Gene: ECT2L

345930
ARHGEF32|C6orf91|FBXO49|LFDH|dJ509I19.2|dJ509I19.3|dJ509I19.5
epithelial cell transforming 2 like
protein-coding
6q24.1
Ensembl:ENSG00000203734 Vega:OTTHUMG00000015679 UniprotKB:Q008S8
NC_000006.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.524e-1 (AD)  5.465e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10499204chr6:138895289 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GAN0.558
DNAH70.539
DENND4C0.527
ATAD50.527
CD1090.52
RIPK10.514
TCF7L20.511
STK38L0.51
TOR1AIP20.509
ACOX10.507

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CBY3-0.256
FAM19A4-0.234
ZBTB12-0.232
S1PR5-0.229
CPLX3-0.22
CRHBP-0.207
FIBCD1-0.202
HOXD1-0.2
NXPH4-0.196
OR4F5-0.196

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ECT2L mRNA21354282

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005089Rho guanyl-nucleotide exchange factor activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0035023regulation of Rho protein signal transduction-IEA-  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal