in increased expression of IFNGR1 protein16085646
D014241TrichloroethylenePPARA protein inhibits the reaction [Trichloroethylene results in decreased expression of IFNGR1 mRNA]15363585
C057693troglitazone[troglitazone co-treated with TNF protein] results in increased expression of IFNGR1 mRNA12732648
D014635Valproic AcidValproic Acid results in decreased expression of IFNGR1 mRNA23179753
D014635Valproic AcidValproic Acid results in decreased methylation of IFNGR1 gene29154799
C066075vanadium pentoxidevanadium pentoxide results in decreased expression of IFNGR1 mRNA17459161
D014640VancomycinVancomycin results in decreased expression of IFNGR1 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of IFNGR1 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of IFNGR1 mRNA23034163
C029297vinylidene chloridevinylidene chloride results in increased expression of IFNGR1 mRNA26682919
D019287Zinc SulfateZinc Sulfate results in increased expression of IFNGR1 mRNA19013360
C031238zinc sulfide[cadmium selenide co-treated with zinc sulfide] affects the expression of IFNGR1 mRNA22342292
C088658zoledronic acidzoledronic acid results in increased expression of IFNGR1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004896cytokine receptor activity-IBA21873635  
GO:0004906interferon-gamma receptor activity-TAS2971451  
GO:0005515protein binding-IPI7617032  8156998  8662591  11250200  15780933  
GO:0019955cytokine binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-TAS2971451  
GO:0009615response to virus-TAS2954953  
GO:0019221cytokine-mediated signaling pathway-IBA21873635  
GO:0060333interferon-gamma-mediated signaling pathway-TAS-  
GO:0060334regulation of interferon-gamma-mediated signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS2971451  
GO:0016021integral component of membrane-IBA21873635  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04380Osteoclast differentiation
hsa04630Jak-STAT signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa05140Leishmaniasis
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-877300Interferon gamma signalingTAS
R-HSA-877300Interferon gamma signalingIEA
R-HSA-877312Regulation of IFNG signalingIEA
R-HSA-877312Regulation of IFNG signalingTAS
R-HSA-913531Interferon SignalingTAS
R-HSA-913531Interferon SignalingIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
14763782Polymorphisms in an interferon-gamma receptor-1 gene marker and susceptibility to periodontitis. (2003 Oct)Fraser DAActa Odontol Scand
21859832Interferon-signaling pathway: associations with colon and rectal cancer risk and subsequent survival. (2011 Nov)Slattery MLCarcinogenesis