Gene: APOC4

346
APO-CIV|APOC-IV
apolipoprotein C4
protein-coding
19q13.32
Ensembl:ENSG00000267467 MIM:600745 Vega:OTTHUMG00000180845 UniprotKB:P55056
NC_000019.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHRNB40.686
CLEC5A0.673
TSLP0.653
CD1800.646
TREML40.643
LRRC150.64
POU4F10.638
RBM470.633
PTPN70.626
PLEK20.622

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PVALB-0.337
RAB37-0.328
PRSS16-0.302
TBR1-0.301
MLIP-0.296
RPH3A-0.293
KCNJ3-0.292
NCALD-0.291
ZNF385B-0.291
CYP4A11-0.289

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of APOC4 mRNA26690555
D000082AcetaminophenAcetaminophen affects the expression of APOC4 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of APOC4 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of APOC4 mRNA16483693
C006780bisphenol Abisphenol A results in increased expression of APOC4 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of APOC4 mRNA24768697|2518105
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of APOC4 promoter22457795
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of APOC4 mRNA15963342
D002635Chenodeoxycholic AcidChenodeoxycholic Acid results in decreased expression of APOC4 mRNA27174168
D002746Chlorpromazine[Chlorpromazine co-treated with Cholic Acids] affects the expression of APOC4 mRNA27344345
D002793Cholic Acids[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of APOC4 mRNA27344345
D002793Cholic Acids[Chlorpromazine co-treated with Cholic Acids] affects the expression of APOC4 mRNA27344345
D002793Cholic Acids[Cyclosporine co-treated with Cholic Acids] affects the expression of APOC4 mRNA27344345
D002994ClofibrateClofibrate results in decreased expression of APOC4 mRNA17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of APOC4 mRNA24386269
D016572Cyclosporine[Cyclosporine co-treated with Cholic Acids] affects the expression of APOC4 mRNA27344345
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of APOC4 mRNA17108234
C056933fumonisin B1fumonisin B1 results in decreased expression of APOC4 mRNA16221962
C039281furanfuran results in decreased expression of APOC4 mRNA25539665|2619464
D017313FenretinideFenretinide results in decreased expression of APOC4 mRNA16671099
D008095Lithocholic AcidLithocholic Acid results in decreased expression of APOC4 mRNA20359477
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of APOC4 mRNA28001369
D0150581-Naphthylisothiocyanate[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of APOC4 mRNA27344345
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of APOC4 mRNA18281256
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of APOC4 mRNA17681415
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of APOC4 mRNA19162173
C006253pirinixic acidpirinixic acid results in decreased expression of APOC4 mRNA19162173
D010936Plant ExtractsPlant Extracts results in decreased expression of APOC4 mRNA23557933
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of APOC4 mRNA19162173
D011374ProgesteroneProgesterone results in decreased expression of APOC4 mRNA18037150
D011441PropylthiouracilPropylthiouracil results in increased expression of APOC4 mRNA24780913
D012524SarinSarin results in increased expression of APOC4 mRNA19522546
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of APOC4 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of APOC4 mRNA21215274
D013853ThioacetamideThioacetamide results in decreased expression of APOC4 mRNA23411599
C057693troglitazone[troglitazone co-treated with TNF protein] results in decreased expression of APOC4 mRNA12732648
C406224valdecoxibvaldecoxib results in decreased expression of APOC4 mRNA24136188

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005319lipid transporter activity-TAS8530039  
GO ID GO Term Qualifier Evidence PubMed
GO:0006629lipid metabolic process-TAS8530039  
GO:0006869lipid transport-IEA-  
GO:0010890positive regulation of sequestering of triglyceride-IBA21873635  
GO:0010890positive regulation of sequestering of triglyceride-IMP18809223  
GO:0034379very-low-density lipoprotein particle assembly-TAS-  
GO:0034447very-low-density lipoprotein particle clearance-TAS-  
GO:0070328triglyceride homeostasis-IBA21873635  
GO:0070328triglyceride homeostasis-IMP8827523  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0034361very-low-density lipoprotein particle-IBA21873635  
GO:0034361very-low-density lipoprotein particle-IDA12700345  17154273  
GO:0034361very-low-density lipoprotein particle-IMP8827523  
GO:0034364high-density lipoprotein particle-IBA21873635  
GO:0034364high-density lipoprotein particle-IDA12700345  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-174824Plasma lipoprotein assembly, remodeling, and clearanceTAS
R-HSA-174824Plasma lipoprotein assembly, remodeling, and clearanceIEA
R-HSA-382551Transport of small moleculesTAS
R-HSA-382551Transport of small moleculesIEA
R-HSA-8866423VLDL assemblyTAS
R-HSA-8963898Plasma lipoprotein assemblyTAS
R-HSA-8964043Plasma lipoprotein clearanceIEA
R-HSA-8964043Plasma lipoprotein clearanceTAS
R-HSA-8964046VLDL clearanceIEA
R-HSA-8964046VLDL clearanceTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22003152Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies. (2012 Jan)Grallert HEur Heart J