Gene: IFNGR2

3460
AF-1|IFGR2|IFNGT1|IMD28
interferon gamma receptor 2
protein-coding
21q22.11
Ensembl:ENSG00000159128 MIM:147569 Vega:OTTHUMG00000065188 UniprotKB:P38484
NG_007570.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.406e-2 (AD)  6.961e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CTSB0.885
RPN10.882
KARS0.879
YIPF10.877
DERL10.87
KDELR20.87
CCT80.869
LDHA0.868
ADPGK0.868
MLX0.866

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.671
OR4F29-0.629
C16orf96-0.236
OR2A14-0.234
PRSS48-0.233
PRAMEF17-0.229
HES5-0.221
PDE11A-0.221
OR10K1-0.22
ZNF98-0.217

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00033Interferon gamma-1bBiotechDrug98059-61-1Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of IFNGR2 mRNA"21346803
C0261142-xylene2-xylene results in increased expression of IFNGR2 mRNA20359517
D000082AcetaminophenAcetaminophen results in decreased expression of IFNGR2 mRNA21420995
D000171AcroleinAcrolein results in increased expression of IFNGR2 mRNA18515264
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of IFNGR2 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of IFNGR2 mRNA24449571
D001151ArsenicArsenic affects the methylation of IFNGR2 gene25304211
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of IFNGR2 mRNA"24160326
D001554BenzeneBenzene results in increased expression of IFNGR2 mRNA20359517
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of IFNGR2 mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of IFNGR2 mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of IFNGR2 mRNA25181051
C028031cadmium acetatecadmium acetate results in decreased expression of IFNGR2 mRNA18155341
C058667cadmium selenide[cadmium selenide co-treated with zinc sulfide] results in increased expression of IFNGR2 mRNA22342292
D002273CarcinogensCarcinogens results in decreased expression of IFNGR2 mRNA22269147
D000068579CelecoxibCelecoxib results in increased expression of IFNGR2 mRNA28201806
C100187chloropicrinchloropicrin results in decreased expression of IFNGR2 mRNA26352163
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of IFNGR220938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of IFNGR2 gene20938992
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of IFNGR2 mRNA28472532
D003300Copper[Disulfiram binds to Copper] which results in increased expression of IFNGR2 mRNA24690739
D019327Copper SulfateCopper Sulfate results in increased expression of IFNGR2 mRNA19549813
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of IFNGR2 mRNA21266533
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of IFNGR2 mRNA24690739
D004237DiuronDiuron results in decreased expression of IFNGR2 mRNA21551480
D004317DoxorubicinDoxorubicin results in decreased expression of IFNGR2 mRNA21040762
D004317Doxorubicin[[MT1 protein co-treated with MT2 protein] affects the susceptibility to Doxorubicin] which affects the expression of IFNGR2 mRNA21040762
D004391DustDust results in increased expression of IFNGR2 mRNA17805423
C044101endotoxin, Escherichia coli"endotoxin, Escherichia coli results in increased expression of IFNGR2 mRNA"15919760
C004912ethylbenzeneethylbenzene results in increased expression of IFNGR2 mRNA20359517
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of IFNGR220938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of IFNGR2 gene20938992
D037741FullerenesFullerenes analog affects the expression of IFNGR2 mRNA22342292
D005839GentamicinsGentamicins results in increased expression of IFNGR2 mRNA22061828
C492448ICG 001ICG 001 results in increased expression of IFNGR2 mRNA26191083
D007213IndomethacinIndomethacin results in increased expression of IFNGR2 mRNA28201806
D015759Ionomycinpyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNGR2 mRNA]15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNGR2 mRNA15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IFNGR2 mRNA25613284
D007545IsoproterenolIsoproterenol results in decreased expression of IFNGR2 mRNA20003209
C410337K 7174K 7174 results in increased expression of IFNGR2 mRNA24086573
D007649KetamineKetamine results in increased expression of IFNGR2 mRNA20080153
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of IFNGR2 mRNA12057914|1591976
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of IFNGR2 mRNA25613284
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of IFNGR220938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of IFNGR2 gene20938992
D008731MethoxychlorMethoxychlor results in increased methylation of IFNGR2 gene23303685
D008752Methylene ChlorideMethylene Chloride results in increased expression of IFNGR2 mRNA20359517
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of IFNGR2 mRNA"20188158
D009153MutagensMutagens results in decreased expression of IFNGR2 mRNA22269147
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of IFNGR2 mRNA"29244179
C022838nickel chloridenickel chloride results in increased expression of IFNGR2 mRNA17312168
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of IFNGR2 mRNA"12756304
D010672PhenytoinPhenytoin results in increased expression of IFNGR2 mRNA14741686
C006253pirinixic acidpirinixic acid results in increased expression of IFNGR2 mRNA18301758|2381119
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNGR2 mRNA]15477007
D011794QuercetinQuercetin results in decreased expression of IFNGR2 mRNA15309432
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of IFNGR2 mRNA19059307
D017632Asbestos, Serpentine"Asbestos, Serpentine affects the expression of IFNGR2 mRNA"24160326
D012822Silicon DioxideSilicon Dioxide results in increased expression of IFNGR2 mRNA23221170
D012834SilverSilver results in decreased expression of IFNGR2 mRNA27131904
D013629Tamoxifen[Tamoxifen co-treated with ESR2 protein] results in increased expression of IFNGR2 mRNA19059307
D013739TestosteroneTestosterone results in decreased expression of IFNGR2 mRNA20403060
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of IFNGR2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of IFNGR2 mRNA25975270
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of IFNGR2 mRNA28973375
D013755Tetradecanoylphorbol Acetatepyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNGR2 mRNA]15477007
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNGR2 mRNA15477007
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of IFNGR2 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of IFNGR2 mRNA22342292
C009495titanium dioxidetitanium dioxide analog results in increased expression of IFNGR2 mRNA25111187
C009495titanium dioxidetitanium dioxide results in increased expression of IFNGR2 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of IFNGR2 mRNA22363418
D014050TolueneToluene results in increased expression of IFNGR2 mRNA20359517
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in increased expression of IFNGR2 mRNA"19647056
D014118Toxins, Biological"Toxins, Biological affects the expression of IFNGR2 mRNA"19682533
D014241TrichloroethyleneTrichloroethylene results in increased expression of IFNGR2 mRNA20359517
C012589trichostatin Atrichostatin A affects the expression of IFNGR2 mRNA28542535
D014635Valproic AcidValproic Acid affects the expression of IFNGR2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of IFNGR2 mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of IFNGR2 gene29154799
C031238zinc sulfide[cadmium selenide co-treated with zinc sulfide] results in increased expression of IFNGR2 mRNA22342292

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004896cytokine receptor activity-IBA21873635  
GO:0004906interferon-gamma receptor activity-TAS9616207  
GO ID GO Term Qualifier Evidence PubMed
GO:0007166cell surface receptor signaling pathway-TAS9616207  
GO:0009615response to virus-TAS8124716  
GO:0019221cytokine-mediated signaling pathway-IBA21873635  
GO:0060333interferon-gamma-mediated signaling pathway-TAS-  
GO:0060334regulation of interferon-gamma-mediated signaling pathway-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005783endoplasmic reticulum-HDA16780588  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005886plasma membrane-HDA16780588  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-TAS8910544  
GO:0016021integral component of membrane-IBA21873635  
GO:0030659cytoplasmic vesicle membrane-IEA-  
KEGG ID KEGG Term
hsa04060Cytokine-cytokine receptor interaction
hsa04380Osteoclast differentiation
hsa04630Jak-STAT signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa05140Leishmaniasis
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
Reactome ID Reactome Term Evidence
R-HSA-1280215Cytokine Signaling in Immune systemTAS
R-HSA-1280215Cytokine Signaling in Immune systemIEA
R-HSA-168256Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-877300Interferon gamma signalingTAS
R-HSA-877300Interferon gamma signalingIEA
R-HSA-877312Regulation of IFNG signalingIEA
R-HSA-877312Regulation of IFNG signalingTAS
R-HSA-913531Interferon SignalingTAS
R-HSA-913531Interferon SignalingIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21859832Interferon-signaling pathway: associations with colon and rectal cancer risk and subsequent survival. (2011 Nov)Slattery MLCarcinogenesis